ID   YJQ3_YEAST              Reviewed;         555 AA.
AC   P46996; D6VW24;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   27-MAR-2024, entry version 132.
DE   RecName: Full=Uncharacterized membrane protein YJL163C;
GN   OrderedLocusNames=YJL163C; ORFNames=J0544;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA   Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA   Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA   Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA   Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA   Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA   Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA   Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA   Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA   Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA   To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA   von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT   "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL   EMBO J. 15:2031-2049(1996).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   TOPOLOGY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 208353 / W303-1A;
RX   PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA   Kim H., Melen K., Oesterberg M., von Heijne G.;
RT   "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
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DR   EMBL; Z49438; CAA89458.1; -; Genomic_DNA.
DR   EMBL; BK006943; DAA08640.1; -; Genomic_DNA.
DR   PIR; S56946; S56946.
DR   RefSeq; NP_012372.1; NM_001181596.1.
DR   AlphaFoldDB; P46996; -.
DR   SMR; P46996; -.
DR   BioGRID; 33596; 116.
DR   DIP; DIP-8000N; -.
DR   STRING; 4932.YJL163C; -.
DR   TCDB; 2.A.1.11.4; the major facilitator superfamily (mfs).
DR   iPTMnet; P46996; -.
DR   PaxDb; 4932-YJL163C; -.
DR   PeptideAtlas; P46996; -.
DR   EnsemblFungi; YJL163C_mRNA; YJL163C; YJL163C.
DR   GeneID; 853276; -.
DR   KEGG; sce:YJL163C; -.
DR   AGR; SGD:S000003699; -.
DR   SGD; S000003699; YJL163C.
DR   VEuPathDB; FungiDB:YJL163C; -.
DR   eggNOG; KOG2816; Eukaryota.
DR   GeneTree; ENSGT00950000183096; -.
DR   HOGENOM; CLU_017517_2_1_1; -.
DR   InParanoid; P46996; -.
DR   OMA; YFENAPM; -.
DR   OrthoDB; 2197769at2759; -.
DR   BioCyc; YEAST:G3O-31603-MONOMER; -.
DR   Reactome; R-SCE-196757; Metabolism of folate and pterines.
DR   Reactome; R-SCE-917937; Iron uptake and transport.
DR   Reactome; R-SCE-9707616; Heme signaling.
DR   BioGRID-ORCS; 853276; 0 hits in 10 CRISPR screens.
DR   PRO; PR:P46996; -.
DR   Proteomes; UP000002311; Chromosome X.
DR   RNAct; P46996; Protein.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; HDA:SGD.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR23507:SF1; GH08173P; 1.
DR   PANTHER; PTHR23507; ZGC:174356; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..555
FT                   /note="Uncharacterized membrane protein YJL163C"
FT                   /id="PRO_0000203027"
FT   TOPO_DOM        1..83
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        105..125
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        147..188
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        210..229
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        251..257
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        279..356
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        378..386
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        408..428
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        429..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        450..459
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        460..480
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        481..491
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        492..512
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        513..523
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        524..544
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        545..555
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          289..311
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   555 AA;  61525 MW;  A72400A0BB80A533 CRC64;
     MSNEDETTRL MSSDEMDYLL ETAGINALEE IISQNDSTGI NLDTNETAQD SSYDSIRRSP
     SILSVAKSVE GEHGRRKLLC LYGLVMIICI AESISMTATI PLVMDKVAEG ISDENGHYDS
     VAVQTIVSSI SSSTMMIAGA ISIFMAGKWG ELSDRIGRVR VFKYMSGIRV IGLLTHVFTL
     SSKMKYHKWA IVLTACIVPS FGGLFALVAN GNSYVSDIVK TEHRMVTIGI MMSCIYATMG
     VGPMFGSFLV KWTHGNGFIP IYTSIAFVIL ALIICETIMV EPRHETQMAH SQSTYTKRRE
     KLRSQSGSDD ARNYQSVTYG KFQIMRLMDL LAPVKKLWLK PDSAGSLVPR HTVILLIVLD
     ILFVCGTTSC MPALILFSTY EYKWHAVELG YFISILGIGR GVVLLVVSPT LLYTLKRIYQ
     HLNHSIDKID IFCIQFSMIV ITLSLFVMIR FGEKTPTSMI IFALLQALSA FCSPTLQSGI
     IKYTSKKHTG EMFGAMALVR SCVMLVIPPI LLKLYGSTVS VNPSLFMYIP FSTSIVAILL
     TFFLRIYKNP PLDGP
//