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P46976

- GLYG_HUMAN

UniProt

P46976 - GLYG_HUMAN

Protein

Glycogenin-1

Gene

GYG1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.

    Catalytic activityi

    UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin.

    Cofactori

    Divalent metal ions. Required for self-glucosylation. Manganese is the most effective.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei86 – 861By similarity
    Metal bindingi102 – 1021ManganeseBy similarity
    Metal bindingi104 – 1041ManganeseBy similarity
    Sitei160 – 1601Important for catalytic activityBy similarity
    Sitei163 – 1631Important for catalytic activityBy similarity
    Metal bindingi212 – 2121ManganeseBy similarity

    GO - Molecular functioni

    1. glucose binding Source: Ensembl
    2. glycogenin glucosyltransferase activity Source: Reactome
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: UniProtKB

    GO - Biological processi

    1. carbohydrate metabolic process Source: Reactome
    2. glucose metabolic process Source: Reactome
    3. glycogen biosynthetic process Source: Reactome
    4. glycogen catabolic process Source: Reactome
    5. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Glycogen biosynthesis

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:HS08931-MONOMER.
    ReactomeiREACT_1008. Glycogen breakdown (glycogenolysis).
    REACT_169208. Glycogen synthesis.
    REACT_200783. Myoclonic epilepsy of Lafora.
    UniPathwayiUPA00164.

    Protein family/group databases

    CAZyiGT8. Glycosyltransferase Family 8.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycogenin-1 (EC:2.4.1.186)
    Short name:
    GN-1
    Short name:
    GN1
    Gene namesi
    Name:GYG1
    Synonyms:GYG
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:4699. GYG1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. extracellular vesicular exosome Source: UniProt
    3. membrane Source: UniProtKB

    Pathology & Biotechi

    Involvement in diseasei

    Glycogen storage disease 15 (GSD15) [MIM:613507]: A metabolic disorder resulting in muscle weakness, associated with the glycogen depletion in skeletal muscle, and cardiac arrhythmia, associated with the accumulation of abnormal storage material in the heart. The skeletal muscle shows a marked predominance of slow-twitch, oxidative muscle fibers and mitochondrial proliferation.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti83 – 831T → M in GSD15; inactivation of the autoglucosylation. 1 Publication
    VAR_063768

    Keywords - Diseasei

    Disease mutation, Glycogen storage disease

    Organism-specific databases

    MIMi613507. phenotype.
    Orphaneti263297. Glycogen storage disease due to glycogenin deficiency.
    PharmGKBiPA29077.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 350349Glycogenin-1PRO_0000215176Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylthreonine2 Publications
    Modified residuei44 – 441PhosphoserineBy similarity
    Glycosylationi195 – 1951O-linked (Glc...)By similarity

    Post-translational modificationi

    Self-glycosylated by the transfer of glucose residues from UDP-glucose to itself, forming an alpha-1,4-glycan of around 10 residues attached to Tyr-195.
    Phosphorylated.By similarity

    Keywords - PTMi

    Acetylation, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP46976.
    PaxDbiP46976.
    PRIDEiP46976.

    PTM databases

    PhosphoSiteiP46976.

    Expressioni

    Gene expression databases

    ArrayExpressiP46976.
    BgeeiP46976.
    CleanExiHS_GYG1.
    GenevestigatoriP46976.

    Organism-specific databases

    HPAiHPA030497.

    Interactioni

    Subunit structurei

    Homodimer tightly complexed to the 86 kDa catalytic subunit of glycogen synthase GYS1.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GYS1P138074EBI-740533,EBI-740553

    Protein-protein interaction databases

    BioGridi109247. 9 interactions.
    IntActiP46976. 13 interactions.
    MINTiMINT-5000544.
    STRINGi9606.ENSP00000340736.

