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P46892 (CD11B_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 11B
Alternative name(s):
Cell division cycle 2-like protein kinase 1
Cell division protein kinase 11
Cyclin-dependent kinase 11
EC=2.7.11.22
Galactosyltransferase-associated protein kinase p58/GTA
PITSLRE serine/threonine-protein kinase CDC2L1
Gene names
Name:Cdk11b
Synonyms:Cdc2l1, Cdk11
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length436 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a negative regulator of the normal cell cycle progression. In vitro, this protein kinase has been shown to phosphorylate a number of substrates, including histone h1, casein, and galactosyltransferase. May function in regulating proliferation by the phosphorylation and subsequent plasma membrane targeting of galactosyltransferase.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium.

Subcellular location

Cytoplasm. Nucleus membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Cytoplasm › perinuclear region.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence AAA88509.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 436436Cyclin-dependent kinase 11B
PRO_0000085710

Regions

Domain79 – 364286Protein kinase
Nucleotide binding85 – 939ATP By similarity
Region30 – 4415Calmodulin-binding Potential
Motif25 – 306Nuclear localization signal Potential

Sites

Active site2031Proton acceptor By similarity
Binding site1081ATP By similarity

Amino acid modifications

Modified residue1231Phosphoserine; by CDK7 By similarity
Modified residue1291Phosphothreonine; by CDK7 By similarity
Modified residue2301Phosphoserine By similarity
Modified residue2351Phosphotyrosine By similarity
Modified residue2361Phosphothreonine By similarity
Modified residue3921Phosphothreonine By similarity
Modified residue3931Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P46892 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: D2BA9BC73EAD3D27

FASTA43649,547
        10         20         30         40         50         60 
MKSEKSRTTS WLFQSHEVTE ILGRVKKNRK KLVKGLHRAG PPPEKNYLPD SPALSPIELK 

        70         80         90        100        110        120 
QELPKYLPAL QGCRSVEEFQ CLNRIEEGTY GVVYRAKDKK TDEIVALKRL KMEKEKEGFP 

       130        140        150        160        170        180 
LTSIREINTI LKAQHPNIVT VREIVVGSNM DKIYIVMNYV EHDLKSLMET MKQPFLPGEV 

       190        200        210        220        230        240 
KTLMIQLLSG VKHLHDNWIL HRDLKTSNLL LTHAGILKVG DFGLAREYGS PLKAYTPVVV 

       250        260        270        280        290        300 
TLWYRAPELL LGAKEYSTAC DMWSVGCIFG ELLTQKPLFP GKSDIDQINK IFKDIGTPSE 

       310        320        330        340        350        360 
KIWPGYSELP AVKKMTFSEL PYNNLRKRFG ALLSDQGFDL MNKFLTYYPG RRINAEDGLK 

       370        380        390        400        410        420 
HEYFRETPLP IDPSMFPTWP AKSEQQCVKR GTSPKPPEGG LGYSQLGDDD LKETGFHLTT 

       430 
TNDGAVSCRP WCSLLF

« Hide

References

[1]"Characterization of the synthesis and expression of the GTA-kinase from transformed and normal rodent cells."
Kerr M., Fischer J.E., Purushotham K.R., Gao D., Nakagawa Y., Maeda N., Ghanta V., Hiramoto R., Chegini N., Humphreys-Beher M.G.
Biochim. Biophys. Acta 1218:375-387(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L24388 mRNA. Translation: AAA88509.1. Different initiation.
IPIIPI00557555.
PIRS47628.
UniGeneRn.10204.
Rn.129782.

3D structure databases

ProteinModelPortalP46892.
ModBaseSearch...

PTM databases

PhosphoSiteP46892.

Proteomic databases

PRIDEP46892.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

RGD628604. Cdk11b.

Phylogenomic databases

HOVERGENHBG014652.

Enzyme and pathway databases

BRENDA2.7.11.22. 5301.

Gene expression databases

GenevestigatorP46892.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. False negative.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio623956.

Entry information

Entry nameCD11B_RAT
AccessionPrimary (citable) accession number: P46892
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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