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Protein

Altered inheritance of mitochondria protein 23, mitochondrial

Gene

AIM23

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ribosome binding Source: SGD
  • translation initiation factor activity Source: SGD

GO - Biological processi

  • mitochondrial translational initiation Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31580-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Altered inheritance of mitochondria protein 23, mitochondrial
Gene namesi
Name:AIM23
Ordered Locus Names:YJL131C
ORF Names:J0682
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome X

Organism-specific databases

CYGDiYJL131c.
EuPathDBiFungiDB:YJL131C.
SGDiS000003667. AIM23.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Increases frequency of mitochondrial genome loss.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3232MitochondrionSequence AnalysisAdd
BLAST
Chaini33 – 356324Altered inheritance of mitochondria protein 23, mitochondrialPRO_0000203039Add
BLAST

Proteomic databases

MaxQBiP47015.
PaxDbiP47015.

Interactioni

Protein-protein interaction databases

BioGridi33625. 5 interactions.
DIPiDIP-5684N.
IntActiP47015. 1 interaction.
MINTiMINT-491609.
STRINGi4932.YJL131C.

Structurei

3D structure databases

ProteinModelPortaliP47015.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIM23 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG47128.
InParanoidiP47015.
OMAiKHIKISW.
OrthoDBiEOG7SBNZP.

Family and domain databases

Gene3Di3.30.110.10. 1 hit.
InterProiIPR029427. AIM23.
IPR019815. Translation_initiation_fac_3_C.
[Graphical view]
PfamiPF14877. mIF3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47015-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKVPLSDVL SQKMLFLKSF RYFHCTKYFS RDNASSTTDI FRNAMKRKRE
60 70 80 90 100
LANLKEQSHG NVARNAAFPK EYIKRPKQVP RNATNRKKIL ITWSTGTDRA
110 120 130 140 150
KEAANSVVSE IFKKNHKGNI KVVDPTTHRI EASNIRYFAK GIDLDKVGLS
160 170 180 190 200
IVNVEQIDNE NQIPLVKIVE SRVALKKYSD FLAKKKEKEL MELGVLNKSY
210 220 230 240 250
KNLVTDKKED NLKHIKISWQ IESDDLKRQK AHEIVSLLKK GNKVTLYLDD
260 270 280 290 300
KNNINSNNWL ENFEELDRSQ KGEPPRLPES VFQKRAAVLE TLKEIVSEYA
310 320 330 340 350
NDPVLLGNMN SKMIMKLIPK DVKPQNNDKR ALKELRKKER QEKLQKRIQR

KKMNEM
Length:356
Mass (Da):41,461
Last modified:February 1, 1996 - v1
Checksum:iBCF907223417B6C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87371 Genomic DNA. Translation: CAA60824.1.
Z49406 Genomic DNA. Translation: CAA89426.1.
M27174 Genomic DNA. No translation available.
BK006943 Genomic DNA. Translation: DAA08670.1.
PIRiS55181.
RefSeqiNP_012404.1. NM_001181564.1.

Genome annotation databases

EnsemblFungiiYJL131C; YJL131C; YJL131C.
GeneIDi853310.
KEGGisce:YJL131C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87371 Genomic DNA. Translation: CAA60824.1.
Z49406 Genomic DNA. Translation: CAA89426.1.
M27174 Genomic DNA. No translation available.
BK006943 Genomic DNA. Translation: DAA08670.1.
PIRiS55181.
RefSeqiNP_012404.1. NM_001181564.1.

3D structure databases

ProteinModelPortaliP47015.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33625. 5 interactions.
DIPiDIP-5684N.
IntActiP47015. 1 interaction.
MINTiMINT-491609.
STRINGi4932.YJL131C.

Proteomic databases

MaxQBiP47015.
PaxDbiP47015.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL131C; YJL131C; YJL131C.
GeneIDi853310.
KEGGisce:YJL131C.

Organism-specific databases

CYGDiYJL131c.
EuPathDBiFungiDB:YJL131C.
SGDiS000003667. AIM23.

Phylogenomic databases

eggNOGiNOG47128.
InParanoidiP47015.
OMAiKHIKISW.
OrthoDBiEOG7SBNZP.

Enzyme and pathway databases

BioCyciYEAST:G3O-31580-MONOMER.

Miscellaneous databases

NextBioi973645.
PROiP47015.

Family and domain databases

Gene3Di3.30.110.10. 1 hit.
InterProiIPR029427. AIM23.
IPR019815. Translation_initiation_fac_3_C.
[Graphical view]
PfamiPF14877. mIF3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of a 40.7 kb segment from the left arm of yeast chromosome X reveals 14 known genes and 13 new open reading frames including homologues of genes clustered on the right arm of chromosome XI."
    Katsoulou C., Tzermia M., Tavernarakis N., Alexandraki D.
    Yeast 12:787-797(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Organization of the yeast URA2 gene: identification of a defective dihydroorotase-like domain in the multifunctional carbamoylphosphate synthetase-aspartate transcarbamylase complex."
    Souciet J.-L., Nagy M., le Gouar M., Lacroute F., Potier S.
    Gene 79:59-70(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-124.
    Strain: ATCC 28383 / FL100 / VTT C-80102.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics."
    Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.
    J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  8. "Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis."
    Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J., Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M., Troyanskaya O.G., Caudy A.A.
    PLoS Genet. 5:E1000407-E1000407(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiAIM23_YEAST
AccessioniPrimary (citable) accession number: P47015
Secondary accession number(s): D6VW54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 24, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 319 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.