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Protein

Arrestin-related trafficking adapter 3

Gene

ALY2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli.1 Publication

Miscellaneous

Present with 49 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • protein binding, bridging Source: SGD
  • ubiquitin protein ligase binding Source: SGD

GO - Biological processi

  • positive regulation of ubiquitin-dependent endocytosis Source: SGD
  • regulation of intracellular transport Source: SGD
  • signal transduction Source: InterPro
  • ubiquitin-dependent endocytosis Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-31541-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Arrestin-related trafficking adapter 3
Alternative name(s):
Arrestin-like protein 2
Gene namesi
Name:ALY2
Synonyms:ART3
Ordered Locus Names:YJL084C
ORF Names:J0934
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL084C
SGDiS000003620 ALY2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002030491 – 1046Arrestin-related trafficking adapter 3Add BLAST1046

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei155PhosphoserineCombined sources1
Modified residuei162PhosphoserineCombined sources1
Modified residuei213PhosphoserineCombined sources1
Modified residuei586PhosphoserineCombined sources1
Modified residuei826PhosphoserineCombined sources1
Modified residuei838PhosphoserineCombined sources1
Modified residuei900PhosphoserineCombined sources1
Modified residuei1022PhosphoserineCombined sources1
Modified residuei1023PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated by RSP5.1 Publication
Phosphorylated by the cyclin-CDKs PCL6-PHO85 and PCL7-PHO85.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP47029
PaxDbiP47029
PRIDEiP47029

PTM databases

iPTMnetiP47029

Interactioni

Subunit structurei

Interacts with PCL6, PCL7 and RSP5.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RSP5P399405EBI-25974,EBI-16219

GO - Molecular functioni

  • protein binding, bridging Source: SGD
  • ubiquitin protein ligase binding Source: SGD

Protein-protein interaction databases

BioGridi33672, 97 interactors
DIPiDIP-1497N
IntActiP47029, 9 interactors
MINTiP47029
STRINGi4932.YJL084C

Structurei

3D structure databases

ProteinModelPortaliP47029
SMRiP47029
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ALY1 family.Curated

Phylogenomic databases

GeneTreeiENSGT00730000113838
InParanoidiP47029
KOiK20061
OMAiKAKNMGN
OrthoDBiEOG092C2P4Q

Family and domain databases

Gene3Di2.60.40.640, 2 hits
InterProiView protein in InterPro
IPR011021 Arrestin-like_N
IPR014752 Arrestin_C
IPR011022 Arrestin_C-like
IPR014756 Ig_E-set
PfamiView protein in Pfam
PF02752 Arrestin_C, 1 hit
PF00339 Arrestin_N, 1 hit
SMARTiView protein in SMART
SM01017 Arrestin_C, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit

Sequencei

Sequence statusi: Complete.

P47029-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMDQSISSP LFPMEKDIDI PLDATPLAQS SSLQLFIHLA EPVVFLQGFD
60 70 80 90 100
PQKTEYPSVV LRGCLVVRIL KPTKLKSISL SFKGYSRTEW PEGIPPKRQE
110 120 130 140 150
FVEIKDIVDH TWALYPPTEQ KSKKKMDASA PNESNNAANN FLTKESGASL
160 170 180 190 200
YRTLSDNETI TSRKNSISGL SSLNLSPLGA PGNSSVNVKD RESRQRSRSS
210 220 230 240 250
SVTSSNGPSR NLSPINLLKR ATSPSVSHHN YKPTTTSIFS DLLNNTFTHN
260 270 280 290 300
DAASHHGHHI PTSSNHLAMT SNNFTSGSGG EFFVFQPGDY IYAFEELIPQ
310 320 330 340 350
AYPESIKADF GFVEYFLFAS IERPGAFKSN ISARQVVNIV RTQAHNSVEE
360 370 380 390 400
SEPIIISRDW ENQLYYDIVI ASKDIILDAF LPITFKFAPL DKVTLHRIRI
410 420 430 440 450
YVTETMEYYC REKKVHRMEP TKKFLLTEQK GPKLPNLPND ANLSKAKNMG
460 470 480 490 500
NLLQDPKNGD LVNKEYEYQI FIPSRFNNHQ QLHPDTSYEN IKANHWIKIC
510 520 530 540 550
LRLSRVVDNK RKHYEISIDS PIHVLHRLCS HANTLLPSYD GHPASFPKET
560 570 580 590 600
DSSISSILES SDDNINLYHN SNIFFPKEVL SSPVLSPNVQ PLDILIPHLP
610 620 630 640 650
STSLTRNSRQ FNRNSKSHPS DNTIFNSAKL KSNIYQPESL QRELASPQAI
660 670 680 690 700
PLSPITSPMS NMEVPPPDFD FSSDFISDAA SGTTTTEVSS SESSILPRDP
710 720 730 740 750
PSYKDTVLHD NNQKRRPNSK HPTPPSLKAS HPNKNSDKNS SETLNKKESM
760 770 780 790 800
SKIEENKHKR ETTPKKRENR DVKSLSTPQR EESKDSTSTG NQSNEKNRKR
810 820 830 840 850
VLSLSSSLHS SPNNSGFAHS ALGNLSNESL RSLNRRESVQ DNLPSTIRHD
860 870 880 890 900
NPFFTDLNQV LIEDELKNHD KNELNRHSTN TSSTPASARS SFDYSGINIS
910 920 930 940 950
KDKLNMEPLL SKTETLTNKV NEDSFLRPND SYVDLLEPSV DTTIDITAPY
960 970 980 990 1000
ARNSSAWHPL QNDNDNNQFS PLLGSNENFL NAANAQNSAE SDHNNDIFTQ
1010 1020 1030 1040
GSGLTESSKN SDSEERFISR LSSPEKVLIN TLDNESGLQS INESTL
Length:1,046
Mass (Da):117,216
Last modified:November 1, 1997 - v2
Checksum:iEAC5711EE1AB1C66
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti852P → G in CAA58486 (PubMed:7483841).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83502 Genomic DNA Translation: CAA58486.1
Z49359 Genomic DNA Translation: CAA89377.1
X88851 Genomic DNA Translation: CAA61319.1
BK006943 Genomic DNA Translation: DAA08715.1
PIRiS56026
RefSeqiNP_012451.1, NM_001181517.1

Genome annotation databases

EnsemblFungiiYJL084C; YJL084C; YJL084C
GeneIDi853361
KEGGisce:YJL084C

Similar proteinsi

Entry informationi

Entry nameiALY2_YEAST
AccessioniPrimary (citable) accession number: P47029
Secondary accession number(s): D6VW99, Q05742
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names
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