Reviewed,
UniProtKB/Swiss-Prot P46937 (YAP1_HUMAN)
Last modified
June 16, 2009.
Version 88.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 65 kDa Yes-associated protein Alternative name(s): YAP65 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 454 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Subunit structure | Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif By similarity. |
| Post-translational modification | Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.8 |
| Sequence similarities | Contains 1 WW domain. |
Ontologies
| Keywords | |
|---|---|
| PTM | Phosphoprotein |
| Technical term | 3D-structure |
| Gene Ontology (GO) | |
| Molecular function | protein binding Ref.1 Inferred from physical interaction. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||
Molecule processing | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 454 | 454 | 65 kDa Yes-associated protein | PRO_0000076071 | ||||||||||||
Regions | ||||||||||||||||
| Domain | 171 – 204 | 34 | WW | |||||||||||||
| Compositional bias | 3 – 49 | 47 | Pro-rich | |||||||||||||
| Compositional bias | 221 – 312 | 92 | Gln-rich | |||||||||||||
Amino acid modifications | ||||||||||||||||
| Modified residue | 61 | 1 | Phosphoserine Ref.8 | |||||||||||||
| Modified residue | 109 | 1 | Phosphoserine Ref.3 Ref.7 | |||||||||||||
| Modified residue | 110 | 1 | Phosphothreonine Ref.3 Ref.4 | |||||||||||||
| Modified residue | 127 | 1 | Phosphoserine Ref.8 | |||||||||||||
| Modified residue | 128 | 1 | Phosphoserine Ref.8 | |||||||||||||
| Modified residue | 131 | 1 | Phosphoserine Ref.8 | |||||||||||||
| Modified residue | 138 | 1 | Phosphoserine Ref.8 | |||||||||||||
| Modified residue | 143 | 1 | Phosphothreonine Ref.4 Ref.8 | |||||||||||||
| Modified residue | 149 | 1 | Phosphoserine Ref.8 | |||||||||||||
| Modified residue | 154 | 1 | Phosphothreonine Ref.4 Ref.8 | |||||||||||||
| Modified residue | 236 | 1 | Phosphoserine Ref.8 | |||||||||||||
| Modified residue | 238 | 1 | Phosphoserine Ref.5 | |||||||||||||
| Modified residue | 251 | 1 | Phosphoserine Ref.8 | |||||||||||||
| Modified residue | 317 | 1 | Phosphoserine Ref.8 | |||||||||||||
| Modified residue | 321 | 1 | Phosphoserine Ref.6 | |||||||||||||
Secondary structure | ||||||||||||||||
Helix Strand Turn | ||||||||||||||||
| Beta strand | 188 – 191 | 4 | ||||||||||||||
| Turn | 192 – 195 | 4 | ||||||||||||||
| Beta strand | 196 – 200 | 5 | ||||||||||||||
| Turn | 202 – 204 | 3 | ||||||||||||||
| Beta strand | 205 – 207 | 3 | ||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain." Sudol M., Bork P., Einbond A., Kastury K., Druck T., Negrini M., Huebner K., Lehman D. J. Biol. Chem. 270:14733-14741(1995) [PubMed: 7782338] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Lung. |
| [2] | "Characterization of the WW domain of human Yes-associated protein and its polyproline containing ligands." Chen H.I., Einbond A., Kwak S.-J., Linn H., Koepf E., Peterson S., Kelly J.W., Sudol M. J. Biol. Chem. 272:17070-17077(1997) [PubMed: 9202023] [Abstract] Cited for: INTERACTION WITH WBP1 AND WBP2. |
| [3] | "Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109 AND THR-110, MASS SPECTROMETRY. Tissue: Epithelium. |
| [4] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-110; THR-143 AND THR-154, MASS SPECTROMETRY. Tissue: Epithelium. |
| [5] | "A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238, MASS SPECTROMETRY. Tissue: Epithelium. |
| [6] | "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321, MASS SPECTROMETRY. |
| [7] | "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109, MASS SPECTROMETRY. |
| [8] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61; SER-127; SER-128; SER-131; SER-138; THR-143; SER-149; THR-154; SER-236; SER-251 AND SER-317, MASS SPECTROMETRY. |
| [9] | "Solution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope." Pires J.R., Taha-Nejad F., Toepert F., Ast T., Hoffmueller U., Schneider-Mergener J., Kuehne R., Macias M.J., Oschkinat H. J. Mol. Biol. 314:1147-1156(2001) [PubMed: 11743730] [Abstract] Cited for: STRUCTURE BY NMR OF 165-210 OF WILD-TYPE AND MUTANT LYS-190 IN COMPLEX WITH PRO-RICH PEPTIDES. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| X80507 Genomic DNA. Translation: CAA56672.1. | |||||||||||||||||||||||||||||||
| IPI | IPI00009326. | ||||||||||||||||||||||||||||||
| PIR | A56954. | ||||||||||||||||||||||||||||||
| RefSeq | NP_006097.1. | ||||||||||||||||||||||||||||||
| UniGene | Hs.503692 | ||||||||||||||||||||||||||||||
3D structure databases | |||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||
| SMR | P46937. Positions 165-210. | ||||||||||||||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||||||||||||||
| IntAct | P46937. 1 interaction. | ||||||||||||||||||||||||||||||
PTM databases | |||||||||||||||||||||||||||||||
| PhosphoSite | P46937. | ||||||||||||||||||||||||||||||
Proteomic databases | |||||||||||||||||||||||||||||||
| PRIDE | P46937. | ||||||||||||||||||||||||||||||
Genome annotation databases | |||||||||||||||||||||||||||||||
| Ensembl | ENSG00000137693. Homo sapiens. [Contig view] | ||||||||||||||||||||||||||||||
| GeneID | 10413. | ||||||||||||||||||||||||||||||
Organism-specific databases | |||||||||||||||||||||||||||||||
| GeneCards | GC11P101486. | ||||||||||||||||||||||||||||||
| H-InvDB | HIX0010062. | ||||||||||||||||||||||||||||||
| HGNC | HGNC:16262. YAP1. | ||||||||||||||||||||||||||||||
| HPA | CAB009370. | ||||||||||||||||||||||||||||||
| MIM | 606608. gene. | ||||||||||||||||||||||||||||||
| PharmGKB | PA24564. | ||||||||||||||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||||||||||||||
| HOVERGEN | P46937. | ||||||||||||||||||||||||||||||
Enzyme and pathway databases | |||||||||||||||||||||||||||||||
| Pathway_Interaction_DB | tgfbrpathway. TGF-beta receptor signaling. | ||||||||||||||||||||||||||||||
Gene expression databases | |||||||||||||||||||||||||||||||
| ArrayExpress | P46937. | ||||||||||||||||||||||||||||||
| Bgee | P46937. | ||||||||||||||||||||||||||||||
| CleanEx | HS_YAP1. | ||||||||||||||||||||||||||||||
| GermOnline | ENSG00000137693. Homo sapiens. | ||||||||||||||||||||||||||||||
Family and domain databases | |||||||||||||||||||||||||||||||
| InterPro | IPR001202. WW_Rsp5_WWP. [Graphical view] | ||||||||||||||||||||||||||||||
| Pfam | PF00397. WW. 1 hit. [Graphical view] | ||||||||||||||||||||||||||||||
| SMART | SM00456. WW. 1 hit. [Graphical view] | ||||||||||||||||||||||||||||||
| PROSITE | PS01159. WW_DOMAIN_1. 1 hit. PS50020. WW_DOMAIN_2. 1 hit. [Graphical view] | ||||||||||||||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||||||||||||||
Other Resources | |||||||||||||||||||||||||||||||
| NextBio | 39472. | ||||||||||||||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||||||||||||||
Entry information
| Entry name | YAP1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P46937 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


