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P46977

- STT3A_HUMAN

UniProt

P46977 - STT3A_HUMAN

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Protein
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
Gene
STT3A, ITM1, TMC
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). SST3A seems to be involved in complex substrate specificity. STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient cotranslational glycosylation and mediate glycosylation of sites that have been skipped by STT3A.1 Publication

Catalytic activityi

Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.

Pathwayi

GO - Molecular functioni

  1. dolichyl-diphosphooligosaccharide-protein glycotransferase activity Source: UniProtKB
  2. oligosaccharyl transferase activity Source: InterPro
  3. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. co-translational protein modification Source: UniProtKB
  3. post-translational protein modification Source: Reactome
  4. protein N-linked glycosylation via asparagine Source: UniProtKB
  5. protein glycosylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_22426. Asparagine N-linked glycosylation.
SignaLinkiP46977.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT66. Glycosyltransferase Family 66.
TCDBi9.B.142.3.4. the integral membrane glycosyltransferase family 39 (gt39) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (EC:2.4.99.18)
Short name:
Oligosaccharyl transferase subunit STT3A
Short name:
STT3-A
Alternative name(s):
B5
Integral membrane protein 1
Transmembrane protein TMC
Gene namesi
Name:STT3A
Synonyms:ITM1, TMC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:6172. STT3A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei18 – 3821Helical; Reviewed prediction
Add
BLAST
Topological domaini39 – 11476Lumenal Reviewed prediction
Add
BLAST
Transmembranei115 – 13521Helical; Reviewed prediction
Add
BLAST
Topological domaini136 – 16934Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei170 – 19021Helical; Reviewed prediction
Add
BLAST
Topological domaini191 – 20818Lumenal Reviewed prediction
Add
BLAST
Transmembranei209 – 22921Helical; Reviewed prediction
Add
BLAST
Topological domaini230 – 2356Cytoplasmic Reviewed prediction
Transmembranei236 – 25924Helical; Reviewed prediction
Add
BLAST
Topological domaini260 – 2656Lumenal Reviewed prediction
Transmembranei266 – 28621Helical; Reviewed prediction
Add
BLAST
Topological domaini287 – 30014Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei301 – 32121Helical; Reviewed prediction
Add
BLAST
Topological domaini322 – 35938Lumenal Reviewed prediction
Add
BLAST
Transmembranei360 – 38021Helical; Reviewed prediction
Add
BLAST
Topological domaini381 – 3833Cytoplasmic Reviewed prediction
Transmembranei384 – 40421Helical; Reviewed prediction
Add
BLAST
Topological domaini405 – 4051Lumenal Reviewed prediction
Transmembranei406 – 42621Helical; Reviewed prediction
Add
BLAST
Topological domaini427 – 45327Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei454 – 47421Helical; Reviewed prediction
Add
BLAST
Topological domaini475 – 705231Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: Reactome
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: InterPro
  4. oligosaccharyltransferase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Congenital disorder of glycosylation 1W (CDG1W) [MIM:615596]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti626 – 6261V → A in CDG1W; affects activity resulting in hypoglycosylation of STT3A-specific substrates. 1 Publication
VAR_070944

Keywords - Diseasei

Congenital disorder of glycosylation, Disease mutation

Organism-specific databases

MIMi615596. phenotype.
Orphaneti370921. STT3A-CDG.
PharmGKBiPA29969.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 705705Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
PRO_0000072290Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi537 – 5371N-linked (GlcNAc...)1 Publication
Glycosylationi544 – 5441N-linked (GlcNAc...)1 Publication
Glycosylationi548 – 5481N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP46977.
PaxDbiP46977.
PRIDEiP46977.

PTM databases

PhosphoSiteiP46977.

Expressioni

Tissue specificityi

Expressed at high levels in placenta, liver, muscle and pancreas, and at very low levels in brain, lung and kidney. Expressed in skin fibroblasts (at protein level).1 Publication

Gene expression databases

ArrayExpressiP46977.
BgeeiP46977.
CleanExiHS_STT3A.
GenevestigatoriP46977.

Organism-specific databases

HPAiHPA030735.

Interactioni

Subunit structurei

Component of the oligosaccharyltransferase (OST) complex By similarity. OST seems to exist in different forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Also identified as part of a complex which includes CANX, DERL1, DERL2, DDOST/OST48, RPN1, RPN2, SELK, VIMP, STT3A AND VCP. This contains known members of the OST complex and may be a form of this complex.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IRAK2O431872EBI-719212,EBI-447733
Sarm1Q6PDS32EBI-719212,EBI-6117196From a different organism.
TMEM173Q86WV62EBI-719212,EBI-2800345

Protein-protein interaction databases

BioGridi109908. 10 interactions.
IntActiP46977. 14 interactions.
MINTiMINT-1407187.
STRINGi9606.ENSP00000376472.

Structurei

3D structure databases

ProteinModelPortaliP46977.
SMRiP46977. Positions 20-183, 474-701.

Family & Domainsi

Sequence similaritiesi

Belongs to the STT3 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1287.
HOGENOMiHOG000157471.
HOVERGENiHBG010606.
InParanoidiP46977.
KOiK07151.
OMAiSAVLYHV.
OrthoDBiEOG7VHSWP.
PhylomeDBiP46977.
TreeFamiTF300822.

Family and domain databases

InterProiIPR003674. Oligo_trans_STT3.
[Graphical view]
PfamiPF02516. STT3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P46977-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTKFGFLRLS YEKQDTLLKL LILSMAAVLS FSTRLFAVLR FESVIHEFDP    50
YFNYRTTRFL AEEGFYKFHN WFDDRAWYPL GRIIGGTIYP GLMITSAAIY 100
HVLHFFHITI DIRNVCVFLA PLFSSFTTIV TYHLTKELKD AGAGLLAAAM 150
IAVVPGYISR SVAGSYDNEG IAIFCMLLTY YMWIKAVKTG SICWAAKCAL 200
AYFYMVSSWG GYVFLINLIP LHVLVLMLTG RFSHRIYVAY CTVYCLGTIL 250
SMQISFVGFQ PVLSSEHMAA FGVFGLCQIH AFVDYLRSKL NPQQFEVLFR 300
SVISLVGFVL LTVGALLMLT GKISPWTGRF YSLLDPSYAK NNIPIIASVS 350
EHQPTTWSSY YFDLQLLVFM FPVGLYYCFS NLSDARIFII MYGVTSMYFS 400
AVMVRLMLVL APVMCILSGI GVSQVLSTYM KNLDISRPDK KSKKQQDSTY 450
PIKNEVASGM ILVMAFFLIT YTFHSTWVTS EAYSSPSIVL SARGGDGSRI 500
IFDDFREAYY WLRHNTPEDA KVMSWWDYGY QITAMANRTI LVDNNTWNNT 550
HISRVGQAMA STEEKAYEIM RELDVSYVLV IFGGLTGYSS DDINKFLWMV 600
RIGGSTDTGK HIKENDYYTP TGEFRVDREG SPVLLNCLMY KMCYYRFGQV 650
YTEAKRPPGF DRVRNAEIGN KDFELDVLEE AYTTEHWLVR IYKVKDLDNR 700
GLSRT 705
Length:705
Mass (Da):80,530
Last modified:April 8, 2008 - v2
Checksum:i71426CA5598B51C4
GO
Isoform 2 (identifier: P46977-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.

Show »
Length:613
Mass (Da):69,589
Checksum:iB37EB58A0D0776FC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti626 – 6261V → A in CDG1W; affects activity resulting in hypoglycosylation of STT3A-specific substrates. 1 Publication
VAR_070944

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9292Missing in isoform 2.
VSP_055106Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611A → S in AAL77539. 1 Publication
Sequence conflicti117 – 1171V → M in BAG58686. 1 Publication
Sequence conflicti128 – 1281T → S in AAB05994. 1 Publication
Sequence conflicti133 – 1331H → L in AAB05994. 1 Publication
Sequence conflicti252 – 2521M → R in AAB05994. 1 Publication
Sequence conflicti270 – 2701A → G in AAB05994. 1 Publication
Sequence conflicti415 – 4151C → S in AAB05994. 1 Publication
Sequence conflicti454 – 4541N → I in AAB05994. 1 Publication
Sequence conflicti494 – 4941G → D in AAL77539. 1 Publication
Sequence conflicti681 – 6811A → G in AAB05994. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L38961 mRNA. Translation: AAB05994.1.
L47337 mRNA. Translation: AAL77539.1.
AK290040 mRNA. Translation: BAF82729.1.
AK290657 mRNA. Translation: BAF83346.1.
AK295892 mRNA. Translation: BAG58686.1.
BT007100 mRNA. Translation: AAP35764.1.
AP001132 Genomic DNA. No translation available.
AP001494 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67647.1.
BC020965 mRNA. Translation: AAH20965.1.
BC048348 mRNA. Translation: AAH48348.2.
CCDSiCCDS8458.1. [P46977-1]
PIRiS70029.
RefSeqiNP_001265432.1. NM_001278503.1.
NP_001265433.1. NM_001278504.1.
NP_689926.1. NM_152713.4.
UniGeneiHs.504237.
Hs.659244.

Genome annotation databases

EnsembliENST00000392708; ENSP00000376472; ENSG00000134910.
ENST00000529196; ENSP00000436962; ENSG00000134910.
ENST00000531491; ENSP00000432820; ENSG00000134910.
GeneIDi3703.
KEGGihsa:3703.
UCSCiuc001qcd.2. human. [P46977-1]

Polymorphism databases

DMDMi182676409.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L38961 mRNA. Translation: AAB05994.1 .
L47337 mRNA. Translation: AAL77539.1 .
AK290040 mRNA. Translation: BAF82729.1 .
AK290657 mRNA. Translation: BAF83346.1 .
AK295892 mRNA. Translation: BAG58686.1 .
BT007100 mRNA. Translation: AAP35764.1 .
AP001132 Genomic DNA. No translation available.
AP001494 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67647.1 .
BC020965 mRNA. Translation: AAH20965.1 .
BC048348 mRNA. Translation: AAH48348.2 .
CCDSi CCDS8458.1. [P46977-1 ]
PIRi S70029.
RefSeqi NP_001265432.1. NM_001278503.1.
NP_001265433.1. NM_001278504.1.
NP_689926.1. NM_152713.4.
UniGenei Hs.504237.
Hs.659244.

3D structure databases

ProteinModelPortali P46977.
SMRi P46977. Positions 20-183, 474-701.
ModBasei Search...

Protein-protein interaction databases

BioGridi 109908. 10 interactions.
IntActi P46977. 14 interactions.
MINTi MINT-1407187.
STRINGi 9606.ENSP00000376472.

Protein family/group databases

CAZyi GT66. Glycosyltransferase Family 66.
TCDBi 9.B.142.3.4. the integral membrane glycosyltransferase family 39 (gt39) family.

PTM databases

PhosphoSitei P46977.

Polymorphism databases

DMDMi 182676409.

Proteomic databases

MaxQBi P46977.
PaxDbi P46977.
PRIDEi P46977.

Protocols and materials databases

DNASUi 3703.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000392708 ; ENSP00000376472 ; ENSG00000134910 .
ENST00000529196 ; ENSP00000436962 ; ENSG00000134910 .
ENST00000531491 ; ENSP00000432820 ; ENSG00000134910 .
GeneIDi 3703.
KEGGi hsa:3703.
UCSCi uc001qcd.2. human. [P46977-1 ]

Organism-specific databases

CTDi 3703.
GeneCardsi GC11P125462.
HGNCi HGNC:6172. STT3A.
HPAi HPA030735.
MIMi 601134. gene.
615596. phenotype.
neXtProti NX_P46977.
Orphaneti 370921. STT3A-CDG.
PharmGKBi PA29969.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1287.
HOGENOMi HOG000157471.
HOVERGENi HBG010606.
InParanoidi P46977.
KOi K07151.
OMAi SAVLYHV.
OrthoDBi EOG7VHSWP.
PhylomeDBi P46977.
TreeFami TF300822.

Enzyme and pathway databases

UniPathwayi UPA00378 .
Reactomei REACT_22426. Asparagine N-linked glycosylation.
SignaLinki P46977.

Miscellaneous databases

ChiTaRSi STT3A. human.
GenomeRNAii 3703.
NextBioi 14511.
PROi P46977.
SOURCEi Search...

Gene expression databases

ArrayExpressi P46977.
Bgeei P46977.
CleanExi HS_STT3A.
Genevestigatori P46977.

Family and domain databases

InterProi IPR003674. Oligo_trans_STT3.
[Graphical view ]
Pfami PF02516. STT3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a highly conserved mouse and human integral membrane protein (Itm1) and genetic mapping to mouse chromosome 9."
    Hong G., Deleersnjider W., Kozak C.A., van Marck E., Tylzanowski P., Merregaert J.
    Genomics 31:295-300(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Isolation, characterization, and mapping to human chromosome 11q24-25 of a cDNA encoding a highly conserved putative transmembrane protein, TMC."
    Lissy N.A., Bellacosa A., Sonoda G., Miller P.D., Jhanwar S.C., Testa J.R.
    Biochim. Biophys. Acta 1306:137-141(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Hippocampus.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Duodenum and Lung.
  8. "Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties."
    Kelleher D.J., Karaoglu D., Mandon E.C., Gilmore R.
    Mol. Cell 12:101-111(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE OLIGOSACCHARYLTRANSFERASE (OST) COMPLEX, TISSUE SPECIFICITY.
  9. "Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits."
    Shibatani T., David L.L., McCormack A.L., Frueh K., Skach W.R.
    Biochemistry 44:5982-5992(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE OLIGOSACCHARYLTRANSFERASE (OST) COMPLEX.
  10. "Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms."
    Ruiz-Canada C., Kelleher D.J., Gilmore R.
    Cell 136:272-283(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-537; ASN-544 AND ASN-548.
    Tissue: Liver.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Selenoprotein K binds multiprotein complexes and is involved in the regulation of endoplasmic reticulum homeostasis."
    Shchedrina V.A., Everley R.A., Zhang Y., Gygi S.P., Hatfield D.L., Gladyshev V.N.
    J. Biol. Chem. 286:42937-42948(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH CANX; DERL1; DERL2; DDOST; RPN1; RPN2; SELK; VCP AND VIMP.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Mutations in STT3A and STT3B cause two congenital disorders of glycosylation."
    Shrimal S., Ng B.G., Losfeld M.E., Gilmore R., Freeze H.H.
    Hum. Mol. Genet. 22:4638-4645(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CDG1W ALA-626, CHARACTERIZATION OF VARIANT CDG1W ALA-626.

Entry informationi

Entry nameiSTT3A_HUMAN
AccessioniPrimary (citable) accession number: P46977
Secondary accession number(s): B4DJ24
, E9PNQ1, Q86XU9, Q8TE35, Q8WUB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 8, 2008
Last modified: September 3, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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