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Protein

Protein BTN1

Gene

YHC3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Plays a role in vacuolar arginine transport. Involved in pH homeostasis. May be involved in ion homeostasis together with IST2. Not necessary for mitochondrial function or ATP synthase degradation.5 Publications

GO - Biological processi

  • arginine transport Source: SGD
  • lysine transport Source: SGD
  • regulation of intracellular pH Source: SGD
  • vacuolar transport Source: GO_Central
  • vacuole organization Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31522-MONOMER.

Protein family/group databases

TCDBi2.A.57.5.2. the equilibrative nucleoside transporter (ent) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BTN1
Gene namesi
Name:YHC3
Synonyms:BTN1
Ordered Locus Names:YJL059W
ORF Names:J1139
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL059W.
SGDiS000003595. YHC3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Transmembranei369 – 389HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000002083631 – 408Protein BTN1Add BLAST378

Interactioni

Protein-protein interaction databases

BioGridi33695. 22 interactors.
DIPiDIP-4761N.
IntActiP47040. 1 interactor.
MINTiMINT-567364.

Structurei

3D structure databases

ProteinModelPortaliP47040.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the battenin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000003249.
HOGENOMiHOG000164765.
InParanoidiP47040.
KOiK12389.
OMAiKHIEKPC.
OrthoDBiEOG092C3EEJ.

Family and domain databases

InterProiIPR003492. Battenin_disease_Cln3.
IPR018460. Battenin_disease_Cln3_subgr.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR10981. PTHR10981. 1 hit.
PfamiPF02487. CLN3. 1 hit.
[Graphical view]
PIRSFiPIRSF015974. CLN3_BTN1. 1 hit.
PRINTSiPR01315. BATTENIN.
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47040-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKSHQIYC YFWLFGLINN VLYVVILSAA VDIVGPTLPK SLVLLADIFP
60 70 80 90 100
SLAIKLCSPF FIDRIKYSYR IWSLITMSCL GMFLVSFKNL FVCLLGISFA
110 120 130 140 150
SISSGFGEVT FLQLTHYYKQ ISLNGWSSGT GGAGIIGGAS YMFLTSIFKV
160 170 180 190 200
PVKLTLLVFS LLPFAFLFYF KLESNDTNLT YQSLQQIDEA EDDQLVPFPV
210 220 230 240 250
AFTHTNASQS LYSTRQHILQ TVKRLRRLVF PYMVPLTTVY LFEYLINQAV
260 270 280 290 300
APTLLFPING DERSKSMPFF FHKYRDIYVT YGTLYQLGVF ISRSFGHLMR
310 320 330 340 350
MRSLYILAFL QGVNLCITVL QSWFYVTHSP WAVMILIFYE GFLGGASYVN
360 370 380 390 400
TFLNILEQED PDETEFAMGA VSIADSFGVF LAALLGLGLE PKLCRHQIAD

DRPWCRME
Length:408
Mass (Da):46,383
Last modified:February 1, 1996 - v1
Checksum:iBAB6891F676E80EE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti162L → P in AAT93158 (PubMed:17322287).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti181Y → F in strain: K289-3A. 1 Publication1
Natural varianti328H → R in strain: K289-3A. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058447 Genomic DNA. Translation: AAC61258.1.
Z49334 Genomic DNA. Translation: CAA89350.1.
AY693139 Genomic DNA. Translation: AAT93158.1.
BK006943 Genomic DNA. Translation: DAA08739.1.
PIRiS56831.
RefSeqiNP_012476.1. NM_001181492.1.

Genome annotation databases

EnsemblFungiiYJL059W; YJL059W; YJL059W.
GeneIDi853387.
KEGGisce:YJL059W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058447 Genomic DNA. Translation: AAC61258.1.
Z49334 Genomic DNA. Translation: CAA89350.1.
AY693139 Genomic DNA. Translation: AAT93158.1.
BK006943 Genomic DNA. Translation: DAA08739.1.
PIRiS56831.
RefSeqiNP_012476.1. NM_001181492.1.

3D structure databases

ProteinModelPortaliP47040.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33695. 22 interactors.
DIPiDIP-4761N.
IntActiP47040. 1 interactor.
MINTiMINT-567364.

Protein family/group databases

TCDBi2.A.57.5.2. the equilibrative nucleoside transporter (ent) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL059W; YJL059W; YJL059W.
GeneIDi853387.
KEGGisce:YJL059W.

Organism-specific databases

EuPathDBiFungiDB:YJL059W.
SGDiS000003595. YHC3.

Phylogenomic databases

GeneTreeiENSGT00390000003249.
HOGENOMiHOG000164765.
InParanoidiP47040.
KOiK12389.
OMAiKHIEKPC.
OrthoDBiEOG092C3EEJ.

Enzyme and pathway databases

BioCyciYEAST:G3O-31522-MONOMER.

Miscellaneous databases

PROiP47040.

Family and domain databases

InterProiIPR003492. Battenin_disease_Cln3.
IPR018460. Battenin_disease_Cln3_subgr.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR10981. PTHR10981. 1 hit.
PfamiPF02487. CLN3. 1 hit.
[Graphical view]
PIRSFiPIRSF015974. CLN3_BTN1. 1 hit.
PRINTSiPR01315. BATTENIN.
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBTN1_YEAST
AccessioniPrimary (citable) accession number: P47040
Secondary accession number(s): D6VWC3, O60004, Q6B1E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.