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Protein

Transcriptional coactivator YAP1

Gene

YAP1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional coactivator YAP1
Short name:
Yes-associated protein 1
Alternative name(s):
65 kDa Yes-associated protein1 Publication
Short name:
YAP651 Publication
Protein yorkie homolog
Gene namesi
Name:YAP1
Synonyms:YAP65
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000760731 – 448Transcriptional coactivator YAP1Add BLAST448

Post-translational modificationi

Phosphorylated by LATS1 and LATS2; leading to cytoplasmic translocation and inactivation.By similarity

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TP53BP2Q13625-26EBI-7804091,EBI-287091From a different organism.

Protein-protein interaction databases

BioGridi676433. 1 interactor.
IntActiP46936. 1 interactor.
MINTiMINT-3167006.

Structurei

3D structure databases

ProteinModelPortaliP46936.
SMRiP46936.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini169 – 202WWPROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni251 – 448Transactivation domainAdd BLAST198

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili85 – 99By similarityAdd BLAST15
Coiled coili258 – 303Sequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 48Pro-richAdd BLAST46

Sequence similaritiesi

Belongs to the YAP1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000007854.
HOVERGENiHBG002748.
InParanoidiP46936.
KOiK16687.
PhylomeDBiP46936.

Family and domain databases

CDDicd00201. WW. 1 hit.
InterProiView protein in InterPro
IPR001202. WW_dom.
PfamiView protein in Pfam
PF00397. WW. 1 hit.
SMARTiView protein in SMART
SM00456. WW. 1 hit.
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiView protein in PROSITE
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P46936-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPGQPQPQQ PPQAAQPPAP QQAAPQPPGA GSGAPGGAAQ PPGAGPPPAG
60 70 80 90 100
HQIVHVRGDS ETDLEALFNA VMNPKGANVP HTLPMRLRKL PDSFFKPPEP
110 120 130 140 150
KAHSRQASTD AGTAGALTPQ HVRAHSSPAS LQLGAVSPGT LTPSGVVTGP
160 170 180 190 200
GAPSSQHLRQ SSFEIPDDVP LPPGWEMAKT PSGQRYFLNH IDQTTTWQDP
210 220 230 240 250
RKAMLSQMNV TAPTSPPVQQ NLMNSASAMN QRISQSAPVK QPPPLAPQSP
260 270 280 290 300
QGGVMGGSSS NQQQQMRLQQ LQMEKERLRL KHQELLRQEL ALRSQLPTME
310 320 330 340 350
QDGGSQNPVS SPGMSQELRT MTTNSSDPFL NSGTYHSRDE STDSGLSMSS
360 370 380 390 400
YSVPRTPDDF LNSVDEMDTG DSISQSNIPS HQNRFPDYLE AIPGTNVDLG
410 420 430 440
TLEGDGMNIE GEELMPSLQE ALSSDILNDM ESVLAATKPD KESFLTWL
Length:448
Mass (Da):47,822
Last modified:November 1, 1995 - v1
Checksum:i719CC8D0F879A38D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76483 mRNA. Translation: CAA54021.1.
PIRiI50730.
RefSeqiNP_990574.1. NM_205243.1.
UniGeneiGga.3093.

Genome annotation databases

GeneIDi396171.
KEGGigga:396171.

Similar proteinsi

Entry informationi

Entry nameiYAP1_CHICK
AccessioniPrimary (citable) accession number: P46936
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: August 30, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families