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P46960

- PGTB2_SCHPO

UniProt

P46960 - PGTB2_SCHPO

Protein

Geranylgeranyl transferase type-2 subunit beta

Gene

ptb1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified.

    Catalytic activityi

    Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi224 – 2241ZincBy similarity
    Metal bindingi224 – 2241Zinc; catalyticBy similarity
    Metal bindingi226 – 2261ZincBy similarity
    Metal bindingi226 – 2261Zinc; catalyticBy similarity
    Metal bindingi276 – 2761ZincBy similarity
    Metal bindingi276 – 2761Zinc; via tele nitrogen; catalyticBy similarity

    GO - Molecular functioni

    1. Rab geranylgeranyltransferase activity Source: UniProtKB
    2. Rab GTPase binding Source: UniProtKB
    3. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to nitrogen starvation Source: PomBase
    2. ER to Golgi vesicle-mediated transport Source: PomBase
    3. negative regulation of G0 to G1 transition Source: PomBase
    4. protein geranylgeranylation Source: UniProtKB
    5. protein targeting to membrane Source: PomBase

    Keywords - Molecular functioni

    Prenyltransferase, Transferase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Geranylgeranyl transferase type-2 subunit beta (EC:2.5.1.60)
    Alternative name(s):
    Geranylgeranyl transferase type II subunit beta
    Short name:
    GGTase-II-beta
    Type II protein geranyl-geranyltransferase subunit beta
    Gene namesi
    Name:ptb1
    ORF Names:SPAC167.02
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC167.02.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nucleus Source: PomBase
    3. Rab-protein geranylgeranyltransferase complex Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Geranylgeranyl transferase type-2 subunit betaPRO_0000119779Add
    BLAST

    Proteomic databases

    MaxQBiP46960.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit.

    Protein-protein interaction databases

    MINTiMINT-4690355.
    STRINGi4896.SPAC167.02-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP46960.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati54 – 9542PFTB 1Add
    BLAST
    Repeati102 – 14342PFTB 2Add
    BLAST
    Repeati150 – 19142PFTB 3Add
    BLAST
    Repeati197 – 23943PFTB 4Add
    BLAST
    Repeati246 – 28843PFTB 5Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni176 – 1783Geranylgeranyl diphosphate bindingBy similarity
    Regioni218 – 23013Geranylgeranyl diphosphate bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 5 PFTB repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5029.
    HOGENOMiHOG000180334.
    KOiK05956.
    OMAiESHAGLI.
    OrthoDBiEOG7FJH9X.
    PhylomeDBiP46960.

    Family and domain databases

    Gene3Di1.50.10.20. 1 hit.
    InterProiIPR001330. Prenyltrans.
    IPR026873. Ptb1.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view]
    PANTHERiPTHR11774:SF9. PTHR11774:SF9. 1 hit.
    PfamiPF00432. Prenyltrans. 5 hits.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P46960-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVLLRDKHI SYLHDIGNRT DELDFWLKEH LHVSAIYWSC MSFWLLKKKD    50
    QIDKERIVSF LLSCLTESGG FACYPGHDDH ITNTVYAVQV LAMLDSLHVV 100
    DKDKVASYII GLQNEDGSMK GDRWGEIDAR FLYSGINCLA ILGKLDYLNK 150
    NTAVDWLMKC YNFDGGFGLC PGAESHGAMV FTCVAALKIL NKLDLIDEEL 200
    LGWWISERQV KGGGLNGRPE KLPDSCYGWW DLSPLAIIGK LDWIDRNQLI 250
    DFLLGTQDAD SGGFADRKED ATDVYHTCFS LAGLSLLQFP NIEPVDPRFC 300
    LPLEVTQKMK L 311
    Length:311
    Mass (Da):35,092
    Last modified:November 1, 1995 - v1
    Checksum:i2AB617FC769D3B08
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92183 Genomic DNA. Translation: CAA63094.1.
    CU329670 Genomic DNA. Translation: CAA22847.1.
    PIRiS65091.
    RefSeqiNP_593383.1. NM_001018815.2.

    Genome annotation databases

    EnsemblFungiiSPAC167.02.1; SPAC167.02.1:pep; SPAC167.02.
    GeneIDi2543284.
    KEGGispo:SPAC167.02.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92183 Genomic DNA. Translation: CAA63094.1 .
    CU329670 Genomic DNA. Translation: CAA22847.1 .
    PIRi S65091.
    RefSeqi NP_593383.1. NM_001018815.2.

    3D structure databases

    ProteinModelPortali P46960.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4690355.
    STRINGi 4896.SPAC167.02-1.

    Proteomic databases

    MaxQBi P46960.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC167.02.1 ; SPAC167.02.1:pep ; SPAC167.02 .
    GeneIDi 2543284.
    KEGGi spo:SPAC167.02.

    Organism-specific databases

    PomBasei SPAC167.02.

    Phylogenomic databases

    eggNOGi COG5029.
    HOGENOMi HOG000180334.
    KOi K05956.
    OMAi ESHAGLI.
    OrthoDBi EOG7FJH9X.
    PhylomeDBi P46960.

    Miscellaneous databases

    NextBioi 20804303.
    PROi P46960.

    Family and domain databases

    Gene3Di 1.50.10.20. 1 hit.
    InterProi IPR001330. Prenyltrans.
    IPR026873. Ptb1.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view ]
    PANTHERi PTHR11774:SF9. PTHR11774:SF9. 1 hit.
    Pfami PF00432. Prenyltrans. 5 hits.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of ptb1, a gene for the beta subunit of the type-II geranylgeranyltransferase from the fission yeast Schizosaccharomyces pombe."
      Godfrey R., Davey J.
      Yeast 12:479-482(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiPGTB2_SCHPO
    AccessioniPrimary (citable) accession number: P46960
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3