Reviewed, UniProtKB/Swiss-Prot P46988 (PFD1_YEAST)

Names and origin

Protein names

Recommended name:
    Prefoldin subunit 1
Alternative name(s):
    Genes involved in microtubule biogenesis protein 6
    Gim complex subunit 6
      Short name=GimC subunit 6

Gene names

Name:	GIM6
Synonyms:	PFD1
Ordered Locus Names:	YJL179W
ORF Names:	J0488

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	109 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Subunit structure	Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.
Miscellaneous	Present with 721 molecules/cell in log phase SD medium. Ref.3
Sequence similarities	Belongs to the prefoldin subunit beta family.

Ontologies

Keywords
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cytoskeleton organization Inferred from mutant phenotype. Source: SGD protein folding Inferred from mutant phenotype. Source: SGD
Cellular component	prefoldin complex Inferred from mutant phenotype. Source: SGD
Molecular function	unfolded protein binding Inferred from mutant phenotype. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 109	109	Prefoldin subunit 1		PRO_0000124834

Sequences

	Sequence		Length	Mass (Da)
	P46988-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: C4CEF93960A6BADC	FASTA	109	12,738
	10 20 30 40 50 60 MSQIAQEMTV SLRNARTQLD MVNQQLAYLD RQEKLAELTK KELESYPTDK VWRSCGKSFI 70 80 90 100 LQDKSKYVND LSHAETVLLD QRKTLKIKKN YLETTVEKTI DNLKALMKN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L. EMBO J. 15:2031-2049(1996) [PubMed: 8641269] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	"Compartmentation of protein folding in vivo: sequestration of non-native polypeptide by the chaperonin-GimC system." Siegers K., Waldmann T., Leroux M.R., Grein K., Shevchenko A., Schiebel E., Hartl F.U. EMBO J. 18:75-84(1999) [PubMed: 9878052] [Abstract] Cited for: IDENTIFICATION IN THE PREFOLDIN COMPLEX.
[3]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z49454 Genomic DNA. Translation: CAA89474.1.
PIR	S56962.
RefSeq	NP_012356.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:2110N.
IntAct	P46988. 9 interactions.
STRING	P46988.
Proteomic databases
PRIDE	P46988.
Genome annotation databases
Ensembl	YJL179W; YJL179W; YJL179W; Saccharomyces cerevisiae. [Genome view]
GeneID	853260.
KEGG	sce:YJL179W.
NMPDR	fig|4932.3.peg.3320.
Organism-specific databases
CYGD	YJL179w.
SGD	S000003715. PFD1.
Phylogenomic databases
HOGENOM	P46988.
OMA	IEMDNQL
OrthoDB	EOG9FTXGZ
Gene expression databases
ArrayExpress	P46988.
Genevestigator	P46988.
GermOnline	YJL179W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR002777. PFD_beta-like. IPR009053. Prefoldin. [Graphical view]
Pfam	PF01920. Prefoldin_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	973517.

Entry information

Entry name

PFD1_YEAST

Accession

Primary (citable) accession number: P46988

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	November 24, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)