##gff-version 3
P46946	UniProtKB	Chain	1	345	.	.	.	ID=PRO_0000097565;Note=DNA endonuclease SAE2	
P46946	UniProtKB	Region	21	172	.	.	.	Note=DNA-binding	
P46946	UniProtKB	Region	265	290	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P46946	UniProtKB	Modified residue	143	143	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19779198;Dbxref=PMID:19779198	
P46946	UniProtKB	Modified residue	267	267	.	.	.	Note=Phosphoserine%3B by CDC28;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18716619,ECO:0000269|PubMed:20150422;Dbxref=PMID:18716619,PMID:20150422	
P46946	UniProtKB	Mutagenesis	72	72	.	.	.	Note=Reduces DNA damage-induced phosphorylation%3B when associated with A-73%2C A-75%2C A-76 and A-90. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121837;Dbxref=PMID:15121837	
P46946	UniProtKB	Mutagenesis	73	73	.	.	.	Note=Reduces DNA damage-induced phosphorylation%3B when associated with A-73%2C A-75%2C A-76 and A-90. Abolishes DNA damage-induced phosphorylation and function in DNA repair%3B when associated with A-90%2C A-249%2C A-279 and A-289. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15121837,ECO:0000269|PubMed:16861895,ECO:0000269|PubMed:18670132;Dbxref=PMID:15121837,PMID:16861895,PMID:18670132	
P46946	UniProtKB	Mutagenesis	75	75	.	.	.	Note=Reduces DNA damage-induced phosphorylation%3B when associated with A-72%2C A-75%2C A-76 and A-90. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121837;Dbxref=PMID:15121837	
P46946	UniProtKB	Mutagenesis	76	76	.	.	.	Note=Reduces DNA damage-induced phosphorylation%3B when associated with A-72%2C A-73%2C A-75 and A-90. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121837;Dbxref=PMID:15121837	
P46946	UniProtKB	Mutagenesis	90	90	.	.	.	Note=Reduces DNA damage-induced phosphorylation%3B when associated with A-72%2C A-73%2C A-75 and A-76. Abolishes DNA damage-induced phosphorylation and function in DNA repair%3B when associated with A-73%2C A-249%2C A-279 and A-289. T->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15121837,ECO:0000269|PubMed:16861895,ECO:0000269|PubMed:18670132;Dbxref=PMID:15121837,PMID:16861895,PMID:18670132	
P46946	UniProtKB	Mutagenesis	223	223	.	.	.	Note=Leads to camptothecin hypersensitivity and loss of function%3B when associated with A-225. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18716619;Dbxref=PMID:18716619	
P46946	UniProtKB	Mutagenesis	225	225	.	.	.	Note=Leads to camptothecin hypersensitivity and loss of function%3B when associated with A-223. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18716619;Dbxref=PMID:18716619	
P46946	UniProtKB	Mutagenesis	249	249	.	.	.	Note=Reduces DNA damage-induced phosphorylation%3B when associated with A-278%2C A-279%2C and A-289. Abolishes DNA damage-induced phosphorylation and function in DNA repair%3B when associated with A-73%2C A-90%2C A-279 and A-289. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15121837,ECO:0000269|PubMed:16861895,ECO:0000269|PubMed:18670132;Dbxref=PMID:15121837,PMID:16861895,PMID:18670132	
P46946	UniProtKB	Mutagenesis	267	267	.	.	.	Note=Leads to camptothecin hypersensitivity and loss of function. S->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18716619,ECO:0000269|PubMed:20150422;Dbxref=PMID:18716619,PMID:20150422	
P46946	UniProtKB	Mutagenesis	267	267	.	.	.	Note=Leads to constitutive activation of the DNA repair function. S->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18716619,ECO:0000269|PubMed:20150422;Dbxref=PMID:18716619,PMID:20150422	
P46946	UniProtKB	Mutagenesis	270	270	.	.	.	Note=Abolishes DNA-binding and endonuclease activity. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18042458;Dbxref=PMID:18042458	
P46946	UniProtKB	Mutagenesis	278	278	.	.	.	Note=Reduces DNA damage-induced phosphorylation%3B when associated with A-249%2C A-279%2C and A-289. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15121837;Dbxref=PMID:15121837	
P46946	UniProtKB	Mutagenesis	279	279	.	.	.	Note=Reduces DNA damage-induced phosphorylation%3B when associated with A-249%2C A-278%2C and A-289. Abolishes DNA damage-induced phosphorylation and function in DNA repair%3B when associated with A-73%2C A-90%2C A-249 and A-289. T->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15121837,ECO:0000269|PubMed:16861895,ECO:0000269|PubMed:18670132;Dbxref=PMID:15121837,PMID:16861895,PMID:18670132	
P46946	UniProtKB	Mutagenesis	289	289	.	.	.	Note=Reduces DNA damage-induced phosphorylation%3B when associated with A-249%2C A-278%2C and A-279. Abolishes DNA damage-induced phosphorylation and function in DNA repair%3B when associated with A-73%2C A-90%2C A-249 and A-279. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15121837,ECO:0000269|PubMed:16861895,ECO:0000269|PubMed:18670132;Dbxref=PMID:15121837,PMID:16861895,PMID:18670132