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Protein

F-box protein DAS1

Gene

DAS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity).By similarity

Miscellaneous

Present with 195 molecules/cell in log phase SD medium.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-31593-MONOMER
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box protein DAS1
Alternative name(s):
DST1-delta 6-azauracil sensitivity protein 1
Gene namesi
Name:DAS1
Ordered Locus Names:YJL149W
ORF Names:J0634
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL149W
SGDiS000003685 DAS1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199711 – 663F-box protein DAS1Add BLAST663

Proteomic databases

MaxQBiP47005
PaxDbiP47005
PRIDEiP47005
TopDownProteomicsiP47005

Interactioni

Subunit structurei

Interacts with SKP1. Component of the probable SCF(DAS1) complex containing CDC53, SKP1, RBX1 and DAS1.4 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi33609, 78 interactors
DIPiDIP-6404N
IntActiP47005, 7 interactors
MINTiP47005
STRINGi4932.YJL149W

Structurei

3D structure databases

ProteinModelPortaliP47005
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 91F-boxPROSITE-ProRule annotationAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi533 – 539Poly-Asp7
Compositional biasi647 – 652Poly-Asn6

Phylogenomic databases

GeneTreeiENSGT00530000066426
InParanoidiP47005
OMAiYPSVRTQ
OrthoDBiEOG092C113B

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SUPFAMiSSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequencei

Sequence statusi: Complete.

P47005-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFQDYFQKK KAAFINRNNK SNADASALRD INDININFAA KSKNYVFPLT
60 70 80 90 100
KLPDELMQEV FSHLPQPDRL QLCLVNKRLN KIATKLLYRR IYLNDSNVVK
110 120 130 140 150
SDFMHLAINW TLLNLPSSLK EEESRDIANC KLKKLIETLQ NNIHITEVIQ
160 170 180 190 200
WIRINWDLDS TLQRSILSIL CNQGKSLQRL ENVTDPACND IISNGHFSRS
210 220 230 240 250
NVSSFDMAPP NSLPEMVVPE NYIPNLTKYL SQRISSRLSH MTLFIDPLKL
260 270 280 290 300
FNYLYPLDIK LQIIDLKLHW RREFYNNDYF VKKIRPGNPL TKLSEVFDKR
310 320 330 340 350
TLKILTIISW NDTLLKRETE MLKDFKEFEN LEDLSLISIK QDVHILVDLF
360 370 380 390 400
SSLTNLKRLK MDFLEEYVPE PTNPHIFLSI LLACSKLQFI DLRYDGLIPQ
410 420 430 440 450
IINIQENKFQ LNQQCNCTNC QIVFSDILKG KIFMFPEDYY IHDLQDIAAK
460 470 480 490 500
DIFKMMKYLS LLPYSKACDA YPSVRTQPMN LTNFVTKMNR NLLEYRNSKS
510 520 530 540 550
QLVPKIVNNP HQHSTVTSTS TAHMSEPEMI IIDDDDDDDE INAAIPPSSD
560 570 580 590 600
DTAATISTDL ELPHESLTKR DIIMCYHALI HHFKSIYVTF LKSFPHLRFL
610 620 630 640 650
MLNDIPTIVM EENNERIFEP VFYHYDYKSN LYGWSKESNK NLENDSNNNN
660
NNSDTIARIA TVM
Length:663
Mass (Da):77,367
Last modified:February 1, 1996 - v1
Checksum:iC48B6CAB40920027
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49425 Genomic DNA Translation: CAA89445.1
X87371 Genomic DNA Translation: CAA60806.1
BK006943 Genomic DNA Translation: DAA08652.1
PIRiS55164
RefSeqiNP_012386.1, NM_001181582.1

Genome annotation databases

EnsemblFungiiYJL149W; YJL149W; YJL149W
GeneIDi853292
KEGGisce:YJL149W

Similar proteinsi

Entry informationi

Entry nameiDAS1_YEAST
AccessioniPrimary (citable) accession number: P47005
Secondary accession number(s): D6VW36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health