P47015 (AIM23_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Altered inheritance of mitochondria protein 23, mitochondrial

Gene names

Name:	AIM23
Ordered Locus Names:	YJL131C
ORF Names:	J0682

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Mitochondrion Ref.5 Ref.7.
Disruption phenotype	Increases frequency of mitochondrial genome loss. Ref.8
Miscellaneous	Present with 319 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the AIM23 family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	mitochondrion Inferred from direct assay Ref.5Ref.7. Source: SGD
Molecular_function	ribosome binding Inferred from direct assay PubMed 22457064. Source: SGD translation initiation factor activity Inferred from sequence or structural similarity PubMed 22457064. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 32	32	Mitochondrion Potential
	Chain	33 – 356	324	Altered inheritance of mitochondria protein 23, mitochondrial		PRO_0000203039

Sequences

	Sequence		Length	Mass (Da)
	P47015 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: BCF907223417B6C2	FASTA	356	41,461
	10 20 30 40 50 60 MLKVPLSDVL SQKMLFLKSF RYFHCTKYFS RDNASSTTDI FRNAMKRKRE LANLKEQSHG 70 80 90 100 110 120 NVARNAAFPK EYIKRPKQVP RNATNRKKIL ITWSTGTDRA KEAANSVVSE IFKKNHKGNI 130 140 150 160 170 180 KVVDPTTHRI EASNIRYFAK GIDLDKVGLS IVNVEQIDNE NQIPLVKIVE SRVALKKYSD 190 200 210 220 230 240 FLAKKKEKEL MELGVLNKSY KNLVTDKKED NLKHIKISWQ IESDDLKRQK AHEIVSLLKK 250 260 270 280 290 300 GNKVTLYLDD KNNINSNNWL ENFEELDRSQ KGEPPRLPES VFQKRAAVLE TLKEIVSEYA 310 320 330 340 350 NDPVLLGNMN SKMIMKLIPK DVKPQNNDKR ALKELRKKER QEKLQKRIQR KKMNEM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of a 40.7 kb segment from the left arm of yeast chromosome X reveals 14 known genes and 13 new open reading frames including homologues of genes clustered on the right arm of chromosome XI." Katsoulou C., Tzermia M., Tavernarakis N., Alexandraki D. Yeast 12:787-797(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L. EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Organization of the yeast URA2 gene: identification of a defective dihydroorotase-like domain in the multifunctional carbamoylphosphate synthetase-aspartate transcarbamylase complex." Souciet J.-L., Nagy M., le Gouar M., Lacroute F., Potier S. Gene 79:59-70(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-124. Strain: ATCC 28383 / FL100 / VTT C-80102.
[5]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]	"Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A. J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[8]	"Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis." Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J., Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M., Troyanskaya O.G., Caudy A.A. PLoS Genet. 5:E1000407-E1000407(2009) [PubMed] [Europe PMC] [Abstract] Cited for: DISRUPTION PHENOTYPE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X87371 Genomic DNA. Translation: CAA60824.1. Z49406 Genomic DNA. Translation: CAA89426.1. M27174 Genomic DNA. No translation available. BK006943 Genomic DNA. Translation: DAA08670.1.
PIR	S55181.
RefSeq	NP_012404.1. NM_001181564.1.
3D structure databases
ProteinModelPortal	P47015.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5684N.
MINT	MINT-491609.
STRING	4932.YJL131C.
Proteomic databases
PaxDb	P47015.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YJL131C; YJL131C; YJL131C.
GeneID	853310.
KEGG	sce:YJL131C.
Organism-specific databases
CYGD	YJL131c.
SGD	S000003667. AIM23.
Phylogenomic databases
eggNOG	NOG47128.
OMA	KHIKISW.
OrthoDB	EOG4XWK7C.
Enzyme and pathway databases
BioCyc	YEAST:G3O-31580-MONOMER.
Gene expression databases
Genevestigator	P47015.
GermOnline	YJL131C. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	973645.

Entry information

Entry name

AIM23_YEAST

Accession

Primary (citable) accession number: P47015
Secondary accession number(s): D6VW54

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 29, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program