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P46970

- NMD5_YEAST

UniProt

P46970 - NMD5_YEAST

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Protein
Nonsense-mediated mRNA decay protein 5
Gene
NMD5, KAP119, YJR132W, J2112
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Active in protein import into the nucleus. Its major import substrate is transcription elongation factor TFIIS.1 Publication

GO - Molecular functioni

  1. protein transporter activity Source: SGD

GO - Biological processi

  1. protein import into nucleus Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31750-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nonsense-mediated mRNA decay protein 5
Alternative name(s):
Karyopherin-119
Gene namesi
Name:NMD5
Synonyms:KAP119
Ordered Locus Names:YJR132W
ORF Names:J2112
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJR132w.
SGDiS000003893. NMD5.

Subcellular locationi

Nucleus. Cytoplasm 2 Publications

GO - Cellular componenti

  1. cytoplasm Source: SGD
  2. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10481048Nonsense-mediated mRNA decay protein 5
PRO_0000096880Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei977 – 9771Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP46970.
PaxDbiP46970.
PeptideAtlasiP46970.

Expressioni

Gene expression databases

GenevestigatoriP46970.

Interactioni

Subunit structurei

GTP-bound Ran dissociates the isolated NMD5/TFIIS complex.1 Publication

Protein-protein interaction databases

BioGridi33887. 73 interactions.
DIPiDIP-2326N.
IntActiP46970. 36 interactions.
MINTiMINT-561722.
STRINGi4932.YJR132W.

Structurei

3D structure databases

ProteinModelPortaliP46970.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 10481Importin N-terminal
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5656.
GeneTreeiENSGT00550000074736.
HOGENOMiHOG000248078.
OMAiYKLFKSD.
OrthoDBiEOG7QK0MD.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46970-1 [UniParc]FASTAAdd to Basket

« Hide

MDITELLQCF ACTLDHNAAV RTNAETHLKN ASKVPGFLGA CLDIIAADEV     50
PENIKLSASL YFKNKITYGW SAGARQGSNE LLDSHVDPDE KPVVKDMLIK 100
TMVSVSKTSP RCIRVLKSAL TVIISEDYPS KKWGNLLPNS LELLANEDIT 150
VTYVGLLCLA EIFRTYRWKN NDERQDLEEL ILNYFPALLN YGANVLFQDG 200
KYMNNEQIGE LVKLIIKIYK FVSYHDLPFT LQRSESFTPW ACFFVSIIQQ 250
PLPQEVLAIS DIEVRSKNPW VKCKKWALAN LYRLFQRYAS TSLTRKFQYD 300
EFKQMYCEEF LTQFLQVVFD QIEKWGTGQL WLSDECLYYI LNFVEQCVVQ 350
KTTWKLVGPH YNVILQHVIF PLLKPTAETL EAFDNDPQEY INRNMDFWDV 400
GYSPDLAALA LLTTCVTKRG KTTLQPTLEF MVSTLQSAVG DYNNIMLDNA 450
LQIESCLRIF SSIIDRLITK DSPFASEMEK FILTYVLPFF KSQYGFLQSR 500
VCDICSKLGS MDFKDPVITS TIYEGVMNCL NNSSNSLPVE LTAALALQTF 550
ISDDQFNMKL SEHVVPTMQK LLSLSNDFES DVISGVMQDF VEQFAEQLQP 600
FGVELMNTLV QQFLKLAIDL HETSNLDPDS FTNVDSIPDE SDKQMAALGI 650
LSTTISILLS FENSPEILKN LEQSFYPAAE FILKNDIEDF YRECCEFVEN 700
STFLLRDITP ISWKILELIG ECNRKPDSMV SYYLSDFMLA LNNILIYGRN 750
ELKKNEFYTK IIFEIYQKAV TAEDNSLDDL RVVFDLSQEL VLALDDSLPQ 800
QYRERLLADV VGSILTQKNE LKTNVVFSVT AFNVVISNMI TEPLITLQYL 850
KQQGCLEIFF QTWITDYIPN YKRCYDIKLS VLALLKIILK LESNDYSVLN 900
LENLVPQLGS IVTQLASRLP TALRQLANQR KEFSSSGFEE DTKWDENFLD 950
VGDDDENDDE GDLTEKYLEL IKNRADSLDF VDGYDAKETF DDLEEDPLTG 1000
SILDTVDVYK VFKESIANLQ HVDSNRYQGI LRHLTPADQE LFMGIMNA 1048
Length:1,048
Mass (Da):119,967
Last modified:September 21, 2011 - v2
Checksum:i90312C1AAE515949
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti258 – 2581A → S in CAA89663. 1 Publication
Sequence conflicti517 – 5171V → I in AAA74490. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31375 Genomic DNA. Translation: AAA74490.1.
Z49632 Genomic DNA. Translation: CAA89663.1.
BK006943 Genomic DNA. Translation: DAA08916.2.
PIRiS57155.
RefSeqiNP_012666.2. NM_001181790.2.

Genome annotation databases

EnsemblFungiiYJR132W; YJR132W; YJR132W.
GeneIDi853596.
KEGGisce:YJR132W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31375 Genomic DNA. Translation: AAA74490.1 .
Z49632 Genomic DNA. Translation: CAA89663.1 .
BK006943 Genomic DNA. Translation: DAA08916.2 .
PIRi S57155.
RefSeqi NP_012666.2. NM_001181790.2.

3D structure databases

ProteinModelPortali P46970.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33887. 73 interactions.
DIPi DIP-2326N.
IntActi P46970. 36 interactions.
MINTi MINT-561722.
STRINGi 4932.YJR132W.

Proteomic databases

MaxQBi P46970.
PaxDbi P46970.
PeptideAtlasi P46970.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJR132W ; YJR132W ; YJR132W .
GeneIDi 853596.
KEGGi sce:YJR132W.

Organism-specific databases

CYGDi YJR132w.
SGDi S000003893. NMD5.

Phylogenomic databases

eggNOGi COG5656.
GeneTreei ENSGT00550000074736.
HOGENOMi HOG000248078.
OMAi YKLFKSD.
OrthoDBi EOG7QK0MD.

Enzyme and pathway databases

BioCyci YEAST:G3O-31750-MONOMER.

Miscellaneous databases

NextBioi 974412.

Gene expression databases

Genevestigatori P46970.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001494. Importin-beta_N.
[Graphical view ]
Pfami PF03810. IBN_N. 1 hit.
[Graphical view ]
SMARTi SM00913. IBN_N. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. He F., Jacobson A.
    Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 258.
    Strain: ATCC 204508 / S288c.
  4. "A novel nuclear import pathway for the transcription factor TFIIS."
    Albertini M., Pemberton L.F., Rosenblum J.S., Blobel G.
    J. Cell Biol. 143:1447-1455(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, SUBUNIT.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-977, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-977, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNMD5_YEAST
AccessioniPrimary (citable) accession number: P46970
Secondary accession number(s): D6VWV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: September 21, 2011
Last modified: June 11, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 13500 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

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