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Protein

Geranylgeranyl transferase type-2 subunit beta

Gene

ptb1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified.

Catalytic activityi

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi224ZincBy similarity1
Metal bindingi224Zinc; catalyticBy similarity1
Metal bindingi226ZincBy similarity1
Metal bindingi226Zinc; catalyticBy similarity1
Metal bindingi276ZincBy similarity1
Metal bindingi276Zinc; via tele nitrogen; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: PomBase
  • negative regulation of G0 to G1 transition Source: PomBase
  • protein geranylgeranylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-SPO-6803205. TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain.

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl transferase type-2 subunit beta (EC:2.5.1.60)
Alternative name(s):
Geranylgeranyl transferase type II subunit beta
Short name:
GGTase-II-beta
Type II protein geranyl-geranyltransferase subunit beta
Gene namesi
Name:ptb1
ORF Names:SPAC167.02
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC167.02.
PomBaseiSPAC167.02. ptb1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
  • Rab-protein geranylgeranyltransferase complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001197791 – 311Geranylgeranyl transferase type-2 subunit betaAdd BLAST311

Proteomic databases

MaxQBiP46960.
PRIDEiP46960.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-4690355.

Structurei

3D structure databases

ProteinModelPortaliP46960.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati54 – 95PFTB 1Add BLAST42
Repeati102 – 143PFTB 2Add BLAST42
Repeati150 – 191PFTB 3Add BLAST42
Repeati197 – 239PFTB 4Add BLAST43
Repeati246 – 288PFTB 5Add BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni176 – 178Geranylgeranyl diphosphate bindingBy similarity3
Regioni218 – 230Geranylgeranyl diphosphate bindingBy similarityAdd BLAST13

Sequence similaritiesi

Contains 5 PFTB repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000180334.
InParanoidiP46960.
KOiK05956.
OMAiVLSCQHE.
OrthoDBiEOG092C3IJW.
PhylomeDBiP46960.

Family and domain databases

CDDicd02894. GGTase-II. 1 hit.
Gene3Di1.50.10.20. 1 hit.
InterProiIPR001330. PFTB_repeat.
IPR026873. Ptb1.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PANTHERiPTHR11774:SF11. PTHR11774:SF11. 1 hit.
PfamiPF00432. Prenyltrans. 5 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.

Sequencei

Sequence statusi: Complete.

P46960-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLLRDKHI SYLHDIGNRT DELDFWLKEH LHVSAIYWSC MSFWLLKKKD
60 70 80 90 100
QIDKERIVSF LLSCLTESGG FACYPGHDDH ITNTVYAVQV LAMLDSLHVV
110 120 130 140 150
DKDKVASYII GLQNEDGSMK GDRWGEIDAR FLYSGINCLA ILGKLDYLNK
160 170 180 190 200
NTAVDWLMKC YNFDGGFGLC PGAESHGAMV FTCVAALKIL NKLDLIDEEL
210 220 230 240 250
LGWWISERQV KGGGLNGRPE KLPDSCYGWW DLSPLAIIGK LDWIDRNQLI
260 270 280 290 300
DFLLGTQDAD SGGFADRKED ATDVYHTCFS LAGLSLLQFP NIEPVDPRFC
310
LPLEVTQKMK L
Length:311
Mass (Da):35,092
Last modified:November 1, 1995 - v1
Checksum:i2AB617FC769D3B08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92183 Genomic DNA. Translation: CAA63094.1.
CU329670 Genomic DNA. Translation: CAA22847.1.
PIRiS65091.
RefSeqiNP_593383.1. NM_001018815.2.

Genome annotation databases

EnsemblFungiiSPAC167.02.1; SPAC167.02.1:pep; SPAC167.02.
GeneIDi2543284.
KEGGispo:SPAC167.02.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92183 Genomic DNA. Translation: CAA63094.1.
CU329670 Genomic DNA. Translation: CAA22847.1.
PIRiS65091.
RefSeqiNP_593383.1. NM_001018815.2.

3D structure databases

ProteinModelPortaliP46960.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4690355.

Proteomic databases

MaxQBiP46960.
PRIDEiP46960.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC167.02.1; SPAC167.02.1:pep; SPAC167.02.
GeneIDi2543284.
KEGGispo:SPAC167.02.

Organism-specific databases

EuPathDBiFungiDB:SPAC167.02.
PomBaseiSPAC167.02. ptb1.

Phylogenomic databases

HOGENOMiHOG000180334.
InParanoidiP46960.
KOiK05956.
OMAiVLSCQHE.
OrthoDBiEOG092C3IJW.
PhylomeDBiP46960.

Enzyme and pathway databases

ReactomeiR-SPO-6803205. TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain.

Miscellaneous databases

PROiP46960.

Family and domain databases

CDDicd02894. GGTase-II. 1 hit.
Gene3Di1.50.10.20. 1 hit.
InterProiIPR001330. PFTB_repeat.
IPR026873. Ptb1.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PANTHERiPTHR11774:SF11. PTHR11774:SF11. 1 hit.
PfamiPF00432. Prenyltrans. 5 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPGTB2_SCHPO
AccessioniPrimary (citable) accession number: P46960
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.