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P47034 (ICS3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Increased copper sensitivity protein 3
Gene names
Name:ICS3
Ordered Locus Names:YJL077C
ORF Names:J1033
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length131 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Disruption phenotype

Increases sensitivity to copper. Ref.4

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 131131Increased copper sensitivity protein 3
PRO_0000203052

Regions

Transmembrane35 – 5521Helical; Potential
Transmembrane74 – 9421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P47034 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 1A5AB2ABC6C8BB97

FASTA13114,828
        10         20         30         40         50         60 
MHISLPTRNK SYFRIRTRTY QIGLYHSDSS PIRDISVLHL LIATLCTIFF PIFFSLSKVQ 

        70         80         90        100        110        120 
VVQWQGTTIS KNCIALTMSF PLNAIPGMYL IIAFPRLQTV IPLQRNTPVR ITKSVIVKGA 

       130 
VSVPRISSPM H 

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. expand/collapse author list , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach."
Entian K.-D., Schuster T., Hegemann J.H., Becher D., Feldmann H., Gueldener U., Goetz R., Hansen M., Hollenberg C.P., Jansen G., Kramer W., Klein S., Koetter P., Kricke J., Launhardt H., Mannhaupt G., Maierl A., Meyer P. expand/collapse author list , Mewes W., Munder T., Niedenthal R.K., Ramezani Rad M., Roehmer A., Roemer A., Rose M., Schaefer B., Siegler M.-L., Vetter J., Wilhelm N., Wolf K., Zimmermann F.K., Zollner A., Hinnen A.
Mol. Gen. Genet. 262:683-702(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z49352 Genomic DNA. Translation: CAA89369.1.
AY692701 Genomic DNA. Translation: AAT92720.1.
BK006943 Genomic DNA. Translation: DAA08723.1.
PIRS56853.
RefSeqNP_012458.1. NM_001181510.1.

3D structure databases

ProteinModelPortalP47034.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33679. 5 interactions.
MINTMINT-4806718.
STRING4932.YJL077C.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYJL077C; YJL077C; YJL077C.
GeneID853368.
KEGGsce:YJL077C.

Organism-specific databases

CYGDYJL077c.
SGDS000003613. ICS3.

Phylogenomic databases

OrthoDBEOG7V4BB9.

Enzyme and pathway databases

BioCycYEAST:G3O-31534-MONOMER.

Gene expression databases

GenevestigatorP47034.

Family and domain databases

ProtoNetSearch...

Other

NextBio973804.

Entry information

Entry nameICS3_YEAST
AccessionPrimary (citable) accession number: P47034
Secondary accession number(s): D6VWA7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD