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P46960

- PGTB2_SCHPO

UniProt

P46960 - PGTB2_SCHPO

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Protein
Geranylgeranyl transferase type-2 subunit beta
Gene
ptb1, SPAC167.02
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified.

Catalytic activityi

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi224 – 2241Zinc By similarity
Metal bindingi224 – 2241Zinc; catalytic By similarity
Metal bindingi226 – 2261Zinc By similarity
Metal bindingi226 – 2261Zinc; catalytic By similarity
Metal bindingi276 – 2761Zinc By similarity
Metal bindingi276 – 2761Zinc; via tele nitrogen; catalytic By similarity

GO - Molecular functioni

  1. Rab GTPase binding Source: UniProtKB
  2. Rab geranylgeranyltransferase activity Source: UniProtKB
  3. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: PomBase
  2. cellular response to nitrogen starvation Source: PomBase
  3. negative regulation of G0 to G1 transition Source: PomBase
  4. protein geranylgeranylation Source: UniProtKB
  5. protein targeting to membrane Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl transferase type-2 subunit beta (EC:2.5.1.60)
Alternative name(s):
Geranylgeranyl transferase type II subunit beta
Short name:
GGTase-II-beta
Type II protein geranyl-geranyltransferase subunit beta
Gene namesi
Name:ptb1
ORF Names:SPAC167.02
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC167.02.

Subcellular locationi

GO - Cellular componenti

  1. Rab-protein geranylgeranyltransferase complex Source: UniProtKB
  2. cytosol Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Geranylgeranyl transferase type-2 subunit beta
PRO_0000119779Add
BLAST

Proteomic databases

MaxQBiP46960.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.

Protein-protein interaction databases

MINTiMINT-4690355.
STRINGi4896.SPAC167.02-1.

Structurei

3D structure databases

ProteinModelPortaliP46960.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati54 – 9542PFTB 1
Add
BLAST
Repeati102 – 14342PFTB 2
Add
BLAST
Repeati150 – 19142PFTB 3
Add
BLAST
Repeati197 – 23943PFTB 4
Add
BLAST
Repeati246 – 28843PFTB 5
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni176 – 1783Geranylgeranyl diphosphate binding By similarity
Regioni218 – 23013Geranylgeranyl diphosphate binding By similarity
Add
BLAST

Sequence similaritiesi

Contains 5 PFTB repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5029.
HOGENOMiHOG000180334.
KOiK05956.
OMAiESHAGLI.
OrthoDBiEOG7FJH9X.
PhylomeDBiP46960.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR001330. Prenyltrans.
IPR026873. Ptb1.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PANTHERiPTHR11774:SF9. PTHR11774:SF9. 1 hit.
PfamiPF00432. Prenyltrans. 5 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.

Sequencei

Sequence statusi: Complete.

P46960-1 [UniParc]FASTAAdd to Basket

« Hide

MAVLLRDKHI SYLHDIGNRT DELDFWLKEH LHVSAIYWSC MSFWLLKKKD    50
QIDKERIVSF LLSCLTESGG FACYPGHDDH ITNTVYAVQV LAMLDSLHVV 100
DKDKVASYII GLQNEDGSMK GDRWGEIDAR FLYSGINCLA ILGKLDYLNK 150
NTAVDWLMKC YNFDGGFGLC PGAESHGAMV FTCVAALKIL NKLDLIDEEL 200
LGWWISERQV KGGGLNGRPE KLPDSCYGWW DLSPLAIIGK LDWIDRNQLI 250
DFLLGTQDAD SGGFADRKED ATDVYHTCFS LAGLSLLQFP NIEPVDPRFC 300
LPLEVTQKMK L 311
Length:311
Mass (Da):35,092
Last modified:November 1, 1995 - v1
Checksum:i2AB617FC769D3B08
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92183 Genomic DNA. Translation: CAA63094.1.
CU329670 Genomic DNA. Translation: CAA22847.1.
PIRiS65091.
RefSeqiNP_593383.1. NM_001018815.2.

Genome annotation databases

EnsemblFungiiSPAC167.02.1; SPAC167.02.1:pep; SPAC167.02.
GeneIDi2543284.
KEGGispo:SPAC167.02.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92183 Genomic DNA. Translation: CAA63094.1 .
CU329670 Genomic DNA. Translation: CAA22847.1 .
PIRi S65091.
RefSeqi NP_593383.1. NM_001018815.2.

3D structure databases

ProteinModelPortali P46960.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4690355.
STRINGi 4896.SPAC167.02-1.

Proteomic databases

MaxQBi P46960.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC167.02.1 ; SPAC167.02.1:pep ; SPAC167.02 .
GeneIDi 2543284.
KEGGi spo:SPAC167.02.

Organism-specific databases

PomBasei SPAC167.02.

Phylogenomic databases

eggNOGi COG5029.
HOGENOMi HOG000180334.
KOi K05956.
OMAi ESHAGLI.
OrthoDBi EOG7FJH9X.
PhylomeDBi P46960.

Miscellaneous databases

NextBioi 20804303.
PROi P46960.

Family and domain databases

Gene3Di 1.50.10.20. 1 hit.
InterProi IPR001330. Prenyltrans.
IPR026873. Ptb1.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
PANTHERi PTHR11774:SF9. PTHR11774:SF9. 1 hit.
Pfami PF00432. Prenyltrans. 5 hits.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of ptb1, a gene for the beta subunit of the type-II geranylgeranyltransferase from the fission yeast Schizosaccharomyces pombe."
    Godfrey R., Davey J.
    Yeast 12:479-482(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPGTB2_SCHPO
AccessioniPrimary (citable) accession number: P46960
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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