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Protein

Glycine betaine transport ATP-binding protein OpuAA

Gene

opuAA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in a multicomponent binding-protein-dependent transport system for glycine betaine. Probably responsible for energy coupling to the transport system.2 Publications

Catalytic activityi

ATP + H2O + quaternary amine(Out) = ADP + phosphate + quaternary amine(In).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 738ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU02980-MONOMER.
BRENDAi3.6.3.32. 658.

Protein family/group databases

TCDBi3.A.1.12.2. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine betaine transport ATP-binding protein OpuAA (EC:3.6.3.32)
Alternative name(s):
Quaternary-amine-transporting ATPase
Gene namesi
Name:opuAA
Ordered Locus Names:BSU02980
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Glycine betaine transport ATP-binding protein OpuAAPRO_0000092674Add
BLAST

Proteomic databases

PaxDbiP46920.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (OpuAA), two transmembrane proteins (OpuAB) and a solute-binding protein (OpuAC).1 Publication

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100001638.

Structurei

3D structure databases

ProteinModelPortaliP46920.
SMRiP46920. Positions 10-397.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 270237ABC transporterPROSITE-ProRule annotationAdd
BLAST
Domaini284 – 34057CBS 1PROSITE-ProRule annotationAdd
BLAST
Domaini344 – 40360CBS 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated
Contains 1 ABC transporter domain.PROSITE-ProRule annotation
Contains 2 CBS domains.PROSITE-ProRule annotation

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

eggNOGiENOG4108IJ7. Bacteria.
COG4175. LUCA.
InParanoidiP46920.
KOiK02000.
OMAiPLIRLEM.
PhylomeDBiP46920.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR000644. CBS_dom.
IPR005892. Gly-betaine_transp_ATP-bd.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
PF00571. CBS. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00116. CBS. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01186. proV. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51371. CBS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46920-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVDEKPIKI KVEKVSKIFG KQTKKAVQML ANGKTKKEIL KATGSTVGVN
60 70 80 90 100
QADFEVYDGE IFVIMGLSGS GKSTLVRMLN RLIEPTAGNI YIDGDMITNM
110 120 130 140 150
SKDQLREVRR KKISMVFQKF ALFPHRTILE NTEYGLELQG VDKQERQQKA
160 170 180 190 200
LESLKLVGLE GFEHQYPDQL SGGMQQRVGL ARALTNDPDI LLMDEAFSAL
210 220 230 240 250
DPLIRKDMQD ELLDLHDNVG KTIIFITHDL DEALRIGDRI VLMKDGNIVQ
260 270 280 290 300
IGTPEEILMN PSNEYVEKFV EDVDLSKVLT AGHIMKRAET VRIDKGPRVA
310 320 330 340 350
LTLMKNLGIS SIYAVDKQKK LLGVIYASDA KKAAESDLSL QDILNTEFTT
360 370 380 390 400
VPENTYLTEI FDVVSDANIP IAVVDEKQRM KGIVVRGALI GALAGNNEYI
410
NAEGTNEQTQ DPSAQEVK
Length:418
Mass (Da):46,468
Last modified:June 16, 2009 - v3
Checksum:iE7A32E331F3103E5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351T → A in BAA08932 (PubMed:8969502).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17292 Genomic DNA. Translation: AAC43455.1.
D50453 Genomic DNA. Translation: BAA08932.1.
AL009126 Genomic DNA. Translation: CAB12092.2.
PIRiI40535.
RefSeqiNP_388180.2. NC_000964.3.
WP_003246301.1. NZ_JNCM01000030.1.

Genome annotation databases

EnsemblBacteriaiCAB12092; CAB12092; BSU02980.
GeneIDi938362.
KEGGibsu:BSU02980.
PATRICi18972155. VBIBacSub10457_0306.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17292 Genomic DNA. Translation: AAC43455.1.
D50453 Genomic DNA. Translation: BAA08932.1.
AL009126 Genomic DNA. Translation: CAB12092.2.
PIRiI40535.
RefSeqiNP_388180.2. NC_000964.3.
WP_003246301.1. NZ_JNCM01000030.1.

3D structure databases

ProteinModelPortaliP46920.
SMRiP46920. Positions 10-397.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100001638.

Protein family/group databases

TCDBi3.A.1.12.2. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP46920.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12092; CAB12092; BSU02980.
GeneIDi938362.
KEGGibsu:BSU02980.
PATRICi18972155. VBIBacSub10457_0306.

Phylogenomic databases

eggNOGiENOG4108IJ7. Bacteria.
COG4175. LUCA.
InParanoidiP46920.
KOiK02000.
OMAiPLIRLEM.
PhylomeDBiP46920.

Enzyme and pathway databases

BioCyciBSUB:BSU02980-MONOMER.
BRENDAi3.6.3.32. 658.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR000644. CBS_dom.
IPR005892. Gly-betaine_transp_ATP-bd.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
PF00571. CBS. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00116. CBS. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01186. proV. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51371. CBS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOPUAA_BACSU
AccessioniPrimary (citable) accession number: P46920
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 16, 2009
Last modified: September 7, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.