ID   AIM23_YEAST             Reviewed;         356 AA.
AC   P47015; D6VW54;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   27-MAR-2024, entry version 142.
DE   RecName: Full=Altered inheritance of mitochondria protein 23, mitochondrial;
DE   Flags: Precursor;
GN   Name=AIM23; OrderedLocusNames=YJL131C; ORFNames=J0682;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 96604 / S288c / FY1679;
RX   PubMed=8813765;
RX   DOI=10.1002/(sici)1097-0061(19960630)12:8<787::aid-yea954>3.0.co;2-4;
RA   Katsoulou C., Tzermia M., Tavernarakis N., Alexandraki D.;
RT   "Sequence analysis of a 40.7 kb segment from the left arm of yeast
RT   chromosome X reveals 14 known genes and 13 new open reading frames
RT   including homologues of genes clustered on the right arm of chromosome
RT   XI.";
RL   Yeast 12:787-797(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA   Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA   Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA   Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA   Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA   Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA   Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA   Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA   Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA   Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA   To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA   von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT   "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL   EMBO J. 15:2031-2049(1996).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-124.
RC   STRAIN=ATCC 28383 / FL100 / VTT C-80102;
RX   PubMed=2570735; DOI=10.1016/0378-1119(89)90092-9;
RA   Souciet J.-L., Nagy M., le Gouar M., Lacroute F., Potier S.;
RT   "Organization of the yeast URA2 gene: identification of a defective
RT   dihydroorotase-like domain in the multifunctional carbamoylphosphate
RT   synthetase-aspartate transcarbamylase complex.";
RL   Gene 79:59-70(1989).
RN   [5]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [6]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [7]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RX   PubMed=16823961; DOI=10.1021/pr050477f;
RA   Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.;
RT   "Toward the complete yeast mitochondrial proteome: multidimensional
RT   separation techniques for mitochondrial proteomics.";
RL   J. Proteome Res. 5:1543-1554(2006).
RN   [8]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=19300474; DOI=10.1371/journal.pgen.1000407;
RA   Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J.,
RA   Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M.,
RA   Troyanskaya O.G., Caudy A.A.;
RT   "Computationally driven, quantitative experiments discover genes required
RT   for mitochondrial biogenesis.";
RL   PLoS Genet. 5:E1000407-E1000407(2009).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14562095,
CC       ECO:0000269|PubMed:16823961}.
CC   -!- DISRUPTION PHENOTYPE: Increases frequency of mitochondrial genome loss.
CC       {ECO:0000269|PubMed:19300474}.
CC   -!- MISCELLANEOUS: Present with 319 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the AIM23 family. {ECO:0000305}.
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DR   EMBL; X87371; CAA60824.1; -; Genomic_DNA.
DR   EMBL; Z49406; CAA89426.1; -; Genomic_DNA.
DR   EMBL; M27174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK006943; DAA08670.1; -; Genomic_DNA.
DR   PIR; S55181; S55181.
DR   RefSeq; NP_012404.1; NM_001181564.1.
DR   AlphaFoldDB; P47015; -.
DR   BioGRID; 33625; 181.
DR   DIP; DIP-5684N; -.
DR   IntAct; P47015; 1.
DR   MINT; P47015; -.
DR   STRING; 4932.YJL131C; -.
DR   MaxQB; P47015; -.
DR   PaxDb; 4932-YJL131C; -.
DR   PeptideAtlas; P47015; -.
DR   EnsemblFungi; YJL131C_mRNA; YJL131C; YJL131C.
DR   GeneID; 853310; -.
DR   KEGG; sce:YJL131C; -.
DR   AGR; SGD:S000003667; -.
DR   SGD; S000003667; AIM23.
DR   VEuPathDB; FungiDB:YJL131C; -.
DR   eggNOG; ENOG502RY27; Eukaryota.
DR   HOGENOM; CLU_057910_0_0_1; -.
DR   InParanoid; P47015; -.
DR   OMA; KHIKISW; -.
DR   OrthoDB; 2027796at2759; -.
DR   BioCyc; YEAST:G3O-31580-MONOMER; -.
DR   BioGRID-ORCS; 853310; 1 hit in 10 CRISPR screens.
DR   PRO; PR:P47015; -.
DR   Proteomes; UP000002311; Chromosome X.
DR   RNAct; P47015; Protein.
DR   GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR   GO; GO:0097177; F:mitochondrial ribosome binding; IDA:SGD.
DR   GO; GO:0003743; F:translation initiation factor activity; ISS:SGD.
DR   GO; GO:0070124; P:mitochondrial translational initiation; IGI:SGD.
DR   InterPro; IPR029427; AIM23.
DR   Pfam; PF14877; mIF3; 1.
PE   1: Evidence at protein level;
KW   Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..32
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           33..356
FT                   /note="Altered inheritance of mitochondria protein 23,
FT                   mitochondrial"
FT                   /id="PRO_0000203039"
SQ   SEQUENCE   356 AA;  41461 MW;  BCF907223417B6C2 CRC64;
     MLKVPLSDVL SQKMLFLKSF RYFHCTKYFS RDNASSTTDI FRNAMKRKRE LANLKEQSHG
     NVARNAAFPK EYIKRPKQVP RNATNRKKIL ITWSTGTDRA KEAANSVVSE IFKKNHKGNI
     KVVDPTTHRI EASNIRYFAK GIDLDKVGLS IVNVEQIDNE NQIPLVKIVE SRVALKKYSD
     FLAKKKEKEL MELGVLNKSY KNLVTDKKED NLKHIKISWQ IESDDLKRQK AHEIVSLLKK
     GNKVTLYLDD KNNINSNNWL ENFEELDRSQ KGEPPRLPES VFQKRAAVLE TLKEIVSEYA
     NDPVLLGNMN SKMIMKLIPK DVKPQNNDKR ALKELRKKER QEKLQKRIQR KKMNEM
//