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Protein

Increased copper sensitivity protein 3

Gene

ICS3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Enzyme and pathway databases

BioCyciYEAST:G3O-31534-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Increased copper sensitivity protein 3
Gene namesi
Name:ICS3
Ordered Locus Names:YJL077C
ORF Names:J1033
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome X

Organism-specific databases

CYGDiYJL077c.
SGDiS000003613. ICS3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST
Transmembranei74 – 9421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Increases sensitivity to copper.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 131131Increased copper sensitivity protein 3PRO_0000203052Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP47034.

Interactioni

Protein-protein interaction databases

BioGridi33679. 5 interactions.
MINTiMINT-4806718.
STRINGi4932.YJL077C.

Structurei

3D structure databases

ProteinModelPortaliP47034.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG7V4BB9.

Sequencei

Sequence statusi: Complete.

P47034-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHISLPTRNK SYFRIRTRTY QIGLYHSDSS PIRDISVLHL LIATLCTIFF
60 70 80 90 100
PIFFSLSKVQ VVQWQGTTIS KNCIALTMSF PLNAIPGMYL IIAFPRLQTV
110 120 130
IPLQRNTPVR ITKSVIVKGA VSVPRISSPM H
Length:131
Mass (Da):14,828
Last modified:January 31, 1996 - v1
Checksum:i1A5AB2ABC6C8BB97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49352 Genomic DNA. Translation: CAA89369.1.
AY692701 Genomic DNA. Translation: AAT92720.1.
BK006943 Genomic DNA. Translation: DAA08723.1.
PIRiS56853.
RefSeqiNP_012458.1. NM_001181510.1.

Genome annotation databases

EnsemblFungiiYJL077C; YJL077C; YJL077C.
GeneIDi853368.
KEGGisce:YJL077C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49352 Genomic DNA. Translation: CAA89369.1.
AY692701 Genomic DNA. Translation: AAT92720.1.
BK006943 Genomic DNA. Translation: DAA08723.1.
PIRiS56853.
RefSeqiNP_012458.1. NM_001181510.1.

3D structure databases

ProteinModelPortaliP47034.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33679. 5 interactions.
MINTiMINT-4806718.
STRINGi4932.YJL077C.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL077C; YJL077C; YJL077C.
GeneIDi853368.
KEGGisce:YJL077C.

Organism-specific databases

CYGDiYJL077c.
SGDiS000003613. ICS3.

Phylogenomic databases

OrthoDBiEOG7V4BB9.

Enzyme and pathway databases

BioCyciYEAST:G3O-31534-MONOMER.

Miscellaneous databases

NextBioi973804.

Gene expression databases

GenevestigatoriP47034.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiICS3_YEAST
AccessioniPrimary (citable) accession number: P47034
Secondary accession number(s): D6VWA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 1996
Last sequence update: January 31, 1996
Last modified: January 6, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.