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P46960 (PGTB2_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Geranylgeranyl transferase type-2 subunit beta
EC=2.5.1.60
Alternative name(s):
Geranylgeranyl transferase type II subunit beta
Short name=GGTase-II-beta
Type II protein geranyl-geranyltransferase subunit beta
Gene names
Name:ptb1
ORF Names:SPAC167.02
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified.

Catalytic activity

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subunit structure

Heterodimer of an alpha and a beta subunit.

Sequence similarities

Belongs to the protein prenyltransferase subunit beta family.

Contains 5 PFTB repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Geranylgeranyl transferase type-2 subunit beta
PRO_0000119779

Regions

Repeat54 – 9542PFTB 1
Repeat102 – 14342PFTB 2
Repeat150 – 19142PFTB 3
Repeat197 – 23943PFTB 4
Repeat246 – 28843PFTB 5

Sites

Metal binding2241Zinc By similarity
Metal binding2261Zinc By similarity
Metal binding2761Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
P46960 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 2AB617FC769D3B08

FASTA31135,092
        10         20         30         40         50         60 
MAVLLRDKHI SYLHDIGNRT DELDFWLKEH LHVSAIYWSC MSFWLLKKKD QIDKERIVSF 

        70         80         90        100        110        120 
LLSCLTESGG FACYPGHDDH ITNTVYAVQV LAMLDSLHVV DKDKVASYII GLQNEDGSMK 

       130        140        150        160        170        180 
GDRWGEIDAR FLYSGINCLA ILGKLDYLNK NTAVDWLMKC YNFDGGFGLC PGAESHGAMV 

       190        200        210        220        230        240 
FTCVAALKIL NKLDLIDEEL LGWWISERQV KGGGLNGRPE KLPDSCYGWW DLSPLAIIGK 

       250        260        270        280        290        300 
LDWIDRNQLI DFLLGTQDAD SGGFADRKED ATDVYHTCFS LAGLSLLQFP NIEPVDPRFC 

       310 
LPLEVTQKMK L

« Hide

References

« Hide 'large scale' references
[1]"Sequence of ptb1, a gene for the beta subunit of the type-II geranylgeranyltransferase from the fission yeast Schizosaccharomyces pombe."
Godfrey R., Davey J.
Yeast 12:479-482(1996) [PubMed: 8740421] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X92183 Genomic DNA. Translation: CAA63094.1.
CU329670 Genomic DNA. Translation: CAA22847.1.
PIRS65091.
RefSeqNP_593383.1. NM_001018815.1.

3D structure databases

ProteinModelPortalP46960.
ModBaseSearch...

Protein-protein interaction databases

STRINGP46960.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC167.02.1; SPAC167.02.1:pep; SPAC167.02.
GeneID2543284.
GenomeReviewsGene locus ptb1 in contig CU329670_GR.
KEGGspo:SPAC167.02.
NMPDRfig|4896.1.peg.3353.

Organism-specific databases

GeneDB_SpombeSPAC167.02.

Phylogenomic databases

eggNOGfuNOG04206.
GeneTreeEFGT00050000004981.
HOGENOMHBG716455.
OMAGLIYCCV.
OrthoDBEOG43V34B.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-001072-MONOMER.

Gene expression databases

ArrayExpressP46960.

Family and domain databases

InterProIPR001330. Prenyltrans.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
KOK05956.
PfamPF00432. Prenyltrans. 5 hits.
[Graphical view]
SUPFAMSSF48239. Terp_cyc_toroid. 1 hit.
ProtoNetSearch...

Entry information

Entry namePGTB2_SCHPO
AccessionPrimary (citable) accession number: P46960
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: December 14, 2011
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents