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Protein

Glycogenin-2

Gene

GLG2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Self-glucosylating initiator of glycogen synthesis. Catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues. These chains act as primers for the elongation reaction catalyzed by glycogen synthase. Capable of transferring glucosyl residues to unbound acceptors such as free oligoglucans or oligoglucan derivatives.3 Publications

Miscellaneous

Present with 981 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin.

GO - Molecular functioni

  • glycogenin glucosyltransferase activity Source: SGD
  • UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  • glycogen biosynthetic process Source: SGD

Keywordsi

Molecular functionTransferase
Biological processGlycogen biosynthesis

Enzyme and pathway databases

BioCyciYEAST:MONOMER3O-4031
ReactomeiR-SCE-3322077 Glycogen synthesis
R-SCE-6798695 Neutrophil degranulation
R-SCE-70221 Glycogen breakdown (glycogenolysis)

Protein family/group databases

CAZyiGT8 Glycosyltransferase Family 8

Names & Taxonomyi

Protein namesi
Recommended name:
Glycogenin-2 (EC:2.4.1.186)
Alternative name(s):
Glycogen synthesis initiator protein 2
Glycogenin glucosyltransferase 2
Gene namesi
Name:GLG2
Ordered Locus Names:YJL137C
ORF Names:J0663
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL137C
SGDiS000003673 GLG2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi230Y → F: Eliminates glycogen accumulation; when associated with F-232 and F-367. 1 Publication1
Mutagenesisi232Y → F: Eliminates glycogen accumulation; when associated with F-230 and F-367. 1 Publication1
Mutagenesisi367Y → F: Eliminates glycogen accumulation; when associated with F-230 and F-232. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002151821 – 380Glycogenin-2Add BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi230O-linked (Glc...) tyrosine1 Publication1
Glycosylationi232O-linked (Glc...) tyrosine1 Publication1
Glycosylationi367O-linked (Glc...) tyrosineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP47011
PaxDbiP47011
PRIDEiP47011

Interactioni

Subunit structurei

Interacts with glycogen synthase GSY2.1 Publication

Protein-protein interaction databases

BioGridi33620, 53 interactors
DIPiDIP-1345N
IntActiP47011, 2 interactors
MINTiP47011
STRINGi4932.YJL137C

Structurei

3D structure databases

ProteinModelPortaliP47011
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000004721
InParanoidiP47011
KOiK00750
OMAiMELCHEY
OrthoDBiEOG092C395N

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR002495 Glyco_trans_8
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF01501 Glyco_transf_8, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

P47011-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKVAICTL LYSRDYLPGA LTLAYQLQKL LKHAVVEDEI TLCLLIEKKL
60 70 80 90 100
FGDEFKPQEI ALIRSLFKEI IIIEPLKDQE KSIEKNKANL ELLKRPELSH
110 120 130 140 150
TLLKARLWEL VQFDQVLFLD ADTLPLNKEF FEILRLYPEQ TRFQIAAVPD
160 170 180 190 200
IGWPDMFNTG VLLLIPDLDM ATSLQDFLIK TVSIDGADQG IFNQFFNPIC
210 220 230 240 250
NYSKEVLHKV SPLMEWIRLP FTYNVTMPNY GYQSSPAMNF FQQHIRLIHF
260 270 280 290 300
IGTFKPWSRN TTDYDDHYYQ LWRSTQRELY SECHLSNYFT HLQLGNIETE
310 320 330 340 350
TNFYHEPPCL QDLLNHGKRE NQKHVDLDIT SVDRNASQKS TAEKHDIEKP
360 370 380
TSKPQSAFKF DWESTDYLDR VQRAFPKPDT
Length:380
Mass (Da):44,546
Last modified:February 1, 1996 - v1
Checksum:i36BDF556DEF397C0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti241Missing AA sequence (PubMed:8900126).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25436 Genomic DNA Translation: AAA91644.1
X87371 Genomic DNA Translation: CAA60818.1
Z49412 Genomic DNA Translation: CAA89432.1
BK006943 Genomic DNA Translation: DAA08663.1
PIRiS55176
RefSeqiNP_012398.1, NM_001181570.1

Genome annotation databases

EnsemblFungiiYJL137C; YJL137C; YJL137C
GeneIDi853304
KEGGisce:YJL137C

Similar proteinsi

Entry informationi

Entry nameiGLG2_YEAST
AccessioniPrimary (citable) accession number: P47011
Secondary accession number(s): D6VW47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

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