Reviewed,
UniProtKB/Swiss-Prot P46891 (COF_ECOLI)
Last modified
June 16, 2009.
Version 58.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: HMP-PP phosphatase EC=3.6.1.- | ||||
| Gene names |
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| Organism | Escherichia coli (strain K12) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 83333 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 272 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P). Can also hydrolyze other substrates such as MeO-HMP-PP and CF(3)-HMP-PP. Ref.6 |
| Sequence similarities | Belongs to the HAD-like hydrolase superfamily. Cof family. |
Ontologies
| Keywords | |
|---|---|
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | metabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Inferred from electronic annotation. Source: HAMAP protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 272 | 272 | HMP-PP phosphatase HAMAP MF_01847 | PRO_0000054418 | |||||
Experimental info | |||||||||
| Sequence conflict | 173 | 1 | C → S in BAA11650. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Patzer S.I., Hantke K. Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12 / MC4100 / ATCC 35695 / DSM 6574. |
| [2] | "Nucleotide sequence analysis of the E. coli chromosome around the 10.0 min region." Hatada E., Ohmori H., Qiao Y., Tsuji M., Fukuda R. Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911. |
| [3] | "Sequence of minutes 4-25 of Escherichia coli." Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076. |
| [4] | "The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076. |
| [5] | "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911. |
| [6] | "A genetic screen for the identification of thiamin metabolic genes." Lawhorn B.G., Gerdes S.Y., Begley T.P. J. Biol. Chem. 279:43555-43559(2004) [PubMed: 15292217] [Abstract] Cited for: FUNCTION. Strain: K12 / MG1655 / ATCC 47076. |
Cross-references
Sequence databases | |
|---|---|
| Z54355 Genomic DNA. Translation: CAA91181.1. Different initiation. D82943 Genomic DNA. Translation: BAA11650.1. U82664 Genomic DNA. Translation: AAB40202.1. Different initiation. U00096 Genomic DNA. Translation: AAC73549.1. Different initiation. AP009048 Genomic DNA. Translation: BAE76226.1. | |
| PIR | F64774. |
| RefSeq | AP_001096.1. NP_414980.2. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P46891. 1 interaction. |
Genome annotation databases | |
| GeneID | 945089. |
| GenomeReviews | Gene locus JW0436 in contig AP009048_GR. Gene locus b0446 in contig U00096_GR. |
| KEGG | ecj:JW0436. eco:b0446. |
Organism-specific databases | |
| EchoBASE | EB3007. |
| EcoGene | EG13216. cof. |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P46891. |
| OMA | P46891. SAMDCLE. |
Enzyme and pathway databases | |
| BioCyc | EcoCyc:G6246-MON. MetaCyc:G6246-MON. |
Family and domain databases | |
| HAMAP | MF_01847. [Tree] |
| InterPro | IPR005834. Dehalogen-like_hydro. IPR006379. HAD-SF_hydro_IIB. IPR000150. Hypothet_cof. [Graphical view] |
| Pfam | PF00702. Hydrolase. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00099. Cof-subfamily. 1 hit. TIGR01484. HAD-SF-IIB. 1 hit. |
| PROSITE | PS01228. COF_1. 1 hit. PS01229. COF_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | COF_ECOLI | ||||||||
| Accession | Primary (citable) accession number: P46891 Secondary accession number(s): P71208, P77198, Q2MBY0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Escherichia coli Escherichia coli (strain K12): entries and cross-references to EcoGene |
| SIMILARITY comments Index of protein domains and families |

Clusters with


