Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Anaerobic regulatory protein

Gene

fnr

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

It is involved in the activation of genes necessary for anaerobic respiration.

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi223Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi227Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi230Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi235Iron-sulfur (4Fe-4S)Sequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi178 – 197H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciBSUB:BSU37310-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic regulatory protein
Gene namesi
Name:fnr
Ordered Locus Names:BSU37310
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001001731 – 238Anaerobic regulatory proteinAdd BLAST238

Proteomic databases

PaxDbiP46908.

Expressioni

Inductioni

By anaerobiosis.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100020166.

Structurei

3D structure databases

ProteinModelPortaliP46908.
SMRiP46908.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini145 – 219HTH crp-typePROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni223 – 235Essential for the oxygen-regulated activityAdd BLAST13

Domaini

The cysteine cluster which is probably involved in the coordination of the [4Fe-4S] cluster is located at the C-terminal part of the protein.

Phylogenomic databases

eggNOGiENOG4107V6Q. Bacteria.
COG0664. LUCA.
HOGENOMiHOG000088909.
InParanoidiP46908.
KOiK01420.
OMAiGVEMFAG.
PhylomeDBiP46908.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiView protein in InterPro
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP.
IPR014710. RmlC-like_jellyroll.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00027. cNMP_binding. 1 hit.
PF13545. HTH_Crp_2. 1 hit.
SMARTiView protein in SMART
SM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF51206. SSF51206. 1 hit.
PROSITEiView protein in PROSITE
PS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P46908-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFLSVRPSD SDLISSDLYE LLESISTKRK MEKHTYLFRE GMDAEELYLI
60 70 80 90 100
QSGLIEIGKL TSDGKDLTLR ICQKHDIVGE LTLFTEEPRY MLSAKVLEDG
110 120 130 140 150
EVLVINKNKL EKELIQNGAL TFEFMKWMST HLRKIQSKIR DLLLHGKKGA
160 170 180 190 200
LYSTLIRLSN SYGVERSDGI LINIVLTNQD LAKFCAAARE SVNRMLGDLR
210 220 230
KKGVISIDES GKIILHKRDY LRCEIECENC PLEICNID
Length:238
Mass (Da):27,218
Last modified:November 1, 1995 - v1
Checksum:iB7079A37EFC7A03B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49884 Genomic DNA. Translation: CAA90042.1.
AL009126 Genomic DNA. Translation: CAB15759.1.
PIRiS60081.
RefSeqiNP_391612.1. NC_000964.3.
WP_003243241.1. NZ_JNCM01000034.1.

Genome annotation databases

EnsemblBacteriaiCAB15759; CAB15759; BSU37310.
GeneIDi937050.
KEGGibsu:BSU37310.
PATRICifig|224308.179.peg.4042.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFNR_BACSU
AccessioniPrimary (citable) accession number: P46908
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 7, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList