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P46950

- SNG1_YEAST

UniProt

P46950 - SNG1_YEAST

Protein

Nitrosoguanidine resistance protein SNG1

Gene

SNG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    May function as a N-methyl-N'nitro-N-nitrosoguanidine (MNNG) export permease.

    GO - Biological processi

    1. nucleobase-containing compound transport Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30883-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nitrosoguanidine resistance protein SNG1
    Gene namesi
    Name:SNG1
    Ordered Locus Names:YGR197C
    ORF Names:G7591
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGR197c.
    SGDiS000003429. SNG1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 547547Nitrosoguanidine resistance protein SNG1PRO_0000072007Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei91 – 911Phosphothreonine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Inductioni

    Transcriptionally regulated by PDR8.1 Publication

    Gene expression databases

    GenevestigatoriP46950.

    Interactioni

    Protein-protein interaction databases

    BioGridi33450. 17 interactions.
    DIPiDIP-8148N.
    IntActiP46950. 1 interaction.
    STRINGi4932.YGR197C.

    Structurei

    3D structure databases

    ProteinModelPortaliP46950.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei109 – 12921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei318 – 33821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei363 – 38321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei394 – 41421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei418 – 43821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei457 – 47721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei488 – 50821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    To yeast YJR015W.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42045.
    GeneTreeiENSGT00390000015455.
    HOGENOMiHOG000141871.
    OMAiCENMAMV.
    OrthoDBiEOG70KGZQ.

    Family and domain databases

    InterProiIPR022703. DUF3533.
    [Graphical view]
    PfamiPF12051. DUF3533. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P46950-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKSVGDEES QYIEDPSFAA AAAFTGGRDG VSYSNQRFAE GSGHSSDLAK    50
    SLEDYRPPDE KPSSLSSVGE GGANEEEKGG NDGGPLARIQ TGLFSPRLRN 100
    HRKKILSKFV LNNFFIACVC VSLISIYWGA CYGTDRYFFK VKNIVVLQDA 150
    PSNTSVQSIS AIIPSLLASV PGTWHIYNAT SFHRKFGTTN STEIDRKIVD 200
    LIYDERYWLA LNVKPNATDT LYNSLISQDA NSEFNSSIFF ESVFESGRDP 250
    SSVKSTILPL MQQLEVRLQK YYVKEYLPSL MSNITSNDRD LNINMENWAI 300
    AGQLLFTYND YRPFADRILM APLQVGLIYC ILLTVLQLSL YGKLHGEMAR 350
    VLKPKHILIY RLLISWATYF LLSIGFCTVS AIFRIDFTPA FGRGGFVVYW 400
    MSTWLVMMAV GGANENVLSL VIAYCPPYLS IWLMTWIILN ISASFYPMVL 450
    NNEFYRYGYI MPIHNAVDIY KVIFLNLTKR KMGRNYGILV AWVALNTSLM 500
    PFCMKFAGKK MQKNAMQAAE AAVAAATQRA SRPAEANTDK NNNPPGN 547
    Length:547
    Mass (Da):61,293
    Last modified:November 1, 1995 - v1
    Checksum:iD4421BA2DED55420
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti117 – 1171A → V in CAA52881. (PubMed:7753113)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74920 Genomic DNA. Translation: CAA52881.1.
    X82775 Genomic DNA. Translation: CAA58016.1.
    Z72982 Genomic DNA. Translation: CAA97224.1.
    BK006941 Genomic DNA. Translation: DAA08290.1.
    PIRiS53920.
    RefSeqiNP_011713.1. NM_001181326.1.

    Genome annotation databases

    EnsemblFungiiYGR197C; YGR197C; YGR197C.
    GeneIDi853111.
    KEGGisce:YGR197C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74920 Genomic DNA. Translation: CAA52881.1 .
    X82775 Genomic DNA. Translation: CAA58016.1 .
    Z72982 Genomic DNA. Translation: CAA97224.1 .
    BK006941 Genomic DNA. Translation: DAA08290.1 .
    PIRi S53920.
    RefSeqi NP_011713.1. NM_001181326.1.

    3D structure databases

    ProteinModelPortali P46950.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33450. 17 interactions.
    DIPi DIP-8148N.
    IntActi P46950. 1 interaction.
    STRINGi 4932.YGR197C.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGR197C ; YGR197C ; YGR197C .
    GeneIDi 853111.
    KEGGi sce:YGR197C.

    Organism-specific databases

    CYGDi YGR197c.
    SGDi S000003429. SNG1.

    Phylogenomic databases

    eggNOGi NOG42045.
    GeneTreei ENSGT00390000015455.
    HOGENOMi HOG000141871.
    OMAi CENMAMV.
    OrthoDBi EOG70KGZQ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30883-MONOMER.

    Miscellaneous databases

    NextBioi 973127.

    Gene expression databases

    Genevestigatori P46950.

    Family and domain databases

    InterProi IPR022703. DUF3533.
    [Graphical view ]
    Pfami PF12051. DUF3533. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SNG1 -- a new gene involved in nitrosoguanidine resistance in Saccharomyces cerevisiae."
      Grey M., Pich C.T., Haase E., Brendel M.
      Mutat. Res. 346:207-214(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The complete sequence of a 9000 bp fragment of the right arm of Saccharomyces cerevisiae chromosome VII contains four previously unknown open reading frames."
      Guerreiro P., Maia e Silva A., Barreiros T., Arroyo J., Garcia-Gonzalez M., Garcia-Saez M.I., Rodrigues-Pousada C., Nombela C.
      Yeast 11:1087-1091(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. "A general strategy to uncover transcription factor properties identifies a new regulator of drug resistance in yeast."
      Hikkel I., Lucau-Danila A., Delaveau T., Marc P., Devaux F., Jacq C.
      J. Biol. Chem. 278:11427-11432(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSNG1_YEAST
    AccessioniPrimary (citable) accession number: P46950
    Secondary accession number(s): D6VUX9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3