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Protein

Protein HIT1

Gene

HIT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri8 – 4942HIT-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. box C/D snoRNP assembly Source: SGD
  2. maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31689-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HIT1
Gene namesi
Name:HIT1
Ordered Locus Names:YJR055W
ORF Names:J1705
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome X

Organism-specific databases

CYGDiYJR055w.
EuPathDBiFungiDB:YJR055W.
SGDiS000003816. HIT1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 164164Protein HIT1PRO_0000173556Add
BLAST

Proteomic databases

MaxQBiP46973.
PaxDbiP46973.

Expressioni

Gene expression databases

GenevestigatoriP46973.

Interactioni

Protein-protein interaction databases

BioGridi33810. 15 interactions.
DIPiDIP-4241N.
IntActiP46973. 1 interaction.
MINTiMINT-511259.
STRINGi4932.YJR055W.

Structurei

Secondary structure

1
164
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi77 – 848Combined sources
Helixi87 – 926Combined sources
Helixi96 – 11015Combined sources
Beta strandi119 – 1224Combined sources
Helixi123 – 13412Combined sources
Turni135 – 1373Combined sources
Helixi146 – 16015Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MJFNMR-B70-164[»]
ProteinModelPortaliP46973.
SMRiP46973. Positions 70-164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 HIT-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri8 – 4942HIT-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG40084.
HOGENOMiHOG000246653.
InParanoidiP46973.
OMAiACYKNEE.
OrthoDBiEOG7J18BW.

Family and domain databases

InterProiIPR007529. Znf_HIT.
[Graphical view]
PfamiPF04438. zf-HIT. 1 hit.
[Graphical view]
PROSITEiPS51083. ZF_HIT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46973-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSSAVKCGI CRGVDGKYKC PKCGVRYCSL KCYKDAAKHV HKESEQPRAG
60 70 80 90 100
TEANVEVVNN DKIINSSLAM NKTLKTKAFD DIYQNSAELQ ELLKYNTVKF
110 120 130 140 150
HLAKVYRILS STVNDGSSGK MNSDLQKELA VNYLNTLRYG GIHYNEAIEE
160
FCQILLDKLN AVKK
Length:164
Mass (Da):18,376
Last modified:November 1, 1995 - v1
Checksum:iEAC6ABB5457F87AA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti36 – 372AA → RR in BAA01878 (PubMed:1325386).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11103 Genomic DNA. Translation: BAA01878.1.
Z49555 Genomic DNA. Translation: CAA89583.1.
L47993 Genomic DNA. Translation: AAB39281.1.
AY558097 Genomic DNA. Translation: AAS56423.1.
BK006943 Genomic DNA. Translation: DAA08842.1.
PIRiS57074.
RefSeqiNP_012589.1. NM_001181713.1.

Genome annotation databases

EnsemblFungiiYJR055W; YJR055W; YJR055W.
GeneIDi853516.
KEGGisce:YJR055W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11103 Genomic DNA. Translation: BAA01878.1.
Z49555 Genomic DNA. Translation: CAA89583.1.
L47993 Genomic DNA. Translation: AAB39281.1.
AY558097 Genomic DNA. Translation: AAS56423.1.
BK006943 Genomic DNA. Translation: DAA08842.1.
PIRiS57074.
RefSeqiNP_012589.1. NM_001181713.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MJFNMR-B70-164[»]
ProteinModelPortaliP46973.
SMRiP46973. Positions 70-164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33810. 15 interactions.
DIPiDIP-4241N.
IntActiP46973. 1 interaction.
MINTiMINT-511259.
STRINGi4932.YJR055W.

Proteomic databases

MaxQBiP46973.
PaxDbiP46973.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJR055W; YJR055W; YJR055W.
GeneIDi853516.
KEGGisce:YJR055W.

Organism-specific databases

CYGDiYJR055w.
EuPathDBiFungiDB:YJR055W.
SGDiS000003816. HIT1.

Phylogenomic databases

eggNOGiNOG40084.
HOGENOMiHOG000246653.
InParanoidiP46973.
OMAiACYKNEE.
OrthoDBiEOG7J18BW.

Enzyme and pathway databases

BioCyciYEAST:G3O-31689-MONOMER.

Miscellaneous databases

NextBioi974187.
PROiP46973.

Gene expression databases

GenevestigatoriP46973.

Family and domain databases

InterProiIPR007529. Znf_HIT.
[Graphical view]
PfamiPF04438. zf-HIT. 1 hit.
[Graphical view]
PROSITEiPS51083. ZF_HIT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Ty element-induced temperature-sensitive mutations of Saccharomyces cerevisiae."
    Kawakami K., Shafer B.K., Garfinkel D.J., Strathern J.N., Nakamura Y.
    Genetics 131:821-832(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Analysis of a 62 kb DNA sequence of chromosome X reveals 36 open reading frames and a gene cluster with a counterpart on chromosome XI."
    Huang M.-E., Manus V., Chuat J.-C., Galibert F.
    Yeast 12:869-875(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHIT1_YEAST
AccessioniPrimary (citable) accession number: P46973
Secondary accession number(s): D6VWM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 29, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2730 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.