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Protein

Protein PRY1

Gene

PRY1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Secreted protein required for efficient export of lipids such as acetylated sterols. Acts in detoxification of hydrophobic compounds.1 Publication

GO - Molecular functioni

  • cholesterol binding Source: SGD
  • magnesium ion binding Source: SGD
  • sterol binding Source: SGD

GO - Biological processi

  • sterol transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31536-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PRY1Curated
Alternative name(s):
Pathogenesis-related protein 11 Publication
Gene namesi
Name:PRY11 Publication
Ordered Locus Names:YJL079C
ORF Names:J1022
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL079C.
SGDiS000003615. PRY1.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000000631720 – 299Protein PRY1Add BLAST280

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP47032.
PRIDEiP47032.

Miscellaneous databases

PMAP-CutDBP47032.

Interactioni

Protein-protein interaction databases

BioGridi33677. 25 interactors.
DIPiDIP-3857N.
IntActiP47032. 1 interactor.
MINTiMINT-557532.

Structurei

Secondary structure

1299
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi161 – 174Combined sources14
Helixi187 – 198Combined sources12
Beta strandi212 – 221Combined sources10
Helixi223 – 231Combined sources9
Helixi232 – 236Combined sources5
Turni246 – 248Combined sources3
Helixi249 – 254Combined sources6
Beta strandi261 – 268Combined sources8
Turni271 – 273Combined sources3
Beta strandi275 – 283Combined sources9
Helixi291 – 294Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5JYSX-ray1.90A2-299[»]
ProteinModelPortaliP47032.
SMRiP47032.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini167 – 281SCPAdd BLAST115

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi102 – 165Ala/Ser/Thr-richAdd BLAST64

Domaini

The SCP domain is necessary and sufficient for lipid export and sterol-binding.1 Publication

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000020276.
InParanoidiP47032.
OMAiICEYAPR.
OrthoDBiEOG092C5ER9.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 2 hits.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47032-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLSKLSILT SALATSALAA PAVVTVTEHA HEAAVVTVQG VVYVENGQTR
60 70 80 90 100
TTYETLAPAS TATPTSTATA LVAPPVAPSS ASSNSDVVLS ALKNLASVWG
110 120 130 140 150
KTTDSTTTLT SSESTSQSLA QATTTSTPAA ASTTSTPAAT TTTSQAAATS
160 170 180 190 200
SASSSDSDLS DFASSVLAEH NKKRALHKDT PALSWSDTLA SYAQDYADNY
210 220 230 240 250
DCSGTLTHSG GPYGENLALG YDGPAAVDAW YNEISNYDFS NPGFSSNTGH
260 270 280 290
FTQVVWKSTT QVGCGIKTCG GAWGDYVICS YDPAGNYEGE YADNVEPLA
Length:299
Mass (Da):30,634
Last modified:February 1, 1996 - v1
Checksum:iA316769CA87C5679
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49354 Genomic DNA. Translation: CAA89372.1.
X83502 Genomic DNA. Translation: CAA58491.1.
X88851 Genomic DNA. Translation: CAA61315.1.
AY558306 Genomic DNA. Translation: AAS56632.1.
BK006943 Genomic DNA. Translation: DAA08720.1.
PIRiS56031.
RefSeqiNP_012456.1. NM_001181512.1.

Genome annotation databases

EnsemblFungiiYJL079C; YJL079C; YJL079C.
GeneIDi853366.
KEGGisce:YJL079C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49354 Genomic DNA. Translation: CAA89372.1.
X83502 Genomic DNA. Translation: CAA58491.1.
X88851 Genomic DNA. Translation: CAA61315.1.
AY558306 Genomic DNA. Translation: AAS56632.1.
BK006943 Genomic DNA. Translation: DAA08720.1.
PIRiS56031.
RefSeqiNP_012456.1. NM_001181512.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5JYSX-ray1.90A2-299[»]
ProteinModelPortaliP47032.
SMRiP47032.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33677. 25 interactors.
DIPiDIP-3857N.
IntActiP47032. 1 interactor.
MINTiMINT-557532.

Proteomic databases

MaxQBiP47032.
PRIDEiP47032.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL079C; YJL079C; YJL079C.
GeneIDi853366.
KEGGisce:YJL079C.

Organism-specific databases

EuPathDBiFungiDB:YJL079C.
SGDiS000003615. PRY1.

Phylogenomic databases

GeneTreeiENSGT00390000020276.
InParanoidiP47032.
OMAiICEYAPR.
OrthoDBiEOG092C5ER9.

Enzyme and pathway databases

BioCyciYEAST:G3O-31536-MONOMER.

Miscellaneous databases

PMAP-CutDBP47032.
PROiP47032.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 2 hits.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRY1_YEAST
AccessioniPrimary (citable) accession number: P47032
Secondary accession number(s): D6VWA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 556 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.