P47032 (PRY1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein PRY1

Alternative name(s):
Pathogen related in Sc 1

Gene names

Name:	PRY1
Ordered Locus Names:	YJL079C
ORF Names:	J1022

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Miscellaneous	Present with 556 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the CRISP family. Contains 1 SCP domain.

Ontologies

Keywords
Domain	Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	sterol transport Inferred from mutant phenotype PubMed 23027975. Source: SGD
Cellular_component	endoplasmic reticulum Inferred from direct assay PubMed 11914276. Source: SGD extracellular region Inferred from direct assay PubMed 11935221. Source: SGD fungal-type vacuole Inferred from direct assay PubMed 14562095. Source: SGD nuclear envelope Inferred from direct assay PubMed 11914276. Source: SGD
Molecular_function	sterol binding Inferred from mutant phenotype PubMed 23027975. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 299	280	Protein PRY1		PRO_0000006317
Regions
	Domain	167 – 281	115	SCP
	Compositional bias	102 – 165	64	Ala/Ser/Thr-rich

Sequences

	Sequence		Length	Mass (Da)
	P47032 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: A316769CA87C5679	FASTA	299	30,634
	10 20 30 40 50 60 MKLSKLSILT SALATSALAA PAVVTVTEHA HEAAVVTVQG VVYVENGQTR TTYETLAPAS 70 80 90 100 110 120 TATPTSTATA LVAPPVAPSS ASSNSDVVLS ALKNLASVWG KTTDSTTTLT SSESTSQSLA 130 140 150 160 170 180 QATTTSTPAA ASTTSTPAAT TTTSQAAATS SASSSDSDLS DFASSVLAEH NKKRALHKDT 190 200 210 220 230 240 PALSWSDTLA SYAQDYADNY DCSGTLTHSG GPYGENLALG YDGPAAVDAW YNEISNYDFS 250 260 270 280 290 NPGFSSNTGH FTQVVWKSTT QVGCGIKTCG GAWGDYVICS YDPAGNYEGE YADNVEPLA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of a 33.1 kb fragment from the left arm of Saccharomyces cerevisiae chromosome X, including putative proteins with leucine zippers, a fungal Zn(II)2-Cys6 binuclear cluster domain and a putative alpha 2-SCB-alpha 2 binding site." Miosga T., Schaaff-Gerstenschlaeger I., Chalwatzis N., Baur A., Boles E., Fournier C., Schmitt S., Velten C., Wilhelm N., Zimmermann F.K. Yeast 11:681-689(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L. EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z49354 Genomic DNA. Translation: CAA89372.1. X83502 Genomic DNA. Translation: CAA58491.1. X88851 Genomic DNA. Translation: CAA61315.1. AY558306 Genomic DNA. Translation: AAS56632.1. BK006943 Genomic DNA. Translation: DAA08720.1.
PIR	S56031.
RefSeq	NP_012456.1. NM_001181512.1.
3D structure databases
ProteinModelPortal	P47032.
SMR	P47032. Positions 162-297.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3857N.
IntAct	P47032. 1 interaction.
MINT	MINT-557532.
STRING	4932.YJL079C.
Proteomic databases
PaxDb	P47032.
PeptideAtlas	P47032.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YJL079C; YJL079C; YJL079C.
GeneID	853366.
KEGG	sce:YJL079C.
Organism-specific databases
CYGD	YJL079c.
SGD	S000003615. PRY1.
Phylogenomic databases
eggNOG	COG2340.
GeneTree	ENSGT00390000020276.
OMA	SAWTSAW.
OrthoDB	EOG41RT4K.
Gene expression databases
Genevestigator	P47032.
GermOnline	YJL079C. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	3.40.33.10. 1 hit.
InterPro	IPR001283. Allrgn_V5/Tpx1. IPR018244. Allrgn_V5/Tpx1_CS. IPR014044. CAP_domain. [Graphical view]
PANTHER	PTHR10334. PTHR10334. 1 hit.
Pfam	PF00188. CAP. 1 hit. [Graphical view]
PRINTS	PR00837. V5TPXLIKE.
SMART	SM00198. SCP. 1 hit. [Graphical view]
SUPFAM	SSF55797. SCP-like_extracellular. 1 hit.
PROSITE	PS01009. CRISP_1. 1 hit. PS01010. CRISP_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	973798.
PMAP-CutDB	P47032.

Entry information

Entry name

PRY1_YEAST

Accession

Primary (citable) accession number: P47032
Secondary accession number(s): D6VWA4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program