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P46960

- PGTB2_SCHPO

UniProt

P46960 - PGTB2_SCHPO

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Protein

Geranylgeranyl transferase type-2 subunit beta

Gene

ptb1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified.

Catalytic activityi

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi224 – 2241ZincBy similarity
Metal bindingi224 – 2241Zinc; catalyticBy similarity
Metal bindingi226 – 2261ZincBy similarity
Metal bindingi226 – 2261Zinc; catalyticBy similarity
Metal bindingi276 – 2761ZincBy similarity
Metal bindingi276 – 2761Zinc; via tele nitrogen; catalyticBy similarity

GO - Molecular functioni

  1. Rab geranylgeranyltransferase activity Source: UniProtKB
  2. Rab GTPase binding Source: UniProtKB
  3. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. cellular response to nitrogen starvation Source: PomBase
  2. ER to Golgi vesicle-mediated transport Source: PomBase
  3. negative regulation of G0 to G1 transition Source: PomBase
  4. protein geranylgeranylation Source: UniProtKB
  5. protein targeting to plasma membrane Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl transferase type-2 subunit beta (EC:2.5.1.60)
Alternative name(s):
Geranylgeranyl transferase type II subunit beta
Short name:
GGTase-II-beta
Type II protein geranyl-geranyltransferase subunit beta
Gene namesi
Name:ptb1
ORF Names:SPAC167.02
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC167.02.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
  3. Rab-protein geranylgeranyltransferase complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Geranylgeranyl transferase type-2 subunit betaPRO_0000119779Add
BLAST

Proteomic databases

MaxQBiP46960.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.

Protein-protein interaction databases

MINTiMINT-4690355.
STRINGi4896.SPAC167.02-1.

Structurei

3D structure databases

ProteinModelPortaliP46960.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati54 – 9542PFTB 1Add
BLAST
Repeati102 – 14342PFTB 2Add
BLAST
Repeati150 – 19142PFTB 3Add
BLAST
Repeati197 – 23943PFTB 4Add
BLAST
Repeati246 – 28843PFTB 5Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni176 – 1783Geranylgeranyl diphosphate bindingBy similarity
Regioni218 – 23013Geranylgeranyl diphosphate bindingBy similarityAdd
BLAST

Sequence similaritiesi

Contains 5 PFTB repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5029.
HOGENOMiHOG000180334.
InParanoidiP46960.
KOiK05956.
OMAiESHAGLI.
OrthoDBiEOG7FJH9X.
PhylomeDBiP46960.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR001330. Prenyltrans.
IPR026873. Ptb1.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PANTHERiPTHR11774:SF9. PTHR11774:SF9. 1 hit.
PfamiPF00432. Prenyltrans. 5 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.

Sequencei

Sequence statusi: Complete.

P46960-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVLLRDKHI SYLHDIGNRT DELDFWLKEH LHVSAIYWSC MSFWLLKKKD
60 70 80 90 100
QIDKERIVSF LLSCLTESGG FACYPGHDDH ITNTVYAVQV LAMLDSLHVV
110 120 130 140 150
DKDKVASYII GLQNEDGSMK GDRWGEIDAR FLYSGINCLA ILGKLDYLNK
160 170 180 190 200
NTAVDWLMKC YNFDGGFGLC PGAESHGAMV FTCVAALKIL NKLDLIDEEL
210 220 230 240 250
LGWWISERQV KGGGLNGRPE KLPDSCYGWW DLSPLAIIGK LDWIDRNQLI
260 270 280 290 300
DFLLGTQDAD SGGFADRKED ATDVYHTCFS LAGLSLLQFP NIEPVDPRFC
310
LPLEVTQKMK L
Length:311
Mass (Da):35,092
Last modified:November 1, 1995 - v1
Checksum:i2AB617FC769D3B08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92183 Genomic DNA. Translation: CAA63094.1.
CU329670 Genomic DNA. Translation: CAA22847.1.
PIRiS65091.
RefSeqiNP_593383.1. NM_001018815.2.

Genome annotation databases

EnsemblFungiiSPAC167.02.1; SPAC167.02.1:pep; SPAC167.02.
GeneIDi2543284.
KEGGispo:SPAC167.02.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92183 Genomic DNA. Translation: CAA63094.1 .
CU329670 Genomic DNA. Translation: CAA22847.1 .
PIRi S65091.
RefSeqi NP_593383.1. NM_001018815.2.

3D structure databases

ProteinModelPortali P46960.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4690355.
STRINGi 4896.SPAC167.02-1.

Proteomic databases

MaxQBi P46960.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC167.02.1 ; SPAC167.02.1:pep ; SPAC167.02 .
GeneIDi 2543284.
KEGGi spo:SPAC167.02.

Organism-specific databases

PomBasei SPAC167.02.

Phylogenomic databases

eggNOGi COG5029.
HOGENOMi HOG000180334.
InParanoidi P46960.
KOi K05956.
OMAi ESHAGLI.
OrthoDBi EOG7FJH9X.
PhylomeDBi P46960.

Miscellaneous databases

NextBioi 20804303.
PROi P46960.

Family and domain databases

Gene3Di 1.50.10.20. 1 hit.
InterProi IPR001330. Prenyltrans.
IPR026873. Ptb1.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
PANTHERi PTHR11774:SF9. PTHR11774:SF9. 1 hit.
Pfami PF00432. Prenyltrans. 5 hits.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of ptb1, a gene for the beta subunit of the type-II geranylgeranyltransferase from the fission yeast Schizosaccharomyces pombe."
    Godfrey R., Davey J.
    Yeast 12:479-482(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPGTB2_SCHPO
AccessioniPrimary (citable) accession number: P46960
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3