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P46950 (SNG1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nitrosoguanidine resistance protein SNG1
Gene names
Name:SNG1
Ordered Locus Names:YGR197C
ORF Names:G7591
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length547 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May function as a N-methyl-N'nitro-N-nitrosoguanidine (MNNG) export permease.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Induction

Transcriptionally regulated by PDR8. Ref.5

Sequence similarities

To yeast YJR015W.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 547547Nitrosoguanidine resistance protein SNG1
PRO_0000072007

Regions

Transmembrane109 – 12921Helical; Potential
Transmembrane159 – 17921Helical; Potential
Transmembrane318 – 33821Helical; Potential
Transmembrane363 – 38321Helical; Potential
Transmembrane394 – 41421Helical; Potential
Transmembrane418 – 43821Helical; Potential
Transmembrane457 – 47721Helical; Potential
Transmembrane488 – 50821Helical; Potential

Amino acid modifications

Modified residue911Phosphothreonine Ref.6 Ref.7 Ref.8

Experimental info

Sequence conflict1171A → V in CAA52881. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P46950 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: D4421BA2DED55420

FASTA54761,293
        10         20         30         40         50         60 
MTKSVGDEES QYIEDPSFAA AAAFTGGRDG VSYSNQRFAE GSGHSSDLAK SLEDYRPPDE 

        70         80         90        100        110        120 
KPSSLSSVGE GGANEEEKGG NDGGPLARIQ TGLFSPRLRN HRKKILSKFV LNNFFIACVC 

       130        140        150        160        170        180 
VSLISIYWGA CYGTDRYFFK VKNIVVLQDA PSNTSVQSIS AIIPSLLASV PGTWHIYNAT 

       190        200        210        220        230        240 
SFHRKFGTTN STEIDRKIVD LIYDERYWLA LNVKPNATDT LYNSLISQDA NSEFNSSIFF 

       250        260        270        280        290        300 
ESVFESGRDP SSVKSTILPL MQQLEVRLQK YYVKEYLPSL MSNITSNDRD LNINMENWAI 

       310        320        330        340        350        360 
AGQLLFTYND YRPFADRILM APLQVGLIYC ILLTVLQLSL YGKLHGEMAR VLKPKHILIY 

       370        380        390        400        410        420 
RLLISWATYF LLSIGFCTVS AIFRIDFTPA FGRGGFVVYW MSTWLVMMAV GGANENVLSL 

       430        440        450        460        470        480 
VIAYCPPYLS IWLMTWIILN ISASFYPMVL NNEFYRYGYI MPIHNAVDIY KVIFLNLTKR 

       490        500        510        520        530        540 
KMGRNYGILV AWVALNTSLM PFCMKFAGKK MQKNAMQAAE AAVAAATQRA SRPAEANTDK 


NNNPPGN 

« Hide

References

« Hide 'large scale' references
[1]"SNG1 -- a new gene involved in nitrosoguanidine resistance in Saccharomyces cerevisiae."
Grey M., Pich C.T., Haase E., Brendel M.
Mutat. Res. 346:207-214(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete sequence of a 9000 bp fragment of the right arm of Saccharomyces cerevisiae chromosome VII contains four previously unknown open reading frames."
Guerreiro P., Maia e Silva A., Barreiros T., Arroyo J., Garcia-Gonzalez M., Garcia-Saez M.I., Rodrigues-Pousada C., Nombela C.
Yeast 11:1087-1091(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. expand/collapse author list , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"A general strategy to uncover transcription factor properties identifies a new regulator of drug resistance in yeast."
Hikkel I., Lucau-Danila A., Delaveau T., Marc P., Devaux F., Jacq C.
J. Biol. Chem. 278:11427-11432(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[6]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
[7]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X74920 Genomic DNA. Translation: CAA52881.1.
X82775 Genomic DNA. Translation: CAA58016.1.
Z72982 Genomic DNA. Translation: CAA97224.1.
BK006941 Genomic DNA. Translation: DAA08290.1.
PIRS53920.
RefSeqNP_011713.1. NM_001181326.1.

3D structure databases

ProteinModelPortalP46950.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33450. 16 interactions.
DIPDIP-8148N.
IntActP46950. 1 interaction.
STRING4932.YGR197C.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYGR197C; YGR197C; YGR197C.
GeneID853111.
KEGGsce:YGR197C.

Organism-specific databases

CYGDYGR197c.
SGDS000003429. SNG1.

Phylogenomic databases

eggNOGNOG42045.
GeneTreeENSGT00390000015455.
HOGENOMHOG000141871.
OMACENMAMV.
OrthoDBEOG70KGZQ.

Enzyme and pathway databases

BioCycYEAST:G3O-30883-MONOMER.

Gene expression databases

GenevestigatorP46950.

Family and domain databases

InterProIPR022703. DUF3533.
[Graphical view]
PfamPF12051. DUF3533. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio973127.

Entry information

Entry nameSNG1_YEAST
AccessionPrimary (citable) accession number: P46950
Secondary accession number(s): D6VUX9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 19, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD