Reviewed,
UniProtKB/Swiss-Prot P46999 (PIR5_YEAST)
Last modified
November 24, 2009.
Version 61.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cell wall protein PIR5 Alternative name(s): Protein with internal repeats 5 | ||||||
| Gene names |
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| Organism | Saccharomyces cerevisiae (Baker's yeast) [Complete proteome] | ||||||
| Taxonomic identifier | 4932 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 287 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Component of the outer cell wall layer By similarity. May be involved in meiosis and sporulation. |
| Subcellular location | Secreted › cell wall By similarity. Note: Covalently attached to the cell wall By similarity. |
| Induction | Cell cycle-regulated. Expression peaks during mitosis. Ref.5 |
| Domain | The PIR1/2/3 repeats are required for the covalent linkage to the cell wall By similarity. Their number varies among different strains of S.cerevisiae. |
| Post-translational modification | Covalently linked to beta-1,3-glucan of the inner cell wall layer via an alkali-sensitive ester linkage between the gamma-carboxyl group of glutamic acids, arising from specific glutamines within the PIR1/2/3 repeats, and hydroxyl groups of glucoses of beta-1,3-glucan chains By similarity. |
| Sequence similarities | Belongs to the PIR protein family. Contains 4 PIR1/2/3 repeats. |
| Sequence caution | The sequence CAA89455.1 differs from that shown. Reason: Frameshift at position 174. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell wall Secreted |
| Domain | Repeat Signal |
| PTM | Cleavage on pair of basic residues |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | cell wall Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular regionInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 21 | 21 | Potential | ||||||
| Propeptide | 22 – 62 | 41 | By similarity | PRO_0000377623 | |||||
| Chain | 63 – 287 | 225 | Cell wall protein PIR5 | PRO_0000014333 | |||||
Regions | |||||||||
| Repeat | 62 – 80 | 19 | PIR1/2/3 1 | ||||||
| Repeat | 81 – 99 | 19 | PIR1/2/3 2 | ||||||
| Repeat | 104 – 122 | 19 | PIR1/2/3 3 | ||||||
| Repeat | 144 – 162 | 19 | PIR1/2/3 4 | ||||||
Sites | |||||||||
| Site | 62 – 63 | 2 | Cleavage; by KEX2 Potential | ||||||
| Site | 72 | 1 | Covalent attachment to cell wall glycan By similarity | ||||||
| Site | 91 | 1 | Covalent attachment to cell wall glycan By similarity | ||||||
| Site | 114 | 1 | Covalent attachment to cell wall glycan By similarity | ||||||
| Site | 154 | 1 | Covalent attachment to cell wall glycan By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. Karpfinger-Hartl L.EMBO J. 15:2031-2049(1996) [PubMed: 8641269] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679. |
| [2] | "Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii." Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A., Gates K., Gaffney T.D., Philippsen P. Genome Biol. 4:R45.1-R45.13(2003) [PubMed: 12844361] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 144-223. Strain: ATCC 204511 / S288c / AB972. |
| [3] | "Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae." Enyenihi A.H., Saunders W.S. Genetics 163:47-54(2003) [PubMed: 12586695] [Abstract] Cited for: FUNCTION. |
| [4] | "Sequencing and comparison of yeast species to identify genes and regulatory elements." Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S. Nature 423:241-254(2003) [PubMed: 12748633] [Abstract] Cited for: IDENTIFICATION OF FRAMESHIFT. |
| [5] | "New weakly expressed cell cycle-regulated genes in yeast." de Lichtenberg U., Wernersson R., Jensen T.S., Nielsen H.B., Fausboell A., Schmidt P., Hansen F.B., Knudsen S., Brunak S. Yeast 22:1191-1201(2005) [PubMed: 16278933] [Abstract] Cited for: INDUCTION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| Z49435 Genomic DNA. Translation: CAA89455.1. Frameshift. AY260893 Genomic DNA. Translation: AAP21761.1. | |
| PIR | S56943. |
| RefSeq | NP_012375.2. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:1909N. |
| IntAct | P46999. 2 interactions. |
Genome annotation databases | |
| Ensembl | YJL160C; YJL160C; YJL160C; Saccharomyces cerevisiae. [Genome view] |
| GeneID | 853280. |
| KEGG | sce:YJL160C. |
| NMPDR | fig|4932.3.peg.3339. |
Organism-specific databases | |
| CYGD | YJL160c. |
| SGD | S000003696. YJL160C. |
Phylogenomic databases | |
| HOGENOM | P46999. |
| OrthoDB | EOG97H76C |
Gene expression databases | |
| ArrayExpress | P46999. |
| Genevestigator | P46999. |
| GermOnline | YJL160C. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR000420. Yeast_PIR. [Graphical view] |
| Pfam | PF00399. PIR. 4 hits. [Graphical view] |
| PROSITE | PS00929. PIR_REPEAT_1. 4 hits. PS50256. PIR_REPEAT_2. 4 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 973570. |
| PMAP-CutDB | P46999. |
Entry information
| Entry name | PIR5_YEAST | ||||||||
| Accession | Primary (citable) accession number: P46999 Secondary accession number(s): Q86ZS0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome X Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names |

Clusters with


