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Protein

Signal peptidase complex subunit SPC1

Gene

SPC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nonessential component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum. SPC3 is not required for signal peptidase activity.1 Publication

Miscellaneous

Present with 5550 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • protein targeting to ER Source: SGD
  • signal peptide processing Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-31655-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex subunit SPC1
Alternative name(s):
Microsomal signal peptidase subunit 1
Gene namesi
Name:SPC1
Ordered Locus Names:YJR010C-A
ORF Names:YJR010BW
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR010C-A
SGDiS000003770 SPC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 28CytoplasmicSequence analysisAdd BLAST27
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Topological domaini50LumenalSequence analysis1
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Topological domaini72 – 94CytoplasmicSequence analysisAdd BLAST23

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002151622 – 94Signal peptidase complex subunit SPC1Add BLAST93

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP46965
PaxDbiP46965
PRIDEiP46965

PTM databases

iPTMnetiP46965

Interactioni

Subunit structurei

Component of the signal peptidase complex (SPC), which consists of SPC1, SPC2, SPC3 and SEC11. SPC associates with the translocon complex. SPC1 interacts with SBH1 and SEB2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SEC11P153674EBI-17823,EBI-16513

Protein-protein interaction databases

BioGridi33767, 136 interactors
ComplexPortaliCPX-1835 Signal peptidase complex
DIPiDIP-2770N
IntActiP46965, 17 interactors
MINTiP46965
STRINGi4932.YJR010C-A

Structurei

3D structure databases

ProteinModelPortaliP46965
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPCS1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000000815
InParanoidiP46965
KOiK12946
OMAiTAYGISC
OrthoDBiEOG092C5P2Z

Family and domain databases

InterProiView protein in InterPro
IPR037713 Spc1
IPR009542 SPC12
PANTHERiPTHR13202 PTHR13202, 1 hit
PTHR13202:SF0 PTHR13202:SF0, 1 hit
PfamiView protein in Pfam
PF06645 SPC12, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46965-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEILQDVQR KLVFPIDFPS QRKTEKFQQL SLMIGALVAC ILGFAQQSLK
60 70 80 90
VLLTAYGISC VITLICVLPA YPWYNKQKLR WAQPKIEINV DQYD
Length:94
Mass (Da):10,819
Last modified:November 1, 1995 - v1
Checksum:i814D7C7A49F49D6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26257 Genomic DNA Translation: AAC49366.1
Z49510 Genomic DNA Translation: CAA89533.1
Z49511 Genomic DNA Translation: CAA89535.1
AY557861 Genomic DNA Translation: AAS56187.1
BK006943 Genomic DNA Translation: DAA08802.1
PIRiS61934
RefSeqiNP_012544.1, NM_001181667.1

Genome annotation databases

EnsemblFungiiYJR010C-A; YJR010C-A; YJR010C-A
GeneIDi853467
KEGGisce:YJR010C-A

Similar proteinsi

Entry informationi

Entry nameiSPC1_YEAST
AccessioniPrimary (citable) accession number: P46965
Secondary accession number(s): D6VWI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 20, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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