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P46950

- SNG1_YEAST

UniProt

P46950 - SNG1_YEAST

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Protein
Nitrosoguanidine resistance protein SNG1
Gene
SNG1, YGR197C, G7591
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May function as a N-methyl-N'nitro-N-nitrosoguanidine (MNNG) export permease.

GO - Biological processi

  1. nucleobase-containing compound transport Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30883-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nitrosoguanidine resistance protein SNG1
Gene namesi
Name:SNG1
Ordered Locus Names:YGR197C
ORF Names:G7591
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR197c.
SGDiS000003429. SNG1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei109 – 12921Helical; Reviewed prediction
Add
BLAST
Transmembranei159 – 17921Helical; Reviewed prediction
Add
BLAST
Transmembranei318 – 33821Helical; Reviewed prediction
Add
BLAST
Transmembranei363 – 38321Helical; Reviewed prediction
Add
BLAST
Transmembranei394 – 41421Helical; Reviewed prediction
Add
BLAST
Transmembranei418 – 43821Helical; Reviewed prediction
Add
BLAST
Transmembranei457 – 47721Helical; Reviewed prediction
Add
BLAST
Transmembranei488 – 50821Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 547547Nitrosoguanidine resistance protein SNG1
PRO_0000072007Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei91 – 911Phosphothreonine3 Publications

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

Transcriptionally regulated by PDR8.1 Publication

Gene expression databases

GenevestigatoriP46950.

Interactioni

Protein-protein interaction databases

BioGridi33450. 17 interactions.
DIPiDIP-8148N.
IntActiP46950. 1 interaction.
STRINGi4932.YGR197C.

Structurei

3D structure databases

ProteinModelPortaliP46950.

Family & Domainsi

Sequence similaritiesi

To yeast YJR015W.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42045.
GeneTreeiENSGT00390000015455.
HOGENOMiHOG000141871.
OMAiCENMAMV.
OrthoDBiEOG70KGZQ.

Family and domain databases

InterProiIPR022703. DUF3533.
[Graphical view]
PfamiPF12051. DUF3533. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46950-1 [UniParc]FASTAAdd to Basket

« Hide

MTKSVGDEES QYIEDPSFAA AAAFTGGRDG VSYSNQRFAE GSGHSSDLAK    50
SLEDYRPPDE KPSSLSSVGE GGANEEEKGG NDGGPLARIQ TGLFSPRLRN 100
HRKKILSKFV LNNFFIACVC VSLISIYWGA CYGTDRYFFK VKNIVVLQDA 150
PSNTSVQSIS AIIPSLLASV PGTWHIYNAT SFHRKFGTTN STEIDRKIVD 200
LIYDERYWLA LNVKPNATDT LYNSLISQDA NSEFNSSIFF ESVFESGRDP 250
SSVKSTILPL MQQLEVRLQK YYVKEYLPSL MSNITSNDRD LNINMENWAI 300
AGQLLFTYND YRPFADRILM APLQVGLIYC ILLTVLQLSL YGKLHGEMAR 350
VLKPKHILIY RLLISWATYF LLSIGFCTVS AIFRIDFTPA FGRGGFVVYW 400
MSTWLVMMAV GGANENVLSL VIAYCPPYLS IWLMTWIILN ISASFYPMVL 450
NNEFYRYGYI MPIHNAVDIY KVIFLNLTKR KMGRNYGILV AWVALNTSLM 500
PFCMKFAGKK MQKNAMQAAE AAVAAATQRA SRPAEANTDK NNNPPGN 547
Length:547
Mass (Da):61,293
Last modified:November 1, 1995 - v1
Checksum:iD4421BA2DED55420
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti117 – 1171A → V in CAA52881. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74920 Genomic DNA. Translation: CAA52881.1.
X82775 Genomic DNA. Translation: CAA58016.1.
Z72982 Genomic DNA. Translation: CAA97224.1.
BK006941 Genomic DNA. Translation: DAA08290.1.
PIRiS53920.
RefSeqiNP_011713.1. NM_001181326.1.

Genome annotation databases

EnsemblFungiiYGR197C; YGR197C; YGR197C.
GeneIDi853111.
KEGGisce:YGR197C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74920 Genomic DNA. Translation: CAA52881.1 .
X82775 Genomic DNA. Translation: CAA58016.1 .
Z72982 Genomic DNA. Translation: CAA97224.1 .
BK006941 Genomic DNA. Translation: DAA08290.1 .
PIRi S53920.
RefSeqi NP_011713.1. NM_001181326.1.

3D structure databases

ProteinModelPortali P46950.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33450. 17 interactions.
DIPi DIP-8148N.
IntActi P46950. 1 interaction.
STRINGi 4932.YGR197C.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR197C ; YGR197C ; YGR197C .
GeneIDi 853111.
KEGGi sce:YGR197C.

Organism-specific databases

CYGDi YGR197c.
SGDi S000003429. SNG1.

Phylogenomic databases

eggNOGi NOG42045.
GeneTreei ENSGT00390000015455.
HOGENOMi HOG000141871.
OMAi CENMAMV.
OrthoDBi EOG70KGZQ.

Enzyme and pathway databases

BioCyci YEAST:G3O-30883-MONOMER.

Miscellaneous databases

NextBioi 973127.

Gene expression databases

Genevestigatori P46950.

Family and domain databases

InterProi IPR022703. DUF3533.
[Graphical view ]
Pfami PF12051. DUF3533. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "SNG1 -- a new gene involved in nitrosoguanidine resistance in Saccharomyces cerevisiae."
    Grey M., Pich C.T., Haase E., Brendel M.
    Mutat. Res. 346:207-214(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete sequence of a 9000 bp fragment of the right arm of Saccharomyces cerevisiae chromosome VII contains four previously unknown open reading frames."
    Guerreiro P., Maia e Silva A., Barreiros T., Arroyo J., Garcia-Gonzalez M., Garcia-Saez M.I., Rodrigues-Pousada C., Nombela C.
    Yeast 11:1087-1091(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "A general strategy to uncover transcription factor properties identifies a new regulator of drug resistance in yeast."
    Hikkel I., Lucau-Danila A., Delaveau T., Marc P., Devaux F., Jacq C.
    J. Biol. Chem. 278:11427-11432(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSNG1_YEAST
AccessioniPrimary (citable) accession number: P46950
Secondary accession number(s): D6VUX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

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