SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P46892

- CD11B_RAT

UniProt

P46892 - CD11B_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cyclin-dependent kinase 11B

Gene
Cdk11b, Cdc2l1, Cdk11
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Acts as a negative regulator of the normal cell cycle progression. In vitro, this protein kinase has been shown to phosphorylate a number of substrates, including histone h1, casein, and galactosyltransferase. May function in regulating proliferation by the phosphorylation and subsequent plasma membrane targeting of galactosyltransferase.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei108 – 1081ATP By similarity
Active sitei203 – 2031Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi85 – 939ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 11B
Alternative name(s):
Cell division cycle 2-like protein kinase 1
Cell division protein kinase 11
Cyclin-dependent kinase 11 (EC:2.7.11.22)
Galactosyltransferase-associated protein kinase p58/GTA
PITSLRE serine/threonine-protein kinase CDC2L1
Gene namesi
Name:Cdk11b
Synonyms:Cdc2l1, Cdk11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi628604. Cdk11b.

Subcellular locationi

GO - Cellular componenti

  1. nuclear membrane Source: UniProtKB-SubCell
  2. perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Cyclin-dependent kinase 11BPRO_0000085710Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei123 – 1231Phosphoserine; by CDK7 By similarity
Modified residuei129 – 1291Phosphothreonine; by CDK7 By similarity
Modified residuei230 – 2301Phosphoserine By similarity
Modified residuei235 – 2351Phosphotyrosine By similarity
Modified residuei236 – 2361Phosphothreonine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP46892.

PTM databases

PhosphoSiteiP46892.

Expressioni

Gene expression databases

GenevestigatoriP46892.

Interactioni

Protein-protein interaction databases

MINTiMINT-4655594.

Structurei

3D structure databases

ProteinModelPortaliP46892.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini79 – 364286Protein kinaseAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni30 – 4415Calmodulin-binding Reviewed predictionAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi25 – 306Nuclear localization signal Reviewed prediction

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG014652.
PhylomeDBiP46892.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46892-1 [UniParc]FASTAAdd to Basket

« Hide

MKSEKSRTTS WLFQSHEVTE ILGRVKKNRK KLVKGLHRAG PPPEKNYLPD    50
SPALSPIELK QELPKYLPAL QGCRSVEEFQ CLNRIEEGTY GVVYRAKDKK 100
TDEIVALKRL KMEKEKEGFP LTSIREINTI LKAQHPNIVT VREIVVGSNM 150
DKIYIVMNYV EHDLKSLMET MKQPFLPGEV KTLMIQLLSG VKHLHDNWIL 200
HRDLKTSNLL LTHAGILKVG DFGLAREYGS PLKAYTPVVV TLWYRAPELL 250
LGAKEYSTAC DMWSVGCIFG ELLTQKPLFP GKSDIDQINK IFKDIGTPSE 300
KIWPGYSELP AVKKMTFSEL PYNNLRKRFG ALLSDQGFDL MNKFLTYYPG 350
RRINAEDGLK HEYFRETPLP IDPSMFPTWP AKSEQQCVKR GTSPKPPEGG 400
LGYSQLGDDD LKETGFHLTT TNDGAVSCRP WCSLLF 436
Length:436
Mass (Da):49,547
Last modified:November 1, 1995 - v1
Checksum:iD2BA9BC73EAD3D27
GO

Sequence cautioni

The sequence AAA88509.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L24388 mRNA. Translation: AAA88509.1. Different initiation.
PIRiS47628.
UniGeneiRn.10204.
Rn.129782.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L24388 mRNA. Translation: AAA88509.1 . Different initiation.
PIRi S47628.
UniGenei Rn.10204.
Rn.129782.

3D structure databases

ProteinModelPortali P46892.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4655594.

PTM databases

PhosphoSitei P46892.

Proteomic databases

PRIDEi P46892.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 628604. Cdk11b.

Phylogenomic databases

HOVERGENi HBG014652.
PhylomeDBi P46892.

Enzyme and pathway databases

BRENDAi 2.7.11.22. 5301.

Miscellaneous databases

NextBioi 623956.

Gene expression databases

Genevestigatori P46892.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of the synthesis and expression of the GTA-kinase from transformed and normal rodent cells."
    Kerr M., Fischer J.E., Purushotham K.R., Gao D., Nakagawa Y., Maeda N., Ghanta V., Hiramoto R., Chegini N., Humphreys-Beher M.G.
    Biochim. Biophys. Acta 1218:375-387(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Salivary gland.

Entry informationi

Entry nameiCD11B_RAT
AccessioniPrimary (citable) accession number: P46892
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi