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Protein

Transcriptional coactivator YAP1

Gene

YAP1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional coactivator YAP1
Short name:
Yes-associated protein 1
Alternative name(s):
65 kDa Yes-associated protein1 Publication
Short name:
YAP651 Publication
Protein yorkie homolog
Gene namesi
Name:YAP1
Synonyms:YAP65
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Both phosphorylation and cell density can regulate its subcellular localization. Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus. At low density, predominantly nuclear and is translocated to the cytoplasm at high density.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Transcriptional coactivator YAP1PRO_0000076073Add
BLAST

Post-translational modificationi

Phosphorylated by LATS1 and LATS2; leading to cytoplasmic translocation and inactivation.By similarity

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TP53BP2Q13625-26EBI-7804091,EBI-287091From a different organism.

Protein-protein interaction databases

BioGridi676433. 1 interaction.
IntActiP46936. 1 interaction.
MINTiMINT-3167006.

Structurei

3D structure databases

ProteinModelPortaliP46936.
SMRiP46936. Positions 163-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini169 – 20234WWPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni251 – 448198Transactivation domainAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili85 – 9915By similarityAdd
BLAST
Coiled coili258 – 30346Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 4846Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the YAP1 family.Curated
Contains 1 WW domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000007854.
HOVERGENiHBG002748.
InParanoidiP46936.
KOiK16687.
PhylomeDBiP46936.

Family and domain databases

InterProiIPR001202. WW_dom.
[Graphical view]
PfamiPF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46936-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPGQPQPQQ PPQAAQPPAP QQAAPQPPGA GSGAPGGAAQ PPGAGPPPAG
60 70 80 90 100
HQIVHVRGDS ETDLEALFNA VMNPKGANVP HTLPMRLRKL PDSFFKPPEP
110 120 130 140 150
KAHSRQASTD AGTAGALTPQ HVRAHSSPAS LQLGAVSPGT LTPSGVVTGP
160 170 180 190 200
GAPSSQHLRQ SSFEIPDDVP LPPGWEMAKT PSGQRYFLNH IDQTTTWQDP
210 220 230 240 250
RKAMLSQMNV TAPTSPPVQQ NLMNSASAMN QRISQSAPVK QPPPLAPQSP
260 270 280 290 300
QGGVMGGSSS NQQQQMRLQQ LQMEKERLRL KHQELLRQEL ALRSQLPTME
310 320 330 340 350
QDGGSQNPVS SPGMSQELRT MTTNSSDPFL NSGTYHSRDE STDSGLSMSS
360 370 380 390 400
YSVPRTPDDF LNSVDEMDTG DSISQSNIPS HQNRFPDYLE AIPGTNVDLG
410 420 430 440
TLEGDGMNIE GEELMPSLQE ALSSDILNDM ESVLAATKPD KESFLTWL
Length:448
Mass (Da):47,822
Last modified:November 1, 1995 - v1
Checksum:i719CC8D0F879A38D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76483 mRNA. Translation: CAA54021.1.
PIRiI50730.
RefSeqiNP_990574.1. NM_205243.1.
UniGeneiGga.3093.

Genome annotation databases

GeneIDi396171.
KEGGigga:396171.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76483 mRNA. Translation: CAA54021.1.
PIRiI50730.
RefSeqiNP_990574.1. NM_205243.1.
UniGeneiGga.3093.

3D structure databases

ProteinModelPortaliP46936.
SMRiP46936. Positions 163-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676433. 1 interaction.
IntActiP46936. 1 interaction.
MINTiMINT-3167006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396171.
KEGGigga:396171.

Organism-specific databases

CTDi10413.

Phylogenomic databases

HOGENOMiHOG000007854.
HOVERGENiHBG002748.
InParanoidiP46936.
KOiK16687.
PhylomeDBiP46936.

Miscellaneous databases

PROiP46936.

Family and domain databases

InterProiIPR001202. WW_dom.
[Graphical view]
PfamiPF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product."
    Sudol M.
    Oncogene 9:2145-2152(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: White leghorn.

Entry informationi

Entry nameiYAP1_CHICK
AccessioniPrimary (citable) accession number: P46936
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.