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P46892

- CD11B_RAT

UniProt

P46892 - CD11B_RAT

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Protein
Cyclin-dependent kinase 11B
Gene
Cdk11b, Cdc2l1, Cdk11
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Acts as a negative regulator of the normal cell cycle progression. In vitro, this protein kinase has been shown to phosphorylate a number of substrates, including histone h1, casein, and galactosyltransferase. May function in regulating proliferation by the phosphorylation and subsequent plasma membrane targeting of galactosyltransferase.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei108 – 1081ATP By similarity
Active sitei203 – 2031Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi85 – 939ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.22. 5301.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 11B
    Alternative name(s):
    Cell division cycle 2-like protein kinase 1
    Cell division protein kinase 11
    Cyclin-dependent kinase 11 (EC:2.7.11.22)
    Galactosyltransferase-associated protein kinase p58/GTA
    PITSLRE serine/threonine-protein kinase CDC2L1
    Gene namesi
    Name:Cdk11b
    Synonyms:Cdc2l1, Cdk11
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi628604. Cdk11b.

    Subcellular locationi

    GO - Cellular componenti

    1. nuclear membrane Source: UniProtKB-SubCell
    2. perinuclear region of cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 436436Cyclin-dependent kinase 11B
    PRO_0000085710Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei123 – 1231Phosphoserine; by CDK7 By similarity
    Modified residuei129 – 1291Phosphothreonine; by CDK7 By similarity
    Modified residuei230 – 2301Phosphoserine By similarity
    Modified residuei235 – 2351Phosphotyrosine By similarity
    Modified residuei236 – 2361Phosphothreonine By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP46892.

    PTM databases

    PhosphoSiteiP46892.

    Expressioni

    Gene expression databases

    GenevestigatoriP46892.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4655594.

    Structurei

    3D structure databases

    ProteinModelPortaliP46892.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini79 – 364286Protein kinase
    Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni30 – 4415Calmodulin-binding Reviewed prediction
    Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi25 – 306Nuclear localization signal Reviewed prediction

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG014652.
    PhylomeDBiP46892.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P46892-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSEKSRTTS WLFQSHEVTE ILGRVKKNRK KLVKGLHRAG PPPEKNYLPD    50
    SPALSPIELK QELPKYLPAL QGCRSVEEFQ CLNRIEEGTY GVVYRAKDKK 100
    TDEIVALKRL KMEKEKEGFP LTSIREINTI LKAQHPNIVT VREIVVGSNM 150
    DKIYIVMNYV EHDLKSLMET MKQPFLPGEV KTLMIQLLSG VKHLHDNWIL 200
    HRDLKTSNLL LTHAGILKVG DFGLAREYGS PLKAYTPVVV TLWYRAPELL 250
    LGAKEYSTAC DMWSVGCIFG ELLTQKPLFP GKSDIDQINK IFKDIGTPSE 300
    KIWPGYSELP AVKKMTFSEL PYNNLRKRFG ALLSDQGFDL MNKFLTYYPG 350
    RRINAEDGLK HEYFRETPLP IDPSMFPTWP AKSEQQCVKR GTSPKPPEGG 400
    LGYSQLGDDD LKETGFHLTT TNDGAVSCRP WCSLLF 436
    Length:436
    Mass (Da):49,547
    Last modified:November 1, 1995 - v1
    Checksum:iD2BA9BC73EAD3D27
    GO

    Sequence cautioni

    The sequence AAA88509.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L24388 mRNA. Translation: AAA88509.1. Different initiation.
    PIRiS47628.
    UniGeneiRn.10204.
    Rn.129782.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L24388 mRNA. Translation: AAA88509.1 . Different initiation.
    PIRi S47628.
    UniGenei Rn.10204.
    Rn.129782.

    3D structure databases

    ProteinModelPortali P46892.
    ModBasei Search...

    Protein-protein interaction databases

    MINTi MINT-4655594.

    PTM databases

    PhosphoSitei P46892.

    Proteomic databases

    PRIDEi P46892.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 628604. Cdk11b.

    Phylogenomic databases

    HOVERGENi HBG014652.
    PhylomeDBi P46892.

    Enzyme and pathway databases

    BRENDAi 2.7.11.22. 5301.

    Miscellaneous databases

    NextBioi 623956.

    Gene expression databases

    Genevestigatori P46892.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the synthesis and expression of the GTA-kinase from transformed and normal rodent cells."
      Kerr M., Fischer J.E., Purushotham K.R., Gao D., Nakagawa Y., Maeda N., Ghanta V., Hiramoto R., Chegini N., Humphreys-Beher M.G.
      Biochim. Biophys. Acta 1218:375-387(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiCD11B_RAT
    AccessioniPrimary (citable) accession number: P46892
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: April 16, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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