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P46984 (GON7_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein GON7
Alternative name(s):
Low-dye-binding protein 6
Polarized growth chromatin-associated controller 2
Gene names
Name:GON7
Synonyms:LDB6, PCC2
Ordered Locus Names:YJL184W
ORF Names:J0420
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length123 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the EKC/KEOPS complex which promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. Ref.6 Ref.7

Subunit structure

Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1. Ref.6 Ref.7

Subcellular location

Nucleus Potential. Chromosome › telomere Probable.

Induction

Accumulates in response to hyperosmostic conditions. Ref.4

Miscellaneous

Present with 2180 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the GON7 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

BUD32P533236EBI-26178,EBI-3809
KAE1P361328EBI-26178,EBI-26411

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 123123Protein GON7
PRO_0000203021

Sequences

Sequence LengthMass (Da)Tools
P46984 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 437EAF6CF1332CC8

FASTA12313,605
        10         20         30         40         50         60 
MKLPVAQYSA PDGVEKSFAP IRDDPRYMTT EGRTTGPSDH VLNAGQIDRD KPSEPERTKD 

        70         80         90        100        110        120 
GSQLTYLGQL RTQLTGLQDD INEFLTGRME LAKNKKKAGA DEKRIQEEIN QLLDGGDGDE 


DAV

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. expand/collapse author list , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Highly hydrophilic proteins in prokaryotes and eukaryotes are common during conditions of water deficit."
Garay-Arroyo A., Colmenero-Flores J.M., Garciarrubio A., Covarrubias A.A.
J. Biol. Chem. 275:5668-5674(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Yeast homolog of a cancer-testis antigen defines a new transcription complex."
Kisseleva-Romanova E., Lopreiato R., Baudin-Baillieu A., Rousselle J.-C., Ilan L., Hofmann K., Namane A., Mann C., Libri D.
EMBO J. 25:3576-3585(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: MASS SPECTROMETRY, IDENTIFICATION IN THE EKC/KEOPS COMPLEX, FUNCTION OF THE EKC/KEOPS COMPLEX.
[7]"A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator."
Downey M., Houlsworth R., Maringele L., Rollie A., Brehme M., Galicia S., Guillard S., Partington M., Zubko M.K., Krogan N.J., Emili A., Greenblatt J.F., Harrington L., Lydall D., Durocher D.
Cell 124:1155-1168(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN THE EKC/KEOPS COMPLEX.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z49459 Genomic DNA. Translation: CAA89479.1.
AY558252 Genomic DNA. Translation: AAS56578.1.
BK006943 Genomic DNA. Translation: DAA08622.1.
PIRS56967.
RefSeqNP_012351.1. NM_001181617.1.

3D structure databases

ProteinModelPortalP46984.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-1474N.
IntActP46984. 11 interactions.
MINTMINT-389214.
STRING4932.YJL184W.

Proteomic databases

PaxDbP46984.
PeptideAtlasP46984.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYJL184W; YJL184W; YJL184W.
GeneID853255.
KEGGsce:YJL184W.

Organism-specific databases

CYGDYJL184w.
SGDS000003720. GON7.

Phylogenomic databases

eggNOGNOG41613.
HOGENOMHOG000247898.
KOK15903.
OMADRDKPSD.
OrthoDBEOG4H1F5J.

Gene expression databases

GenevestigatorP46984.
GermOnlineYJL184W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR014849. EKC/KEOPS_Gon7.
[Graphical view]
PfamPF08738. Gon7. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio973505.

Entry information

Entry nameGON7_YEAST
AccessionPrimary (citable) accession number: P46984
Secondary accession number(s): D6VW06
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 3, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents