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Protein

Protein SIP4

Gene

SIP4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Interacts with the SNF1 protein kinase.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi46 – 7328Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • negative regulation of invasive growth in response to glucose limitation Source: SGD
  • positive regulation of gluconeogenesis Source: SGD
  • positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source Source: SGD
  • transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31544-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SIP4
Gene namesi
Name:SIP4
Ordered Locus Names:YJL089W
ORF Names:J0922
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL089W.
SGDiS000003625. SIP4.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 829829Protein SIP4PRO_0000114979Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi33668. 64 interactions.
DIPiDIP-840N.

Structurei

3D structure databases

ProteinModelPortaliP46954.
SMRiP46954. Positions 45-93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000068569.
InParanoidiP46954.
OMAiFWCFQFL.
OrthoDBiEOG7TF7JM.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46954-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRKYGRSY SLDDTDSCSN KVLIVPTGQS SSNAITDFSV RKAHACDRCR
60 70 80 90 100
LKKIKCDGLK PNCSNCAKID FPCKTSDKLS RRGLPKGYTE LLEKEVVRLT
110 120 130 140 150
NMNASSSANA NSNLPFINDT FYCFDNYNTQ SENQRFLGHL TWNILTNTFP
160 170 180 190 200
TQKAVVFTDD RNNIDLQLQL LTNFLNLNGD FNHLPNFLLL KYDYNLQFLK
210 220 230 240 250
NLLSVIIKDF FKRQNSLLLL LYPTNLWKNL LLDKINSTAM TGEPITLLAL
260 270 280 290 300
LYIIQFTWSC FDDFKLFKVT KLIVSLTTNS KLDLKVLQLV NLSIFYFMGA
310 320 330 340 350
SVDSCKSKSS LTEHSNVNSV IWTNDLLNLN FTNILNMGLY INPKNLIPIS
360 370 380 390 400
GNNNNNKSNE EDDRIVTFWC FQFLSSWWSL IQGLPKSNFL TEEFQPKSIS
410 420 430 440 450
VLEIPRLKPF EILLNFIIYS LDGCNLLNIS SLNVSDPNFQ FFQNELESFK
460 470 480 490 500
KNLLLWNLYH NLSDHDNFRF LTSSSNKKLT TNLLLKNLTG LNHKLNQPDF
510 520 530 540 550
VEIQLTLFYL SLKLMTLKEG DQDLKKEDIS LEILSLYFLI LTDDSNNDDN
560 570 580 590 600
QQLQPQQLNL YHFTPFNSID IIDLCLNNLN NWSLSLKYES GQNQPHSSKI
610 620 630 640 650
KFEKFQNFLN HWCPIWYYDE FSTNPFLQIL KINFKLLPFE TIHYSQEEQR
660 670 680 690 700
LLISLNKLRY LDAVSSFNSS SVKSNFASKV NTQLNLLQHS SSNSNFLDAS
710 720 730 740 750
PYDFNKIFMN NFENYDYETD EGYAEDDDEE DSDSDNSLPL EIPFKKSKNK
760 770 780 790 800
CKNRNKELSQ RLSLFENRDS NSVDFNTDTN LNLNPDSPSV TSSKKKYLDH
810 820
IILDNRDIVS NHDSSKQKFK IQNILNSTF
Length:829
Mass (Da):96,005
Last modified:November 1, 1995 - v1
Checksum:i5B1185166E55E3F7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti656 – 6561N → T in AAB04119 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17643 Genomic DNA. Translation: AAB04119.1.
X83502 Genomic DNA. Translation: CAA58479.1.
Z49364 Genomic DNA. Translation: CAA89382.1.
BK006943 Genomic DNA. Translation: DAA08711.1.
PIRiS50246.
RefSeqiNP_012446.1. NM_001181522.1.

Genome annotation databases

EnsemblFungiiYJL089W; YJL089W; YJL089W.
GeneIDi853356.
KEGGisce:YJL089W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17643 Genomic DNA. Translation: AAB04119.1.
X83502 Genomic DNA. Translation: CAA58479.1.
Z49364 Genomic DNA. Translation: CAA89382.1.
BK006943 Genomic DNA. Translation: DAA08711.1.
PIRiS50246.
RefSeqiNP_012446.1. NM_001181522.1.

3D structure databases

ProteinModelPortaliP46954.
SMRiP46954. Positions 45-93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33668. 64 interactions.
DIPiDIP-840N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL089W; YJL089W; YJL089W.
GeneIDi853356.
KEGGisce:YJL089W.

Organism-specific databases

EuPathDBiFungiDB:YJL089W.
SGDiS000003625. SIP4.

Phylogenomic databases

GeneTreeiENSGT00530000068569.
InParanoidiP46954.
OMAiFWCFQFL.
OrthoDBiEOG7TF7JM.

Enzyme and pathway databases

BioCyciYEAST:G3O-31544-MONOMER.

Miscellaneous databases

PROiP46954.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Lesage P., Yang X., Carlson M.
    Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Sequence analysis of a 33.1 kb fragment from the left arm of Saccharomyces cerevisiae chromosome X, including putative proteins with leucine zippers, a fungal Zn(II)2-Cys6 binuclear cluster domain and a putative alpha 2-SCB-alpha 2 binding site."
    Miosga T., Schaaff-Gerstenschlaeger I., Chalwatzis N., Baur A., Boles E., Fournier C., Schmitt S., Velten C., Wilhelm N., Zimmermann F.K.
    Yeast 11:681-689(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiSIP4_YEAST
AccessioniPrimary (citable) accession number: P46954
Secondary accession number(s): D6VW95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.