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Protein

DNA replication regulator DPB11

Gene

DPB11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a role in the initiation of DNA replication. Required at S-phase checkpoint. Required for the association of PSF1 with origins. Also required for the proper activation of RAD53 in response to DNA damage and replication blocks. Multicopy suppressor of DPB2 mutation. Overexpression restores the growth defect conferred by POL2 mutation.3 Publications

GO - Molecular functioni

  • protein kinase activator activity Source: SGD

GO - Biological processi

  • DNA replication checkpoint Source: SGD
  • DNA replication initiation Source: SGD
  • double-strand break repair via break-induced replication Source: SGD
  • mating type switching Source: SGD
  • mismatch repair Source: SGD
  • mitotic DNA replication checkpoint Source: GO_Central
  • mitotic G2 DNA damage checkpoint Source: SGD
  • positive regulation of protein phosphorylation Source: SGD
  • recombinational repair Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle, DNA replication

Enzyme and pathway databases

BioCyciYEAST:G3O-31545-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication regulator DPB11
Gene namesi
Name:DPB11
Ordered Locus Names:YJL090C
ORF Names:J0918
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL090C.
SGDiS000003626. DPB11.

Subcellular locationi

GO - Cellular componenti

  • DNA replication preinitiation complex Source: SGD
  • replication fork Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000799891 – 764DNA replication regulator DPB11Add BLAST764

Proteomic databases

MaxQBiP47027.
PRIDEiP47027.

PTM databases

iPTMnetiP47027.

Interactioni

Subunit structurei

Interacts with SLD2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LCD1Q043776EBI-25984,EBI-35652
MEC1P381112EBI-25984,EBI-6668
RAD9P147379EBI-25984,EBI-14788
SLD2P342525EBI-25984,EBI-26824

Protein-protein interaction databases

BioGridi33667. 102 interactors.
DIPiDIP-5037N.
IntActiP47027. 9 interactors.
MINTiMINT-570502.

Structurei

3D structure databases

ProteinModelPortaliP47027.
SMRiP47027.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 99BRCT 1PROSITE-ProRule annotationAdd BLAST99
Domaini129 – 220BRCT 2PROSITE-ProRule annotationAdd BLAST92
Domaini322 – 418BRCT 3PROSITE-ProRule annotationAdd BLAST97

Sequence similaritiesi

Contains 3 BRCT domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000112252.
InParanoidiP47027.
KOiK03507.
OMAiIWNSIMD.
OrthoDBiEOG092C0BFA.

Family and domain databases

CDDicd00027. BRCT. 1 hit.
Gene3Di3.40.50.10190. 4 hits.
InterProiIPR001357. BRCT_dom.
[Graphical view]
PfamiPF00533. BRCT. 2 hits.
PF16589. BRCT_2. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 3 hits.
[Graphical view]
SUPFAMiSSF52113. SSF52113. 5 hits.
PROSITEiPS50172. BRCT. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47027-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPFQGITFC PTAINNEILA KKISKKIIKL GGIFSKDLTR QVNVLVVGST
60 70 80 90 100
TNTNKFKFAV KHRFDIIFID IQAIDDIYQL WLSGENILPD SNTATMTGST
110 120 130 140 150
YEMLKILYRR FSFKYLHNFN IFIGRITDTN ITSIDSLVRS IKKLGCSSYN
160 170 180 190 200
YQNFVIKDTS SHNDDDDQGQ NGQISIFVTD TLLGARVNAA IEQNIPIVHF
210 220 230 240 250
KWILDCQKRS ALLPYDPYYL LPNIKDLPYD SIGSNSCDCW DKINTTFPTN
260 270 280 290 300
IDAQSSLQRQ QSSSTLTPSL PKTSSLLNKF KPKGEKIWDK AMSLQQHSKT
310 320 330 340 350
NFSVLGQSPL SINNKQEDLS DNSTLIFKNC AFIIHHIFPG NHRSILTKIV
360 370 380 390 400
VQNGGKIETS YLSGIYDHSY YIIPSNKALD SFNDLPEIID DNDGIVTEFF
410 420 430 440 450
IERCLYYQKL LHPIDLWSKP FLSTIEFQVS SSSKLLHHEF SSSPFLNVTI
460 470 480 490 500
TGFSGVELLH LTKVLNLLKP MGINYVEYLN KSTDILLINL AALPSIPKTH
510 520 530 540 550
PLWSNEFSDL FTQFCINNNN DDPGDNNRKD FQNNSILRNS MKRKIEYIKK
560 570 580 590 600
FHSIPVVTPA FIFKLLSAAS GENNEIFLNN IKWCIICPRG HKDDFKCKIK
610 620 630 640 650
KPYYTSISSE KKYQNNDPKI DKTILLKRNN SSLSEHSMKD TKNELLQKIR
660 670 680 690 700
ETDSGRKKRS VSSSIMDVSS ERQMPDTKRI KLESLPKNFV PKQIKRTTSW
710 720 730 740 750
GTIMSENVPT EQPTAISNPE EIPRTEEVSH TQVTYGSIQD KKRTASLEKP
760
MRRQTRNQTK ELDS
Length:764
Mass (Da):87,241
Last modified:February 1, 1996 - v1
Checksum:i79B3A9BC7815E440
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72Q → K in BAA07725 (PubMed:8524850).Curated1
Sequence conflicti295 – 296QQ → HR in BAA07725 (PubMed:8524850).Curated2
Sequence conflicti515C → Y in BAA07725 (PubMed:8524850).Curated1
Sequence conflicti603Y → C in BAA07725 (PubMed:8524850).Curated1
Sequence conflicti656R → K in BAA07725 (PubMed:8524850).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42168 Genomic DNA. Translation: BAA07725.2.
X83502 Genomic DNA. Translation: CAA58477.1.
Z49365 Genomic DNA. Translation: CAA89383.1.
BK006943 Genomic DNA. Translation: DAA08710.1.
PIRiS56017.
RefSeqiNP_012445.1. NM_001181523.1.

Genome annotation databases

EnsemblFungiiYJL090C; YJL090C; YJL090C.
GeneIDi853355.
KEGGisce:YJL090C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42168 Genomic DNA. Translation: BAA07725.2.
X83502 Genomic DNA. Translation: CAA58477.1.
Z49365 Genomic DNA. Translation: CAA89383.1.
BK006943 Genomic DNA. Translation: DAA08710.1.
PIRiS56017.
RefSeqiNP_012445.1. NM_001181523.1.

3D structure databases

ProteinModelPortaliP47027.
SMRiP47027.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33667. 102 interactors.
DIPiDIP-5037N.
IntActiP47027. 9 interactors.
MINTiMINT-570502.

PTM databases

iPTMnetiP47027.

Proteomic databases

MaxQBiP47027.
PRIDEiP47027.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL090C; YJL090C; YJL090C.
GeneIDi853355.
KEGGisce:YJL090C.

Organism-specific databases

EuPathDBiFungiDB:YJL090C.
SGDiS000003626. DPB11.

Phylogenomic databases

HOGENOMiHOG000112252.
InParanoidiP47027.
KOiK03507.
OMAiIWNSIMD.
OrthoDBiEOG092C0BFA.

Enzyme and pathway databases

BioCyciYEAST:G3O-31545-MONOMER.

Miscellaneous databases

PROiP47027.

Family and domain databases

CDDicd00027. BRCT. 1 hit.
Gene3Di3.40.50.10190. 4 hits.
InterProiIPR001357. BRCT_dom.
[Graphical view]
PfamiPF00533. BRCT. 2 hits.
PF16589. BRCT_2. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 3 hits.
[Graphical view]
SUPFAMiSSF52113. SSF52113. 5 hits.
PROSITEiPS50172. BRCT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPB11_YEAST
AccessioniPrimary (citable) accession number: P47027
Secondary accession number(s): D6VW94, Q05712
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 540 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.