P46888 (USPC_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Universal stress protein C

Gene names

Name:	uspC
Synonyms:	yecG
Ordered Locus Names:	b1895, JW1884

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Required for resistance to DNA-damaging agents. Ref.5
Subcellular location	Cytoplasm By similarity.
Induction	During growth inhibition caused by the exhaustion of any of a variety of nutrients (carbon, nitrogen, phosphate, sulfate, required amino acid) or by the presence of a variety of toxic agents. Positively regulated by guanosine 3',5'-bisphosphate (ppGpp) and by a RecA/FtsK-dependent regulatory pathway. Ref.5
Sequence similarities	Belongs to the universal stress protein A family.

Ontologies

Keywords
Cellular component	Cytoplasm
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	response to stress Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein complex scaffold Inferred from direct assay. Source: EcoCyc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 142	142	Universal stress protein C		PRO_0000147408

Sequences

	Sequence		Length	Mass (Da)
	P46888 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 87DFEE19A8EE58FC	FASTA	142	15,633
	10 20 30 40 50 60 MSYSNILVAV AVTPESQQLL AKAVSIARPV KGHISLITLA SDPEMYNQLA APMLEDLRSV 70 80 90 100 110 120 MHEETQSFLD KLIQDAGYPV DKTFIAYGEL SEHILEVCHK HHFDLVICGN HNHSFFSRAS 130 140 CSAKRVIASS EVDVLLVPLT GD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Estep P., O'Keeffe T., Robison K., Church G.M. Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12 / EMG2.
[2]	"A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map." Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S. , Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y., Horiuchi T. DNA Res. 3:379-392(1996) [PubMed: 9097040] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"The universal stress protein paralogues of Escherichia coli are co-ordinately regulated and co-operate in the defence against DNA damage." Gustavsson N., Diez A., Nystroem T. Mol. Microbiol. 43:107-117(2002) [PubMed: 11849540] [Abstract] Cited for: FUNCTION, GENE NAME, TRANSCRIPTIONAL REGULATION. Strain: K12 / MC4100 / ATCC 35695 / DSM 6574.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U27211 Genomic DNA. Translation: AAA68603.1. U00096 Genomic DNA. Translation: AAC74965.1. AP009048 Genomic DNA. Translation: BAA15716.1.
PIR	G64952.
RefSeq	NP_416409.1. NC_000913.2.
3D structure databases
ProteinModelPortal	P46888.
SMR	P46888. Positions 2-141.
ModBase	Search...
Protein-protein interaction databases
IntAct	P46888. 5 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000001335; EBESCP00000001335; EBESCG00000001108. EBESCT00000014430; EBESCP00000013721; EBESCG00000013491.
GeneID	946404.
GenomeReviews	Gene locus JW1884 in contig AP009048_GR. Gene locus b1895 in contig U00096_GR.
KEGG	ecj:JW1884. eco:b1895.
PATRIC	32119117. VBIEscCol129921_1976.
Organism-specific databases
EchoBASE	EB2704.
EcoGene	EG12862. uspC.
Phylogenomic databases
eggNOG	COG0589.
GeneTree	EBGT00050000009429.
HOGENOM	HBG733992.
OMA	SIARPVN.
PhylomeDB	P46888.
ProtClustDB	PRK10116.
Enzyme and pathway databases
BioCyc	EcoCyc:G7031-MONOMER.
Gene expression databases
Genevestigator	P46888.
Family and domain databases
InterPro	IPR014729. Rossmann-like_a/b/a_fold. IPR006016. UspA. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K14064.
Pfam	PF00582. Usp. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

USPC_ECOLI

Accession

Primary (citable) accession number: P46888

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program