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P47032

- PRY1_YEAST

UniProt

P47032 - PRY1_YEAST

Protein

Protein PRY1

Gene

PRY1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Secreted protein required for efficient export of lipids such as acetylated sterols. Acts in detoxification of hydrophobic compounds.1 Publication

    GO - Molecular functioni

    1. sterol binding Source: SGD

    GO - Biological processi

    1. sterol transport Source: SGD

    Keywords - Biological processi

    Lipid transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31536-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein PRY1
    Alternative name(s):
    Pathogenesis-related protein 1
    Gene namesi
    Name:PRY1
    Ordered Locus Names:YJL079C
    ORF Names:J1022
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJL079c.
    SGDiS000003615. PRY1.

    Subcellular locationi

    Secreted 2 Publications

    GO - Cellular componenti

    1. extracellular region Source: SGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 299280Protein PRY1PRO_0000006317Add
    BLAST

    Post-translational modificationi

    O-glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP47032.
    PaxDbiP47032.
    PeptideAtlasiP47032.

    Miscellaneous databases

    PMAP-CutDBP47032.

    Expressioni

    Gene expression databases

    GenevestigatoriP47032.

    Interactioni

    Protein-protein interaction databases

    BioGridi33677. 24 interactions.
    DIPiDIP-3857N.
    IntActiP47032. 1 interaction.
    MINTiMINT-557532.
    STRINGi4932.YJL079C.

    Structurei

    3D structure databases

    ProteinModelPortaliP47032.
    SMRiP47032. Positions 162-297.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini167 – 281115SCPAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi102 – 16564Ala/Ser/Thr-richAdd
    BLAST

    Domaini

    The SCP domain is necessary and sufficient for lipid export and sterol-binding.1 Publication

    Sequence similaritiesi

    Belongs to the CRISP family.Curated
    Contains 1 SCP domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2340.
    GeneTreeiENSGT00390000020276.
    OMAiYNHNIHR.
    OrthoDBiEOG7HHX5C.

    Family and domain databases

    Gene3Di3.40.33.10. 1 hit.
    InterProiIPR001283. Allrgn_V5/Tpx1.
    IPR018244. Allrgn_V5/Tpx1_CS.
    IPR014044. CAP_domain.
    [Graphical view]
    PANTHERiPTHR10334. PTHR10334. 1 hit.
    PfamiPF00188. CAP. 1 hit.
    [Graphical view]
    PRINTSiPR00837. V5TPXLIKE.
    SMARTiSM00198. SCP. 1 hit.
    [Graphical view]
    SUPFAMiSSF55797. SSF55797. 1 hit.
    PROSITEiPS01009. CRISP_1. 1 hit.
    PS01010. CRISP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P47032-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLSKLSILT SALATSALAA PAVVTVTEHA HEAAVVTVQG VVYVENGQTR    50
    TTYETLAPAS TATPTSTATA LVAPPVAPSS ASSNSDVVLS ALKNLASVWG 100
    KTTDSTTTLT SSESTSQSLA QATTTSTPAA ASTTSTPAAT TTTSQAAATS 150
    SASSSDSDLS DFASSVLAEH NKKRALHKDT PALSWSDTLA SYAQDYADNY 200
    DCSGTLTHSG GPYGENLALG YDGPAAVDAW YNEISNYDFS NPGFSSNTGH 250
    FTQVVWKSTT QVGCGIKTCG GAWGDYVICS YDPAGNYEGE YADNVEPLA 299
    Length:299
    Mass (Da):30,634
    Last modified:February 1, 1996 - v1
    Checksum:iA316769CA87C5679
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49354 Genomic DNA. Translation: CAA89372.1.
    X83502 Genomic DNA. Translation: CAA58491.1.
    X88851 Genomic DNA. Translation: CAA61315.1.
    AY558306 Genomic DNA. Translation: AAS56632.1.
    BK006943 Genomic DNA. Translation: DAA08720.1.
    PIRiS56031.
    RefSeqiNP_012456.1. NM_001181512.1.

    Genome annotation databases

    EnsemblFungiiYJL079C; YJL079C; YJL079C.
    GeneIDi853366.
    KEGGisce:YJL079C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49354 Genomic DNA. Translation: CAA89372.1 .
    X83502 Genomic DNA. Translation: CAA58491.1 .
    X88851 Genomic DNA. Translation: CAA61315.1 .
    AY558306 Genomic DNA. Translation: AAS56632.1 .
    BK006943 Genomic DNA. Translation: DAA08720.1 .
    PIRi S56031.
    RefSeqi NP_012456.1. NM_001181512.1.

    3D structure databases

    ProteinModelPortali P47032.
    SMRi P47032. Positions 162-297.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33677. 24 interactions.
    DIPi DIP-3857N.
    IntActi P47032. 1 interaction.
    MINTi MINT-557532.
    STRINGi 4932.YJL079C.

    Proteomic databases

    MaxQBi P47032.
    PaxDbi P47032.
    PeptideAtlasi P47032.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJL079C ; YJL079C ; YJL079C .
    GeneIDi 853366.
    KEGGi sce:YJL079C.

    Organism-specific databases

    CYGDi YJL079c.
    SGDi S000003615. PRY1.

    Phylogenomic databases

    eggNOGi COG2340.
    GeneTreei ENSGT00390000020276.
    OMAi YNHNIHR.
    OrthoDBi EOG7HHX5C.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31536-MONOMER.

    Miscellaneous databases

    NextBioi 973798.
    PMAP-CutDB P47032.

    Gene expression databases

    Genevestigatori P47032.

    Family and domain databases

    Gene3Di 3.40.33.10. 1 hit.
    InterProi IPR001283. Allrgn_V5/Tpx1.
    IPR018244. Allrgn_V5/Tpx1_CS.
    IPR014044. CAP_domain.
    [Graphical view ]
    PANTHERi PTHR10334. PTHR10334. 1 hit.
    Pfami PF00188. CAP. 1 hit.
    [Graphical view ]
    PRINTSi PR00837. V5TPXLIKE.
    SMARTi SM00198. SCP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55797. SSF55797. 1 hit.
    PROSITEi PS01009. CRISP_1. 1 hit.
    PS01010. CRISP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of a 33.1 kb fragment from the left arm of Saccharomyces cerevisiae chromosome X, including putative proteins with leucine zippers, a fungal Zn(II)2-Cys6 binuclear cluster domain and a putative alpha 2-SCB-alpha 2 binding site."
      Miosga T., Schaaff-Gerstenschlaeger I., Chalwatzis N., Baur A., Boles E., Fournier C., Schmitt S., Velten C., Wilhelm N., Zimmermann F.K.
      Yeast 11:681-689(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "Sequence-based approach for identification of cell wall proteins in Saccharomyces cerevisiae."
      Terashima H., Fukuchi S., Nakai K., Arisawa M., Hamada K., Yabuki N., Kitada K.
      Curr. Genet. 40:311-316(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "Pathogen-Related Yeast (PRY) proteins and members of the CAP superfamily are secreted sterol-binding proteins."
      Choudhary V., Schneiter R.
      Proc. Natl. Acad. Sci. U.S.A. 109:16882-16887(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, STEROL-BINDING, SUBCELLULAR LOCATION, GLYCOSYLATION.

    Entry informationi

    Entry nameiPRY1_YEAST
    AccessioniPrimary (citable) accession number: P47032
    Secondary accession number(s): D6VWA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 556 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3