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P46993

- ASG7_YEAST

UniProt

P46993 - ASG7_YEAST

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Protein

Protein ASG7

Gene

ASG7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Required for receptor inhibition of inappropriately expressed a-factor receptor (STE3) in MAT a cells. Inhibits signaling by relocalizing the G protein beta-gamma (STE4-STE18) subunit to intracellular mebranes. May also be a mechanism for the down-regulation of the mating pheromone response after the zygotic fusion event, promoting the transition of the new diploid cell to vegetative growth.3 Publications

GO - Biological processi

  1. conjugation with cellular fusion Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31607-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ASG7
Alternative name(s):
A-specific gene 7 protein
Gene namesi
Name:ASG7
Ordered Locus Names:YJL170C
ORF Names:J0514
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

SGDiS000003706. ASG7.

Subcellular locationi

Endomembrane system 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Protein ASG7PRO_0000203025Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei121 – 1211Phosphoserine1 Publication
Modified residuei123 – 1231Phosphoserine1 Publication
Modified residuei125 – 1251Phosphoserine1 Publication
Modified residuei153 – 1531Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP46993.

Expressioni

Inductioni

Induced by alpha-pheromone. Repressed by the ALPHA2-MCM1 repressor.2 Publications

Gene expression databases

GenevestigatoriP46993.

Interactioni

Protein-protein interaction databases

BioGridi33590. 12 interactions.
DIPiDIP-5416N.
IntActiP46993. 1 interaction.
MINTiMINT-529434.
STRINGi4932.YJL170C.

Structurei

3D structure databases

ProteinModelPortaliP46993.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4949LumenalSequence AnalysisAdd
BLAST
Topological domaini71 – 184114CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini206 – 2094LumenalSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei50 – 7021HelicalSequence AnalysisAdd
BLAST
Transmembranei185 – 20521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG74535.
InParanoidiP46993.
OMAiANHHIVE.
OrthoDBiEOG7J18CN.

Sequencei

Sequence statusi: Complete.

P46993-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTLASSIEH KTKHLAAPFE NDENPWMKKY CCQCKSCKMS VPVQPWLPRF
60 70 80 90 100
FVFGILCPVF WLVNLLAWWF LQYWQPHELE FHDLQEDEYP GFYEYEAITK
110 120 130 140 150
RTVIPIKEEV LQEIRVMQNF SDSNSEEYYE SKDGMPSSFL NVNTEQVEDE
160 170 180 190 200
NDTLKKYRYA FLKKVAHDVL ESHDLLRKTF RDWNLRSLLG LLIDSILIIF

VVLLCKKSR
Length:209
Mass (Da):24,946
Last modified:April 29, 2008 - v2
Checksum:i504DFEDD9063F6AF
GO

Sequence cautioni

The sequence CAA89465.1 differs from that shown. Reason: Frameshift at position 16.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49445 Genomic DNA. Translation: CAA89465.1. Frameshift.
BK006943 Genomic DNA. Translation: DAA08634.1.
PIRiS56953.
RefSeqiNP_012365.2. NM_001181603.1.

Genome annotation databases

EnsemblFungiiYJL170C; YJL170C; YJL170C.
GeneIDi853269.
KEGGisce:YJL170C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49445 Genomic DNA. Translation: CAA89465.1 . Frameshift.
BK006943 Genomic DNA. Translation: DAA08634.1 .
PIRi S56953.
RefSeqi NP_012365.2. NM_001181603.1.

3D structure databases

ProteinModelPortali P46993.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33590. 12 interactions.
DIPi DIP-5416N.
IntActi P46993. 1 interaction.
MINTi MINT-529434.
STRINGi 4932.YJL170C.

Proteomic databases

PaxDbi P46993.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJL170C ; YJL170C ; YJL170C .
GeneIDi 853269.
KEGGi sce:YJL170C.

Organism-specific databases

SGDi S000003706. ASG7.

Phylogenomic databases

eggNOGi NOG74535.
InParanoidi P46993.
OMAi ANHHIVE.
OrthoDBi EOG7J18CN.

Enzyme and pathway databases

BioCyci YEAST:G3O-31607-MONOMER.

Miscellaneous databases

NextBioi 973541.

Gene expression databases

Genevestigatori P46993.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Identification of target sites of the alpha2-Mcm1 repressor complex in the yeast genome."
    Zhong H., McCord R., Vershon A.K.
    Genome Res. 9:1040-1047(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  4. "Asg7p-Ste3p inhibition of pheromone signaling: regulation of the zygotic transition to vegetative growth."
    Roth A.F., Nelson B., Boone C., Davis N.G.
    Mol. Cell. Biol. 20:8815-8825(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Localization and signaling of G(beta) subunit Ste4p are controlled by a-factor receptor and the a-specific protein Asg7p."
    Kim J., Bortz E., Zhong H., Leeuw T., Leberer E., Vershon A.K., Hirsch J.P.
    Mol. Cell. Biol. 20:8826-8835(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION BY PHEROMONE, SUBCELLULAR LOCATION.
  6. "Autocrine activation of the pheromone response pathway in matalpha2-cells is attenuated by SST2- and ASG7-dependent mechanisms."
    Rivers D.M., Sprague G.F. Jr.
    Mol. Genet. Genomics 270:225-233(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
    Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
    Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF FRAMESHIFT.
  8. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  9. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-121; SER-123; SER-125 AND THR-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.

Entry informationi

Entry nameiASG7_YEAST
AccessioniPrimary (citable) accession number: P46993
Secondary accession number(s): D6VW18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: April 29, 2008
Last modified: October 29, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3