P47019 (ALB1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribosome biogenesis protein ALB1

Gene names

Name:	ALB1
Ordered Locus Names:	YJL122W
ORF Names:	J0723

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	With ARX1, involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm. Ref.7 Ref.8 Ref.9 Ref.10
Subunit structure	Component of the nucleoplasmic and cytoplasmic pre-60S ribosomal particles. Interacts directly with ARX1. Ref.7
Subcellular location	Cytoplasm. Nucleus Ref.4 Ref.7 Ref.10.
Miscellaneous	Present with 4780 molecules/cell in log phase SD medium. Ref.5
Sequence similarities	Belongs to the ALB1 family.

Ontologies

Keywords
Biological process	Ribosome biogenesis Transport
Cellular component	Cytoplasm Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ribosomal large subunit biogenesis Inferred from genetic interaction Ref.7. Source: SGD transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from direct assay Ref.7. Source: SGD nucleus Inferred from direct assay Ref.4Ref.7. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
REI1	P38344	1	EBI-26061,EBI-21136

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 175	175	Ribosome biogenesis protein ALB1		PRO_0000203041

Sequences

	Sequence		Length	Mass (Da)
	P47019 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 3DECC43269EBB6D3	FASTA	175	19,287
	10 20 30 40 50 60 MPSKNSINRP KLTSNLHHKV HSLNKKRAQR ERAGLLKPAR SSVNSKSGEI KSVALDLYFQ 70 80 90 100 110 120 NKKNESQNST AVTLQNASSS PASITTRTLS KKRAKKIERN LKYATQRKLL VDASAKLEDE 130 140 150 160 170 MDIDLDGGKK VKENEKKSSL TLVKEALWSV IDDTASQGLI IENGQGTTLG GPFFP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequencing analysis of a 40.2 kb fragment of yeast chromosome X reveals 19 open reading frames including URA2 (5' end), TRK1, PBS2, SPT10, GCD14, RPE1, PHO86, NCA3, ASF1, CCT7, GZF3, two tRNA genes, three remnant delta elements and a Ty4 transposon." Cziepluch C., Kordes E., Pujol A., Jauniaux J.-C. Yeast 12:1471-1474(1996) [PubMed: 8948101] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L. EMBO J. 15:2031-2049(1996) [PubMed: 8641269] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]	"Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes." Fleischer T.C., Weaver C.M., McAfee K.J., Jennings J.L., Link A.J. Genes Dev. 20:1294-1307(2006) [PubMed: 16702403] [Abstract] Cited for: COPURIFICATION WITH RIBOSOMAL COMPLEXES, MASS SPECTROMETRY.
[7]	"A functional network involved in the recycling of nucleocytoplasmic pre-60S factors." Lebreton A., Saveanu C., Decourty L., Rain J.-C., Jacquier A., Fromont-Racine M. J. Cell Biol. 173:349-360(2006) [PubMed: 16651379] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN THE PRE-60S RIBOSOME, INTERACTION WITH ARX1.
[8]	"The budding yeast rRNA and ribosome biosynthesis (RRB) regulon contains over 200 genes." Wade C.H., Umbarger M.A., McAlear M.A. Yeast 23:293-306(2006) [PubMed: 16544271] [Abstract] Cited for: FUNCTION.
[9]	"The specialized cytosolic J-protein, Jjj1, functions in 60S ribosomal subunit biogenesis." Meyer A.E., Hung N.-J., Yang P., Johnson A.W., Craig E.A. Proc. Natl. Acad. Sci. U.S.A. 104:1558-1563(2007) [PubMed: 17242366] [Abstract] Cited for: FUNCTION.
[10]	"The Hsp40 chaperone Jjj1 is required for the nucleo-cytoplasmic recycling of preribosomal factors in Saccharomyces cerevisiae." Demoinet E., Jacquier A., Lutfalla G., Fromont-Racine M. RNA 13:1570-1581(2007) [PubMed: 17652132] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z49397 Genomic DNA. Translation: CAA89417.1. BK006943 Genomic DNA. Translation: DAA08680.1.
PIR	S56903.
RefSeq	NP_012413.1. NM_001181555.1.
3D structure databases
ProteinModelPortal	P47019.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-6452N.
IntAct	P47019. 4 interactions.
MINT	MINT-704048.
STRING	P47019.
Proteomic databases
PeptideAtlas	P47019.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YJL122W; YJL122W; YJL122W.
GeneID	853320.
KEGG	sce:YJL122W.
NMPDR	fig|4932.3.peg.3382.
Organism-specific databases
CYGD	YJL122w.
SGD	S000003658. ALB1.
Phylogenomic databases
eggNOG	fuNOG10981.
HOGENOM	HBG397695.
OMA	AKKIERN.
OrthoDB	EOG43NBPG.
Gene expression databases
ArrayExpress	P47019.
Genevestigator	P47019.
GermOnline	YJL122W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR015218. Ribosomal_mat_Alb1_yeast. IPR022784. Ribosome_bgen_Alb1. [Graphical view]
KO	K14814.
Pfam	PF09135. Alb1. 1 hit. [Graphical view]
ProDom	PD100605. Ribosomal_mat_Alb1. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other
NextBio	973672.

Entry information

Entry name

ALB1_YEAST

Accession

Primary (citable) accession number: P47019
Secondary accession number(s): D6VW64

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	December 14, 2011
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program