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P47030

- TAX4_YEAST

UniProt

P47030 - TAX4_YEAST

Protein

Protein TAX4

Gene

TAX4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    With IRS4, acts as a positive regulator of INP51 activity and phosphatidylinositol 4,5-bisphosphate turnover. Negatively regulates signaling through the cell integrity pathway, including the MAP kinase SLT2.1 Publication

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. protein binding Source: IntAct

    GO - Biological processi

    1. autophagy Source: SGD
    2. cellular response to starvation Source: SGD
    3. fungal-type cell wall organization Source: SGD
    4. inositol lipid-mediated signaling Source: SGD
    5. lipid metabolic process Source: UniProtKB-KW

    Keywords - Biological processi

    Lipid metabolism

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31540-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein TAX4
    Gene namesi
    Name:TAX4
    Ordered Locus Names:YJL083W
    ORF Names:J1002
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJL083w.
    SGDiS000003619. TAX4.

    Subcellular locationi

    GO - Cellular componenti

    1. pre-autophagosomal structure Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 604604Protein TAX4PRO_0000203050Add
    BLAST

    Proteomic databases

    MaxQBiP47030.
    PaxDbiP47030.

    Expressioni

    Gene expression databases

    GenevestigatoriP47030.

    Interactioni

    Subunit structurei

    Interacts with INP51.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    INP51P405593EBI-25970,EBI-24915

    Protein-protein interaction databases

    BioGridi33673. 29 interactions.
    IntActiP47030. 5 interactions.
    MINTiMINT-598564.
    STRINGi4932.YJL083W.

    Structurei

    3D structure databases

    ProteinModelPortaliP47030.
    SMRiP47030. Positions 484-551.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini469 – 55991EHAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi182 – 23958Ser-richAdd
    BLAST
    Compositional biasi397 – 42226His-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the IRS4 family.Curated
    Contains 1 EH domain.Curated

    Phylogenomic databases

    eggNOGiNOG267304.
    GeneTreeiENSGT00530000068452.
    OMAiWRNILAS.
    OrthoDBiEOG747PVG.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR000261. EPS15_homology.
    [Graphical view]
    SMARTiSM00027. EH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47030-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHFPKKKHSG NLSVVELPKE ALQDSLTAAQ ITFKRYAHPN GNAGSAERPR    50
    HLKVESAPVV KSEPSLPRMR QPEPRSINHQ YSRETLPGHS EAFSVPTTPL 100
    QTIHYDVRNK ASNSPSSIAA AETAAYLAHT NSFSNRSSGV GSRDPVMDTE 150
    TKPPRAPSAL KNELQLNRMR IPPPSYDNNV RSRSISPQVS YSTSLSSSCS 200
    ISSDGEETSY REKSTDEAFP PEPSMSSYSL ASKASAKASL TDPSQRQQES 250
    DYTAMNKLNG GNIIYKGTLP DLIPRSQRKT SKPRFKHRLL RSPEQQQENL 300
    SRVYSDQTQN GRAIINTQQN VKLKTTMRRG KYAITDNDET FPYDRKSVSS 350
    DSDTDEDSNV MEIKDKKKKS RRSKIKKGLK TTAAVVGSST SVLPFPHHHH 400
    HHHQLHNPNS HHLHTHHHTS SHKFNEDKPW KSHRDLGFIT EQERKRYESM 450
    WVSNRYSYLR LLPWWPSLAN EDDESHLQPL NLPQDGLMLN LVVKDIWYRS 500
    NLPRDLLVQI YNMVDTRKDG TLDRKSFIVG MWLVDQCLYG RKLTNELDQR 550
    VWNSVDGYVL GTINVKPATS DHYHNANNPL DKPSKLSVRQ ELKNIKRDLR 600
    NVRI 604
    Length:604
    Mass (Da):68,768
    Last modified:February 1, 1996 - v1
    Checksum:iE17C6C71D9FBFBD6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49358 Genomic DNA. Translation: CAA89376.1.
    X83502 Genomic DNA. Translation: CAA58487.1.
    X88851 Genomic DNA. Translation: CAA61318.1.
    BK006943 Genomic DNA. Translation: DAA08716.1.
    PIRiS56027.
    RefSeqiNP_012452.1. NM_001181516.1.

    Genome annotation databases

    EnsemblFungiiYJL083W; YJL083W; YJL083W.
    GeneIDi853362.
    KEGGisce:YJL083W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49358 Genomic DNA. Translation: CAA89376.1 .
    X83502 Genomic DNA. Translation: CAA58487.1 .
    X88851 Genomic DNA. Translation: CAA61318.1 .
    BK006943 Genomic DNA. Translation: DAA08716.1 .
    PIRi S56027.
    RefSeqi NP_012452.1. NM_001181516.1.

    3D structure databases

    ProteinModelPortali P47030.
    SMRi P47030. Positions 484-551.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33673. 29 interactions.
    IntActi P47030. 5 interactions.
    MINTi MINT-598564.
    STRINGi 4932.YJL083W.

    Proteomic databases

    MaxQBi P47030.
    PaxDbi P47030.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJL083W ; YJL083W ; YJL083W .
    GeneIDi 853362.
    KEGGi sce:YJL083W.

    Organism-specific databases

    CYGDi YJL083w.
    SGDi S000003619. TAX4.

    Phylogenomic databases

    eggNOGi NOG267304.
    GeneTreei ENSGT00530000068452.
    OMAi WRNILAS.
    OrthoDBi EOG747PVG.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31540-MONOMER.

    Miscellaneous databases

    NextBioi 973786.

    Gene expression databases

    Genevestigatori P47030.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR000261. EPS15_homology.
    [Graphical view ]
    SMARTi SM00027. EH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of a 33.1 kb fragment from the left arm of Saccharomyces cerevisiae chromosome X, including putative proteins with leucine zippers, a fungal Zn(II)2-Cys6 binuclear cluster domain and a putative alpha 2-SCB-alpha 2 binding site."
      Miosga T., Schaaff-Gerstenschlaeger I., Chalwatzis N., Baur A., Boles E., Fournier C., Schmitt S., Velten C., Wilhelm N., Zimmermann F.K.
      Yeast 11:681-689(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: DOMAIN.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Negative regulation of phosphatidylinositol 4,5-bisphosphate levels by the INP51-associated proteins TAX4 and IRS4."
      Morales-Johansson H., Jenoe P., Cooke F.T., Hall M.N.
      J. Biol. Chem. 279:39604-39610(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH INP51.

    Entry informationi

    Entry nameiTAX4_YEAST
    AccessioniPrimary (citable) accession number: P47030
    Secondary accession number(s): D6VWA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 396 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3