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P46999

- PIR5_YEAST

UniProt

P46999 - PIR5_YEAST

Protein

Cell wall protein PIR5

Gene

PIR5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (16 May 2006)
      Previous versions | rss
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    Functioni

    Component of the outer cell wall layer By similarity. May be involved in meiosis and sporulation.By similarity1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei62 – 632Cleavage; by KEX2Sequence Analysis
    Sitei72 – 721Covalent attachment to cell wall glycanBy similarity
    Sitei91 – 911Covalent attachment to cell wall glycanBy similarity
    Sitei114 – 1141Covalent attachment to cell wall glycanBy similarity
    Sitei154 – 1541Covalent attachment to cell wall glycanBy similarity

    GO - Molecular functioni

    1. structural constituent of cell wall Source: InterPro

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31600-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell wall protein PIR5
    Alternative name(s):
    Protein with internal repeats 5
    Gene namesi
    Name:PIR5
    Ordered Locus Names:YJL160C
    ORF Names:J0555
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJL160c.
    SGDiS000003696. YJL160C.

    Subcellular locationi

    Secretedcell wall By similarity
    Note: Covalently attached to the cell wall.By similarity

    GO - Cellular componenti

    1. cell wall Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell wall, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Propeptidei22 – 6241By similarityPRO_0000377623Add
    BLAST
    Chaini63 – 287225Cell wall protein PIR5PRO_0000014333Add
    BLAST

    Post-translational modificationi

    Covalently linked to beta-1,3-glucan of the inner cell wall layer via an alkali-sensitive ester linkage between the gamma-carboxyl group of glutamic acids, arising from specific glutamines within the PIR1/2/3 repeats, and hydroxyl groups of glucoses of beta-1,3-glucan chains.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues

    Proteomic databases

    PaxDbiP46999.

    Miscellaneous databases

    PMAP-CutDBP46999.

    Expressioni

    Inductioni

    Cell cycle-regulated. Expression peaks during mitosis.1 Publication

    Gene expression databases

    GenevestigatoriP46999.

    Interactioni

    Protein-protein interaction databases

    BioGridi33600. 106 interactions.
    DIPiDIP-1909N.
    IntActiP46999. 2 interactions.
    MINTiMINT-395257.
    STRINGi4932.YJL160C.

    Structurei

    3D structure databases

    ProteinModelPortaliP46999.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati62 – 8019PIR1/2/3 1Add
    BLAST
    Repeati81 – 9919PIR1/2/3 2Add
    BLAST
    Repeati104 – 12219PIR1/2/3 3Add
    BLAST
    Repeati144 – 16219PIR1/2/3 4Add
    BLAST

    Domaini

    The PIR1/2/3 repeats are required for the covalent linkage to the cell wall By similarity. Their number varies among different strains of S.cerevisiae.By similarity

    Sequence similaritiesi

    Belongs to the PIR protein family.Curated
    Contains 4 PIR1/2/3 repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG38801.
    GeneTreeiENSGT00390000008137.
    HOGENOMiHOG000248193.
    OrthoDBiEOG7FNCJZ.

    Family and domain databases

    InterProiIPR000420. Yeast_PIR.
    [Graphical view]
    PfamiPF00399. PIR. 4 hits.
    [Graphical view]
    PROSITEiPS00929. PIR_REPEAT_1. 4 hits.
    PS50256. PIR_REPEAT_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P46999-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHYKKAFLAS LLSSIALTAY APPEPWATLT PSSKMDGGTT EYRTSFGLAV    50
    IPFTVTESKV KRNVISQIND GQVQVTTQKL PHPVSQIGDG QIQVTTQKVP 100
    PVVSHIVSQI GDGQLQITTA KNVVTKSTIA VPSKTVTATA TSTATAVSQI 150
    HDGQVQVTIS SASSSSVLSK SKLEPTKKPN NEKVIKVQAC KSSGTLAITL 200
    QGGVLIDSSG RIGSIVANRQ FQFDGPPPQA GAIYAGGWSI TKHGTLAIGD 250
    NDVFYQCLSG TFYNLYDQSI GGQCNPVHLQ TVGLVDC 287
    Length:287
    Mass (Da):30,215
    Last modified:May 16, 2006 - v2
    Checksum:i3E02845EA0DD7F33
    GO

    Sequence cautioni

    The sequence CAA89455.1 differs from that shown. Reason: Frameshift at position 174.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49435 Genomic DNA. Translation: CAA89455.1. Frameshift.
    AY260893 Genomic DNA. Translation: AAP21761.1.
    BK006943 Genomic DNA. Translation: DAA08643.1.
    PIRiS56943.
    RefSeqiNP_012375.2. NM_001181593.1.

    Genome annotation databases

    EnsemblFungiiYJL160C; YJL160C; YJL160C.
    GeneIDi853280.
    KEGGisce:YJL160C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49435 Genomic DNA. Translation: CAA89455.1 . Frameshift.
    AY260893 Genomic DNA. Translation: AAP21761.1 .
    BK006943 Genomic DNA. Translation: DAA08643.1 .
    PIRi S56943.
    RefSeqi NP_012375.2. NM_001181593.1.

    3D structure databases

    ProteinModelPortali P46999.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33600. 106 interactions.
    DIPi DIP-1909N.
    IntActi P46999. 2 interactions.
    MINTi MINT-395257.
    STRINGi 4932.YJL160C.

    Proteomic databases

    PaxDbi P46999.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJL160C ; YJL160C ; YJL160C .
    GeneIDi 853280.
    KEGGi sce:YJL160C.

    Organism-specific databases

    CYGDi YJL160c.
    SGDi S000003696. YJL160C.

    Phylogenomic databases

    eggNOGi NOG38801.
    GeneTreei ENSGT00390000008137.
    HOGENOMi HOG000248193.
    OrthoDBi EOG7FNCJZ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31600-MONOMER.

    Miscellaneous databases

    NextBioi 973570.
    PMAP-CutDB P46999.

    Gene expression databases

    Genevestigatori P46999.

    Family and domain databases

    InterProi IPR000420. Yeast_PIR.
    [Graphical view ]
    Pfami PF00399. PIR. 4 hits.
    [Graphical view ]
    PROSITEi PS00929. PIR_REPEAT_1. 4 hits.
    PS50256. PIR_REPEAT_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii."
      Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A., Gates K., Gaffney T.D., Philippsen P.
      Genome Biol. 4:R45.1-R45.13(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 144-223.
      Strain: ATCC 204511 / S288c / AB972.
    4. "Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae."
      Enyenihi A.H., Saunders W.S.
      Genetics 163:47-54(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
      Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
      Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF FRAMESHIFT.
    6. Cited for: INDUCTION.

    Entry informationi

    Entry nameiPIR5_YEAST
    AccessioniPrimary (citable) accession number: P46999
    Secondary accession number(s): D6VW27, Q86ZS0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3