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Protein

Protein ASG7

Gene

ASG7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for receptor inhibition of inappropriately expressed a-factor receptor (STE3) in MAT a cells. Inhibits signaling by relocalizing the G protein beta-gamma (STE4-STE18) subunit to intracellular mebranes. May also be a mechanism for the down-regulation of the mating pheromone response after the zygotic fusion event, promoting the transition of the new diploid cell to vegetative growth.3 Publications

GO - Biological processi

  • conjugation with cellular fusion Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31607-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ASG7
Alternative name(s):
A-specific gene 7 protein
Gene namesi
Name:ASG7
Ordered Locus Names:YJL170C
ORF Names:J0514
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL170C.
SGDiS000003706. ASG7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49LumenalSequence analysisAdd BLAST49
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 184CytoplasmicSequence analysisAdd BLAST114
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Topological domaini206 – 209LumenalSequence analysis4

GO - Cellular componenti

  • endomembrane system Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002030251 – 209Protein ASG7Add BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei121PhosphoserineCombined sources1
Modified residuei123PhosphoserineCombined sources1
Modified residuei125PhosphoserineCombined sources1
Modified residuei153PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP46993.

PTM databases

iPTMnetiP46993.

Expressioni

Inductioni

Induced by alpha-pheromone. Repressed by the ALPHA2-MCM1 repressor.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi33590. 11 interactors.
DIPiDIP-5416N.
IntActiP46993. 1 interactor.
MINTiMINT-529434.

Structurei

3D structure databases

ProteinModelPortaliP46993.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP46993.
OMAiESCHRTE.
OrthoDBiEOG092C5RPJ.

Sequencei

Sequence statusi: Complete.

P46993-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTLASSIEH KTKHLAAPFE NDENPWMKKY CCQCKSCKMS VPVQPWLPRF
60 70 80 90 100
FVFGILCPVF WLVNLLAWWF LQYWQPHELE FHDLQEDEYP GFYEYEAITK
110 120 130 140 150
RTVIPIKEEV LQEIRVMQNF SDSNSEEYYE SKDGMPSSFL NVNTEQVEDE
160 170 180 190 200
NDTLKKYRYA FLKKVAHDVL ESHDLLRKTF RDWNLRSLLG LLIDSILIIF

VVLLCKKSR
Length:209
Mass (Da):24,946
Last modified:April 29, 2008 - v2
Checksum:i504DFEDD9063F6AF
GO

Sequence cautioni

The sequence CAA89465 differs from that shown. Reason: Frameshift at position 16.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49445 Genomic DNA. Translation: CAA89465.1. Frameshift.
BK006943 Genomic DNA. Translation: DAA08634.1.
PIRiS56953.
RefSeqiNP_012365.2. NM_001181603.1.

Genome annotation databases

EnsemblFungiiYJL170C; YJL170C; YJL170C.
GeneIDi853269.
KEGGisce:YJL170C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49445 Genomic DNA. Translation: CAA89465.1. Frameshift.
BK006943 Genomic DNA. Translation: DAA08634.1.
PIRiS56953.
RefSeqiNP_012365.2. NM_001181603.1.

3D structure databases

ProteinModelPortaliP46993.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33590. 11 interactors.
DIPiDIP-5416N.
IntActiP46993. 1 interactor.
MINTiMINT-529434.

PTM databases

iPTMnetiP46993.

Proteomic databases

PRIDEiP46993.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL170C; YJL170C; YJL170C.
GeneIDi853269.
KEGGisce:YJL170C.

Organism-specific databases

EuPathDBiFungiDB:YJL170C.
SGDiS000003706. ASG7.

Phylogenomic databases

InParanoidiP46993.
OMAiESCHRTE.
OrthoDBiEOG092C5RPJ.

Enzyme and pathway databases

BioCyciYEAST:G3O-31607-MONOMER.

Miscellaneous databases

PROiP46993.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiASG7_YEAST
AccessioniPrimary (citable) accession number: P46993
Secondary accession number(s): D6VW18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: April 29, 2008
Last modified: November 2, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.