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Protein

Solute carrier family 2, facilitated glucose transporter member 1

Gene

SLC2A1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei316 – 3161MonosaccharideBy similarity
Binding sitei387 – 3871MonosaccharideBy similarity

GO - Molecular functioni

GO - Biological processi

  • glucose transmembrane transport Source: GOC
  • glucose transport Source: UniProtKB
  • protein complex assembly Source: UniProtKB
  • response to dexamethasone Source: AgBase
  • response to insulin Source: AgBase
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-GGA-352832. Glucose transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 1
Alternative name(s):
Glucose transporter type 1
Short name:
GLUT-1
Short name:
GT1
Gene namesi
Name:SLC2A1
Synonyms:GLUT1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicBy similarity
Transmembranei11 – 3222Helical; Name=1By similarityAdd
BLAST
Topological domaini33 – 6533ExtracellularBy similarityAdd
BLAST
Transmembranei66 – 8621Helical; Name=2By similarityAdd
BLAST
Topological domaini87 – 893CytoplasmicBy similarity
Transmembranei90 – 11122Helical; Name=3By similarityAdd
BLAST
Topological domaini112 – 1198ExtracellularBy similarity
Transmembranei120 – 14324Helical; Name=4By similarityAdd
BLAST
Topological domaini144 – 15411CytoplasmicBy similarityAdd
BLAST
Transmembranei155 – 17521Helical; Name=5By similarityAdd
BLAST
Topological domaini176 – 1849ExtracellularBy similarity
Transmembranei185 – 20521Helical; Name=6By similarityAdd
BLAST
Topological domaini206 – 27065CytoplasmicBy similarityAdd
BLAST
Transmembranei271 – 29222Helical; Name=7By similarityAdd
BLAST
Topological domaini293 – 30513ExtracellularBy similarityAdd
BLAST
Transmembranei306 – 32722Helical; Name=8By similarityAdd
BLAST
Topological domaini328 – 3336CytoplasmicBy similarity
Transmembranei334 – 35421Helical; Name=9By similarityAdd
BLAST
Topological domaini355 – 36410ExtracellularBy similarity
Transmembranei365 – 38723Helical; Name=10By similarityAdd
BLAST
Topological domaini388 – 40013CytoplasmicBy similarityAdd
BLAST
Transmembranei401 – 42121Helical; Name=11By similarityAdd
BLAST
Topological domaini422 – 4287ExtracellularBy similarity
Transmembranei429 – 44921Helical; Name=12By similarityAdd
BLAST
Topological domaini450 – 49041CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Solute carrier family 2, facilitated glucose transporter member 1PRO_0000050344Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP46896.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000007795.

Structurei

3D structure databases

ProteinModelPortaliP46896.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni281 – 2877Monosaccharide bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP46896.
KOiK07299.
PhylomeDBiP46896.

Family and domain databases

InterProiIPR002439. Glu_transpt_1.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01190. GLUCTRSPORT1.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESGSKMTAR LMLAVGGAVL GSLQFGYNTG VINRPQKVIE DFYNHTWLYR
60 70 80 90 100
YEEPISPATL TTLWSLSVAI FSVGGMIGSF SVGLFVNRFG RRNSMLMSNI
110 120 130 140 150
LAFLAAVLMG FSKMALSFEM LILGRFIIGL YSGLTTGFVP MYVGEVSPTA
160 170 180 190 200
LRGALGTFHQ LGIVLGILIA QVFGLDLIMG NDSLWPLLLG FIFVPALLQC
210 220 230 240 250
IILPFAPESP RFLLINRNEE NKAKSVLKKL RGTTDVSSDL QEMKEESRQM
260 270 280 290 300
MREKKVTIME LFRSPMYRQP ILIAIVLQLS QQLSGINAVF YYSTSIFEKS
310 320 330 340 350
GVEQPVYATI GSGVVNTAFT VVSLFVVERA GRRTLHLIGL AGMAGCAILM
360 370 380 390 400
TIALTLLDQM PWMSYLSIVA IFGFVAFFEI GPGPIPWFIV AELFSQGPRP
410 420 430 440 450
AAFAVAGLSN WTSNFIVGMG FQYIAQLCGS YVFIIFTVLL VLFFIFTYFK
460 470 480 490
VPETKGRTFD EIAYRFRQGG ASQSDKTPDE FHSLGADSQV
Length:490
Mass (Da):54,087
Last modified:November 1, 1995 - v1
Checksum:i63BB176812D06104
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07300 mRNA. Translation: AAB02037.1.
RefSeqiNP_990540.1. NM_205209.1.
UniGeneiGga.1040.

Genome annotation databases

GeneIDi396130.
KEGGigga:396130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07300 mRNA. Translation: AAB02037.1.
RefSeqiNP_990540.1. NM_205209.1.
UniGeneiGga.1040.

3D structure databases

ProteinModelPortaliP46896.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000007795.

Proteomic databases

PaxDbiP46896.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396130.
KEGGigga:396130.

Organism-specific databases

CTDi6513.

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP46896.
KOiK07299.
PhylomeDBiP46896.

Enzyme and pathway databases

ReactomeiR-GGA-352832. Glucose transport.

Miscellaneous databases

PROiP46896.

Family and domain databases

InterProiIPR002439. Glu_transpt_1.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01190. GLUCTRSPORT1.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of the avian GLUT1 glucose transporter: differential regulation of GLUT1 and GLUT3 in chicken embryo fibroblasts."
    Wagstaff P., Kang H.Y., Mylott D., Robbins P.J., White M.K.
    Mol. Biol. Cell 6:1575-1589(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGTR1_CHICK
AccessioniPrimary (citable) accession number: P46896
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 8, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.