P46973 (HIT1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein HIT1

Gene names

Name:	HIT1
Ordered Locus Names:	YJR055W
ORF Names:	J1705

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	164 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Miscellaneous	Present with 2730 molecules/cell in log phase SD medium.
Sequence similarities	Contains 1 HIT-type zinc finger.

Ontologies

Keywords
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay PubMed 14562095. Source: SGD nucleus Inferred from direct assay PubMed 14562095. Source: SGD
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 164	164	Protein HIT1		PRO_0000173556
Regions
	Zinc finger	8 – 49	42	HIT-type
Experimental info
	Sequence conflict	36 – 37	2	AA → RR in BAA01878. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P46973 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: EAC6ABB5457F87AA	FASTA	164	18,376
	10 20 30 40 50 60 MVSSAVKCGI CRGVDGKYKC PKCGVRYCSL KCYKDAAKHV HKESEQPRAG TEANVEVVNN 70 80 90 100 110 120 DKIINSSLAM NKTLKTKAFD DIYQNSAELQ ELLKYNTVKF HLAKVYRILS STVNDGSSGK 130 140 150 160 MNSDLQKELA VNYLNTLRYG GIHYNEAIEE FCQILLDKLN AVKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Ty element-induced temperature-sensitive mutations of Saccharomyces cerevisiae." Kawakami K., Shafer B.K., Garfinkel D.J., Strathern J.N., Nakamura Y. Genetics 131:821-832(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Analysis of a 62 kb DNA sequence of chromosome X reveals 36 open reading frames and a gene cluster with a counterpart on chromosome XI." Huang M.-E., Manus V., Chuat J.-C., Galibert F. Yeast 12:869-875(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L. EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[5]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D11103 Genomic DNA. Translation: BAA01878.1. Z49555 Genomic DNA. Translation: CAA89583.1. L47993 Genomic DNA. Translation: AAB39281.1. AY558097 Genomic DNA. Translation: AAS56423.1. BK006943 Genomic DNA. Translation: DAA08842.1.
PIR	S57074.
RefSeq	NP_012589.1. NM_001181713.1.
3D structure databases
ProteinModelPortal	P46973.
SMR	P46973. Positions 1-47.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4241N.
IntAct	P46973. 1 interaction.
MINT	MINT-511259.
STRING	4932.YJR055W.
Proteomic databases
PaxDb	P46973.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YJR055W; YJR055W; YJR055W.
GeneID	853516.
KEGG	sce:YJR055W.
Organism-specific databases
CYGD	YJR055w.
SGD	S000003816. HIT1.
Phylogenomic databases
eggNOG	NOG40084.
HOGENOM	HOG000246653.
OMA	ACYKNEE.
OrthoDB	EOG4S1XHV.
Gene expression databases
Genevestigator	P46973.
GermOnline	YJR055W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR007529. Znf_HIT. [Graphical view]
Pfam	PF04438. zf-HIT. 1 hit. [Graphical view]
PROSITE	PS51083. ZF_HIT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	974187.

Entry information

Entry name

HIT1_YEAST

Accession

Primary (citable) accession number: P46973
Secondary accession number(s): D6VWM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	April 3, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program