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P46993

- ASG7_YEAST

UniProt

P46993 - ASG7_YEAST

Protein

Protein ASG7

Gene

ASG7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Required for receptor inhibition of inappropriately expressed a-factor receptor (STE3) in MAT a cells. Inhibits signaling by relocalizing the G protein beta-gamma (STE4-STE18) subunit to intracellular mebranes. May also be a mechanism for the down-regulation of the mating pheromone response after the zygotic fusion event, promoting the transition of the new diploid cell to vegetative growth.3 Publications

    GO - Biological processi

    1. conjugation with cellular fusion Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31607-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein ASG7
    Alternative name(s):
    A-specific gene 7 protein
    Gene namesi
    Name:ASG7
    Ordered Locus Names:YJL170C
    ORF Names:J0514
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    SGDiS000003706. ASG7.

    Subcellular locationi

    Endomembrane system 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endomembrane system Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 209209Protein ASG7PRO_0000203025Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei121 – 1211Phosphoserine1 Publication
    Modified residuei123 – 1231Phosphoserine1 Publication
    Modified residuei125 – 1251Phosphoserine1 Publication
    Modified residuei153 – 1531Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP46993.

    Expressioni

    Inductioni

    Induced by alpha-pheromone. Repressed by the ALPHA2-MCM1 repressor.2 Publications

    Gene expression databases

    GenevestigatoriP46993.

    Interactioni

    Protein-protein interaction databases

    BioGridi33590. 12 interactions.
    DIPiDIP-5416N.
    IntActiP46993. 1 interaction.
    MINTiMINT-529434.
    STRINGi4932.YJL170C.

    Structurei

    3D structure databases

    ProteinModelPortaliP46993.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4949LumenalSequence AnalysisAdd
    BLAST
    Topological domaini71 – 184114CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini206 – 2094LumenalSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei50 – 7021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei185 – 20521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG74535.
    OMAiANHHIVE.
    OrthoDBiEOG7J18CN.

    Sequencei

    Sequence statusi: Complete.

    P46993-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTLASSIEH KTKHLAAPFE NDENPWMKKY CCQCKSCKMS VPVQPWLPRF    50
    FVFGILCPVF WLVNLLAWWF LQYWQPHELE FHDLQEDEYP GFYEYEAITK 100
    RTVIPIKEEV LQEIRVMQNF SDSNSEEYYE SKDGMPSSFL NVNTEQVEDE 150
    NDTLKKYRYA FLKKVAHDVL ESHDLLRKTF RDWNLRSLLG LLIDSILIIF 200
    VVLLCKKSR 209
    Length:209
    Mass (Da):24,946
    Last modified:April 29, 2008 - v2
    Checksum:i504DFEDD9063F6AF
    GO

    Sequence cautioni

    The sequence CAA89465.1 differs from that shown. Reason: Frameshift at position 16.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49445 Genomic DNA. Translation: CAA89465.1. Frameshift.
    BK006943 Genomic DNA. Translation: DAA08634.1.
    PIRiS56953.
    RefSeqiNP_012365.2. NM_001181603.1.

    Genome annotation databases

    EnsemblFungiiYJL170C; YJL170C; YJL170C.
    GeneIDi853269.
    KEGGisce:YJL170C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49445 Genomic DNA. Translation: CAA89465.1 . Frameshift.
    BK006943 Genomic DNA. Translation: DAA08634.1 .
    PIRi S56953.
    RefSeqi NP_012365.2. NM_001181603.1.

    3D structure databases

    ProteinModelPortali P46993.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33590. 12 interactions.
    DIPi DIP-5416N.
    IntActi P46993. 1 interaction.
    MINTi MINT-529434.
    STRINGi 4932.YJL170C.

    Proteomic databases

    PaxDbi P46993.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJL170C ; YJL170C ; YJL170C .
    GeneIDi 853269.
    KEGGi sce:YJL170C.

    Organism-specific databases

    SGDi S000003706. ASG7.

    Phylogenomic databases

    eggNOGi NOG74535.
    OMAi ANHHIVE.
    OrthoDBi EOG7J18CN.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31607-MONOMER.

    Miscellaneous databases

    NextBioi 973541.

    Gene expression databases

    Genevestigatori P46993.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Identification of target sites of the alpha2-Mcm1 repressor complex in the yeast genome."
      Zhong H., McCord R., Vershon A.K.
      Genome Res. 9:1040-1047(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    4. "Asg7p-Ste3p inhibition of pheromone signaling: regulation of the zygotic transition to vegetative growth."
      Roth A.F., Nelson B., Boone C., Davis N.G.
      Mol. Cell. Biol. 20:8815-8825(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Localization and signaling of G(beta) subunit Ste4p are controlled by a-factor receptor and the a-specific protein Asg7p."
      Kim J., Bortz E., Zhong H., Leeuw T., Leberer E., Vershon A.K., Hirsch J.P.
      Mol. Cell. Biol. 20:8826-8835(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION BY PHEROMONE, SUBCELLULAR LOCATION.
    6. "Autocrine activation of the pheromone response pathway in matalpha2-cells is attenuated by SST2- and ASG7-dependent mechanisms."
      Rivers D.M., Sprague G.F. Jr.
      Mol. Genet. Genomics 270:225-233(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
      Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
      Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF FRAMESHIFT.
    8. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    9. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-121; SER-123; SER-125 AND THR-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.

    Entry informationi

    Entry nameiASG7_YEAST
    AccessioniPrimary (citable) accession number: P46993
    Secondary accession number(s): D6VW18
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3