Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphatidylinositol transfer protein SFH5

Gene

SFH5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane.3 Publications

Miscellaneous

Present with 6540 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • phosphatidylinositol transporter activity Source: SGD

GO - Biological processi

  • Golgi to plasma membrane protein transport Source: SGD
  • phosphatidylinositol metabolic process Source: SGD
  • phospholipid transport Source: SGD
  • regulation of establishment of cell polarity Source: SGD
  • regulation of exocytosis Source: SGD

Keywordsi

Biological processLipid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31589-MONOMER

Chemistry databases

SwissLipidsiSLP:000000358

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol transfer protein SFH5
Short name:
PITP SFH5
Alternative name(s):
SEC14 homolog 5
Gene namesi
Name:SFH5
Ordered Locus Names:YJL145W
ORF Names:J0644
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL145W
SGDiS000003681 SFH5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002030331 – 294Phosphatidylinositol transfer protein SFH5Add BLAST294

Proteomic databases

MaxQBiP47008
PaxDbiP47008
PRIDEiP47008

PTM databases

CarbonylDBiP47008

Interactioni

Protein-protein interaction databases

BioGridi33613, 57 interactors
IntActiP47008, 2 interactors
MINTiP47008
STRINGi4932.YJL145W

Structurei

3D structure databases

ProteinModelPortaliP47008
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 266CRAL-TRIOPROSITE-ProRule annotationAdd BLAST167

Sequence similaritiesi

Belongs to the SFH5 family.Curated

Phylogenomic databases

HOGENOMiHOG000048479
InParanoidiP47008
KOiK19996
OMAiWIFWLFK
OrthoDBiEOG092C3OBG

Family and domain databases

CDDicd00170 SEC14, 1 hit
Gene3Di3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
PfamiView protein in Pfam
PF00650 CRAL_TRIO, 1 hit
SMARTiView protein in SMART
SM00516 SEC14, 1 hit
SUPFAMiSSF52087 SSF52087, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit

Sequencei

Sequence statusi: Complete.

P47008-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFDNDSEKQ VFDKLKKAIP GIIKEKCAGY DELYGYKLNP EGLTQEEVDK
60 70 80 90 100
YYDEKIADRL TYKLCKAYQF EYSTIVQNLI DILNWRREFN PLSCAYKEVH
110 120 130 140 150
NTELQNVGIL TFDANGDANK KAVTWNLYGQ LVKKKELFQN VDKFVRYRIG
160 170 180 190 200
LMEKGLSLLD FTSSDNNYMT QVHDYKGVSV WRMDSDIKNC SKTVIGIFQK
210 220 230 240 250
YYPELLYAKY FVNVPTVFGW VYDLIKKFVD ETTRKKFVVL TDGSKLGQYL
260 270 280 290
KDCPYEGYGG KDKKNNLTKQ NVTNVHPTEY GLYILQKQII EDVE
Length:294
Mass (Da):34,388
Last modified:February 1, 1996 - v1
Checksum:iE75B80F3AB56EF70
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70F → S in AAS56909 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87371 Genomic DNA Translation: CAA60810.1
Z49420 Genomic DNA Translation: CAA89440.1
AY558583 Genomic DNA Translation: AAS56909.1
BK006943 Genomic DNA Translation: DAA08656.1
PIRiS55168
RefSeqiNP_012390.1, NM_001181578.1

Genome annotation databases

EnsemblFungiiYJL145W; YJL145W; YJL145W
GeneIDi853296
KEGGisce:YJL145W

Similar proteinsi

Entry informationi

Entry nameiSFH5_YEAST
AccessioniPrimary (citable) accession number: P47008
Secondary accession number(s): D6VW40, Q6Q535
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health