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Protein

Protein TAX4

Gene

TAX4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

With IRS4, acts as a positive regulator of INP51 activity and phosphatidylinositol 4,5-bisphosphate turnover. Negatively regulates signaling through the cell integrity pathway, including the MAP kinase SLT2.1 Publication

GO - Biological processi

  1. autophagy Source: SGD
  2. cellular response to starvation Source: SGD
  3. fungal-type cell wall organization Source: SGD
  4. inositol lipid-mediated signaling Source: SGD
  5. lipid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Lipid metabolism

Enzyme and pathway databases

BioCyciYEAST:G3O-31540-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TAX4
Gene namesi
Name:TAX4
Ordered Locus Names:YJL083W
ORF Names:J1002
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome X

Organism-specific databases

CYGDiYJL083w.
SGDiS000003619. TAX4.

Subcellular locationi

GO - Cellular componenti

  1. pre-autophagosomal structure Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 604604Protein TAX4PRO_0000203050Add
BLAST

Proteomic databases

MaxQBiP47030.
PaxDbiP47030.

Expressioni

Gene expression databases

GenevestigatoriP47030.

Interactioni

Subunit structurei

Interacts with INP51.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
INP51P405593EBI-25970,EBI-24915

Protein-protein interaction databases

BioGridi33673. 29 interactions.
IntActiP47030. 5 interactions.
MINTiMINT-598564.
STRINGi4932.YJL083W.

Structurei

3D structure databases

ProteinModelPortaliP47030.
SMRiP47030. Positions 484-551.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini469 – 55991EHAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi182 – 23958Ser-richAdd
BLAST
Compositional biasi397 – 42226His-richAdd
BLAST

Sequence similaritiesi

Belongs to the IRS4 family.Curated
Contains 1 EH domain.Curated

Phylogenomic databases

eggNOGiNOG267304.
GeneTreeiENSGT00530000068452.
InParanoidiP47030.
OrthoDBiEOG747PVG.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR000261. EPS15_homology.
[Graphical view]
SMARTiSM00027. EH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47030-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHFPKKKHSG NLSVVELPKE ALQDSLTAAQ ITFKRYAHPN GNAGSAERPR
60 70 80 90 100
HLKVESAPVV KSEPSLPRMR QPEPRSINHQ YSRETLPGHS EAFSVPTTPL
110 120 130 140 150
QTIHYDVRNK ASNSPSSIAA AETAAYLAHT NSFSNRSSGV GSRDPVMDTE
160 170 180 190 200
TKPPRAPSAL KNELQLNRMR IPPPSYDNNV RSRSISPQVS YSTSLSSSCS
210 220 230 240 250
ISSDGEETSY REKSTDEAFP PEPSMSSYSL ASKASAKASL TDPSQRQQES
260 270 280 290 300
DYTAMNKLNG GNIIYKGTLP DLIPRSQRKT SKPRFKHRLL RSPEQQQENL
310 320 330 340 350
SRVYSDQTQN GRAIINTQQN VKLKTTMRRG KYAITDNDET FPYDRKSVSS
360 370 380 390 400
DSDTDEDSNV MEIKDKKKKS RRSKIKKGLK TTAAVVGSST SVLPFPHHHH
410 420 430 440 450
HHHQLHNPNS HHLHTHHHTS SHKFNEDKPW KSHRDLGFIT EQERKRYESM
460 470 480 490 500
WVSNRYSYLR LLPWWPSLAN EDDESHLQPL NLPQDGLMLN LVVKDIWYRS
510 520 530 540 550
NLPRDLLVQI YNMVDTRKDG TLDRKSFIVG MWLVDQCLYG RKLTNELDQR
560 570 580 590 600
VWNSVDGYVL GTINVKPATS DHYHNANNPL DKPSKLSVRQ ELKNIKRDLR

NVRI
Length:604
Mass (Da):68,768
Last modified:February 1, 1996 - v1
Checksum:iE17C6C71D9FBFBD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49358 Genomic DNA. Translation: CAA89376.1.
X83502 Genomic DNA. Translation: CAA58487.1.
X88851 Genomic DNA. Translation: CAA61318.1.
BK006943 Genomic DNA. Translation: DAA08716.1.
PIRiS56027.
RefSeqiNP_012452.1. NM_001181516.1.

Genome annotation databases

EnsemblFungiiYJL083W; YJL083W; YJL083W.
GeneIDi853362.
KEGGisce:YJL083W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49358 Genomic DNA. Translation: CAA89376.1.
X83502 Genomic DNA. Translation: CAA58487.1.
X88851 Genomic DNA. Translation: CAA61318.1.
BK006943 Genomic DNA. Translation: DAA08716.1.
PIRiS56027.
RefSeqiNP_012452.1. NM_001181516.1.

3D structure databases

ProteinModelPortaliP47030.
SMRiP47030. Positions 484-551.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33673. 29 interactions.
IntActiP47030. 5 interactions.
MINTiMINT-598564.
STRINGi4932.YJL083W.

Proteomic databases

MaxQBiP47030.
PaxDbiP47030.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL083W; YJL083W; YJL083W.
GeneIDi853362.
KEGGisce:YJL083W.

Organism-specific databases

CYGDiYJL083w.
SGDiS000003619. TAX4.

Phylogenomic databases

eggNOGiNOG267304.
GeneTreeiENSGT00530000068452.
InParanoidiP47030.
OrthoDBiEOG747PVG.

Enzyme and pathway databases

BioCyciYEAST:G3O-31540-MONOMER.

Miscellaneous databases

NextBioi973786.

Gene expression databases

GenevestigatoriP47030.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR000261. EPS15_homology.
[Graphical view]
SMARTiSM00027. EH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of a 33.1 kb fragment from the left arm of Saccharomyces cerevisiae chromosome X, including putative proteins with leucine zippers, a fungal Zn(II)2-Cys6 binuclear cluster domain and a putative alpha 2-SCB-alpha 2 binding site."
    Miosga T., Schaaff-Gerstenschlaeger I., Chalwatzis N., Baur A., Boles E., Fournier C., Schmitt S., Velten C., Wilhelm N., Zimmermann F.K.
    Yeast 11:681-689(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: DOMAIN.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Negative regulation of phosphatidylinositol 4,5-bisphosphate levels by the INP51-associated proteins TAX4 and IRS4."
    Morales-Johansson H., Jenoe P., Cooke F.T., Hall M.N.
    J. Biol. Chem. 279:39604-39610(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH INP51.

Entry informationi

Entry nameiTAX4_YEAST
AccessioniPrimary (citable) accession number: P47030
Secondary accession number(s): D6VWA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 4, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 396 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.