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Reviewed, UniProtKB/Swiss-Prot P46933 (APBB1_RAT)

Last modified November 4, 2008. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Amyloid beta A4 precursor protein-binding family B member 1
Alternative name(s):
    Fe65 protein
Gene names
Name: Apbb1
Synonyms: Fe65
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length711 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

May modulate the internalization of beta-amyloid precursor protein By similarity.

Subunit structure

Binds to the intracellular domain of the beta-amyloid precursor protein. Interacts, through the WW domain, with proline-rich regions of APBB1IP and ENAH By similarity.

Tissue specificity

Brain, not in liver, very low in other tissues. The long (neuron-specific) form is expressed only in brain.

Sequence similarities

Contains 2 PID domains.

Contains 1 WW domain.

Sequence caution

The sequence CAA42999.1 differs from that shown. Reason: Frameshift at position 127.

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

APPP050671EBI-286177,EBI-77613From a different organism.
AppP085921EBI-286177,EBI-286155

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P46933-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P46933-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     463-464: Missing.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 711711Amyloid beta A4 precursor protein-binding family B member 1
PRO_0000076051

Regions

Domain254 – 28633WW
Domain365 – 533169PID 1
Domain538 – 700163PID 2
Compositional bias148 – 18841Glu-rich

Natural variations

Alternative sequence463 – 4642Missing in isoform 2.
VSP_006798

Experimental info

Sequence conflict1371L → K Ref.2
Sequence conflict150 – 1545EEKAA → GRRQR Ref.2
Sequence conflict1721E → EEEDEEEE Ref.2

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Long) [UniParc].

Last modified September 27, 2004. Version 3.
Checksum: A6C9820F5D2BD7BE

FASTA71177,656
        10         20         30         40         50         60 
MSVPSSLSQS AINANSHGGP ALSFPFPLHA AHNQLLNAKL QATAVVPKDL RSAMGEGSVP 

        70         80         90        100        110        120 
EPGPANAKWL KEGQNQLRRA ATAHRDQNRN VTLTLAEEAS QEAETAPLGP KGLMHLYSEL 

       130        140        150        160        170        180 
ELSAHNAANR GLHGSALIIN TQGLGPDEGE EKAAGEVEEE DEDEEEEDEE EEDLSSPQGL 

       190        200        210        220        230        240 
PEPLENVEVP SGPQVLTDGP REHSKSASLL FGMRNSAASD EDSSWATLSQ GSPSYGSPED 

       250        260        270        280        290        300 
TDSFWNPNAF ETDSDLPAGW MRVQDTSGTY YWHIPTGTTQ WEPPGRASPS QGNSPQEESQ 

       310        320        330        340        350        360 
LTWTGFAHQE GFEEGEFWKD EPSEEAPMEL GLKDPEEGTL PFSAQSLSPE PVPQEEENLP 

       370        380        390        400        410        420 
QRNANPGIKC FAVRSLGWVE MTEEELAPGR SSVAVNNCIR QLSYHKNNLH DPMSGGWGEG 

       430        440        450        460        470        480 
KDLLLQLEDE TLKLVEPQNQ TLLHAQPIVS IRVWGVGRDS GRERDFAYVA RDKLTQMLKC 

       490        500        510        520        530        540 
HVFRCEAPAK NIATSLHEIC SKIMSERRNA RCLVNGLSLD HSKLVDVPFQ VEFPAPKNEL 

       550        560        570        580        590        600 
VQKFQVYYLG NVPVAKPVGV DVINGALESV LSSSSREQWT PSHVSVAPAT LTILHQQTEA 

       610        620        630        640        650        660 
VLGECRVRFL SFLAVGRDVH TFAFIMAAGP ASFCCHMFWC EPNAASLSEA VQAACMLRYQ 

       670        680        690        700        710 
KCLDARSQTS TSCLPAPPAE SVARRVGWTV RRGVQSLWGS LKPKRLGSQT P

« Hide

Isoform 2 (Short) [UniParc].

Checksum: 5658754E0D449B6E
Show »

70977,371

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References

[1]"Nuclear signaling of APP cytoplasmic tail."
Cao X., Suedhof T.C.
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"A rat brain mRNA encoding a transcriptional activator homologous to the DNA binding domain of retroviral integrases."
Duilio A., Zambrano N., Mogavero A.R., Ammendola R., Cimino F., Russo T.
Nucleic Acids Res. 19:5269-5274(1991) [PubMed: 1923810] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 121-711 (ISOFORM 2).
Tissue: Brain.
[3]"The DNA sequence encompassing the transcription start site of a TATA-less promoter contains enough information to drive neuron-specific transcription."
Faraonio R., Minopoli G., Porcellini A., Costanzo F., Cimino F., Russo T.
Nucleic Acids Res. 22:4876-4883(1994) [PubMed: 7800475] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 243-530.
Tissue: Brain.

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Cross-references

Sequence databases

AF333983 mRNA. Translation: AAK20835.1.
X60469 mRNA. Translation: CAA42999.1. Frameshift.
X60468 mRNA. Translation: CAA42998.1.
PIRS22571.
S50818.
RefSeqNP_536726.1.
UniGeneRn.19953

3D structure databases

SMRP46933. Positions 242-291.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:682N.
IntActP46933.

PTM databases

PhosphoSiteP46933.

Genome annotation databases

EnsemblENSRNOG00000018020. Rattus norvegicus. [Contig view]
GeneID29722.
KEGGrno:29722.

Organism-specific databases

RGD2122. Apbb1.

Phylogenomic databases

HOVERGENP46933.

Gene expression databases

GermOnlineENSRNOG00000018020. Rattus norvegicus.

Family and domain databases

InterProIPR011993. PH_type.
IPR006020. PTB_PID.
IPR001202. WW_Rsp5_WWP.
[Graphical view]
Gene3DG3DSA:2.30.29.30. PH_type. 2 hits.
PfamPF00640. PID. 2 hits.
PF00397. WW. 1 hit.
[Graphical view]
SMARTSM00462. PTB. 2 hits.
SM00456. WW. 1 hit.
[Graphical view]
PROSITEPS01179. PID. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio610190.

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Entry information

Entry nameAPBB1_RAT
AccessionPrimary (citable) accession number: P46933
Secondary accession number(s): Q99MK3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: September 27, 2004
Last modified: November 4, 2008
This is version 56 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents