P46940 (IQGA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras GTPase-activating-like protein IQGAP1

Alternative name(s):
p195

Gene names

Name:	IQGAP1
Synonyms:	KIAA0051

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1657 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. Ref.7
Subunit structure	Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state. Interacts with RAC1. Does not interact with RHOA. Interacts with TSG101. Interacts with PAK6. Ref.6 Ref.10 Ref.12
Subcellular location	Cell membrane Ref.6.
Tissue specificity	Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas.
Domain	Regions C1 and C2 can either interact with nucleotide-free CDC42, or interact together, depending on the phosphorylation state of Ser-1443. When Ser-1443 is not phosphorylated, C1 and C2 interact, which prevents binding of nucleotide-free CDC42 and promotes binding of GTP-bound CDC42. Phosphorylation of Ser-1443 prevents interaction between C1 and C2, which opens the structure of the C-terminus and allows binding and sequestration of nucleotide-free CDC42 on both C1 and C2. Ref.6
Post-translational modification	Phosphorylation of Ser-1443 by PKC/PRKCE prevents interaction between C1 and C2, allowing binding of nucleotide-free CDC42. Ser-1443 phosphorylation enhances the ability to promote neurite outgrowth.
Sequence similarities	Contains 1 CH (calponin-homology) domain. Contains 4 IQ domains. Contains 1 Ras-GAP domain. Contains 1 WW domain.
Sequence caution	The sequence BAA06123.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat
Ligand	Calmodulin-binding
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to calcium ion Inferred from direct assay PubMed 18567582. Source: BHF-UCL energy reserve metabolic process Traceable author statement. Source: Reactome glomerular visceral epithelial cell development Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of dephosphorylation Inferred from electronic annotation. Source: Compara positive regulation of Ras GTPase activity Inferred from electronic annotation. Source: GOC positive regulation of protein kinase activity Inferred from mutant phenotype PubMed 17563371. Source: BHF-UCL regulation of cytokine production Inferred from electronic annotation. Source: Compara regulation of insulin secretion Traceable author statement. Source: Reactome signal transduction Traceable author statement Ref.1. Source: ProtInc small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro small molecule metabolic process Traceable author statement. Source: Reactome
Cellular_component	actin filament Traceable author statement Ref.8. Source: ProtInc cell leading edge Inferred from electronic annotation. Source: Compara cytoplasm Inferred from direct assay. Source: HPA lateral plasma membrane Inferred from electronic annotation. Source: Compara microtubule Inferred from direct assay PubMed 21525035. Source: UniProtKB midbody Inferred from direct assay PubMed 15166316. Source: UniProtKB neuron projection Inferred from electronic annotation. Source: Compara nucleus Inferred from direct assay. Source: HPA plasma membrane Inferred from direct assay. Source: HPA ribonucleoprotein complex Inferred from electronic annotation. Source: Compara slit diaphragm Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	GTPase activator activity Traceable author statement Ref.1. Source: ProtInc GTPase inhibitor activity Traceable author statement Ref.8. Source: ProtInc Ras GTPase activator activity Inferred from electronic annotation. Source: InterPro calcium ion binding Traceable author statement PubMed 18567582. Source: BHF-UCL calmodulin binding Traceable author statement Ref.8. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CDC42	P60953	2	EBI-297509,EBI-81752
Diaph1	O08808	8	EBI-297509,EBI-1026445	From a different organism.
EGFR	P00533	4	EBI-297509,EBI-297353
ERBB2	P04626	5	EBI-297509,EBI-641062

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed Ref.5

Chain

2 – 1657

1656

Ras GTPase-activating-like protein IQGAP1

PRO_0000056648

Regions

Domain

44 – 159

116

CH

Domain

679 – 712

34

WW

Domain

745 – 774

30

IQ 1

Domain

775 – 804

30

IQ 2

Domain

805 – 834

30

IQ 3

Domain

835 – 864

30

IQ 4

Domain

1004 – 1237

234

Ras-GAP

Region

956 – 1274

319

C1

Region

1276 – 1657

382

C2

Amino acid modifications

Modified residue

2

1

N-acetylserine Ref.5 Ref.13

Modified residue

2

1

Phosphoserine Ref.9 Ref.13

Modified residue

271

1

Phosphothreonine By similarity

Modified residue

330

1

Phosphoserine Ref.13

Modified residue

1441

1

Phosphoserine; by PKC Probable

Modified residue

1443

1

Phosphoserine; by PKC/PRKCE Ref.6 Ref.7 Ref.11 Ref.13

Natural variations

Natural variant

256

1

S → A.
Corresponds to variant rs12324924 [ dbSNP | Ensembl ].

VAR_049134

Experimental info

Mutagenesis

1441

1

S → A: Abolishes neurite outgrowth promoting activity; when associated with A-1443. Ref.7

Mutagenesis

1441

1

S → E: Strongly enhances neurite outgrowth promoting activity; when associated with A-1443. Ref.7

Mutagenesis

1443

1

S → A: Abolishes neurite outgrowth promoting activity; when associated with A-1441. Ref.7

Mutagenesis

1443

1

S → D: Strongly enhances neurite outgrowth promoting activity; when associated with A-1441. Ref.7

Secondary structure

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1657

Helix Strand Turn

Details...

Helix

31 – 58

28

Helix

65 – 67

3

Helix

68 – 72

5

Helix

76 – 85

10

Turn

87 – 89

3

Helix

92 – 94

3

Turn

96 – 99

4

Helix

101 – 105

5

Helix

110 – 112

3

Helix

113 – 126

14

Helix

130 – 132

3

Helix

136 – 140

5

Helix

145 – 161

17

Turn

172 – 174

3

Helix

179 – 188

10

Helix

962 – 981

20

Helix

984 – 991

8

Helix

1000 – 1009

10

Turn

1010 – 1013

4

Helix

1016 – 1037

22

Beta strand

1039 – 1042

4

Helix

1043 – 1046

4

Helix

1050 – 1058

9

Helix

1062 – 1081

20

Helix

1091 – 1106

16

Helix

1118 – 1121

4

Helix

1125 – 1150

26

Helix

1151 – 1155

5

Helix

1158 – 1174

17

Helix

1180 – 1191

12

Helix

1192 – 1196

5

Helix

1197 – 1201

5

Turn

1203 – 1207

5

Helix

1219 – 1236

18

Helix

1246 – 1248

3

Helix

1249 – 1270

22

Helix

1275 – 1278

4

Beta strand

1282 – 1284

3

Turn

1285 – 1287

3

Beta strand

1290 – 1292

3

Helix

1299 – 1311

13

Helix

1313 – 1316

4

Helix

1323 – 1331

9

Beta strand

1561 – 1564

4

Helix

1565 – 1571

7

Beta strand

1572 – 1577

6

Helix

1583 – 1587

5

Beta strand

1589 – 1593

5

Beta strand

1596 – 1599

4

Beta strand

1601 – 1608

8

Beta strand

1615 – 1617

3

Helix

1619 – 1628

10

Beta strand

1632 – 1635

4

Turn

1636 – 1638

3

Beta strand

1639 – 1642

4

Helix

1643 – 1652

10

Sequences

	Sequence		Length	Mass (Da)
	P46940 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: A52EC629596EAC33	FASTA	1,657	189,252
	10 20 30 40 50 60 MSAADEVDGL GVARPHYGSV LDNERLTAEE MDERRRQNVA YEYLCHLEEA KRWMEACLGE 70 80 90 100 110 120 DLPPTTELEE GLRNGVYLAK LGNFFSPKVV SLKKIYDREQ TRYKATGLHF RHTDNVIQWL 130 140 150 160 170 180 NAMDEIGLPK IFYPETTDIY DRKNMPRCIY CIHALSLYLF KLGLAPQIQD LYGKVDFTEE 190 200 210 220 230 240 EINNMKTELE KYGIQMPAFS KIGGILANEL SVDEAALHAA VIAINEAIDR RIPADTFAAL 250 260 270 280 290 300 KNPNAMLVNL EEPLASTYQD ILYQAKQDKM TNAKNRTENS ERERDVYEEL LTQAEIQGNI 310 320 330 340 350 360 NKVNTFSALA NIDLALEQGD ALALFRALQS PALGLRGLQQ QNSDWYLKQL LSDKQQKRQS 370 380 390 400 410 420 GQTDPLQKEE LQSGVDAANS AAQQYQRRLA AVALINAAIQ KGVAEKTVLE LMNPEAQLPQ 430 440 450 460 470 480 VYPFAADLYQ KELATLQRQS PEHNLTHPEL SVAVEMLSSV ALINRALESG DVNTVWKQLS 490 500 510 520 530 540 SSVTGLTNIE EENCQRYLDE LMKLKAQAHA ENNEFITWND IQACVDHVNL VVQEEHERIL 550 560 570 580 590 600 AIGLINEALD EGDAQKTLQA LQIPAAKLEG VLAEVAQHYQ DTLIRAKREK AQEIQDESAV 610 620 630 640 650 660 LWLDEIQGGI WQSNKDTQEA QKFALGIFAI NEAVESGDVG KTLSALRSPD VGLYGVIPEC 670 680 690 700 710 720 GETYHSDLAE AKKKKLAVGD NNSKWVKHWV KGGYYYYHNL ETQEGGWDEP PNFVQNSMQL 730 740 750 760 770 780 SREEIQSSIS GVTAAYNREQ LWLANEGLIT RLQARCRGYL VRQEFRSRMN FLKKQIPAIT 790 800 810 820 830 840 CIQSQWRGYK QKKAYQDRLA YLRSHKDEVV KIQSLARMHQ ARKRYRDRLQ YFRDHINDII 850 860 870 880 890 900 KIQAFIRANK ARDDYKTLIN AEDPPMVVVR KFVHLLDQSD QDFQEELDLM KMREEVITLI 910 920 930 940 950 960 RSNQQLENDL NLMDIKIGLL VKNKITLQDV VSHSKKLTKK NKEQLSDMMM INKQKGGLKA 970 980 990 1000 1010 1020 LSKEKREKLE AYQHLFYLLQ TNPTYLAKLI FQMPQNKSTK FMDSVIFTLY NYASNQREEY 1030 1040 1050 1060 1070 1080 LLLRLFKTAL QEEIKSKVDQ IQEIVTGNPT VIKMVVSFNR GARGQNALRQ ILAPVVKEIM 1090 1100 1110 1120 1130 1140 DDKSLNIKTD PVDIYKSWVN QMESQTGEAS KLPYDVTPEQ ALAHEEVKTR LDSSIRNMRA 1150 1160 1170 1180 1190 1200 VTDKFLSAIV SSVDKIPYGM RFIAKVLKDS LHEKFPDAGE DELLKIIGNL LYYRYMNPAI 1210 1220 1230 1240 1250 1260 VAPDAFDIID LSAGGQLTTD QRRNLGSIAK MLQHAASNKM FLGDNAHLSI INEYLSQSYQ 1270 1280 1290 1300 1310 1320 KFRRFFQTAC DVPELQDKFN VDEYSDLVTL TKPVIYISIG EIINTHTLLL DHQDAIAPEH 1330 1340 1350 1360 1370 1380 NDPIHELLDD LGEVPTIESL IGESSGNLND PNKEALAKTE VSLTLTNKFD VPGDENAEMD 1390 1400 1410 1420 1430 1440 ARTILLNTKR LIVDVIRFQP GETLTEILET PATSEQEAEH QRAMQRRAIR DAKTPDKMKK 1450 1460 1470 1480 1490 1500 SKSVKEDSNL TLQEKKEKIQ TGLKKLTELG TVDPKNKYQE LINDIARDIR NQRRYRQRRK 1510 1520 1530 1540 1550 1560 AELVKLQQTY AALNSKATFY GEQVDYYKSY IKTCLDNLAS KGKVSKKPRE MKGKKSKKIS 1570 1580 1590 1600 1610 1620 LKYTAARLHE KGVLLEIEDL QVNQFKNVIF EISPTEEVGD FEVKAKFMGV QMETFMLHYQ 1630 1640 1650 DLLQLQYEGV AVMKLFDRAK VNVNLLIFLL NKKFYGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a human rasGAP-related protein containing calmodulin-binding motifs." Weissbach L., Settleman J., Kalady M.F., Snijders A.J., Murthy A.E., Yan Y.-X., Bernards A. J. Biol. Chem. 269:20517-20521(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver and Placenta.
[2]	"Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1." Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N., Kawarabayasi Y., Ishikawa K., Tabata S. DNA Res. 1:223-229(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	Bienvenut W.V., Lilla S., Zebisch A., Kolch W. Submitted (MAR-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-25; 81-88; 112-143; 192-230; 466-477; 557-585; 923-935; 989-997; 1391-1397; 1466-1475 AND 1506-1516, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, MASS SPECTROMETRY. Tissue: Colon carcinoma.
[6]	"Phosphorylation of IQGAP1 modulates its binding to Cdc42, revealing a new type of rho-GTPase regulator." Grohmanova K., Schlaepfer D., Hess D., Gutierrez P., Beck M., Kroschewski R. J. Biol. Chem. 279:48495-48504(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 1441-1455, PHOSPHORYLATION AT SER-1443, INTERACTION WITH CDC42 AND RAC1, DOMAIN, SUBCELLULAR LOCATION, MASS SPECTROMETRY.
[7]	"IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner." Li Z., McNulty D.E., Marler K.J.M., Lim L., Hall C., Annan R.S., Sacks D.B. J. Biol. Chem. 280:13871-13878(2005) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 1441-1455, PHOSPHORYLATION AT SER-1441 AND SER-1443, MUTAGENESIS OF SER-1441 AND SER-1443, FUNCTION, MASS SPECTROMETRY.
[8]	"IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs." Hart M.J., Callow M.G., Souza B., Polakis P. EMBO J. 15:2997-3005(1996) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis." Morita E., Sandrin V., Chung H.Y., Morham S.G., Gygi S.P., Rodesch C.K., Sundquist W.I. EMBO J. 26:4215-4227(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TSG101.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1443, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins." Kaur R., Yuan X., Lu M.L., Balk S.P. Prostate 68:1510-1516(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PAK6.
[13]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; SER-330 AND SER-1443, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]	"Solution structure of the carboxyl-terminal RGC domain in human IQGAP1." RIKEN structural genomics initiative (RSGI) Submitted (SEP-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 1559-1657.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L33075 mRNA. Translation: AAA59187.1.
D29640 mRNA. Translation: BAA06123.2. Different initiation.
CH471101 Genomic DNA. Translation: EAX02102.1.
BC151834 mRNA. Translation: AAI51835.1.

IPI

IPI00009342.

PIR

A54854.

RefSeq

NP_003861.1. NM_003870.3.

UniGene

Hs.430551.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1X0H	NMR	-	A	1559-1657	[»]
2RR8	NMR	-	A	26-210	[»]
3FAY	X-ray	2.20	A	962-1345	[»]
3I6X	X-ray	2.50	A/B/C/D	1-191	[»]

ProteinModelPortal

P46940.

ModBase

Search...

Protein-protein interaction databases

IntAct

P46940. 26 interactions.

MINT

MINT-4999354.

STRING

9606.ENSP00000268182.

PTM databases

PhosphoSite

P46940.

Polymorphism databases

DMDM

1170586.

Proteomic databases

PaxDb

P46940.

PeptideAtlas

P46940.

PRIDE

P46940.

Protocols and materials databases

DNASU

8826.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000268182; ENSP00000268182; ENSG00000140575.

GeneID

8826.

KEGG

hsa:8826.

UCSC

uc002bpl.1. human.

Organism-specific databases

CTD

8826.

GeneCards

GC15P090931.

H-InvDB

HIX0172824.

HGNC

HGNC:6110. IQGAP1.

HPA

CAB013302.
HPA014055.

MIM

603379. gene.

neXtProt

NX_P46940.

PharmGKB

PA29910.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5261.

HOGENOM

HOG000004842.

HOVERGEN

HBG052143.

InParanoid

P46940.

KO

K16848.

OMA

MNFLKKQ.

OrthoDB

EOG4RFKRP.

PhylomeDB

P46940.

Enzyme and pathway databases

Pathway_Interaction_DB

lis1pathway. Lissencephaly gene (LIS1) in neuronal migration and development.
vegfr1_2_pathway. Signaling events mediated by VEGFR1 and VEGFR2.

Reactome

REACT_111155. Cell-Cell communication.
REACT_111217. Metabolism.

Gene expression databases

ArrayExpress

P46940.

Bgee

P46940.

CleanEx

HS_IQGAP1.

Genevestigator

P46940.

GermOnline

ENSG00000140575. Homo sapiens.

Family and domain databases

Gene3D

1.10.418.10. 1 hit.
1.10.506.10. 2 hits.

InterPro

IPR001715. CH-domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR001936. RasGAP.
IPR000593. RasGAP_C.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
IPR001202. WW_dom.
[Graphical view]

Pfam

PF00307. CH. 1 hit.
PF00612. IQ. 4 hits.
PF00616. RasGAP. 1 hit.
PF03836. RasGAP_C. 1 hit.
[Graphical view]

SMART

SM00033. CH. 1 hit.
SM00015. IQ. 4 hits.
SM00323. RasGAP. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]

SUPFAM

SSF47576. Calponin-homology. 1 hit.
SSF48350. Rho_GAP. 1 hit.

PROSITE

PS50021. CH. 1 hit.
PS50096. IQ. 4 hits.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

IQGAP1. human.

EvolutionaryTrace

P46940.

GenomeRNAi

8826.

NextBio

33114.

PMAP-CutDB

P46940.

SOURCE

Search...

Entry information

Entry name

IQGA1_HUMAN

Accession

Primary (citable) accession number: P46940
Secondary accession number(s): A7MBM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 140 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.