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P46938

- YAP1_MOUSE

UniProt

P46938 - YAP1_MOUSE

Protein

Yorkie homolog

Gene

Yap1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction By similarity.By similarity

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. proline-rich region binding Source: MGI
    3. protein binding Source: UniProtKB
    4. RNA polymerase II transcription factor binding transcription factor activity Source: MGI
    5. transcription coactivator activity Source: UniProtKB
    6. transcription corepressor activity Source: Ensembl
    7. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. cell proliferation Source: Ensembl
    2. cellular response to gamma radiation Source: UniProtKB
    3. contact inhibition Source: Ensembl
    4. DNA damage induced protein phosphorylation Source: UniProtKB
    5. embryonic heart tube morphogenesis Source: MGI
    6. hippo signaling Source: MGI
    7. keratinocyte differentiation Source: MGI
    8. lateral mesoderm development Source: MGI
    9. negative regulation of epithelial cell differentiation Source: MGI
    10. negative regulation of extrinsic apoptotic signaling pathway Source: MGI
    11. notochord development Source: MGI
    12. paraxial mesoderm development Source: MGI
    13. positive regulation of canonical Wnt signaling pathway Source: MGI
    14. positive regulation of cell proliferation Source: MGI
    15. positive regulation of organ growth Source: MGI
    16. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    17. regulation of canonical Wnt signaling pathway Source: MGI
    18. regulation of cell proliferation Source: MGI
    19. regulation of keratinocyte proliferation Source: MGI
    20. regulation of metanephric nephron tubule epithelial cell differentiation Source: MGI
    21. regulation of stem cell proliferation Source: MGI
    22. somatic stem cell maintenance Source: MGI
    23. transcription from RNA polymerase II promoter Source: GOC
    24. vasculogenesis Source: MGI

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_196516. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
    REACT_196537. Signaling by Hippo.
    REACT_198574. Nuclear signaling by ERBB4.
    REACT_198602. PPARA activates gene expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Yorkie homolog
    Alternative name(s):
    65 kDa Yes-associated protein
    Short name:
    YAP65
    Gene namesi
    Name:Yap1
    Synonyms:Yap, Yap65
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:103262. Yap1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Both phosphorylation and cell density can regulate its subcellular localization. Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus. At low density, predominantly nuclear and is translocated to the cytoplasm at high density By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytosol Source: MGI
    3. membrane Source: MGI
    4. nucleus Source: MGI
    5. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 488488Yorkie homologPRO_0000076072Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei46 – 461Phosphoserine; by LATS1 and LATS2By similarity
    Modified residuei48 – 481PhosphothreonineBy similarity
    Modified residuei94 – 941Phosphoserine; alternate1 Publication
    Modified residuei94 – 941Phosphoserine; by LATS1 and LATS2; alternateBy similarity
    Modified residuei95 – 951PhosphothreonineBy similarity
    Modified residuei104 – 1041Phosphothreonine; by MAPK8 and MAPK9By similarity
    Modified residuei112 – 1121Phosphoserine; by LATS1 and LATS2By similarity
    Modified residuei116 – 1161PhosphoserineBy similarity
    Modified residuei123 – 1231Phosphoserine; by MAPK8 and MAPK9By similarity
    Modified residuei149 – 1491Phosphoserine; by LATS1 and LATS2By similarity
    Modified residuei274 – 2741PhosphoserineBy similarity
    Modified residuei352 – 3521Phosphoserine; by MAPK8 and MAPK9By similarity
    Modified residuei356 – 3561Phosphoserine1 Publication
    Modified residuei382 – 3821Phosphoserine; by LATS1 and LATS2By similarity
    Modified residuei385 – 3851Phosphoserine; by CK1By similarity
    Modified residuei388 – 3881Phosphoserine; by CK1By similarity
    Modified residuei392 – 3921Phosphotyrosine; by ABL1By similarity
    Modified residuei397 – 3971Phosphothreonine; by MAPK8 and MAPK9By similarity

    Post-translational modificationi

    Phosphorylated by LATS1 and LATS2; leading to cytoplasmic translocation and inactivation. Phosphorylated by ABL1; leading to YAP1 stabilization, enhanced interaction with TP73 and recruitment onto proapoptotic genes; in response to DNA damage. Phosphorylation at Ser-385 and Ser-388 by CK1 is triggered by previous phosphorylation at Ser-382 by LATS proteins and leads to YAP1 ubiquitination by SCF(beta-TRCP) E3 ubiquitin ligase and subsequent degradation By similarity. Phosphorylated at Thr-104, Ser-123, Ser-352 and Thr-397 by MAPK8/JNK1 and MAPK9/JNK2, which is required for the regukation of apoptosis by YAP1 By similarity.By similarity
    Ubiquitinated by SCF(beta-TRCP) E3 ubiquitin ligase.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiP46938.
    PaxDbiP46938.
    PRIDEiP46938.

    PTM databases

    PhosphoSiteiP46938.

    Expressioni

    Tissue specificityi

    Isoforms lacking the transactivation domain seen in striatal neurons (at protein level). Ubiquitous. Isoform 2 is expressed at higher levels in the neural tissues. In the embryo, it is expressed in brain, eye, and the maxillary and frontonasal components of the primary palate.3 Publications

    Gene expression databases

    ArrayExpressiP46938.
    BgeeiP46938.
    CleanExiMM_YAP1.
    GenevestigatoriP46938.

    Interactioni

    Subunit structurei

    Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif. The phosphorylated form interacts with YWHAB. Interacts (via WW domains) with LATS1 (via PPxY motif 2). Interacts with LATS2. Interacts (via WW domain 1) with isoform JM-A of ERBB4 (via PPxY motif 2). Interacts with TEAD1, TEAD2 and TEAD3 By similarity. Interacts with TP73 and HCK By similarity. Interacts with RUNX1 By similarity. Interacts with TEAD4. Interacts (via WW domains) with PTPN14 (via PPxY motif 2); this interaction leads to the cytoplasmic sequestration of YAP1 and inhibits its transcriptional co-activator activity By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Ddx17Q501J63EBI-1211949,EBI-911206
    Tp73Q9JJP22EBI-1211949,EBI-1770138

    Protein-protein interaction databases

    BioGridi204611. 28 interactions.
    DIPiDIP-40015N.
    IntActiP46938. 9 interactions.
    MINTiMINT-85211.

    Structurei

    Secondary structure

    1
    488
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi51 – 588
    Beta strandi61 – 633
    Helixi71 – 733
    Helixi79 – 813

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3JUAX-ray3.00B/D/F/H47-85[»]
    ProteinModelPortaliP46938.
    SMRiP46938. Positions 47-85, 150-250.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP46938.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini156 – 18934WW 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini215 – 24834WW 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni276 – 488213Transactivation domainAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili71 – 8515By similarityAdd
    BLAST
    Coiled coili283 – 34462Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi3 – 3432Pro-richAdd
    BLAST

    Domaini

    The first coiled-coil region mediates most of the interaction with TEAD transcription factors.By similarity

    Sequence similaritiesi

    Belongs to the YORKIE family.Curated
    Contains 2 WW domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiCOG5021.
    GeneTreeiENSGT00510000046760.
    HOGENOMiHOG000007854.
    HOVERGENiHBG002748.
    InParanoidiQ91WL1.
    KOiK16687.
    OMAiLRQSSYE.
    OrthoDBiEOG75MVW6.
    PhylomeDBiP46938.
    TreeFamiTF326941.

    Family and domain databases

    InterProiIPR001202. WW_dom.
    [Graphical view]
    PfamiPF00397. WW. 2 hits.
    [Graphical view]
    SMARTiSM00456. WW. 2 hits.
    [Graphical view]
    SUPFAMiSSF51045. SSF51045. 2 hits.
    PROSITEiPS01159. WW_DOMAIN_1. 2 hits.
    PS50020. WW_DOMAIN_2. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms lacking the transactivation domain exist.

