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P47008

- SFH5_YEAST

UniProt

P47008 - SFH5_YEAST

Protein

Phosphatidylinositol transfer protein SFH5

Gene

SFH5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane.3 Publications

    GO - Molecular functioni

    1. phosphatidylinositol transporter activity Source: SGD

    GO - Biological processi

    1. Golgi to plasma membrane protein transport Source: SGD
    2. phosphatidylinositol metabolic process Source: SGD
    3. phospholipid transport Source: SGD
    4. regulation of establishment of cell polarity Source: SGD
    5. regulation of exocytosis Source: SGD

    Keywords - Biological processi

    Lipid transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31589-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol transfer protein SFH5
    Short name:
    PITP SFH5
    Alternative name(s):
    SEC14 homolog 5
    Gene namesi
    Name:SFH5
    Ordered Locus Names:YJL145W
    ORF Names:J0644
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJL145w.
    SGDiS000003681. SFH5.

    Subcellular locationi

    GO - Cellular componenti

    1. cell periphery Source: SGD
    2. cortical endoplasmic reticulum Source: SGD
    3. cytosol Source: SGD
    4. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    5. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Cytoplasm, Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 294294Phosphatidylinositol transfer protein SFH5PRO_0000203033Add
    BLAST

    Proteomic databases

    MaxQBiP47008.
    PaxDbiP47008.
    PeptideAtlasiP47008.

    Expressioni

    Gene expression databases

    GenevestigatoriP47008.

    Interactioni

    Protein-protein interaction databases

    BioGridi33613. 19 interactions.
    IntActiP47008. 2 interactions.
    MINTiMINT-4491120.
    STRINGi4932.YJL145W.

    Structurei

    3D structure databases

    ProteinModelPortaliP47008.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini100 – 266167CRAL-TRIOPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SFH5 family.Curated
    Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG270325.
    HOGENOMiHOG000048479.
    OMAiRIGLMEK.
    OrthoDBiEOG7VQJQ2.

    Family and domain databases

    Gene3Di3.40.525.10. 1 hit.
    InterProiIPR001251. CRAL-TRIO_dom.
    IPR011074. CRAL/TRIO_N_dom.
    [Graphical view]
    PfamiPF00650. CRAL_TRIO. 1 hit.
    PF03765. CRAL_TRIO_N. 1 hit.
    [Graphical view]
    SMARTiSM00516. SEC14. 1 hit.
    [Graphical view]
    SUPFAMiSSF52087. SSF52087. 1 hit.
    PROSITEiPS50191. CRAL_TRIO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47008-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFDNDSEKQ VFDKLKKAIP GIIKEKCAGY DELYGYKLNP EGLTQEEVDK    50
    YYDEKIADRL TYKLCKAYQF EYSTIVQNLI DILNWRREFN PLSCAYKEVH 100
    NTELQNVGIL TFDANGDANK KAVTWNLYGQ LVKKKELFQN VDKFVRYRIG 150
    LMEKGLSLLD FTSSDNNYMT QVHDYKGVSV WRMDSDIKNC SKTVIGIFQK 200
    YYPELLYAKY FVNVPTVFGW VYDLIKKFVD ETTRKKFVVL TDGSKLGQYL 250
    KDCPYEGYGG KDKKNNLTKQ NVTNVHPTEY GLYILQKQII EDVE 294
    Length:294
    Mass (Da):34,388
    Last modified:February 1, 1996 - v1
    Checksum:iE75B80F3AB56EF70
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti70 – 701F → S in AAS56909. (PubMed:17322287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X87371 Genomic DNA. Translation: CAA60810.1.
    Z49420 Genomic DNA. Translation: CAA89440.1.
    AY558583 Genomic DNA. Translation: AAS56909.1.
    BK006943 Genomic DNA. Translation: DAA08656.1.
    PIRiS55168.
    RefSeqiNP_012390.1. NM_001181578.1.

    Genome annotation databases

    EnsemblFungiiYJL145W; YJL145W; YJL145W.
    GeneIDi853296.
    KEGGisce:YJL145W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X87371 Genomic DNA. Translation: CAA60810.1 .
    Z49420 Genomic DNA. Translation: CAA89440.1 .
    AY558583 Genomic DNA. Translation: AAS56909.1 .
    BK006943 Genomic DNA. Translation: DAA08656.1 .
    PIRi S55168.
    RefSeqi NP_012390.1. NM_001181578.1.

    3D structure databases

    ProteinModelPortali P47008.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33613. 19 interactions.
    IntActi P47008. 2 interactions.
    MINTi MINT-4491120.
    STRINGi 4932.YJL145W.

    Proteomic databases

    MaxQBi P47008.
    PaxDbi P47008.
    PeptideAtlasi P47008.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJL145W ; YJL145W ; YJL145W .
    GeneIDi 853296.
    KEGGi sce:YJL145W.

    Organism-specific databases

    CYGDi YJL145w.
    SGDi S000003681. SFH5.

    Phylogenomic databases

    eggNOGi NOG270325.
    HOGENOMi HOG000048479.
    OMAi RIGLMEK.
    OrthoDBi EOG7VQJQ2.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31589-MONOMER.

    Miscellaneous databases

    NextBioi 973609.

    Gene expression databases

    Genevestigatori P47008.

    Family and domain databases

    Gene3Di 3.40.525.10. 1 hit.
    InterProi IPR001251. CRAL-TRIO_dom.
    IPR011074. CRAL/TRIO_N_dom.
    [Graphical view ]
    Pfami PF00650. CRAL_TRIO. 1 hit.
    PF03765. CRAL_TRIO_N. 1 hit.
    [Graphical view ]
    SMARTi SM00516. SEC14. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52087. SSF52087. 1 hit.
    PROSITEi PS50191. CRAL_TRIO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of a 40.7 kb segment from the left arm of yeast chromosome X reveals 14 known genes and 13 new open reading frames including homologues of genes clustered on the right arm of chromosome XI."
      Katsoulou C., Tzermia M., Tavernarakis N., Alexandraki D.
      Yeast 12:787-797(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "Identification of a novel family of nonclassic yeast phosphatidylinositol transfer proteins whose function modulates phospholipase D activity and Sec14p-independent cell growth."
      Li X., Routt S.M., Xie Z., Cui X., Fang M., Kearns M.A., Bard M., Kirsch D.R., Bankaitis V.A.
      Mol. Biol. Cell 11:1989-2005(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHATIDYLINOSITOL-BINDING, SUBCELLULAR LOCATION.
    6. "Subcellular localization of yeast Sec14 homologues and their involvement in regulation of phospholipid turnover."
      Schnabl M., Oskolkova O.V., Holic R., Brezna B., Pichler H., Zagorsek M., Kohlwein S.D., Paltauf F., Daum G., Griac P.
      Eur. J. Biochem. 270:3133-3145(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    9. "Sec14p-like proteins regulate phosphoinositide homoeostasis and intracellular protein and lipid trafficking in yeast."
      Mousley C.J., Tyeryar K.R., Ryan M.M., Bankaitis V.A.
      Biochem. Soc. Trans. 34:346-350(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiSFH5_YEAST
    AccessioniPrimary (citable) accession number: P47008
    Secondary accession number(s): D6VW40, Q6Q535
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 6540 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3