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Reviewed, UniProtKB/Swiss-Prot P46938 (YAP1_MOUSE)

Last modified June 16, 2009. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    65 kDa Yes-associated protein
Alternative name(s):
    YAP65
Gene names
Name: Yap1
Synonyms: Yap, Yap65
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Subunit structure

Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif. Ref.3 Ref.4

Post-translational modification

Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.5 Ref.6

Sequence similarities

Contains 2 WW domains.

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

Wwtr1Q9EPK51EBI-1211949,EBI-1211920

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 47247265 kDa Yes-associated protein
PRO_0000076072

Regions

Domain156 – 18934WW 1
Domain215 – 24834WW 2

Amino acid modifications

Modified residue461Phosphoserine By similarity
Modified residue941Phosphoserine
Modified residue951Phosphothreonine By similarity
Modified residue1121Phosphoserine Ref.5
Modified residue1131Phosphoserine Ref.5
Modified residue1161Phosphoserine By similarity
Modified residue1231Phosphoserine By similarity
Modified residue1281Phosphothreonine By similarity
Modified residue1341Phosphoserine By similarity
Modified residue2611Phosphoserine By similarity
Modified residue2741Phosphoserine By similarity
Modified residue3361Phosphoserine By similarity
Modified residue3401Phosphoserine Ref.6

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Sequences

Sequence LengthMass (Da)Tools
P46938-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 174FD33E0381126C

FASTA47250,703
        10         20         30         40         50         60 
MEPAQQPPPQ PAPQGPAPPS VSPAGTPAAP PAPPAGHQVV HVRGDSETDL EALFNAVMNP 

        70         80         90        100        110        120 
KTANVPQTVP MRLRKLPDSF FKPPEPKSHS RQASTDAGTA GALTPQHVRA HSSPASLQLG 

       130        140        150        160        170        180 
AVSPGTLTAS GVVSGPAAAP AAQHLRQSSF EIPDDVPLPA GWEMAKTSSG QRYFLNHNDQ 

       190        200        210        220        230        240 
TTTWQDPRKA MLSQLNVPAP ASPAVPQTLM NSASGPLPDG WEQAMTQDGE VYYINHKNKT 

       250        260        270        280        290        300 
TSWLDPRLDP RFAMNQRITQ SAPVKQPPPL APQSPQGGVL GGGSSNQQQQ IQLQQLQMEK 

       310        320        330        340        350        360 
ERLRLKQQEL FRQELALRSQ LPTLEQDGGT PNAVSSPGMS QELRTMTTNS SDPFLNSGTY 

       370        380        390        400        410        420 
HSRDESTDSG LSMSSYSIPR TPDDFLNSVD EMDTGDTISQ STLPSQQSRF PDYLEALPGT 

       430        440        450        460        470 
NVDLGTLEGD AMNIEGEELM PSLQEALSSE ILDVESVLAA TKLDKESFLT WL

« Hide

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References

« Hide 'large scale' references
[1]"Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain."
Sudol M., Bork P., Einbond A., Kastury K., Druck T., Negrini M., Huebner K., Lehman D.
J. Biol. Chem. 270:14733-14741(1995) [PubMed: 7782338] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: NIH Swiss.
Tissue: Embryo.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: 129 and C57BL/6.
Tissue: Brain and Mammary gland.
[3]"The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules."
Chen H.I., Sudol M.
Proc. Natl. Acad. Sci. U.S.A. 92:7819-7823(1995) [PubMed: 7644498] [Abstract]
Cited for: INTERACTION WITH WBP1 AND WBP2.
[4]"The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled."
Ermekova K.S., Zambrano N., Linn H., Minopoli G., Gertler F., Russo T., Sudol M.
J. Biol. Chem. 272:32869-32877(1997) [PubMed: 9407065] [Abstract]
Cited for: INTERACTION WITH ENAH.
[5]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed: 17242355] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-112 AND SER-113, MASS SPECTROMETRY.
Tissue: Liver.
[6]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-340, MASS SPECTROMETRY.
[7]"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
Mol. Cell. Proteomics 8:904-912(2009) [PubMed: 19131326] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

X80508 mRNA. Translation: CAA56673.1.
BC039125 mRNA. Translation: AAH39125.1.
BC094313 mRNA. Translation: AAH94313.1.
IPIIPI00621717.
PIRB56954.
RefSeqNP_033560.1.
UniGeneMm.221992

3D structure databases

HSSPHSSP built from PDB template 1K9R based on UniProtKB P46937.
SMRP46938. Positions 150-195.
ModBaseSearch...

Protein-protein interaction databases

IntActP46938. 1 interaction.

PTM databases

PhosphoSiteP46938.

Proteomic databases

PRIDEP46938.

Genome annotation databases

EnsemblENSMUSG00000053110. Mus musculus. [Contig view]
GeneID22601.
KEGGmmu:22601.

Organism-specific databases

MGIMGI:103262. Yap1.

Phylogenomic databases

HOVERGENP46938.

Gene expression databases

ArrayExpressP46938.
BgeeP46938.
CleanExMM_YAP1.
GermOnlineENSMUSG00000053110. Mus musculus.

Family and domain databases

InterProIPR001202. WW_Rsp5_WWP.
[Graphical view]
PfamPF00397. WW. 2 hits.
[Graphical view]
SMARTSM00456. WW. 2 hits.
[Graphical view]
PROSITEPS01159. WW_DOMAIN_1. 2 hits.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio302957.
SOURCESearch...

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Entry information

Entry nameYAP1_MOUSE
AccessionPrimary (citable) accession number: P46938
Secondary accession number(s): Q52KJ5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 16, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents