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P47032

- PRY1_YEAST

UniProt

P47032 - PRY1_YEAST

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Protein

Protein PRY1

Gene

PRY1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Secreted protein required for efficient export of lipids such as acetylated sterols. Acts in detoxification of hydrophobic compounds.1 Publication

GO - Molecular functioni

  1. sterol binding Source: SGD

GO - Biological processi

  1. sterol transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31536-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PRY1
Alternative name(s):
Pathogenesis-related protein 1
Gene namesi
Name:PRY1
Ordered Locus Names:YJL079C
ORF Names:J1022
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJL079c.
SGDiS000003615. PRY1.

Subcellular locationi

Secreted 2 Publications

GO - Cellular componenti

  1. extracellular region Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 299280Protein PRY1PRO_0000006317Add
BLAST

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP47032.
PaxDbiP47032.
PeptideAtlasiP47032.

Miscellaneous databases

PMAP-CutDBP47032.

Expressioni

Gene expression databases

GenevestigatoriP47032.

Interactioni

Protein-protein interaction databases

BioGridi33677. 25 interactions.
DIPiDIP-3857N.
IntActiP47032. 1 interaction.
MINTiMINT-557532.
STRINGi4932.YJL079C.

Structurei

3D structure databases

ProteinModelPortaliP47032.
SMRiP47032. Positions 162-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini167 – 281115SCPAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi102 – 16564Ala/Ser/Thr-richAdd
BLAST

Domaini

The SCP domain is necessary and sufficient for lipid export and sterol-binding.1 Publication

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2340.
GeneTreeiENSGT00390000020276.
InParanoidiP47032.
OMAiYNHNIHR.
OrthoDBiEOG7HHX5C.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47032-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLSKLSILT SALATSALAA PAVVTVTEHA HEAAVVTVQG VVYVENGQTR
60 70 80 90 100
TTYETLAPAS TATPTSTATA LVAPPVAPSS ASSNSDVVLS ALKNLASVWG
110 120 130 140 150
KTTDSTTTLT SSESTSQSLA QATTTSTPAA ASTTSTPAAT TTTSQAAATS
160 170 180 190 200
SASSSDSDLS DFASSVLAEH NKKRALHKDT PALSWSDTLA SYAQDYADNY
210 220 230 240 250
DCSGTLTHSG GPYGENLALG YDGPAAVDAW YNEISNYDFS NPGFSSNTGH
260 270 280 290
FTQVVWKSTT QVGCGIKTCG GAWGDYVICS YDPAGNYEGE YADNVEPLA
Length:299
Mass (Da):30,634
Last modified:February 1, 1996 - v1
Checksum:iA316769CA87C5679
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49354 Genomic DNA. Translation: CAA89372.1.
X83502 Genomic DNA. Translation: CAA58491.1.
X88851 Genomic DNA. Translation: CAA61315.1.
AY558306 Genomic DNA. Translation: AAS56632.1.
BK006943 Genomic DNA. Translation: DAA08720.1.
PIRiS56031.
RefSeqiNP_012456.1. NM_001181512.1.

Genome annotation databases

EnsemblFungiiYJL079C; YJL079C; YJL079C.
GeneIDi853366.
KEGGisce:YJL079C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49354 Genomic DNA. Translation: CAA89372.1 .
X83502 Genomic DNA. Translation: CAA58491.1 .
X88851 Genomic DNA. Translation: CAA61315.1 .
AY558306 Genomic DNA. Translation: AAS56632.1 .
BK006943 Genomic DNA. Translation: DAA08720.1 .
PIRi S56031.
RefSeqi NP_012456.1. NM_001181512.1.

3D structure databases

ProteinModelPortali P47032.
SMRi P47032. Positions 162-297.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33677. 25 interactions.
DIPi DIP-3857N.
IntActi P47032. 1 interaction.
MINTi MINT-557532.
STRINGi 4932.YJL079C.

Proteomic databases

MaxQBi P47032.
PaxDbi P47032.
PeptideAtlasi P47032.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJL079C ; YJL079C ; YJL079C .
GeneIDi 853366.
KEGGi sce:YJL079C.

Organism-specific databases

CYGDi YJL079c.
SGDi S000003615. PRY1.

Phylogenomic databases

eggNOGi COG2340.
GeneTreei ENSGT00390000020276.
InParanoidi P47032.
OMAi YNHNIHR.
OrthoDBi EOG7HHX5C.

Enzyme and pathway databases

BioCyci YEAST:G3O-31536-MONOMER.

Miscellaneous databases

NextBioi 973798.
PMAP-CutDB P47032.

Gene expression databases

Genevestigatori P47032.

Family and domain databases

Gene3Di 3.40.33.10. 1 hit.
InterProi IPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
[Graphical view ]
PANTHERi PTHR10334. PTHR10334. 1 hit.
Pfami PF00188. CAP. 1 hit.
[Graphical view ]
PRINTSi PR00837. V5TPXLIKE.
SMARTi SM00198. SCP. 1 hit.
[Graphical view ]
SUPFAMi SSF55797. SSF55797. 1 hit.
PROSITEi PS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of a 33.1 kb fragment from the left arm of Saccharomyces cerevisiae chromosome X, including putative proteins with leucine zippers, a fungal Zn(II)2-Cys6 binuclear cluster domain and a putative alpha 2-SCB-alpha 2 binding site."
    Miosga T., Schaaff-Gerstenschlaeger I., Chalwatzis N., Baur A., Boles E., Fournier C., Schmitt S., Velten C., Wilhelm N., Zimmermann F.K.
    Yeast 11:681-689(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Sequence-based approach for identification of cell wall proteins in Saccharomyces cerevisiae."
    Terashima H., Fukuchi S., Nakai K., Arisawa M., Hamada K., Yabuki N., Kitada K.
    Curr. Genet. 40:311-316(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Pathogen-Related Yeast (PRY) proteins and members of the CAP superfamily are secreted sterol-binding proteins."
    Choudhary V., Schneiter R.
    Proc. Natl. Acad. Sci. U.S.A. 109:16882-16887(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, STEROL-BINDING, SUBCELLULAR LOCATION, GLYCOSYLATION.

Entry informationi

Entry nameiPRY1_YEAST
AccessioniPrimary (citable) accession number: P47032
Secondary accession number(s): D6VWA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 556 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3