##gff-version 3 P46937 UniProtKB Chain 1 504 . . . ID=PRO_0000076071;Note=Transcriptional coactivator YAP1 P46937 UniProtKB Domain 171 204 . . . Note=WW 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00224 P46937 UniProtKB Domain 230 263 . . . Note=WW 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00224 P46937 UniProtKB Region 1 59 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P46937 UniProtKB Region 91 114 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P46937 UniProtKB Region 133 158 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P46937 UniProtKB Region 275 309 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P46937 UniProtKB Region 291 504 . . . Note=Transactivation domain P46937 UniProtKB Region 355 407 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P46937 UniProtKB Coiled coil 86 100 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20123905;Dbxref=PMID:20123905 P46937 UniProtKB Coiled coil 298 359 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 P46937 UniProtKB Compositional bias 1 36 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P46937 UniProtKB Compositional bias 292 309 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P46937 UniProtKB Modified residue 61 61 . . . Note=Phosphoserine%3B by LATS1 and LATS2;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:17974916,ECO:0000269|PubMed:18158288,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:17974916,PMID:18158288,PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163 P46937 UniProtKB Modified residue 63 63 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:20068231;Dbxref=PMID:20068231 P46937 UniProtKB Modified residue 105 105 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q2EJA0 P46937 UniProtKB Modified residue 109 109 . . . Note=Phosphoserine%3B by LATS1 and LATS2;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:17974916,ECO:0000269|PubMed:18158288,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:17974916,PMID:18158288,PMID:20068231,PMID:23186163 P46937 UniProtKB Modified residue 110 110 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q2EJA0 P46937 UniProtKB Modified residue 119 119 . . . Note=Phosphothreonine%3B by MAPK8 and MAPK9;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:21364637,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:21364637,PMID:23186163 P46937 UniProtKB Modified residue 127 127 . . . Note=Phosphoserine%3B by LATS1 and LATS2;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:17974916,ECO:0000269|PubMed:18158288,ECO:0000269|PubMed:20048001,ECO:0000269|PubMed:28169360,ECO:0007744|PubMed:18669648;Dbxref=PMID:17974916,PMID:18158288,PMID:18669648,PMID:20048001,PMID:28169360 P46937 UniProtKB Modified residue 128 128 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 P46937 UniProtKB Modified residue 131 131 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:24275569 P46937 UniProtKB Modified residue 138 138 . . . Note=Phosphoserine%3B by MAPK8 and MAPK9;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:21364637,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231,PMID:21364637 P46937 UniProtKB Modified residue 154 154 . . . Note=Phosphothreonine%3B by MAPK8 and MAPK9;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:21364637,ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648,PMID:21364637 P46937 UniProtKB Modified residue 164 164 . . . Note=Phosphoserine%3B by LATS1 and LATS2;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17974916,ECO:0000269|PubMed:18158288;Dbxref=PMID:17974916,PMID:18158288 P46937 UniProtKB Modified residue 274 274 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 P46937 UniProtKB Modified residue 289 289 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163 P46937 UniProtKB Modified residue 367 367 . . . Note=Phosphoserine%3B by MAPK8 and MAPK9;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:21364637,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:20068231,PMID:21364637,PMID:21406692 P46937 UniProtKB Modified residue 371 371 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:17525332;Dbxref=PMID:17525332 P46937 UniProtKB Modified residue 381 381 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P46937 UniProtKB Modified residue 382 382 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P46937 UniProtKB Modified residue 388 388 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P46937 UniProtKB Modified residue 397 397 . . . Note=Phosphoserine%3B by LATS1 and LATS2;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17974916,ECO:0000269|PubMed:18158288,ECO:0000269|PubMed:20048001,ECO:0000269|PubMed:28169360;Dbxref=PMID:17974916,PMID:18158288,PMID:20048001,PMID:28169360 P46937 UniProtKB Modified residue 400 400 . . . Note=Phosphoserine%3B by CK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20048001;Dbxref=PMID:20048001 P46937 UniProtKB Modified residue 403 403 . . . Note=Phosphoserine%3B by CK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20048001;Dbxref=PMID:20048001 P46937 UniProtKB Modified residue 407 407 . . . Note=Phosphotyrosine%3B by ABL1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18280240;Dbxref=PMID:18280240 P46937 UniProtKB Modified residue 412 412 . . . Note=Phosphothreonine%3B by MAPK8 and MAPK9;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21364637;Dbxref=PMID:21364637 P46937 UniProtKB Alternative sequence 1 178 . . . ID=VSP_045190;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 P46937 UniProtKB Alternative sequence 230 267 . . . ID=VSP_039053;Note=In isoform 3%2C isoform 5%2C isoform 6 and isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:22939869,ECO:0000303|Ref.3;Dbxref=PMID:22939869 P46937 UniProtKB Alternative sequence 328 343 . . . ID=VSP_039054;Note=In isoform 2 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12807903;Dbxref=PMID:12807903 P46937 UniProtKB Alternative sequence 328 328 . . . ID=VSP_053483;Note=In isoform 7 and isoform 9. Q->QVRPQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:22939869;Dbxref=PMID:22939869 P46937 UniProtKB Alternative sequence 329 343 . . . ID=VSP_039055;Note=In isoform 3 and isoform 8. AMRNINPSTANSPKC->VRP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:22939869;Dbxref=PMID:22939869 P46937 UniProtKB Natural variant 139 139 . . . ID=VAR_071125;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24462371;Dbxref=dbSNP:rs1162286204,PMID:24462371 P46937 UniProtKB Natural variant 227 227 . . . ID=VAR_071126;Note=S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24462371;Dbxref=dbSNP:rs376161041,PMID:24462371 P46937 UniProtKB Natural variant 330 330 . . . ID=VAR_071127;Note=M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24462371;Dbxref=dbSNP:rs777949318,PMID:24462371 P46937 UniProtKB Natural variant 462 462 . . . ID=VAR_071128;Note=G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24462371;Dbxref=PMID:24462371 P46937 UniProtKB Mutagenesis 61 61 . . . Note=In YAP-4SA%3B prevents phosphorylation by LATS1 and LATS2%2C promoting retention in the nucleus%3B when associated with A-109%3B A-127 and A-164. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20048001;Dbxref=PMID:20048001 P46937 UniProtKB Mutagenesis 80 80 . . . Note=No change in interaction with TEAD4. Reduced interaction with TEAD4 and transforming ability%3B when associated with A-84 and A-85. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20123908;Dbxref=PMID:20123908 P46937 UniProtKB Mutagenesis 84 84 . . . Note=Reduced interaction with TEAD4 and transforming ability%3B when associated with A-80 and A-85. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20123908;Dbxref=PMID:20123908 P46937 UniProtKB Mutagenesis 85 85 . . . Note=Reduced interaction with TEAD4 and transforming ability%3B when associated with A-80 and A-84. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20123908;Dbxref=PMID:20123908 P46937 UniProtKB Mutagenesis 86 86 . . . Note=Complete loss of interaction with TEAD1. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20123905;Dbxref=PMID:20123905 P46937 UniProtKB Mutagenesis 89 89 . . . Note=Complete loss of interaction with TEAD1. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20123905;Dbxref=PMID:20123905 P46937 UniProtKB Mutagenesis 91 91 . . . Note=Complete loss of interaction with TEAD1. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20123905;Dbxref=PMID:20123905 P46937 UniProtKB Mutagenesis 94 94 . . . Note=Loss of interaction with TEAD1%2C TEAD2%2C TEAD3 and TEAD4. Loss of transcriptional coactivation activity towards TEAD1%2C TEAD2%2C TEAD3 and TEAD4 but no effect on its activity towards RUNX2 and ERBB4. Abolishes suppression of ciliogenesis. S->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18579750,ECO:0000269|PubMed:20123905;Dbxref=PMID:18579750,PMID:20123905 P46937 UniProtKB Mutagenesis 95 95 . . . Note=Complete loss of interaction with TEAD1. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20123905;Dbxref=PMID:20123905 P46937 UniProtKB Mutagenesis 96 96 . . . Note=Loss of interaction with TEAD1. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20123905;Dbxref=PMID:20123905 P46937 UniProtKB Mutagenesis 109 109 . . . Note=In YAP-4SA%3B prevents phosphorylation by LATS1 and LATS2%2C promoting retention in the nucleus%3B when associated with A-61%3B A-127 and A-164. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20048001;Dbxref=PMID:20048001 P46937 UniProtKB Mutagenesis 122 122 . . . Note=Loss of phosphorylation by LATS1. H->A%2CR%2CN%2CK;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17974916,ECO:0000269|PubMed:18158288;Dbxref=PMID:17974916,PMID:18158288 P46937 UniProtKB Mutagenesis 122 122 . . . Note=Significantly decreased phosphorylation at S-127 and decreased interaction with YWHAB. H->L%2CY;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17974916,ECO:0000269|PubMed:18158288;Dbxref=PMID:17974916,PMID:18158288 P46937 UniProtKB Mutagenesis 124 124 . . . Note=Loss of phosphorylation by LATS1. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18158288;Dbxref=PMID:18158288 P46937 UniProtKB Mutagenesis 127 127 . . . Note=Reduced phosphorylation by LATS2%2C loss of phosphorylation by LATS1%2C loss of interaction with YWHAB%2C decreased interaction with ERBB4 and increased nuclear localization and transcriptional coactivation activity toward ERBB4. In YAP-4SA%3B prevents phosphorylation by LATS1 and LATS2%2C promoting retention in the nucleus%3B when associated with A-61%3B A-109%3B A-127 and A-164. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12807903,ECO:0000269|PubMed:17974916,ECO:0000269|PubMed:18158288,ECO:0000269|PubMed:20048001;Dbxref=PMID:12807903,PMID:17974916,PMID:18158288,PMID:20048001 P46937 UniProtKB Mutagenesis 129 129 . . . Note=No effect on phosphorylation but loss of interaction with YWHAB. P->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17974916;Dbxref=PMID:17974916 P46937 UniProtKB Mutagenesis 164 164 . . . Note=In YAP-4SA%3B prevents phosphorylation by LATS1 and LATS2%2C promoting retention in the nucleus%3B when associated with A-61%3B A-109 and A-127. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20048001;Dbxref=PMID:20048001 P46937 UniProtKB Mutagenesis 199 199 . . . Note=Loss of interaction with ERBB4%2C loss of transcriptional coactivation function toward CTF and reduced interaction with PRRG4%3B when associated with A-202. W->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12807903,ECO:0000269|PubMed:23873930;Dbxref=PMID:12807903,PMID:23873930 P46937 UniProtKB Mutagenesis 202 202 . . . Note=Loss of interaction with ERBB4%2C loss of transcriptional coactivation function toward CTF and reduced interaction with PRRG4%3B when associated with A-199. P->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12807903,ECO:0000269|PubMed:23873930;Dbxref=PMID:12807903,PMID:23873930 P46937 UniProtKB Mutagenesis 217 217 . . . Note=No effect on interaction with PRRG4. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23873930;Dbxref=PMID:23873930 P46937 UniProtKB Mutagenesis 258 258 . . . Note=Reduced interaction with PRRG4%3B when associated with A-261. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23873930;Dbxref=PMID:23873930 P46937 UniProtKB Mutagenesis 261 261 . . . Note=Reduced interaction with PRRG4%3B when associated with A-258. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23873930;Dbxref=PMID:23873930 P46937 UniProtKB Mutagenesis 397 397 . . . Note=Loss of phosphorylation by LATS1. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18158288;Dbxref=PMID:18158288 P46937 UniProtKB Mutagenesis 407 407 . . . Note=Enhanced interaction with TP73. Y->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18280240;Dbxref=PMID:18280240 P46937 UniProtKB Mutagenesis 407 407 . . . Note=No phosphorylation by ABL1 and partial loss of binding to TP73. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18280240;Dbxref=PMID:18280240 P46937 UniProtKB Beta strand 52 54 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8A8Q P46937 UniProtKB Helix 61 73 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8A8Q P46937 UniProtKB Helix 75 77 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6GEI P46937 UniProtKB Helix 86 88 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8A8Q P46937 UniProtKB Helix 93 96 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8A8Q P46937 UniProtKB Beta strand 169 171 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K9Q P46937 UniProtKB Beta strand 177 181 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4REX P46937 UniProtKB Beta strand 183 185 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K9Q P46937 UniProtKB Beta strand 187 191 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4REX P46937 UniProtKB Turn 192 195 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4REX P46937 UniProtKB Beta strand 196 200 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4REX P46937 UniProtKB Helix 202 206 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4REX P46937 UniProtKB Beta strand 233 235 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LAW P46937 UniProtKB Beta strand 238 241 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LAW P46937 UniProtKB Turn 242 244 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LAW P46937 UniProtKB Beta strand 245 250 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LAW P46937 UniProtKB Turn 251 254 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LAW P46937 UniProtKB Beta strand 255 259 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LAW P46937 UniProtKB Beta strand 261 263 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5YDY