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Protein

Transcriptional coactivator YAP1

Gene

Yap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (By similarity).By similarity

GO - Molecular functioni

  • chromatin binding Source: MGI
  • proline-rich region binding Source: MGI
  • protein C-terminus binding Source: MGI
  • RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
  • RNA polymerase II transcription factor binding transcription factor activity Source: MGI
  • transcription coactivator activity Source: UniProtKB
  • transcription corepressor activity Source: MGI
  • transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  • bud elongation involved in lung branching Source: MGI
  • cell morphogenesis Source: MGI
  • cell proliferation Source: MGI
  • cellular response to DNA damage stimulus Source: MGI
  • cellular response to gamma radiation Source: UniProtKB
  • cellular response to retinoic acid Source: MGI
  • contact inhibition Source: MGI
  • DNA damage induced protein phosphorylation Source: UniProtKB
  • embryonic heart tube morphogenesis Source: MGI
  • hippo signaling Source: MGI
  • keratinocyte differentiation Source: MGI
  • lateral mesoderm development Source: MGI
  • lung epithelial cell differentiation Source: MGI
  • negative regulation of epithelial cell differentiation Source: MGI
  • negative regulation of extrinsic apoptotic signaling pathway Source: MGI
  • negative regulation of nucleic acid-templated transcription Source: MGI
  • negative regulation of stem cell differentiation Source: MGI
  • notochord development Source: MGI
  • paraxial mesoderm development Source: MGI
  • positive regulation of canonical Wnt signaling pathway Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of organ growth Source: MGI
  • positive regulation of stem cell maintenance Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of canonical Wnt signaling pathway Source: MGI
  • regulation of cell proliferation Source: MGI
  • regulation of keratinocyte proliferation Source: MGI
  • regulation of metanephric nephron tubule epithelial cell differentiation Source: MGI
  • regulation of neurogenesis Source: MGI
  • regulation of stem cell proliferation Source: MGI
  • somatic stem cell maintenance Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
  • vasculogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_287523. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
REACT_301726. Signaling by Hippo.
REACT_345486. Nuclear signaling by ERBB4.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional coactivator YAP1
Short name:
Yes-associated protein 1
Alternative name(s):
Protein yorkie homolog
Yes-associated protein YAP65 homolog
Gene namesi
Name:Yap1
Synonyms:Yap, Yap65
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:103262. Yap1.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Both phosphorylation and cell density can regulate its subcellular localization. Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus. At low density, predominantly nuclear and is translocated to the cytoplasm at high density (By similarity).By similarity

GO - Cellular componenti

  • cell junction Source: MGI
  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • membrane Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Transcriptional coactivator YAP1PRO_0000076072Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei46 – 461Phosphoserine; by LATS1 and LATS2By similarity
Modified residuei48 – 481PhosphothreonineBy similarity
Modified residuei94 – 941Phosphoserine; alternate1 Publication
Modified residuei94 – 941Phosphoserine; by LATS1 and LATS2; alternateBy similarity
Modified residuei95 – 951PhosphothreonineBy similarity
Modified residuei104 – 1041Phosphothreonine; by MAPK8 and MAPK9By similarity
Modified residuei112 – 1121Phosphoserine; by LATS1 and LATS2By similarity
Modified residuei113 – 1131PhosphoserineBy similarity
Modified residuei116 – 1161PhosphoserineBy similarity
Modified residuei123 – 1231Phosphoserine; by MAPK8 and MAPK9By similarity
Modified residuei149 – 1491Phosphoserine; by LATS1 and LATS2By similarity
Modified residuei274 – 2741PhosphoserineBy similarity
Modified residuei352 – 3521Phosphoserine; by MAPK8 and MAPK9By similarity
Modified residuei356 – 3561Phosphoserine1 Publication
Modified residuei382 – 3821Phosphoserine; by LATS1 and LATS2By similarity
Modified residuei385 – 3851Phosphoserine; by CK1By similarity
Modified residuei388 – 3881Phosphoserine; by CK1By similarity
Modified residuei392 – 3921Phosphotyrosine; by ABL1By similarity
Modified residuei397 – 3971Phosphothreonine; by MAPK8 and MAPK9By similarity

Post-translational modificationi

Phosphorylated by LATS1 and LATS2; leading to cytoplasmic translocation and inactivation. Phosphorylated by ABL1; leading to YAP1 stabilization, enhanced interaction with TP73 and recruitment onto proapoptotic genes; in response to DNA damage. Phosphorylation at Ser-385 and Ser-388 by CK1 is triggered by previous phosphorylation at Ser-382 by LATS proteins and leads to YAP1 ubiquitination by SCF(beta-TRCP) E3 ubiquitin ligase and subsequent degradation (By similarity). Phosphorylated at Thr-104, Ser-123, Ser-352 and Thr-397 by MAPK8/JNK1 and MAPK9/JNK2, which is required for the regukation of apoptosis by YAP1 (By similarity).By similarity
Ubiquitinated by SCF(beta-TRCP) E3 ubiquitin ligase.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP46938.
PaxDbiP46938.
PRIDEiP46938.

PTM databases

PhosphoSiteiP46938.

Expressioni

Tissue specificityi

Isoforms lacking the transactivation domain seen in striatal neurons (at protein level). Ubiquitous. Isoform 2 is expressed at higher levels in the neural tissues. In the embryo, it is expressed in brain, eye, and the maxillary and frontonasal components of the primary palate.3 Publications

Gene expression databases

BgeeiP46938.
CleanExiMM_YAP1.
ExpressionAtlasiP46938. baseline and differential.
GenevisibleiP46938. MM.

Interactioni

Subunit structurei

Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif. The phosphorylated form interacts with YWHAB. Interacts (via WW domains) with LATS1 (via PPxY motif 2). Interacts with LATS2. Interacts (via WW domain 1) with isoform JM-A of ERBB4 (via PPxY motif 2). Interacts with TEAD1, TEAD2 and TEAD3 (By similarity). Interacts with TP73 and HCK (By similarity). Interacts with RUNX1 (By similarity). Interacts with TEAD4. Interacts (via WW domains) with PTPN14 (via PPxY motif 2); this interaction leads to the cytoplasmic sequestration of YAP1 and inhibits its transcriptional co-activator activity (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Ddx17Q501J63EBI-1211949,EBI-911206
Tead1P300512EBI-1211949,EBI-3953905
Tp73Q9JJP22EBI-1211949,EBI-1770138

Protein-protein interaction databases

BioGridi204611. 28 interactions.
DIPiDIP-40015N.
IntActiP46938. 10 interactions.
MINTiMINT-85211.
STRINGi10090.ENSMUSP00000069554.

Structurei

Secondary structure

1
488
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi51 – 588Combined sources
Beta strandi61 – 633Combined sources
Helixi71 – 733Combined sources
Helixi79 – 813Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3JUAX-ray3.00B/D/F/H47-85[»]
ProteinModelPortaliP46938.
SMRiP46938. Positions 47-85, 150-250.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP46938.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini156 – 18934WW 1PROSITE-ProRule annotationAdd
BLAST
Domaini215 – 24834WW 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni276 – 488213Transactivation domainAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili71 – 8515By similarityAdd
BLAST
Coiled coili283 – 34462Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 3432Pro-richAdd
BLAST

Domaini

The first coiled-coil region mediates most of the interaction with TEAD transcription factors.By similarity

Sequence similaritiesi

Belongs to the YAP1 family.Curated
Contains 2 WW domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG5021.
GeneTreeiENSGT00510000046760.
HOGENOMiHOG000007854.
HOVERGENiHBG002748.
InParanoidiP46938.
KOiK16687.
OMAiAMNIEGE.
OrthoDBiEOG75MVW6.
PhylomeDBiP46938.
TreeFamiTF326941.

Family and domain databases

InterProiIPR001202. WW_dom.
[Graphical view]
PfamiPF00397. WW. 2 hits.
[Graphical view]
SMARTiSM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 2 hits.
PROSITEiPS01159. WW_DOMAIN_1. 2 hits.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms lacking the transactivation domain exist.

Isoform 1 (identifier: P46938-1) [UniParc]FASTAAdd to basket

Also known as: YAP2L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPAQQPPPQ PAPQGPAPPS VSPAGTPAAP PAPPAGHQVV HVRGDSETDL
60 70 80 90 100
EALFNAVMNP KTANVPQTVP MRLRKLPDSF FKPPEPKSHS RQASTDAGTA
110 120 130 140 150
GALTPQHVRA HSSPASLQLG AVSPGTLTAS GVVSGPAAAP AAQHLRQSSF
160 170 180 190 200
EIPDDVPLPA GWEMAKTSSG QRYFLNHNDQ TTTWQDPRKA MLSQLNVPAP
210 220 230 240 250
ASPAVPQTLM NSASGPLPDG WEQAMTQDGE VYYINHKNKT TSWLDPRLDP
260 270 280 290 300
RFAMNQRITQ SAPVKQPPPL APQSPQGGVL GGGSSNQQQQ IQLQQLQMEK
310 320 330 340 350
ERLRLKQQEL FRQAIRNINP STANAPKCQE LALRSQLPTL EQDGGTPNAV
360 370 380 390 400
SSPGMSQELR TMTTNSSDPF LNSGTYHSRD ESTDSGLSMS SYSIPRTPDD
410 420 430 440 450
FLNSVDEMDT GDTISQSTLP SQQSRFPDYL EALPGTNVDL GTLEGDAMNI
460 470 480
EGEELMPSLQ EALSSEILDV ESVLAATKLD KESFLTWL
Length:488
Mass (Da):52,383
Last modified:April 20, 2010 - v2
Checksum:i5A2221B74B1400F9
GO
Isoform 2 (identifier: P46938-2) [UniParc]FASTAAdd to basket

Also known as: YAP2

The sequence of this isoform differs from the canonical sequence as follows:
     313-328: Missing.

Show »
Length:472
Mass (Da):50,703
Checksum:i174FD33E0381126C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei313 – 32816Missing in isoform 2. 3 PublicationsVSP_039056Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80508 mRNA. Translation: CAA56673.1.
CH466522 Genomic DNA. Translation: EDL24950.1.
BC014733 mRNA. Translation: AAH14733.1.
BC039125 mRNA. Translation: AAH39125.1.
BC094313 mRNA. Translation: AAH94313.1.
CCDSiCCDS40533.1. [P46938-2]
CCDS52718.1. [P46938-1]
PIRiB56954.
RefSeqiNP_001164618.1. NM_001171147.1. [P46938-1]
NP_033560.1. NM_009534.3. [P46938-2]
UniGeneiMm.221992.
Mm.486262.

Genome annotation databases

EnsembliENSMUST00000065353; ENSMUSP00000069554; ENSMUSG00000053110. [P46938-1]
ENSMUST00000086580; ENSMUSP00000083772; ENSMUSG00000053110. [P46938-2]
GeneIDi22601.
KEGGimmu:22601.
UCSCiuc009ode.2. mouse. [P46938-2]
uc009odf.2. mouse. [P46938-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80508 mRNA. Translation: CAA56673.1.
CH466522 Genomic DNA. Translation: EDL24950.1.
BC014733 mRNA. Translation: AAH14733.1.
BC039125 mRNA. Translation: AAH39125.1.
BC094313 mRNA. Translation: AAH94313.1.
CCDSiCCDS40533.1. [P46938-2]
CCDS52718.1. [P46938-1]
PIRiB56954.
RefSeqiNP_001164618.1. NM_001171147.1. [P46938-1]
NP_033560.1. NM_009534.3. [P46938-2]
UniGeneiMm.221992.
Mm.486262.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3JUAX-ray3.00B/D/F/H47-85[»]
ProteinModelPortaliP46938.
SMRiP46938. Positions 47-85, 150-250.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204611. 28 interactions.
DIPiDIP-40015N.
IntActiP46938. 10 interactions.
MINTiMINT-85211.
STRINGi10090.ENSMUSP00000069554.

PTM databases

PhosphoSiteiP46938.

Proteomic databases

MaxQBiP46938.
PaxDbiP46938.
PRIDEiP46938.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065353; ENSMUSP00000069554; ENSMUSG00000053110. [P46938-1]
ENSMUST00000086580; ENSMUSP00000083772; ENSMUSG00000053110. [P46938-2]
GeneIDi22601.
KEGGimmu:22601.
UCSCiuc009ode.2. mouse. [P46938-2]
uc009odf.2. mouse. [P46938-1]

Organism-specific databases

CTDi10413.
MGIiMGI:103262. Yap1.

Phylogenomic databases

eggNOGiCOG5021.
GeneTreeiENSGT00510000046760.
HOGENOMiHOG000007854.
HOVERGENiHBG002748.
InParanoidiP46938.
KOiK16687.
OMAiAMNIEGE.
OrthoDBiEOG75MVW6.
PhylomeDBiP46938.
TreeFamiTF326941.

Enzyme and pathway databases

ReactomeiREACT_287523. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
REACT_301726. Signaling by Hippo.
REACT_345486. Nuclear signaling by ERBB4.

Miscellaneous databases

ChiTaRSiYap1. mouse.
EvolutionaryTraceiP46938.
NextBioi302957.
PROiP46938.
SOURCEiSearch...

Gene expression databases

BgeeiP46938.
CleanExiMM_YAP1.
ExpressionAtlasiP46938. baseline and differential.
GenevisibleiP46938. MM.

Family and domain databases

InterProiIPR001202. WW_dom.
[Graphical view]
PfamiPF00397. WW. 2 hits.
[Graphical view]
SMARTiSM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 2 hits.
PROSITEiPS01159. WW_DOMAIN_1. 2 hits.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain."
    Sudol M., Bork P., Einbond A., Kastury K., Druck T., Negrini M., Huebner K., Lehman D.
    J. Biol. Chem. 270:14733-14741(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: NIH Swiss.
    Tissue: Embryo.
  2. "WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus."
    Komuro A., Nagai M., Navin N.E., Sudol M.
    J. Biol. Chem. 278:33334-33341(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: 129, C57BL/6 and FVB/N.
    Tissue: Brain, Kidney and Mammary gland.
  5. "The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules."
    Chen H.I., Sudol M.
    Proc. Natl. Acad. Sci. U.S.A. 92:7819-7823(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH WBP1 AND WBP2.
  6. "The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled."
    Ermekova K.S., Zambrano N., Linn H., Minopoli G., Gertler F., Russo T., Sudol M.
    J. Biol. Chem. 272:32869-32877(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ENAH.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  8. "Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73."
    Hoshino M., Qi M.-L., Yoshimura N., Tagawa K., Wada Y.-I., Enokido Y., Marubuchi S., Harjes P., Arai N., Oyanagi K., Blandino G., Sudol M., Rich T., Kanazawa I., Wanker E.E., Saitoe M., Okazawa H.
    J. Cell Biol. 172:589-604(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF ISOFORMS LACKING THE TRANSCRIPTIONAL ACTIVATION DOMAIN, TISSUE SPECIFICITY.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  11. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  12. "Structural basis of YAP recognition by TEAD4 in the hippo pathway."
    Chen L., Chan S.W., Zhang X., Walsh M., Lim C.J., Hong W., Song H.
    Genes Dev. 24:290-300(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TEAD4, X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 47-85 IN COMPLEX WITH TEAD4.
  13. "Heterozygous loss-of-function mutations in YAP1 cause both isolated and syndromic optic fissure closure defects."
    UK10K Consortium
    Williamson K.A., Rainger J., Floyd J.A., Ansari M., Meynert A., Aldridge K.V., Rainger J.K., Anderson C.A., Moore A.T., Hurles M.E., Clarke A., van Heyningen V., Verloes A., Taylor M.S., Wilkie A.O., Fitzpatrick D.R., Hurles M., FitzPatrick D.R.
    , Al-Turki S., Anderson C., Barroso I., Beales P., Bentham J., Bhattacharya S., Carss K., Chatterjee K., Cirak S., Cosgrove C., Daly A., Floyd J., Franklin C., Futema M., Humphries S., McCarthy S., Mitchison H., Muntoni F., Onoufriadis A., Parker V., Payne F., Plagnol V., Raymond L., Savage D., Scambler P., Schmidts M., Semple R., Serra E., Stalker J., van Kogelenberg M., Vijayarangakannan P., Walter K., Wood G.
    Am. J. Hum. Genet. 94:295-302(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiYAP1_MOUSE
AccessioniPrimary (citable) accession number: P46938
Secondary accession number(s): Q52KJ5, Q91WL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 20, 2010
Last modified: July 22, 2015
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.