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Protein

Glycogenin-1

Gene

GYG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.

Catalytic activityi

UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin.

Cofactori

Mn2+Note: Divalent metal ions. Required for self-glucosylation. Manganese is the most effective.

Pathway: glycogen biosynthesis

This protein is involved in the pathway glycogen biosynthesis, which is part of Glycan biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycogen biosynthesis and in Glycan biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861By similarity
Metal bindingi102 – 1021ManganeseBy similarity
Metal bindingi104 – 1041ManganeseBy similarity
Sitei160 – 1601Important for catalytic activityBy similarity
Sitei163 – 1631Important for catalytic activityBy similarity
Metal bindingi212 – 2121ManganeseBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glycogen biosynthesis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS08931-MONOMER.
BRENDAi2.4.1.186. 2681.
ReactomeiREACT_1008. Glycogen breakdown (glycogenolysis).
REACT_169208. Glycogen synthesis.
REACT_264430. Myoclonic epilepsy of Lafora.
REACT_355557. Lysosomal glycogen catabolism.
UniPathwayiUPA00164.

Protein family/group databases

CAZyiGT8. Glycosyltransferase Family 8.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycogenin-1 (EC:2.4.1.186)
Short name:
GN-1
Short name:
GN1
Gene namesi
Name:GYG1
Synonyms:GYG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:4699. GYG1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • lysosomal lumen Source: Reactome
  • membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Glycogen storage disease 15 (GSD15)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA metabolic disorder resulting in muscle weakness, associated with the glycogen depletion in skeletal muscle, and cardiac arrhythmia, associated with the accumulation of abnormal storage material in the heart. The skeletal muscle shows a marked predominance of slow-twitch, oxidative muscle fibers and mitochondrial proliferation.

See also OMIM:613507
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831T → M in GSD15; inactivation of the autoglucosylation. 1 Publication
VAR_063768
Polyglucosan body myopathy 2 (PGBM2)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA glycogen storage disease characterized by polyglucosan accumulation in muscle, and skeletal myopathy without cardiac involvement. Most patients manifest slowly progressive, hip girdle, shoulder girdle, and/or hand and leg muscle weakness. Polyglucosan contains abnormally long and poorly branched glucosyl chains and is variably resistant to digestion by alpha-amylase.

See also OMIM:616199
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161A → P in PGBM2. 1 Publication
VAR_072706
Natural varianti102 – 1021D → H in PGBM2. 1 Publication
VAR_072707

Keywords - Diseasei

Disease mutation, Glycogen storage disease

Organism-specific databases

MIMi613507. phenotype.
616199. phenotype.
Orphaneti263297. Glycogen storage disease due to glycogenin deficiency.
PharmGKBiPA29077.

Polymorphism and mutation databases

BioMutaiGYG1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 350349Glycogenin-1CuratedPRO_0000215176Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonine2 Publications
Modified residuei44 – 441PhosphoserineBy similarity
Glycosylationi195 – 1951O-linked (Glc...)By similarity

Post-translational modificationi

Self-glycosylated by the transfer of glucose residues from UDP-glucose to itself, forming an alpha-1,4-glycan of around 10 residues attached to Tyr-195.
Phosphorylated.By similarity

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP46976.
PaxDbiP46976.
PRIDEiP46976.

PTM databases

PhosphoSiteiP46976.

Expressioni

Gene expression databases

BgeeiP46976.
CleanExiHS_GYG1.
ExpressionAtlasiP46976. baseline and differential.
GenevisibleiP46976. HS.

Organism-specific databases

HPAiHPA030497.

Interactioni

Subunit structurei

Homodimer tightly complexed to the 86 kDa catalytic subunit of glycogen synthase GYS1 (By similarity). Interacts (via C-terminus) with GYS2 (PubMed:17055998). This interaction is required for GYS2-mediated glycogen synthesis (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GYS1P138077EBI-740533,EBI-740553

Protein-protein interaction databases

BioGridi109247. 10 interactions.
IntActiP46976. 13 interactions.
MINTiMINT-5000544.
STRINGi9606.ENSP00000340736.

Structurei

Secondary structure

1
350
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 129Combined sources
Helixi13 – 2816Combined sources
Beta strandi33 – 397Combined sources
Helixi45 – 5410Combined sources
Beta strandi55 – 606Combined sources
Helixi69 – 746Combined sources
Helixi80 – 9112Combined sources
Beta strandi96 – 1016Combined sources
Beta strandi105 – 1073Combined sources
Helixi112 – 1165Combined sources
Beta strandi119 – 1246Combined sources
Beta strandi126 – 1283Combined sources
Beta strandi131 – 1399Combined sources
Helixi143 – 15614Combined sources
Beta strandi159 – 1613Combined sources
Helixi163 – 1708Combined sources
Turni171 – 1766Combined sources
Helixi179 – 1813Combined sources
Helixi185 – 1873Combined sources
Beta strandi188 – 1903Combined sources
Helixi191 – 1955Combined sources
Helixi198 – 2047Combined sources
Helixi205 – 2073Combined sources
Beta strandi209 – 2124Combined sources
Beta strandi215 – 2173Combined sources
Helixi219 – 2213Combined sources
Beta strandi222 – 2254Combined sources
Turni226 – 2294Combined sources
Beta strandi230 – 2323Combined sources
Helixi238 – 2403Combined sources
Helixi244 – 25613Combined sources
Helixi258 – 2614Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3Q4SX-ray1.98A1-262[»]
3QVBX-ray2.26A1-262[»]
3RMVX-ray1.82A1-262[»]
3RMWX-ray1.93A1-262[»]
3T7MX-ray1.80A/B1-262[»]
3T7NX-ray1.98A/B1-262[»]
3T7OX-ray1.85A/B1-262[»]
3U2TX-ray2.05A1-262[»]
3U2UX-ray1.45A/B1-262[»]
3U2VX-ray1.50A/B1-262[»]
3U2WX-ray1.68A/B1-262[»]
3U2XX-ray1.77A/B1-262[»]
ProteinModelPortaliP46976.
SMRiP46976. Positions 1-262.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP46976.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni301 – 33333Interaction with GYS11 PublicationAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5597.
GeneTreeiENSGT00390000004721.
HOGENOMiHOG000008282.
HOVERGENiHBG000681.
InParanoidiP46976.
KOiK00750.
OMAiLQQFGLV.
OrthoDBiEOG7BKCV8.
PhylomeDBiP46976.
TreeFamiTF312839.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR002495. Glyco_trans_8.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR11183. PTHR11183. 1 hit.
PfamiPF01501. Glyco_transf_8. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform GN-1L (identifier: P46976-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDQAFVTLT TNDAYAKGAL VLGSSLKQHR TTRRLVVLAT PQVSDSMRKV
60 70 80 90 100
LETVFDEVIM VDVLDSGDSA HLTLMKRPEL GVTLTKLHCW SLTQYSKCVF
110 120 130 140 150
MDADTLVLAN IDDLFDREEL SAAPDPGWPD CFNSGVFVYQ PSVETYNQLL
160 170 180 190 200
HLASEQGSFD GGDQGILNTF FSSWATTDIR KHLPFIYNLS SISIYSYLPA
210 220 230 240 250
FKVFGASAKV VHFLGRVKPW NYTYDPKTKS VKSEAHDPNM THPEFLILWW
260 270 280 290 300
NIFTTNVLPL LQQFGLVKDT CSYVNVLSDL VYTLAFSCGF CRKEDVSGAI
310 320 330 340 350
SHLSLGEIPA MAQPFVSSEE RKERWEQGQA DYMGADSFDN IKRKLDTYLQ
Length:350
Mass (Da):39,384
Last modified:January 23, 2007 - v4
Checksum:iABAEEB7160DEC4DF
GO
Isoform GN-1 (identifier: P46976-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     277-293: Missing.

Show »
Length:333
Mass (Da):37,479
Checksum:iCD5E3C16F849FF7C
GO
Isoform GN-1S (identifier: P46976-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     204-350: FGASAKVVHF...IKRKLDTYLQ → KMSQEPYHIC...IHFTSLVSDT

Show »
Length:279
Mass (Da):31,467
Checksum:iF8AD62431CBB470E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161A → P in PGBM2. 1 Publication
VAR_072706
Natural varianti83 – 831T → M in GSD15; inactivation of the autoglucosylation. 1 Publication
VAR_063768
Natural varianti102 – 1021D → H in PGBM2. 1 Publication
VAR_072707

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei204 – 350147FGASA…DTYLQ → KMSQEPYHICPLGRSQLWHS RLYPRKNGRNDGNRARLIIW EQIPLTTSRGNLTLTSSRNT AFFCEHIHFTSLVSDT in isoform GN-1S. CuratedVSP_001768Add
BLAST
Alternative sequencei277 – 29317Missing in isoform GN-1. 4 PublicationsVSP_001769Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44131 mRNA. Translation: AAB00114.1.
U31525 mRNA. Translation: AAB09752.1.
X79537 mRNA. Translation: CAA56073.1.
AF065481
, AF065476, AF065477, AF065478, AF065479, AF065480 Genomic DNA. Translation: AAD31084.1.
AF087942 mRNA. Translation: AAD52093.1.
CR536547 mRNA. Translation: CAG38784.1.
AC021059 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78894.1.
CH471052 Genomic DNA. Translation: EAW78895.1.
CH471052 Genomic DNA. Translation: EAW78896.1.
CH471052 Genomic DNA. Translation: EAW78898.1.
CH471052 Genomic DNA. Translation: EAW78900.1.
CH471052 Genomic DNA. Translation: EAW78901.1.
BC000033 mRNA. Translation: AAH00033.1.
CCDSiCCDS3139.1. [P46976-1]
CCDS54654.1. [P46976-2]
CCDS54655.1. [P46976-3]
PIRiJC4695.
RefSeqiNP_001171649.1. NM_001184720.1. [P46976-2]
NP_001171650.1. NM_001184721.1. [P46976-3]
NP_004121.2. NM_004130.3. [P46976-1]
UniGeneiHs.477892.

Genome annotation databases

EnsembliENST00000296048; ENSP00000296048; ENSG00000163754. [P46976-2]
ENST00000345003; ENSP00000340736; ENSG00000163754. [P46976-1]
ENST00000484197; ENSP00000420683; ENSG00000163754. [P46976-3]
GeneIDi2992.
KEGGihsa:2992.
UCSCiuc003ewn.3. human. [P46976-1]
uc003ewo.3. human. [P46976-2]
uc003ewp.3. human.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44131 mRNA. Translation: AAB00114.1.
U31525 mRNA. Translation: AAB09752.1.
X79537 mRNA. Translation: CAA56073.1.
AF065481
, AF065476, AF065477, AF065478, AF065479, AF065480 Genomic DNA. Translation: AAD31084.1.
AF087942 mRNA. Translation: AAD52093.1.
CR536547 mRNA. Translation: CAG38784.1.
AC021059 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78894.1.
CH471052 Genomic DNA. Translation: EAW78895.1.
CH471052 Genomic DNA. Translation: EAW78896.1.
CH471052 Genomic DNA. Translation: EAW78898.1.
CH471052 Genomic DNA. Translation: EAW78900.1.
CH471052 Genomic DNA. Translation: EAW78901.1.
BC000033 mRNA. Translation: AAH00033.1.
CCDSiCCDS3139.1. [P46976-1]
CCDS54654.1. [P46976-2]
CCDS54655.1. [P46976-3]
PIRiJC4695.
RefSeqiNP_001171649.1. NM_001184720.1. [P46976-2]
NP_001171650.1. NM_001184721.1. [P46976-3]
NP_004121.2. NM_004130.3. [P46976-1]
UniGeneiHs.477892.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3Q4SX-ray1.98A1-262[»]
3QVBX-ray2.26A1-262[»]
3RMVX-ray1.82A1-262[»]
3RMWX-ray1.93A1-262[»]
3T7MX-ray1.80A/B1-262[»]
3T7NX-ray1.98A/B1-262[»]
3T7OX-ray1.85A/B1-262[»]
3U2TX-ray2.05A1-262[»]
3U2UX-ray1.45A/B1-262[»]
3U2VX-ray1.50A/B1-262[»]
3U2WX-ray1.68A/B1-262[»]
3U2XX-ray1.77A/B1-262[»]
ProteinModelPortaliP46976.
SMRiP46976. Positions 1-262.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109247. 10 interactions.
IntActiP46976. 13 interactions.
MINTiMINT-5000544.
STRINGi9606.ENSP00000340736.

Protein family/group databases

CAZyiGT8. Glycosyltransferase Family 8.

PTM databases

PhosphoSiteiP46976.

Polymorphism and mutation databases

BioMutaiGYG1.

Proteomic databases

MaxQBiP46976.
PaxDbiP46976.
PRIDEiP46976.

Protocols and materials databases

DNASUi2992.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296048; ENSP00000296048; ENSG00000163754. [P46976-2]
ENST00000345003; ENSP00000340736; ENSG00000163754. [P46976-1]
ENST00000484197; ENSP00000420683; ENSG00000163754. [P46976-3]
GeneIDi2992.
KEGGihsa:2992.
UCSCiuc003ewn.3. human. [P46976-1]
uc003ewo.3. human. [P46976-2]
uc003ewp.3. human.

Organism-specific databases

CTDi2992.
GeneCardsiGC03P148709.
HGNCiHGNC:4699. GYG1.
HPAiHPA030497.
MIMi603942. gene.
613507. phenotype.
616199. phenotype.
neXtProtiNX_P46976.
Orphaneti263297. Glycogen storage disease due to glycogenin deficiency.
PharmGKBiPA29077.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5597.
GeneTreeiENSGT00390000004721.
HOGENOMiHOG000008282.
HOVERGENiHBG000681.
InParanoidiP46976.
KOiK00750.
OMAiLQQFGLV.
OrthoDBiEOG7BKCV8.
PhylomeDBiP46976.
TreeFamiTF312839.

Enzyme and pathway databases

UniPathwayiUPA00164.
BioCyciMetaCyc:HS08931-MONOMER.
BRENDAi2.4.1.186. 2681.
ReactomeiREACT_1008. Glycogen breakdown (glycogenolysis).
REACT_169208. Glycogen synthesis.
REACT_264430. Myoclonic epilepsy of Lafora.
REACT_355557. Lysosomal glycogen catabolism.

Miscellaneous databases

ChiTaRSiGYG1. human.
EvolutionaryTraceiP46976.
GenomeRNAii2992.
NextBioi11858.
PROiP46976.
SOURCEiSearch...

Gene expression databases

BgeeiP46976.
CleanExiHS_GYG1.
ExpressionAtlasiP46976. baseline and differential.
GenevisibleiP46976. HS.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR002495. Glyco_trans_8.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR11183. PTHR11183. 1 hit.
PfamiPF01501. Glyco_transf_8. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human skeletal muscle glycogenin gene: cDNA, tissue expression and chromosomal localization."
    Barbetti F., Rocchi M., Bossolasco M., Cordera R., Sbraccia P., Finelli P., Consalez G.G.
    Biochem. Biophys. Res. Commun. 220:72-77(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM GN-1).
    Tissue: Skeletal muscle.
  2. "The human intron-containing gene for glycogenin maps to chromosome 3, band q24."
    Lomako J., Mazuruk K., Lomako W.M., Alonso M.D., Whelan W.J., Rodriguez I.R.
    Genomics 33:519-522(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM GN-1).
  3. Leffers H., Wiemann S., Ansorge W.
    Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM GN-1S).
    Tissue: Skin.
  4. "Characterization of the human glycogenin-1 gene: identification of a muscle-specific regulatory domain."
    van Maanen M.-H., Fournier P.A., Palmer T.N., Abraham L.J.
    Gene 234:217-226(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM GN-1).
  5. "Structure and chromosomal localization of the human glycogenin-2 gene GYG2."
    Zhai L., Mu J., Zong H., DePaoli-Roach A.A., Roach P.J.
    Gene 242:229-235(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM GN-1L), ALTERNATIVE SPLICING.
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM GN-1).
  7. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM GN-1).
    Tissue: Placenta.
  10. "Interaction between glycogenin and glycogen synthase."
    Skurat A.V., Dietrich A.D., Roach P.J.
    Arch. Biochem. Biophys. 456:93-97(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GYS1.
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  14. Cited for: INVOLVEMENT IN PGBM2, VARIANTS PGBM2 PRO-16 AND HIS-102.
  15. "Crystal structure of human glycogenin-1 (GYG1), apo form."
    Structural genomics consortium (SGC)
    Submitted (FEB-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.98 ANGSTROMS) OF 1-262.
  16. "Glycogenin-1 deficiency and inactivated priming of glycogen synthesis."
    Moslemi A.R., Lindberg C., Nilsson J., Tajsharghi H., Andersson B., Oldfors A.
    N. Engl. J. Med. 362:1203-1210(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GSD15 MET-83, CHARACTERIZATION OF VARIANT GSD15 MET-83.

Entry informationi

Entry nameiGLYG_HUMAN
AccessioniPrimary (citable) accession number: P46976
Secondary accession number(s): D3DNH0
, D3DNH1, D3DNH2, Q6FHZ1, Q9UNV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 147 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.