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P46940

- IQGA1_HUMAN

UniProt

P46940 - IQGA1_HUMAN

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Protein
Ras GTPase-activating-like protein IQGAP1
Gene
IQGAP1, KIAA0051
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.1 Publication

GO - Molecular functioni

  1. GTPase activator activity Source: ProtInc
  2. GTPase inhibitor activity Source: ProtInc
  3. Ras GTPase activator activity Source: InterPro
  4. calcium ion binding Source: BHF-UCL
  5. calmodulin binding Source: BHF-UCL
  6. phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
  7. protein binding Source: UniProtKB
  8. protein kinase binding Source: BHF-UCL
  9. protein phosphatase binding Source: UniProtKB

GO - Biological processi

  1. cellular response to calcium ion Source: BHF-UCL
  2. energy reserve metabolic process Source: Reactome
  3. glomerular visceral epithelial cell development Source: UniProtKB
  4. negative regulation of catalytic activity Source: GOC
  5. negative regulation of dephosphorylation Source: Ensembl
  6. positive regulation of GTPase activity Source: GOC
  7. positive regulation of protein kinase activity Source: BHF-UCL
  8. regulation of cytokine production Source: Ensembl
  9. regulation of insulin secretion Source: Reactome
  10. signal transduction Source: ProtInc
  11. small GTPase mediated signal transduction Source: InterPro
  12. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Enzyme and pathway databases

ReactomeiREACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_23832. Nephrin interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras GTPase-activating-like protein IQGAP1
Alternative name(s):
p195
Gene namesi
Name:IQGAP1
Synonyms:KIAA0051
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:6110. IQGAP1.

Subcellular locationi

Cell membrane 1 Publication

GO - Cellular componenti

  1. actin filament Source: ProtInc
  2. cell junction Source: HPA
  3. cell leading edge Source: Ensembl
  4. cytoplasm Source: HPA
  5. extracellular vesicular exosome Source: UniProt
  6. extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
  7. lateral plasma membrane Source: Ensembl
  8. microtubule Source: UniProtKB
  9. midbody Source: UniProtKB
  10. neuron projection Source: Ensembl
  11. nucleus Source: HPA
  12. plasma membrane Source: HPA
  13. ribonucleoprotein complex Source: Ensembl
  14. slit diaphragm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1441 – 14411S → A: Abolishes neurite outgrowth promoting activity; when associated with A-1443. 1 Publication
Mutagenesisi1441 – 14411S → E: Strongly enhances neurite outgrowth promoting activity; when associated with A-1443. 1 Publication
Mutagenesisi1443 – 14431S → A: Abolishes neurite outgrowth promoting activity; when associated with A-1441. 1 Publication
Mutagenesisi1443 – 14431S → D: Strongly enhances neurite outgrowth promoting activity; when associated with A-1441. 1 Publication

Organism-specific databases

PharmGKBiPA29910.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 16571656Ras GTPase-activating-like protein IQGAP1
PRO_0000056648Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine4 Publications
Modified residuei2 – 21Phosphoserine2 Publications
Modified residuei172 – 1721Phosphotyrosine By similarity
Modified residuei330 – 3301Phosphoserine1 Publication
Modified residuei1441 – 14411Phosphoserine; by PKC Inferred
Modified residuei1443 – 14431Phosphoserine; by PKC/PRKCE4 Publications

Post-translational modificationi

Phosphorylation of Ser-1443 by PKC/PRKCE prevents interaction between C1 and C2, allowing binding of nucleotide-free CDC42. Ser-1443 phosphorylation enhances the ability to promote neurite outgrowth.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP46940.
PaxDbiP46940.
PeptideAtlasiP46940.
PRIDEiP46940.

PTM databases

PhosphoSiteiP46940.

Miscellaneous databases

PMAP-CutDBP46940.

Expressioni

Tissue specificityi

Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas.

Gene expression databases

ArrayExpressiP46940.
BgeeiP46940.
CleanExiHS_IQGAP1.
GenevestigatoriP46940.

Organism-specific databases

HPAiCAB013302.
HPA014055.

Interactioni

Subunit structurei

Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state. Interacts with RAC1. Does not interact with RHOA. Interacts with TSG101. Interacts with PAK6.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ACTN4O437073EBI-297509,EBI-351526
CD2APQ9Y5K64EBI-297509,EBI-298152
CDC42P609532EBI-297509,EBI-81752
CTNNB1P352223EBI-297509,EBI-491549
Diaph1O088088EBI-297509,EBI-1026445From a different organism.
EGFRP005334EBI-297509,EBI-297353
ERBB2P046265EBI-297509,EBI-641062
MAGI1Q96QZ74EBI-297509,EBI-924464
NPHS1O605005EBI-297509,EBI-996920
NPHS2Q9NP854EBI-297509,EBI-6897706
PIP5K1CO60331-46EBI-297509,EBI-8838062
PODXLO005924EBI-297509,EBI-6897823
RNASELQ058232EBI-297509,EBI-8390477
TSG101Q998165EBI-297509,EBI-346882

Protein-protein interaction databases

BioGridi114353. 89 interactions.
IntActiP46940. 48 interactions.
MINTiMINT-4999354.
STRINGi9606.ENSP00000268182.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi31 – 5828
Helixi65 – 673
Helixi68 – 725
Helixi76 – 8510
Turni87 – 893
Helixi92 – 943
Turni96 – 994
Helixi101 – 1055
Helixi110 – 1123
Helixi113 – 12614
Helixi130 – 1323
Helixi136 – 1405
Helixi145 – 16117
Turni172 – 1743
Helixi179 – 18810
Helixi199 – 2013
Turni206 – 2083
Helixi962 – 98120
Helixi984 – 9918
Helixi1000 – 100910
Turni1010 – 10134
Helixi1016 – 103722
Beta strandi1039 – 10424
Helixi1043 – 10464
Helixi1050 – 10589
Helixi1062 – 108120
Helixi1091 – 110616
Helixi1118 – 11214
Helixi1125 – 115026
Helixi1151 – 11555
Helixi1158 – 117417
Helixi1180 – 119112
Helixi1192 – 11965
Helixi1197 – 12015
Turni1203 – 12075
Helixi1219 – 123618
Helixi1246 – 12483
Helixi1249 – 127022
Helixi1275 – 12784
Beta strandi1282 – 12843
Turni1285 – 12873
Beta strandi1290 – 12923
Helixi1299 – 131113
Helixi1313 – 13164
Helixi1323 – 13319
Beta strandi1561 – 15644
Helixi1565 – 15717
Beta strandi1572 – 15776
Helixi1583 – 15875
Beta strandi1589 – 15935
Beta strandi1596 – 15994
Beta strandi1601 – 16088
Beta strandi1615 – 16173
Helixi1619 – 162810
Beta strandi1632 – 16354
Turni1636 – 16383
Beta strandi1639 – 16424
Helixi1643 – 165210

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X0HNMR-A1559-1657[»]
2RR8NMR-A26-210[»]
3FAYX-ray2.20A962-1345[»]
3I6XX-ray2.50A/B/C/D1-191[»]
ProteinModelPortaliP46940.
SMRiP46940. Positions 26-210, 962-1339, 1561-1657.

Miscellaneous databases

EvolutionaryTraceiP46940.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 159116CH
Add
BLAST
Domaini679 – 71234WW
Add
BLAST
Domaini745 – 77430IQ 1
Add
BLAST
Domaini775 – 80430IQ 2
Add
BLAST
Domaini805 – 83430IQ 3
Add
BLAST
Domaini835 – 86430IQ 4
Add
BLAST
Domaini1004 – 1237234Ras-GAP
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni956 – 1274319C1
Add
BLAST
Regioni1276 – 1657382C2
Add
BLAST

Domaini

Regions C1 and C2 can either interact with nucleotide-free CDC42, or interact together, depending on the phosphorylation state of Ser-1443. When Ser-1443 is not phosphorylated, C1 and C2 interact, which prevents binding of nucleotide-free CDC42 and promotes binding of GTP-bound CDC42. Phosphorylation of Ser-1443 prevents interaction between C1 and C2, which opens the structure of the C-terminus and allows binding and sequestration of nucleotide-free CDC42 on both C1 and C2.1 Publication

Sequence similaritiesi

Contains 4 IQ domains.
Contains 1 Ras-GAP domain.
Contains 1 WW domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5261.
HOGENOMiHOG000004842.
HOVERGENiHBG052143.
InParanoidiP46940.
KOiK16848.
OMAiQDILYQA.
OrthoDBiEOG7FNC6M.
PhylomeDBiP46940.
TreeFamiTF313078.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
1.10.506.10. 2 hits.
4.10.270.10. 1 hit.
InterProiIPR001715. CH-domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR027417. P-loop_NTPase.
IPR001936. RasGAP.
IPR000593. RasGAP_C.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF00612. IQ. 4 hits.
PF00616. RasGAP. 1 hit.
PF03836. RasGAP_C. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00015. IQ. 4 hits.
SM00323. RasGAP. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS50096. IQ. 4 hits.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46940-1 [UniParc]FASTAAdd to Basket

« Hide

MSAADEVDGL GVARPHYGSV LDNERLTAEE MDERRRQNVA YEYLCHLEEA     50
KRWMEACLGE DLPPTTELEE GLRNGVYLAK LGNFFSPKVV SLKKIYDREQ 100
TRYKATGLHF RHTDNVIQWL NAMDEIGLPK IFYPETTDIY DRKNMPRCIY 150
CIHALSLYLF KLGLAPQIQD LYGKVDFTEE EINNMKTELE KYGIQMPAFS 200
KIGGILANEL SVDEAALHAA VIAINEAIDR RIPADTFAAL KNPNAMLVNL 250
EEPLASTYQD ILYQAKQDKM TNAKNRTENS ERERDVYEEL LTQAEIQGNI 300
NKVNTFSALA NIDLALEQGD ALALFRALQS PALGLRGLQQ QNSDWYLKQL 350
LSDKQQKRQS GQTDPLQKEE LQSGVDAANS AAQQYQRRLA AVALINAAIQ 400
KGVAEKTVLE LMNPEAQLPQ VYPFAADLYQ KELATLQRQS PEHNLTHPEL 450
SVAVEMLSSV ALINRALESG DVNTVWKQLS SSVTGLTNIE EENCQRYLDE 500
LMKLKAQAHA ENNEFITWND IQACVDHVNL VVQEEHERIL AIGLINEALD 550
EGDAQKTLQA LQIPAAKLEG VLAEVAQHYQ DTLIRAKREK AQEIQDESAV 600
LWLDEIQGGI WQSNKDTQEA QKFALGIFAI NEAVESGDVG KTLSALRSPD 650
VGLYGVIPEC GETYHSDLAE AKKKKLAVGD NNSKWVKHWV KGGYYYYHNL 700
ETQEGGWDEP PNFVQNSMQL SREEIQSSIS GVTAAYNREQ LWLANEGLIT 750
RLQARCRGYL VRQEFRSRMN FLKKQIPAIT CIQSQWRGYK QKKAYQDRLA 800
YLRSHKDEVV KIQSLARMHQ ARKRYRDRLQ YFRDHINDII KIQAFIRANK 850
ARDDYKTLIN AEDPPMVVVR KFVHLLDQSD QDFQEELDLM KMREEVITLI 900
RSNQQLENDL NLMDIKIGLL VKNKITLQDV VSHSKKLTKK NKEQLSDMMM 950
INKQKGGLKA LSKEKREKLE AYQHLFYLLQ TNPTYLAKLI FQMPQNKSTK 1000
FMDSVIFTLY NYASNQREEY LLLRLFKTAL QEEIKSKVDQ IQEIVTGNPT 1050
VIKMVVSFNR GARGQNALRQ ILAPVVKEIM DDKSLNIKTD PVDIYKSWVN 1100
QMESQTGEAS KLPYDVTPEQ ALAHEEVKTR LDSSIRNMRA VTDKFLSAIV 1150
SSVDKIPYGM RFIAKVLKDS LHEKFPDAGE DELLKIIGNL LYYRYMNPAI 1200
VAPDAFDIID LSAGGQLTTD QRRNLGSIAK MLQHAASNKM FLGDNAHLSI 1250
INEYLSQSYQ KFRRFFQTAC DVPELQDKFN VDEYSDLVTL TKPVIYISIG 1300
EIINTHTLLL DHQDAIAPEH NDPIHELLDD LGEVPTIESL IGESSGNLND 1350
PNKEALAKTE VSLTLTNKFD VPGDENAEMD ARTILLNTKR LIVDVIRFQP 1400
GETLTEILET PATSEQEAEH QRAMQRRAIR DAKTPDKMKK SKSVKEDSNL 1450
TLQEKKEKIQ TGLKKLTELG TVDPKNKYQE LINDIARDIR NQRRYRQRRK 1500
AELVKLQQTY AALNSKATFY GEQVDYYKSY IKTCLDNLAS KGKVSKKPRE 1550
MKGKKSKKIS LKYTAARLHE KGVLLEIEDL QVNQFKNVIF EISPTEEVGD 1600
FEVKAKFMGV QMETFMLHYQ DLLQLQYEGV AVMKLFDRAK VNVNLLIFLL 1650
NKKFYGK 1657
Length:1,657
Mass (Da):189,252
Last modified:November 1, 1995 - v1
Checksum:iA52EC629596EAC33
GO

Sequence cautioni

The sequence BAA06123.2 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti256 – 2561S → A.
Corresponds to variant rs12324924 [ dbSNP | Ensembl ].
VAR_049134

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L33075 mRNA. Translation: AAA59187.1.
D29640 mRNA. Translation: BAA06123.2. Different initiation.
CH471101 Genomic DNA. Translation: EAX02102.1.
BC151834 mRNA. Translation: AAI51835.1.
CCDSiCCDS10362.1.
PIRiA54854.
RefSeqiNP_003861.1. NM_003870.3.
UniGeneiHs.430551.

Genome annotation databases

EnsembliENST00000268182; ENSP00000268182; ENSG00000140575.
GeneIDi8826.
KEGGihsa:8826.
UCSCiuc002bpl.1. human.

Polymorphism databases

DMDMi1170586.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L33075 mRNA. Translation: AAA59187.1 .
D29640 mRNA. Translation: BAA06123.2 . Different initiation.
CH471101 Genomic DNA. Translation: EAX02102.1 .
BC151834 mRNA. Translation: AAI51835.1 .
CCDSi CCDS10362.1.
PIRi A54854.
RefSeqi NP_003861.1. NM_003870.3.
UniGenei Hs.430551.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1X0H NMR - A 1559-1657 [» ]
2RR8 NMR - A 26-210 [» ]
3FAY X-ray 2.20 A 962-1345 [» ]
3I6X X-ray 2.50 A/B/C/D 1-191 [» ]
ProteinModelPortali P46940.
SMRi P46940. Positions 26-210, 962-1339, 1561-1657.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114353. 89 interactions.
IntActi P46940. 48 interactions.
MINTi MINT-4999354.
STRINGi 9606.ENSP00000268182.

PTM databases

PhosphoSitei P46940.

Polymorphism databases

DMDMi 1170586.

Proteomic databases

MaxQBi P46940.
PaxDbi P46940.
PeptideAtlasi P46940.
PRIDEi P46940.

Protocols and materials databases

DNASUi 8826.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000268182 ; ENSP00000268182 ; ENSG00000140575 .
GeneIDi 8826.
KEGGi hsa:8826.
UCSCi uc002bpl.1. human.

Organism-specific databases

CTDi 8826.
GeneCardsi GC15P090931.
H-InvDB HIX0172824.
HGNCi HGNC:6110. IQGAP1.
HPAi CAB013302.
HPA014055.
MIMi 603379. gene.
neXtProti NX_P46940.
PharmGKBi PA29910.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5261.
HOGENOMi HOG000004842.
HOVERGENi HBG052143.
InParanoidi P46940.
KOi K16848.
OMAi QDILYQA.
OrthoDBi EOG7FNC6M.
PhylomeDBi P46940.
TreeFami TF313078.

Enzyme and pathway databases

Reactomei REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_23832. Nephrin interactions.

Miscellaneous databases

ChiTaRSi IQGAP1. human.
EvolutionaryTracei P46940.
GeneWikii IQGAP1.
GenomeRNAii 8826.
NextBioi 33114.
PMAP-CutDB P46940.
PROi P46940.
SOURCEi Search...

Gene expression databases

ArrayExpressi P46940.
Bgeei P46940.
CleanExi HS_IQGAP1.
Genevestigatori P46940.

Family and domain databases

Gene3Di 1.10.418.10. 1 hit.
1.10.506.10. 2 hits.
4.10.270.10. 1 hit.
InterProi IPR001715. CH-domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR027417. P-loop_NTPase.
IPR001936. RasGAP.
IPR000593. RasGAP_C.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
IPR001202. WW_dom.
[Graphical view ]
Pfami PF00307. CH. 1 hit.
PF00612. IQ. 4 hits.
PF00616. RasGAP. 1 hit.
PF03836. RasGAP_C. 1 hit.
[Graphical view ]
SMARTi SM00033. CH. 1 hit.
SM00015. IQ. 4 hits.
SM00323. RasGAP. 1 hit.
SM00456. WW. 1 hit.
[Graphical view ]
SUPFAMi SSF47576. SSF47576. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEi PS50021. CH. 1 hit.
PS50096. IQ. 4 hits.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a human rasGAP-related protein containing calmodulin-binding motifs."
    Weissbach L., Settleman J., Kalady M.F., Snijders A.J., Murthy A.E., Yan Y.-X., Bernards A.
    J. Biol. Chem. 269:20517-20521(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver and Placenta.
  2. "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1."
    Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N., Kawarabayasi Y., Ishikawa K., Tabata S.
    DNA Res. 1:223-229(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Bienvenut W.V., Lilla S., Zebisch A., Kolch W.
    Submitted (MAR-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-25; 81-88; 112-143; 192-230; 466-477; 557-585; 923-935; 989-997; 1391-1397; 1466-1475 AND 1506-1516, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Colon carcinoma.
  6. "Phosphorylation of IQGAP1 modulates its binding to Cdc42, revealing a new type of rho-GTPase regulator."
    Grohmanova K., Schlaepfer D., Hess D., Gutierrez P., Beck M., Kroschewski R.
    J. Biol. Chem. 279:48495-48504(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1441-1455, PHOSPHORYLATION AT SER-1443, INTERACTION WITH CDC42 AND RAC1, DOMAIN, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
  7. "IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner."
    Li Z., McNulty D.E., Marler K.J.M., Lim L., Hall C., Annan R.S., Sacks D.B.
    J. Biol. Chem. 280:13871-13878(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1441-1455, PHOSPHORYLATION AT SER-1441 AND SER-1443, MUTAGENESIS OF SER-1441 AND SER-1443, FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY.
  8. "IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs."
    Hart M.J., Callow M.G., Souza B., Polakis P.
    EMBO J. 15:2997-3005(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis."
    Morita E., Sandrin V., Chung H.Y., Morham S.G., Gygi S.P., Rodesch C.K., Sundquist W.I.
    EMBO J. 26:4215-4227(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TSG101.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1443, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins."
    Kaur R., Yuan X., Lu M.L., Balk S.P.
    Prostate 68:1510-1516(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PAK6.
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; SER-330 AND SER-1443, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "Solution structure of the carboxyl-terminal RGC domain in human IQGAP1."
    RIKEN structural genomics initiative (RSGI)
    Submitted (SEP-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 1559-1657.

Entry informationi

Entry nameiIQGA1_HUMAN
AccessioniPrimary (citable) accession number: P46940
Secondary accession number(s): A7MBM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 154 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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