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Protein

Probable alpha-1,6-mannosyltransferase MNN11

Gene

MNN11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for synthesis of full length mannan chains.1 Publication
The M-Pol II complex possesses alpha-1,6-mannosyltransferase activity and is probably involved in the elongation of the mannan backbone of N-linked glycans on cell wall and periplasmic proteins.1 Publication

Miscellaneous

Present with 3480 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • alpha-1,6-mannosyltransferase activity Source: UniProtKB

GO - Biological processi

  • cell wall mannoprotein biosynthetic process Source: UniProtKB
  • protein glycosylation Source: SGD
  • protein N-linked glycosylation Source: SGD

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciYEAST:G3O-31617-MONOMER.

Protein family/group databases

CAZyiGT34. Glycosyltransferase Family 34.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable alpha-1,6-mannosyltransferase MNN11 (EC:2.4.1.-)
Alternative name(s):
Mannan polymerase II complex MNN11 subunit
Short name:
M-Pol II subunit MNN11
Gene namesi
Name:MNN11
Ordered Locus Names:YJL183W
ORF Names:J0425
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL183W.
SGDiS000003719. MNN11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31CytoplasmicSequence analysisAdd BLAST31
Transmembranei32 – 52Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini53 – 422LumenalSequence analysisAdd BLAST370

GO - Cellular componenti

  • alpha-1,6-mannosyltransferase complex Source: UniProtKB

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002151651 – 422Probable alpha-1,6-mannosyltransferase MNN11Add BLAST422

Proteomic databases

MaxQBiP46985.
PRIDEiP46985.

PTM databases

iPTMnetiP46985.
SwissPalmiP46985.

Interactioni

Subunit structurei

Component of the M-Pol II complex composed of ANP1, MNN9, MNN10, MNN11 and HOC1.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33579. 607 interactors.
DIPiDIP-914N.
IntActiP46985. 21 interactors.
MINTiMINT-4491290.
STRINGi4932.YJL183W.

Structurei

3D structure databases

ProteinModelPortaliP46985.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 34 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000057126.
InParanoidiP46985.
KOiK05532.
OMAiQNRVDYA.
OrthoDBiEOG092C2YK6.

Family and domain databases

InterProiView protein in InterPro
IPR008630. Glyco_trans_34.
PfamiView protein in Pfam
PF05637. Glyco_transf_34. 1 hit.

Sequencei

Sequence statusi: Complete.

P46985-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIKPRTKGK TYSSRSVGSQ WFNRLGFKQN KYGTCKFLSI ITAFVFILYF
60 70 80 90 100
FSNRFYPISR SAGASYSPSH GLYINEIPAS SRLIYPHVEH VPVLKQMTVR
110 120 130 140 150
GLYITRLEVD GSKRLILKPE ENALTDEEKK KTTDQILLVK HSFLDHGKLV
160 170 180 190 200
YRKSNDAPEV VVVTLIDFEN YELETIIQIV QNRVDYAQKH QYGVYIRWIQ
210 220 230 240 250
EFLPVLENQN LAESYEFIKP LVIRAAMHAF PTAKYIHFVD QDALLMNLDL
260 270 280 290 300
SLQKYLLDPK IMDLALLKNV PVVANSNIKT YNHFEYSSAK IIIPHDADGN
310 320 330 340 350
IDASSFVIAN DFYGKALIDY LNDPLLRNFP WDNTGDKLSA AIGHILQWHP
360 370 380 390 400
TLLGKTAIVI PKVLASQYDA SLDQEGESGN GASNGDVYHY NEGDLAASFK
410 420
GCRSRGTCAS EIGHMYQKIK KS
Length:422
Mass (Da):47,859
Last modified:September 21, 2011 - v2
Checksum:iB1764ADBC19F9E58
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti298D → G in CAA89478 (PubMed:8641269).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49458 Genomic DNA. Translation: CAA89478.1.
AY692909 Genomic DNA. Translation: AAT92928.1.
BK006943 Genomic DNA. Translation: DAA08623.2.
PIRiS56966.
RefSeqiNP_012352.2. NM_001181616.2.

Genome annotation databases

EnsemblFungiiYJL183W; YJL183W; YJL183W.
GeneIDi853256.
KEGGisce:YJL183W.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMNN11_YEAST
AccessioniPrimary (citable) accession number: P46985
Secondary accession number(s): D6VW07, E9P8Z0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: September 21, 2011
Last modified: July 5, 2017
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names