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P46908 (FNR_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Anaerobic regulatory protein
Gene names
Name:fnr
Ordered Locus Names:BSU37310
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length238 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

It is involved in the activation of genes necessary for anaerobic respiration.

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm Probable.

Induction

By anaerobiosis.

Domain

The cysteine cluster which is probably involved in the coordination of the [4Fe-4S] cluster is located at the C-terminal part of the protein.

Sequence similarities

Contains 1 cyclic nucleotide-binding domain.

Contains 1 HTH crp-type DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 238238Anaerobic regulatory protein
PRO_0000100173

Regions

Domain145 – 21975HTH crp-type
DNA binding178 – 19720H-T-H motif By similarity
Region223 – 23513Essential for the oxygen-regulated activity

Sites

Metal binding2231Iron-sulfur (4Fe-4S) Potential
Metal binding2271Iron-sulfur (4Fe-4S) Potential
Metal binding2301Iron-sulfur (4Fe-4S) Potential
Metal binding2351Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
P46908 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: B7079A37EFC7A03B

FASTA23827,218
        10         20         30         40         50         60 
MNFLSVRPSD SDLISSDLYE LLESISTKRK MEKHTYLFRE GMDAEELYLI QSGLIEIGKL 

        70         80         90        100        110        120 
TSDGKDLTLR ICQKHDIVGE LTLFTEEPRY MLSAKVLEDG EVLVINKNKL EKELIQNGAL 

       130        140        150        160        170        180 
TFEFMKWMST HLRKIQSKIR DLLLHGKKGA LYSTLIRLSN SYGVERSDGI LINIVLTNQD 

       190        200        210        220        230 
LAKFCAAARE SVNRMLGDLR KKGVISIDES GKIILHKRDY LRCEIECENC PLEICNID 

« Hide

References

« Hide 'large scale' references
[1]"Anaerobic transcription activation in Bacillus subtilis: identification of distinct FNR-dependent and -independent regulatory mechanisms."
Cruz Ramos H., Boursier L., Moszer I., Kunst F., Danchin A., Glaser P.
EMBO J. 14:5984-5994(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z49884 Genomic DNA. Translation: CAA90042.1.
AL009126 Genomic DNA. Translation: CAB15759.1.
PIRS60081.
RefSeqNP_391612.1. NC_000964.3.

3D structure databases

ProteinModelPortalP46908.
SMRP46908. Positions 19-225.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224308.BSU37310.

Proteomic databases

PaxDbP46908.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB15759; CAB15759; BSU37310.
GeneID937050.
KEGGbsu:BSU37310.
PATRIC18979500. VBIBacSub10457_3912.

Organism-specific databases

GenoListBSU37310. [Micado]

Phylogenomic databases

eggNOGCOG0664.
HOGENOMHOG000088909.
KOK01420.
OMAWMSTHLR.
OrthoDBEOG6R87DH.
ProtClustDBCLSK872647.

Enzyme and pathway databases

BioCycBSUB:BSU37310-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFNR_BACSU
AccessionPrimary (citable) accession number: P46908
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 19, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList