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Reviewed, UniProtKB/Swiss-Prot P47030 (TAX4_YEAST)

Last modified November 24, 2009. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Protein TAX4
Gene names
Name: TAX4
Ordered Locus Names: YJL083W
ORF Names: J1002
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length604 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

With IRS4, acts as a positive regulator of INP51 activity and phosphatidylinositol 4,5-bisphosphate turnover. Negatively regulates signaling through the cell integrity pathway, including the MAP kinase SLT2. Ref.5

Subunit structure

Interacts with INP51. Ref.5

Miscellaneous

Present with 396 molecules/cell in log phase SD medium. Ref.4

Sequence similarities

Belongs to the IRS4 family.

Contains 1 EH domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

INP51P405591EBI-25970,EBI-24915

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 604604Protein TAX4
PRO_0000203050

Regions

Domain469 – 55991EH
Compositional bias182 – 23958Ser-rich
Compositional bias397 – 42226His-rich

Sequences

Sequence LengthMass (Da)Tools
P47030-1 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: E17C6C71D9FBFBD6

FASTA60468,768
        10         20         30         40         50         60 
MHFPKKKHSG NLSVVELPKE ALQDSLTAAQ ITFKRYAHPN GNAGSAERPR HLKVESAPVV 

        70         80         90        100        110        120 
KSEPSLPRMR QPEPRSINHQ YSRETLPGHS EAFSVPTTPL QTIHYDVRNK ASNSPSSIAA 

       130        140        150        160        170        180 
AETAAYLAHT NSFSNRSSGV GSRDPVMDTE TKPPRAPSAL KNELQLNRMR IPPPSYDNNV 

       190        200        210        220        230        240 
RSRSISPQVS YSTSLSSSCS ISSDGEETSY REKSTDEAFP PEPSMSSYSL ASKASAKASL 

       250        260        270        280        290        300 
TDPSQRQQES DYTAMNKLNG GNIIYKGTLP DLIPRSQRKT SKPRFKHRLL RSPEQQQENL 

       310        320        330        340        350        360 
SRVYSDQTQN GRAIINTQQN VKLKTTMRRG KYAITDNDET FPYDRKSVSS DSDTDEDSNV 

       370        380        390        400        410        420 
MEIKDKKKKS RRSKIKKGLK TTAAVVGSST SVLPFPHHHH HHHQLHNPNS HHLHTHHHTS 

       430        440        450        460        470        480 
SHKFNEDKPW KSHRDLGFIT EQERKRYESM WVSNRYSYLR LLPWWPSLAN EDDESHLQPL 

       490        500        510        520        530        540 
NLPQDGLMLN LVVKDIWYRS NLPRDLLVQI YNMVDTRKDG TLDRKSFIVG MWLVDQCLYG 

       550        560        570        580        590        600 
RKLTNELDQR VWNSVDGYVL GTINVKPATS DHYHNANNPL DKPSKLSVRQ ELKNIKRDLR 


NVRI 

« Hide

References

« Hide 'large scale' references
[1]"Sequence analysis of a 33.1 kb fragment from the left arm of Saccharomyces cerevisiae chromosome X, including putative proteins with leucine zippers, a fungal Zn(II)2-Cys6 binuclear cluster domain and a putative alpha 2-SCB-alpha 2 binding site."
Miosga T., Schaaff-Gerstenschlaeger I., Chalwatzis N., Baur A., Boles E., Fournier C., Schmitt S., Velten C., Wilhelm N., Zimmermann F.K.
Yeast 11:681-689(1995) [PubMed: 7483841] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. expand/collapse author list , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
EMBO J. 15:2031-2049(1996) [PubMed: 8641269] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"Recognition specificity of individual EH domains of mammals and yeast."
Paoluzi S., Castagnoli L., Lauro I., Salcini A.E., Coda L., Fre' S., Confalonieri S., Pelicci P.G., Di Fiore P.P., Cesareni G.
EMBO J. 17:6541-6550(1998) [PubMed: 9822599] [Abstract]
Cited for: DOMAIN.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"Negative regulation of phosphatidylinositol 4,5-bisphosphate levels by the INP51-associated proteins TAX4 and IRS4."
Morales-Johansson H., Jenoe P., Cooke F.T., Hall M.N.
J. Biol. Chem. 279:39604-39610(2004) [PubMed: 15265867] [Abstract]
Cited for: FUNCTION, INTERACTION WITH INP51.
+Additional computationally mapped references.

Cross-references

Sequence databases

Z49358 Genomic DNA. Translation: CAA89376.1.
X83502 Genomic DNA. Translation: CAA58487.1.
X88851 Genomic DNA. Translation: CAA61318.1.
PIRS56027.
RefSeqNP_012452.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActP47030. 2 interactions.
STRINGP47030.

Genome annotation databases

EnsemblYJL083W; YJL083W; YJL083W; Saccharomyces cerevisiae. [Genome view]
GeneID853362.
KEGGsce:YJL083W.
NMPDRfig|4932.3.peg.3421.

Organism-specific databases

CYGDYJL083w.
SGDS000003619. TAX4.

Phylogenomic databases

OrthoDBEOG9H47MJ.

Gene expression databases

ArrayExpressP47030.
GenevestigatorP47030.
GermOnlineYJL083W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR011992. EF-Hand_type.
IPR000261. EPS15_homology.
[Graphical view]
Gene3DG3DSA:1.10.238.10. EF-Hand_type. 1 hit.
SMARTSM00027. EH. 1 hit.
[Graphical view]
PROSITEPS50031. EH. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio973786.

Entry information

Entry nameTAX4_YEAST
AccessionPrimary (citable) accession number: P47030
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 24, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents