Reviewed,
UniProtKB/Swiss-Prot P46933 (APBB1_RAT)
Last modified
November 4, 2008.
Version 56.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Amyloid beta A4 precursor protein-binding family B member 1 Alternative name(s): Fe65 protein | ||||
| Gene names |
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| Organism | Rattus norvegicus (Rat) | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 711 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May modulate the internalization of beta-amyloid precursor protein By similarity. |
| Subunit structure | Binds to the intracellular domain of the beta-amyloid precursor protein. Interacts, through the WW domain, with proline-rich regions of APBB1IP and ENAH By similarity. |
| Tissue specificity | Brain, not in liver, very low in other tissues. The long (neuron-specific) form is expressed only in brain. |
| Sequence similarities | Contains 2 PID domains. Contains 1 WW domain. |
| Sequence caution | The sequence CAA42999.1 differs from that shown. Reason: Frameshift at position 127. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| APP | P05067 | 1 | EBI-286177,EBI-77613 | From a different organism. |
| App | P08592 | 1 | EBI-286177,EBI-286155 |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: P46933-1) Also known as: Long; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: P46933-2) Also known as: Short; The sequence of this isoform differs from the canonical sequence as follows: 463-464: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 711 | 711 | Amyloid beta A4 precursor protein-binding family B member 1 | PRO_0000076051 | |||||
Regions | |||||||||
| Domain | 254 – 286 | 33 | WW | ||||||
| Domain | 365 – 533 | 169 | PID 1 | ||||||
| Domain | 538 – 700 | 163 | PID 2 | ||||||
| Compositional bias | 148 – 188 | 41 | Glu-rich | ||||||
Natural variations | |||||||||
| Alternative sequence | 463 – 464 | 2 | Missing in isoform 2. | VSP_006798 | |||||
Experimental info | |||||||||
| Sequence conflict | 137 | 1 | L → K Ref.2 | ||||||
| Sequence conflict | 150 – 154 | 5 | EEKAA → GRRQR Ref.2 | ||||||
| Sequence conflict | 172 | 1 | E → EEEDEEEE Ref.2 | ||||||
Sequences
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References
| [1] | "Nuclear signaling of APP cytoplasmic tail." Cao X., Suedhof T.C. Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). |
| [2] | "A rat brain mRNA encoding a transcriptional activator homologous to the DNA binding domain of retroviral integrases." Duilio A., Zambrano N., Mogavero A.R., Ammendola R., Cimino F., Russo T. Nucleic Acids Res. 19:5269-5274(1991) [PubMed: 1923810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 121-711 (ISOFORM 2). Tissue: Brain. |
| [3] | "The DNA sequence encompassing the transcription start site of a TATA-less promoter contains enough information to drive neuron-specific transcription." Faraonio R., Minopoli G., Porcellini A., Costanzo F., Cimino F., Russo T. Nucleic Acids Res. 22:4876-4883(1994) [PubMed: 7800475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 243-530. Tissue: Brain. |
Cross-references
Sequence databases | |
|---|---|
| AF333983 mRNA. Translation: AAK20835.1. X60469 mRNA. Translation: CAA42999.1. Frameshift. X60468 mRNA. Translation: CAA42998.1. | |
| PIR | S22571. S50818. |
| RefSeq | NP_536726.1. |
| UniGene | Rn.19953 |
3D structure databases | |
| SMR | P46933. Positions 242-291. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:682N. |
| IntAct | P46933. |
PTM databases | |
| PhosphoSite | P46933. |
Genome annotation databases | |
| Ensembl | ENSRNOG00000018020. Rattus norvegicus. [Contig view] |
| GeneID | 29722. |
| KEGG | rno:29722. |
Organism-specific databases | |
| RGD | 2122. Apbb1. |
Phylogenomic databases | |
| HOVERGEN | P46933. |
Gene expression databases | |
| GermOnline | ENSRNOG00000018020. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR011993. PH_type. IPR006020. PTB_PID. IPR001202. WW_Rsp5_WWP. [Graphical view] |
| Gene3D | G3DSA:2.30.29.30. PH_type. 2 hits. |
| Pfam | PF00640. PID. 2 hits. PF00397. WW. 1 hit. [Graphical view] |
| SMART | SM00462. PTB. 2 hits. SM00456. WW. 1 hit. [Graphical view] |
| PROSITE | PS01179. PID. 2 hits. PS01159. WW_DOMAIN_1. 1 hit. PS50020. WW_DOMAIN_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 610190. |
Entry information
| Entry name | APBB1_RAT | ||||||||
| Accession | Primary (citable) accession number: P46933 Secondary accession number(s): Q99MK3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

Clusters with


