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Protein

Protein TAX4

Gene

TAX4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

With IRS4, acts as a positive regulator of INP51 activity and phosphatidylinositol 4,5-bisphosphate turnover. Negatively regulates signaling through the cell integrity pathway, including the MAP kinase SLT2.1 Publication

Miscellaneous

Present with 396 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • autophagy Source: SGD
  • cellular response to starvation Source: SGD
  • fungal-type cell wall organization Source: SGD
  • inositol lipid-mediated signaling Source: SGD
  • lipid metabolic process Source: UniProtKB-KW

Keywordsi

Biological processLipid metabolism

Enzyme and pathway databases

BioCyciYEAST:G3O-31540-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TAX4
Gene namesi
Name:TAX4
Ordered Locus Names:YJL083W
ORF Names:J1002
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL083W.
SGDiS000003619. TAX4.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002030501 – 604Protein TAX4Add BLAST604

Proteomic databases

MaxQBiP47030.
PRIDEiP47030.

Interactioni

Subunit structurei

Interacts with INP51.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
INP51P405593EBI-25970,EBI-24915

Protein-protein interaction databases

BioGridi33673. 114 interactors.
IntActiP47030. 7 interactors.
MINTiMINT-598564.
STRINGi4932.YJL083W.

Structurei

3D structure databases

ProteinModelPortaliP47030.
SMRiP47030.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini469 – 559EHAdd BLAST91

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi182 – 239Ser-richAdd BLAST58
Compositional biasi397 – 422His-richAdd BLAST26

Sequence similaritiesi

Belongs to the IRS4 family.Curated

Phylogenomic databases

GeneTreeiENSGT00530000068452.
InParanoidiP47030.
OrthoDBiEOG092C2VMY.

Family and domain databases

InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR000261. EH_dom.
SMARTiView protein in SMART
SM00027. EH. 1 hit.
SUPFAMiSSF47473. SSF47473. 2 hits.

Sequencei

Sequence statusi: Complete.

P47030-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHFPKKKHSG NLSVVELPKE ALQDSLTAAQ ITFKRYAHPN GNAGSAERPR
60 70 80 90 100
HLKVESAPVV KSEPSLPRMR QPEPRSINHQ YSRETLPGHS EAFSVPTTPL
110 120 130 140 150
QTIHYDVRNK ASNSPSSIAA AETAAYLAHT NSFSNRSSGV GSRDPVMDTE
160 170 180 190 200
TKPPRAPSAL KNELQLNRMR IPPPSYDNNV RSRSISPQVS YSTSLSSSCS
210 220 230 240 250
ISSDGEETSY REKSTDEAFP PEPSMSSYSL ASKASAKASL TDPSQRQQES
260 270 280 290 300
DYTAMNKLNG GNIIYKGTLP DLIPRSQRKT SKPRFKHRLL RSPEQQQENL
310 320 330 340 350
SRVYSDQTQN GRAIINTQQN VKLKTTMRRG KYAITDNDET FPYDRKSVSS
360 370 380 390 400
DSDTDEDSNV MEIKDKKKKS RRSKIKKGLK TTAAVVGSST SVLPFPHHHH
410 420 430 440 450
HHHQLHNPNS HHLHTHHHTS SHKFNEDKPW KSHRDLGFIT EQERKRYESM
460 470 480 490 500
WVSNRYSYLR LLPWWPSLAN EDDESHLQPL NLPQDGLMLN LVVKDIWYRS
510 520 530 540 550
NLPRDLLVQI YNMVDTRKDG TLDRKSFIVG MWLVDQCLYG RKLTNELDQR
560 570 580 590 600
VWNSVDGYVL GTINVKPATS DHYHNANNPL DKPSKLSVRQ ELKNIKRDLR

NVRI
Length:604
Mass (Da):68,768
Last modified:February 1, 1996 - v1
Checksum:iE17C6C71D9FBFBD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49358 Genomic DNA. Translation: CAA89376.1.
X83502 Genomic DNA. Translation: CAA58487.1.
X88851 Genomic DNA. Translation: CAA61318.1.
BK006943 Genomic DNA. Translation: DAA08716.1.
PIRiS56027.
RefSeqiNP_012452.1. NM_001181516.1.

Genome annotation databases

EnsemblFungiiYJL083W; YJL083W; YJL083W.
GeneIDi853362.
KEGGisce:YJL083W.

Similar proteinsi

Entry informationi

Entry nameiTAX4_YEAST
AccessioniPrimary (citable) accession number: P47030
Secondary accession number(s): D6VWA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 27, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names