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Protein

Target of rapamycin complex 2 subunit BIT61

Gene

BIT61

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway.1 Publication

GO - Biological processi

  • establishment or maintenance of actin cytoskeleton polarity Source: SGD
  • fungal-type cell wall organization Source: SGD
  • regulation of cell growth Source: SGD
  • TORC2 signaling Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31521-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Target of rapamycin complex 2 subunit BIT61
Short name:
TORC2 subunit BIT61
Alternative name(s):
61 kDa binding partner of TOR2 protein
Gene namesi
Name:BIT61
Ordered Locus Names:YJL058C
ORF Names:J1141
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL058C.
SGDiS000003594. BIT61.

Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: SGD
  • TORC2 complex Source: SGD
  • vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002030601 – 543Target of rapamycin complex 2 subunit BIT61Add BLAST543

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58PhosphotyrosineCombined sources1
Modified residuei59PhosphoserineCombined sources1
Modified residuei139PhosphoserineCombined sources1
Modified residuei144PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP47041.
PRIDEiP47041.

PTM databases

iPTMnetiP47041.

Interactioni

Subunit structurei

The target of rapamycin complex 2 (TORC2) is composed of at least AVO1, AVO2, BIT61, LST8, TOR2 and TSC11. TORC2 likely forms a homodimer. Contrary to TORC1, TORC2 does not bind to and is not sensitive to FKBP-rapamycin.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TOR2P326002EBI-25889,EBI-19385

Protein-protein interaction databases

BioGridi33696. 51 interactors.
DIPiDIP-1444N.
IntActiP47041. 18 interactors.
MINTiMINT-388996.

Structurei

3D structure databases

ProteinModelPortaliP47041.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BIT61 family.Curated

Phylogenomic databases

HOGENOMiHOG000095231.
InParanoidiP47041.
OrthoDBiEOG092C1CBW.

Family and domain databases

InterProiIPR013745. Bit61/PRR5.
[Graphical view]
PfamiPF08539. HbrB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47041-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAEDILLRE RTSTTTQRPV NSEQYLNVQL ATAPVKNFQT TSEISRQTLV
60 70 80 90 100
DTSNDDVYSI KNLKGSRNPI SPSVSNVGFQ SIFHTVDHPR SKVSVASNHS
110 120 130 140 150
LRSNDNASAA TSKSGSSQIG ESHSVDTVEC SNNLSKKLSS DAISITQKSL
160 170 180 190 200
HSTPSGRYMK GKASGFFNRR NRAHTTISSD PASFLTDSST LHNSSHSFRN
210 220 230 240 250
VIKNFFQNKS HRHIGQDAIE PAIPNSLSKF LHSSYGRHKS PSQFIHTNAG
260 270 280 290 300
QLVDSGTSVY SLNVNPSGVN PNTIVEDPLS GTDPASPNPV SMLHDLLRNL
310 320 330 340 350
PSLEANYKHF NSQELTTLTN NIWNIFCSNV AELFRTQRIW KLRAKIENFN
360 370 380 390 400
EVLEFYCILK TDPRVTHSGM NRIISDLKEF LVSSLYNLEN QIVFNYSNED
410 420 430 440 450
TINNALKRLG VIWRIFYQEV YYDLAAVLLP LDQSIREDGN STVLKSGNES
460 470 480 490 500
RTHINGNYSI GFLLLMCFRD SIVLPCYENF VNSNDGISKS FQLYIFNQEE
510 520 530 540
ESNVTETDKL TLLQCFGILS TIQSNDRNQR IIEELLAGIR MSI
Length:543
Mass (Da):60,841
Last modified:February 1, 1996 - v1
Checksum:i99F0F96840311F4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49333 Genomic DNA. Translation: CAA89349.1.
AY693068 Genomic DNA. Translation: AAT93087.1.
BK006943 Genomic DNA. Translation: DAA08740.1.
PIRiS56830.
RefSeqiNP_012477.1. NM_001181491.1.

Genome annotation databases

EnsemblFungiiYJL058C; YJL058C; YJL058C.
GeneIDi853388.
KEGGisce:YJL058C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49333 Genomic DNA. Translation: CAA89349.1.
AY693068 Genomic DNA. Translation: AAT93087.1.
BK006943 Genomic DNA. Translation: DAA08740.1.
PIRiS56830.
RefSeqiNP_012477.1. NM_001181491.1.

3D structure databases

ProteinModelPortaliP47041.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33696. 51 interactors.
DIPiDIP-1444N.
IntActiP47041. 18 interactors.
MINTiMINT-388996.

PTM databases

iPTMnetiP47041.

Proteomic databases

MaxQBiP47041.
PRIDEiP47041.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL058C; YJL058C; YJL058C.
GeneIDi853388.
KEGGisce:YJL058C.

Organism-specific databases

EuPathDBiFungiDB:YJL058C.
SGDiS000003594. BIT61.

Phylogenomic databases

HOGENOMiHOG000095231.
InParanoidiP47041.
OrthoDBiEOG092C1CBW.

Enzyme and pathway databases

BioCyciYEAST:G3O-31521-MONOMER.

Miscellaneous databases

PROiP47041.

Family and domain databases

InterProiIPR013745. Bit61/PRR5.
[Graphical view]
PfamiPF08539. HbrB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBIT61_YEAST
AccessioniPrimary (citable) accession number: P47041
Secondary accession number(s): D6VWC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1960 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.