    Isoform 1 (identifier: P46938-1) [UniParc]FASTAAdd to Basket

    Also known as: YAP2L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEPAQQPPPQ PAPQGPAPPS VSPAGTPAAP PAPPAGHQVV HVRGDSETDL    50
    EALFNAVMNP KTANVPQTVP MRLRKLPDSF FKPPEPKSHS RQASTDAGTA 100
    GALTPQHVRA HSSPASLQLG AVSPGTLTAS GVVSGPAAAP AAQHLRQSSF 150
    EIPDDVPLPA GWEMAKTSSG QRYFLNHNDQ TTTWQDPRKA MLSQLNVPAP 200
    ASPAVPQTLM NSASGPLPDG WEQAMTQDGE VYYINHKNKT TSWLDPRLDP 250
    RFAMNQRITQ SAPVKQPPPL APQSPQGGVL GGGSSNQQQQ IQLQQLQMEK 300
    ERLRLKQQEL FRQAIRNINP STANAPKCQE LALRSQLPTL EQDGGTPNAV 350
    SSPGMSQELR TMTTNSSDPF LNSGTYHSRD ESTDSGLSMS SYSIPRTPDD 400
    FLNSVDEMDT GDTISQSTLP SQQSRFPDYL EALPGTNVDL GTLEGDAMNI 450
    EGEELMPSLQ EALSSEILDV ESVLAATKLD KESFLTWL 488
    Length:488
    Mass (Da):52,383
    Last modified:April 20, 2010 - v2
    Checksum:i5A2221B74B1400F9
    GO
    Isoform 2 (identifier: P46938-2) [UniParc]FASTAAdd to Basket

    Also known as: YAP2

    The sequence of this isoform differs from the canonical sequence as follows:
         313-328: Missing.

    Show »
    Length:472
    Mass (Da):50,703
    Checksum:i174FD33E0381126C
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei313 – 32816Missing in isoform 2. 3 PublicationsVSP_039056Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80508 mRNA. Translation: CAA56673.1.
    CH466522 Genomic DNA. Translation: EDL24950.1.
    BC014733 mRNA. Translation: AAH14733.1.
    BC039125 mRNA. Translation: AAH39125.1.
    BC094313 mRNA. Translation: AAH94313.1.
    CCDSiCCDS40533.1. [P46938-2]
    CCDS52718.1. [P46938-1]
    PIRiB56954.
    RefSeqiNP_001164618.1. NM_001171147.1. [P46938-1]
    NP_033560.1. NM_009534.3. [P46938-2]
    UniGeneiMm.221992.
    Mm.486262.

    Genome annotation databases

    EnsembliENSMUST00000065353; ENSMUSP00000069554; ENSMUSG00000053110. [P46938-1]
    ENSMUST00000086580; ENSMUSP00000083772; ENSMUSG00000053110. [P46938-2]
    GeneIDi22601.
    KEGGimmu:22601.
    UCSCiuc009ode.2. mouse. [P46938-2]
    uc009odf.2. mouse. [P46938-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80508 mRNA. Translation: CAA56673.1 .
    CH466522 Genomic DNA. Translation: EDL24950.1 .
    BC014733 mRNA. Translation: AAH14733.1 .
    BC039125 mRNA. Translation: AAH39125.1 .
    BC094313 mRNA. Translation: AAH94313.1 .
    CCDSi CCDS40533.1. [P46938-2 ]
    CCDS52718.1. [P46938-1 ]
    PIRi B56954.
    RefSeqi NP_001164618.1. NM_001171147.1. [P46938-1 ]
    NP_033560.1. NM_009534.3. [P46938-2 ]
    UniGenei Mm.221992.
    Mm.486262.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3JUA X-ray 3.00 B/D/F/H 47-85 [» ]
    ProteinModelPortali P46938.
    SMRi P46938. Positions 47-85, 150-250.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204611. 28 interactions.
    DIPi DIP-40015N.
    IntActi P46938. 9 interactions.
    MINTi MINT-85211.

    PTM databases

    PhosphoSitei P46938.

    Proteomic databases

    MaxQBi P46938.
    PaxDbi P46938.
    PRIDEi P46938.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000065353 ; ENSMUSP00000069554 ; ENSMUSG00000053110 . [P46938-1 ]
    ENSMUST00000086580 ; ENSMUSP00000083772 ; ENSMUSG00000053110 . [P46938-2 ]
    GeneIDi 22601.
    KEGGi mmu:22601.
    UCSCi uc009ode.2. mouse. [P46938-2 ]
    uc009odf.2. mouse. [P46938-1 ]

    Organism-specific databases

    CTDi 10413.
    MGIi MGI:103262. Yap1.

    Phylogenomic databases

    eggNOGi COG5021.
    GeneTreei ENSGT00510000046760.
    HOGENOMi HOG000007854.
    HOVERGENi HBG002748.
    InParanoidi Q91WL1.
    KOi K16687.
    OMAi LRQSSYE.
    OrthoDBi EOG75MVW6.
    PhylomeDBi P46938.
    TreeFami TF326941.

    Enzyme and pathway databases

    Reactomei REACT_196516. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
    REACT_196537. Signaling by Hippo.
    REACT_198574. Nuclear signaling by ERBB4.
    REACT_198602. PPARA activates gene expression.

    Miscellaneous databases

    EvolutionaryTracei P46938.
    NextBioi 302957.
    PROi P46938.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P46938.
    Bgeei P46938.
    CleanExi MM_YAP1.
    Genevestigatori P46938.

    Family and domain databases

    InterProi IPR001202. WW_dom.
    [Graphical view ]
    Pfami PF00397. WW. 2 hits.
    [Graphical view ]
    SMARTi SM00456. WW. 2 hits.
    [Graphical view ]
    SUPFAMi SSF51045. SSF51045. 2 hits.
    PROSITEi PS01159. WW_DOMAIN_1. 2 hits.
    PS50020. WW_DOMAIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain."
      Sudol M., Bork P., Einbond A., Kastury K., Druck T., Negrini M., Huebner K., Lehman D.
      J. Biol. Chem. 270:14733-14741(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: NIH Swiss.
      Tissue: Embryo.
    2. "WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus."
      Komuro A., Nagai M., Navin N.E., Sudol M.
      J. Biol. Chem. 278:33334-33341(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: 129, C57BL/6 and FVB/N.
      Tissue: Brain, Kidney and Mammary gland.
    5. "The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules."
      Chen H.I., Sudol M.
      Proc. Natl. Acad. Sci. U.S.A. 92:7819-7823(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH WBP1 AND WBP2.
    6. "The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled."
      Ermekova K.S., Zambrano N., Linn H., Minopoli G., Gertler F., Russo T., Sudol M.
      J. Biol. Chem. 272:32869-32877(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ENAH.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.
    8. "Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73."
      Hoshino M., Qi M.-L., Yoshimura N., Tagawa K., Wada Y.-I., Enokido Y., Marubuchi S., Harjes P., Arai N., Oyanagi K., Blandino G., Sudol M., Rich T., Kanazawa I., Wanker E.E., Saitoe M., Okazawa H.
      J. Cell Biol. 172:589-604(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF ISOFORMS LACKING THE TRANSCRIPTIONAL ACTIVATION DOMAIN, TISSUE SPECIFICITY.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.
    11. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.
    12. "Structural basis of YAP recognition by TEAD4 in the hippo pathway."
      Chen L., Chan S.W., Zhang X., Walsh M., Lim C.J., Hong W., Song H.
      Genes Dev. 24:290-300(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TEAD4, X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 47-85 IN COMPLEX WITH TEAD4.
    13. "Heterozygous loss-of-function mutations in YAP1 cause both isolated and syndromic optic fissure closure defects."
      UK10K Consortium
      Williamson K.A., Rainger J., Floyd J.A., Ansari M., Meynert A., Aldridge K.V., Rainger J.K., Anderson C.A., Moore A.T., Hurles M.E., Clarke A., van Heyningen V., Verloes A., Taylor M.S., Wilkie A.O., Fitzpatrick D.R., Hurles M., FitzPatrick D.R.
      , Al-Turki S., Anderson C., Barroso I., Beales P., Bentham J., Bhattacharya S., Carss K., Chatterjee K., Cirak S., Cosgrove C., Daly A., Floyd J., Franklin C., Futema M., Humphries S., McCarthy S., Mitchison H., Muntoni F., Onoufriadis A., Parker V., Payne F., Plagnol V., Raymond L., Savage D., Scambler P., Schmidts M., Semple R., Serra E., Stalker J., van Kogelenberg M., Vijayarangakannan P., Walter K., Wood G.
      Am. J. Hum. Genet. 94:295-302(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiYAP1_MOUSE
    AccessioniPrimary (citable) accession number: P46938
    Secondary accession number(s): Q52KJ5, Q91WL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3