    Structurei

    Secondary structure

    1
    350
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 129
    Helixi13 – 2816
    Beta strandi33 – 397
    Helixi45 – 5410
    Beta strandi55 – 606
    Helixi69 – 746
    Helixi80 – 9112
    Beta strandi96 – 1016
    Beta strandi105 – 1073
    Helixi112 – 1165
    Beta strandi119 – 1246
    Beta strandi126 – 1283
    Beta strandi131 – 1399
    Helixi143 – 15614
    Beta strandi159 – 1613
    Helixi163 – 1708
    Turni171 – 1766
    Helixi179 – 1813
    Helixi185 – 1873
    Beta strandi188 – 1903
    Helixi191 – 1955
    Helixi198 – 2047
    Helixi205 – 2073
    Beta strandi209 – 2124
    Beta strandi215 – 2173
    Helixi219 – 2213
    Beta strandi222 – 2254
    Turni226 – 2294
    Beta strandi230 – 2323
    Helixi238 – 2403
    Helixi244 – 25613
    Helixi258 – 2614

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3Q4SX-ray1.98A1-262[»]
    3QVBX-ray2.26A1-262[»]
    3RMVX-ray1.82A1-262[»]
    3RMWX-ray1.93A1-262[»]
    3T7MX-ray1.80A/B1-262[»]
    3T7NX-ray1.98A/B1-262[»]
    3T7OX-ray1.85A/B1-262[»]
    3U2TX-ray2.05A1-262[»]
    3U2UX-ray1.45A/B1-262[»]
    3U2VX-ray1.50A/B1-262[»]
    3U2WX-ray1.68A/B1-262[»]
    3U2XX-ray1.77A/B1-262[»]
    ProteinModelPortaliP46976.
    SMRiP46976. Positions 1-262.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP46976.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni301 – 33333Interaction with GYS1Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG5597.
    HOGENOMiHOG000008282.
    HOVERGENiHBG000681.
    InParanoidiP46976.
    KOiK00750.
    OMAiLQQFGLV.
    OrthoDBiEOG7BKCV8.
    PhylomeDBiP46976.
    TreeFamiTF312839.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR002495. Glyco_trans_8.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF01501. Glyco_transf_8. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform GN-1L (identifier: P46976-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTDQAFVTLT TNDAYAKGAL VLGSSLKQHR TTRRLVVLAT PQVSDSMRKV    50
    LETVFDEVIM VDVLDSGDSA HLTLMKRPEL GVTLTKLHCW SLTQYSKCVF 100
    MDADTLVLAN IDDLFDREEL SAAPDPGWPD CFNSGVFVYQ PSVETYNQLL 150
    HLASEQGSFD GGDQGILNTF FSSWATTDIR KHLPFIYNLS SISIYSYLPA 200
    FKVFGASAKV VHFLGRVKPW NYTYDPKTKS VKSEAHDPNM THPEFLILWW 250
    NIFTTNVLPL LQQFGLVKDT CSYVNVLSDL VYTLAFSCGF CRKEDVSGAI 300
    SHLSLGEIPA MAQPFVSSEE RKERWEQGQA DYMGADSFDN IKRKLDTYLQ 350
    Length:350
    Mass (Da):39,384
    Last modified:January 23, 2007 - v4
    Checksum:iABAEEB7160DEC4DF
    GO
    Isoform GN-1 (identifier: P46976-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         277-293: Missing.

    Show »
    Length:333
    Mass (Da):37,479
    Checksum:iCD5E3C16F849FF7C
    GO
    Isoform GN-1S (identifier: P46976-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         204-350: FGASAKVVHF...IKRKLDTYLQ → KMSQEPYHIC...IHFTSLVSDT

    Show »
    Length:279
    Mass (Da):31,467
    Checksum:iF8AD62431CBB470E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti83 – 831T → M in GSD15; inactivation of the autoglucosylation. 1 Publication
    VAR_063768

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei204 – 350147FGASA…DTYLQ → KMSQEPYHICPLGRSQLWHS RLYPRKNGRNDGNRARLIIW EQIPLTTSRGNLTLTSSRNT AFFCEHIHFTSLVSDT in isoform GN-1S. CuratedVSP_001768Add
    BLAST
    Alternative sequencei277 – 29317Missing in isoform GN-1. 4 PublicationsVSP_001769Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U44131 mRNA. Translation: AAB00114.1.
    U31525 mRNA. Translation: AAB09752.1.
    X79537 mRNA. Translation: CAA56073.1.
    AF065481
    , AF065476, AF065477, AF065478, AF065479, AF065480 Genomic DNA. Translation: AAD31084.1.
    AF087942 mRNA. Translation: AAD52093.1.
    CR536547 mRNA. Translation: CAG38784.1.
    AC021059 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78894.1.
    CH471052 Genomic DNA. Translation: EAW78895.1.
    CH471052 Genomic DNA. Translation: EAW78896.1.
    CH471052 Genomic DNA. Translation: EAW78898.1.
    CH471052 Genomic DNA. Translation: EAW78900.1.
    CH471052 Genomic DNA. Translation: EAW78901.1.
    BC000033 mRNA. Translation: AAH00033.1.
    CCDSiCCDS3139.1. [P46976-1]
    CCDS54654.1. [P46976-2]
    CCDS54655.1. [P46976-3]
    PIRiJC4695.
    RefSeqiNP_001171649.1. NM_001184720.1. [P46976-2]
    NP_001171650.1. NM_001184721.1. [P46976-3]
    NP_004121.2. NM_004130.3. [P46976-1]
    UniGeneiHs.477892.

    Genome annotation databases

    EnsembliENST00000296048; ENSP00000296048; ENSG00000163754. [P46976-2]
    ENST00000345003; ENSP00000340736; ENSG00000163754. [P46976-1]
    ENST00000484197; ENSP00000420683; ENSG00000163754. [P46976-3]
    GeneIDi2992.
    KEGGihsa:2992.
    UCSCiuc003ewn.3. human. [P46976-1]
    uc003ewo.3. human. [P46976-2]
    uc003ewp.3. human.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U44131 mRNA. Translation: AAB00114.1 .
    U31525 mRNA. Translation: AAB09752.1 .
    X79537 mRNA. Translation: CAA56073.1 .
    AF065481
    , AF065476 , AF065477 , AF065478 , AF065479 , AF065480 Genomic DNA. Translation: AAD31084.1 .
    AF087942 mRNA. Translation: AAD52093.1 .
    CR536547 mRNA. Translation: CAG38784.1 .
    AC021059 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78894.1 .
    CH471052 Genomic DNA. Translation: EAW78895.1 .
    CH471052 Genomic DNA. Translation: EAW78896.1 .
    CH471052 Genomic DNA. Translation: EAW78898.1 .
    CH471052 Genomic DNA. Translation: EAW78900.1 .
    CH471052 Genomic DNA. Translation: EAW78901.1 .
    BC000033 mRNA. Translation: AAH00033.1 .
    CCDSi CCDS3139.1. [P46976-1 ]
    CCDS54654.1. [P46976-2 ]
    CCDS54655.1. [P46976-3 ]
    PIRi JC4695.
    RefSeqi NP_001171649.1. NM_001184720.1. [P46976-2 ]
    NP_001171650.1. NM_001184721.1. [P46976-3 ]
    NP_004121.2. NM_004130.3. [P46976-1 ]
    UniGenei Hs.477892.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3Q4S X-ray 1.98 A 1-262 [» ]
    3QVB X-ray 2.26 A 1-262 [» ]
    3RMV X-ray 1.82 A 1-262 [» ]
    3RMW X-ray 1.93 A 1-262 [» ]
    3T7M X-ray 1.80 A/B 1-262 [» ]
    3T7N X-ray 1.98 A/B 1-262 [» ]
    3T7O X-ray 1.85 A/B 1-262 [» ]
    3U2T X-ray 2.05 A 1-262 [» ]
    3U2U X-ray 1.45 A/B 1-262 [» ]
    3U2V X-ray 1.50 A/B 1-262 [» ]
    3U2W X-ray 1.68 A/B 1-262 [» ]
    3U2X X-ray 1.77 A/B 1-262 [» ]
    ProteinModelPortali P46976.
    SMRi P46976. Positions 1-262.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109247. 9 interactions.
    IntActi P46976. 13 interactions.
    MINTi MINT-5000544.
    STRINGi 9606.ENSP00000340736.

    Protein family/group databases

    CAZyi GT8. Glycosyltransferase Family 8.

    PTM databases

    PhosphoSitei P46976.

    Proteomic databases

    MaxQBi P46976.
    PaxDbi P46976.
    PRIDEi P46976.

    Protocols and materials databases

    DNASUi 2992.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296048 ; ENSP00000296048 ; ENSG00000163754 . [P46976-2 ]
    ENST00000345003 ; ENSP00000340736 ; ENSG00000163754 . [P46976-1 ]
    ENST00000484197 ; ENSP00000420683 ; ENSG00000163754 . [P46976-3 ]
    GeneIDi 2992.
    KEGGi hsa:2992.
    UCSCi uc003ewn.3. human. [P46976-1 ]
    uc003ewo.3. human. [P46976-2 ]
    uc003ewp.3. human.

    Organism-specific databases

    CTDi 2992.
    GeneCardsi GC03P148709.
    HGNCi HGNC:4699. GYG1.
    HPAi HPA030497.
    MIMi 603942. gene.
    613507. phenotype.
    neXtProti NX_P46976.
    Orphaneti 263297. Glycogen storage disease due to glycogenin deficiency.
    PharmGKBi PA29077.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5597.
    HOGENOMi HOG000008282.
    HOVERGENi HBG000681.
    InParanoidi P46976.
    KOi K00750.
    OMAi LQQFGLV.
    OrthoDBi EOG7BKCV8.
    PhylomeDBi P46976.
    TreeFami TF312839.

    Enzyme and pathway databases

    UniPathwayi UPA00164 .
    BioCyci MetaCyc:HS08931-MONOMER.
    Reactomei REACT_1008. Glycogen breakdown (glycogenolysis).
    REACT_169208. Glycogen synthesis.
    REACT_200783. Myoclonic epilepsy of Lafora.

    Miscellaneous databases

    EvolutionaryTracei P46976.
    GenomeRNAii 2992.
    NextBioi 11858.
    PROi P46976.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P46976.
    Bgeei P46976.
    CleanExi HS_GYG1.
    Genevestigatori P46976.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR002495. Glyco_trans_8.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF01501. Glyco_transf_8. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The human skeletal muscle glycogenin gene: cDNA, tissue expression and chromosomal localization."
      Barbetti F., Rocchi M., Bossolasco M., Cordera R., Sbraccia P., Finelli P., Consalez G.G.
      Biochem. Biophys. Res. Commun. 220:72-77(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM GN-1).
      Tissue: Skeletal muscle.
    2. "The human intron-containing gene for glycogenin maps to chromosome 3, band q24."
      Lomako J., Mazuruk K., Lomako W.M., Alonso M.D., Whelan W.J., Rodriguez I.R.
      Genomics 33:519-522(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM GN-1).
    3. Leffers H., Wiemann S., Ansorge W.
      Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM GN-1S).
      Tissue: Skin.
    4. "Characterization of the human glycogenin-1 gene: identification of a muscle-specific regulatory domain."
      van Maanen M.-H., Fournier P.A., Palmer T.N., Abraham L.J.
      Gene 234:217-226(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM GN-1).
    5. "Structure and chromosomal localization of the human glycogenin-2 gene GYG2."
      Zhai L., Mu J., Zong H., DePaoli-Roach A.A., Roach P.J.
      Gene 242:229-235(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM GN-1L), ALTERNATIVE SPLICING.
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM GN-1).
    7. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM GN-1).
      Tissue: Placenta.
    10. "Interaction between glycogenin and glycogen synthase."
      Skurat A.V., Dietrich A.D., Roach P.J.
      Arch. Biochem. Biophys. 456:93-97(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GYS1.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Crystal structure of human glycogenin-1 (GYG1), apo form."
      Structural genomics consortium (SGC)
      Submitted (FEB-2011) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.98 ANGSTROMS) OF 1-262.
    15. "Glycogenin-1 deficiency and inactivated priming of glycogen synthesis."
      Moslemi A.R., Lindberg C., Nilsson J., Tajsharghi H., Andersson B., Oldfors A.
      N. Engl. J. Med. 362:1203-1210(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT GSD15 MET-83, CHARACTERIZATION OF VARIANT GSD15 MET-83.

    Entry informationi

    Entry nameiGLYG_HUMAN
    AccessioniPrimary (citable) accession number: P46976
    Secondary accession number(s): D3DNH0
    , D3DNH1, D3DNH2, Q6FHZ1, Q9UNV0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 139 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3