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P47030 (TAX4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein TAX4
Gene names
Name:TAX4
Ordered Locus Names:YJL083W
ORF Names:J1002
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length604 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

With IRS4, acts as a positive regulator of INP51 activity and phosphatidylinositol 4,5-bisphosphate turnover. Negatively regulates signaling through the cell integrity pathway, including the MAP kinase SLT2. Ref.6

Subunit structure

Interacts with INP51. Ref.6

Miscellaneous

Present with 396 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the IRS4 family.

Contains 1 EH domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

INP51P405593EBI-25970,EBI-24915

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 604604Protein TAX4
PRO_0000203050

Regions

Domain469 – 55991EH
Compositional bias182 – 23958Ser-rich
Compositional bias397 – 42226His-rich

Sequences

Sequence LengthMass (Da)Tools
P47030 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: E17C6C71D9FBFBD6

FASTA60468,768
        10         20         30         40         50         60 
MHFPKKKHSG NLSVVELPKE ALQDSLTAAQ ITFKRYAHPN GNAGSAERPR HLKVESAPVV 

        70         80         90        100        110        120 
KSEPSLPRMR QPEPRSINHQ YSRETLPGHS EAFSVPTTPL QTIHYDVRNK ASNSPSSIAA 

       130        140        150        160        170        180 
AETAAYLAHT NSFSNRSSGV GSRDPVMDTE TKPPRAPSAL KNELQLNRMR IPPPSYDNNV 

       190        200        210        220        230        240 
RSRSISPQVS YSTSLSSSCS ISSDGEETSY REKSTDEAFP PEPSMSSYSL ASKASAKASL 

       250        260        270        280        290        300 
TDPSQRQQES DYTAMNKLNG GNIIYKGTLP DLIPRSQRKT SKPRFKHRLL RSPEQQQENL 

       310        320        330        340        350        360 
SRVYSDQTQN GRAIINTQQN VKLKTTMRRG KYAITDNDET FPYDRKSVSS DSDTDEDSNV 

       370        380        390        400        410        420 
MEIKDKKKKS RRSKIKKGLK TTAAVVGSST SVLPFPHHHH HHHQLHNPNS HHLHTHHHTS 

       430        440        450        460        470        480 
SHKFNEDKPW KSHRDLGFIT EQERKRYESM WVSNRYSYLR LLPWWPSLAN EDDESHLQPL 

       490        500        510        520        530        540 
NLPQDGLMLN LVVKDIWYRS NLPRDLLVQI YNMVDTRKDG TLDRKSFIVG MWLVDQCLYG 

       550        560        570        580        590        600 
RKLTNELDQR VWNSVDGYVL GTINVKPATS DHYHNANNPL DKPSKLSVRQ ELKNIKRDLR 


NVRI 

« Hide

References

« Hide 'large scale' references
[1]"Sequence analysis of a 33.1 kb fragment from the left arm of Saccharomyces cerevisiae chromosome X, including putative proteins with leucine zippers, a fungal Zn(II)2-Cys6 binuclear cluster domain and a putative alpha 2-SCB-alpha 2 binding site."
Miosga T., Schaaff-Gerstenschlaeger I., Chalwatzis N., Baur A., Boles E., Fournier C., Schmitt S., Velten C., Wilhelm N., Zimmermann F.K.
Yeast 11:681-689(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. expand/collapse author list , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Recognition specificity of individual EH domains of mammals and yeast."
Paoluzi S., Castagnoli L., Lauro I., Salcini A.E., Coda L., Fre' S., Confalonieri S., Pelicci P.G., Di Fiore P.P., Cesareni G.
EMBO J. 17:6541-6550(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: DOMAIN.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Negative regulation of phosphatidylinositol 4,5-bisphosphate levels by the INP51-associated proteins TAX4 and IRS4."
Morales-Johansson H., Jenoe P., Cooke F.T., Hall M.N.
J. Biol. Chem. 279:39604-39610(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH INP51.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z49358 Genomic DNA. Translation: CAA89376.1.
X83502 Genomic DNA. Translation: CAA58487.1.
X88851 Genomic DNA. Translation: CAA61318.1.
BK006943 Genomic DNA. Translation: DAA08716.1.
PIRS56027.
RefSeqNP_012452.1. NM_001181516.1.

3D structure databases

ProteinModelPortalP47030.
SMRP47030. Positions 430-551.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33673. 27 interactions.
IntActP47030. 5 interactions.
MINTMINT-598564.
STRING4932.YJL083W.

Proteomic databases

PaxDbP47030.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYJL083W; YJL083W; YJL083W.
GeneID853362.
KEGGsce:YJL083W.

Organism-specific databases

CYGDYJL083w.
SGDS000003619. TAX4.

Phylogenomic databases

eggNOGNOG267304.
GeneTreeENSGT00530000068452.
OrthoDBEOG747PVG.

Enzyme and pathway databases

BioCycYEAST:G3O-31540-MONOMER.

Gene expression databases

GenevestigatorP47030.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR000261. EPS15_homology.
[Graphical view]
SMARTSM00027. EH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio973786.

Entry information

Entry nameTAX4_YEAST
AccessionPrimary (citable) accession number: P47030
Secondary accession number(s): D6VWA0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families