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P47030

- TAX4_YEAST

UniProt

P47030 - TAX4_YEAST

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Protein
Protein TAX4
Gene
TAX4, YJL083W, J1002
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

With IRS4, acts as a positive regulator of INP51 activity and phosphatidylinositol 4,5-bisphosphate turnover. Negatively regulates signaling through the cell integrity pathway, including the MAP kinase SLT2.1 Publication

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. autophagy Source: SGD
  2. cellular response to starvation Source: SGD
  3. fungal-type cell wall organization Source: SGD
  4. inositol lipid-mediated signaling Source: SGD
  5. lipid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Lipid metabolism

Enzyme and pathway databases

BioCyciYEAST:G3O-31540-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TAX4
Gene namesi
Name:TAX4
Ordered Locus Names:YJL083W
ORF Names:J1002
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJL083w.
SGDiS000003619. TAX4.

Subcellular locationi

GO - Cellular componenti

  1. pre-autophagosomal structure Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 604604Protein TAX4
PRO_0000203050Add
BLAST

Proteomic databases

MaxQBiP47030.
PaxDbiP47030.

Expressioni

Gene expression databases

GenevestigatoriP47030.

Interactioni

Subunit structurei

Interacts with INP51.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
INP51P405593EBI-25970,EBI-24915

Protein-protein interaction databases

BioGridi33673. 29 interactions.
IntActiP47030. 5 interactions.
MINTiMINT-598564.
STRINGi4932.YJL083W.

Structurei

3D structure databases

ProteinModelPortaliP47030.
SMRiP47030. Positions 484-551.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini469 – 55991EH
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi182 – 23958Ser-rich
Add
BLAST
Compositional biasi397 – 42226His-rich
Add
BLAST

Sequence similaritiesi

Belongs to the IRS4 family.
Contains 1 EH domain.

Phylogenomic databases

eggNOGiNOG267304.
GeneTreeiENSGT00530000068452.
OMAiWRNILAS.
OrthoDBiEOG747PVG.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR000261. EPS15_homology.
[Graphical view]
SMARTiSM00027. EH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47030-1 [UniParc]FASTAAdd to Basket

« Hide

MHFPKKKHSG NLSVVELPKE ALQDSLTAAQ ITFKRYAHPN GNAGSAERPR    50
HLKVESAPVV KSEPSLPRMR QPEPRSINHQ YSRETLPGHS EAFSVPTTPL 100
QTIHYDVRNK ASNSPSSIAA AETAAYLAHT NSFSNRSSGV GSRDPVMDTE 150
TKPPRAPSAL KNELQLNRMR IPPPSYDNNV RSRSISPQVS YSTSLSSSCS 200
ISSDGEETSY REKSTDEAFP PEPSMSSYSL ASKASAKASL TDPSQRQQES 250
DYTAMNKLNG GNIIYKGTLP DLIPRSQRKT SKPRFKHRLL RSPEQQQENL 300
SRVYSDQTQN GRAIINTQQN VKLKTTMRRG KYAITDNDET FPYDRKSVSS 350
DSDTDEDSNV MEIKDKKKKS RRSKIKKGLK TTAAVVGSST SVLPFPHHHH 400
HHHQLHNPNS HHLHTHHHTS SHKFNEDKPW KSHRDLGFIT EQERKRYESM 450
WVSNRYSYLR LLPWWPSLAN EDDESHLQPL NLPQDGLMLN LVVKDIWYRS 500
NLPRDLLVQI YNMVDTRKDG TLDRKSFIVG MWLVDQCLYG RKLTNELDQR 550
VWNSVDGYVL GTINVKPATS DHYHNANNPL DKPSKLSVRQ ELKNIKRDLR 600
NVRI 604
Length:604
Mass (Da):68,768
Last modified:February 1, 1996 - v1
Checksum:iE17C6C71D9FBFBD6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49358 Genomic DNA. Translation: CAA89376.1.
X83502 Genomic DNA. Translation: CAA58487.1.
X88851 Genomic DNA. Translation: CAA61318.1.
BK006943 Genomic DNA. Translation: DAA08716.1.
PIRiS56027.
RefSeqiNP_012452.1. NM_001181516.1.

Genome annotation databases

EnsemblFungiiYJL083W; YJL083W; YJL083W.
GeneIDi853362.
KEGGisce:YJL083W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49358 Genomic DNA. Translation: CAA89376.1 .
X83502 Genomic DNA. Translation: CAA58487.1 .
X88851 Genomic DNA. Translation: CAA61318.1 .
BK006943 Genomic DNA. Translation: DAA08716.1 .
PIRi S56027.
RefSeqi NP_012452.1. NM_001181516.1.

3D structure databases

ProteinModelPortali P47030.
SMRi P47030. Positions 484-551.
ModBasei Search...

Protein-protein interaction databases

BioGridi 33673. 29 interactions.
IntActi P47030. 5 interactions.
MINTi MINT-598564.
STRINGi 4932.YJL083W.

Proteomic databases

MaxQBi P47030.
PaxDbi P47030.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJL083W ; YJL083W ; YJL083W .
GeneIDi 853362.
KEGGi sce:YJL083W.

Organism-specific databases

CYGDi YJL083w.
SGDi S000003619. TAX4.

Phylogenomic databases

eggNOGi NOG267304.
GeneTreei ENSGT00530000068452.
OMAi WRNILAS.
OrthoDBi EOG747PVG.

Enzyme and pathway databases

BioCyci YEAST:G3O-31540-MONOMER.

Miscellaneous databases

NextBioi 973786.

Gene expression databases

Genevestigatori P47030.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR000261. EPS15_homology.
[Graphical view ]
SMARTi SM00027. EH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of a 33.1 kb fragment from the left arm of Saccharomyces cerevisiae chromosome X, including putative proteins with leucine zippers, a fungal Zn(II)2-Cys6 binuclear cluster domain and a putative alpha 2-SCB-alpha 2 binding site."
    Miosga T., Schaaff-Gerstenschlaeger I., Chalwatzis N., Baur A., Boles E., Fournier C., Schmitt S., Velten C., Wilhelm N., Zimmermann F.K.
    Yeast 11:681-689(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: DOMAIN.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Negative regulation of phosphatidylinositol 4,5-bisphosphate levels by the INP51-associated proteins TAX4 and IRS4."
    Morales-Johansson H., Jenoe P., Cooke F.T., Hall M.N.
    J. Biol. Chem. 279:39604-39610(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH INP51.

Entry informationi

Entry nameiTAX4_YEAST
AccessioniPrimary (citable) accession number: P47030
Secondary accession number(s): D6VWA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 396 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

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