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Protein

Universal stress protein C

Gene

uspC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for resistance to DNA-damaging agents.1 Publication

GO - Molecular functioni

  • protein complex scaffold Source: EcoCyc

GO - Biological processi

  • response to salt stress Source: CACAO
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G7031-MONOMER.
ECOL316407:JW1884-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Universal stress protein C
Gene namesi
Name:uspC
Synonyms:yecG
Ordered Locus Names:b1895, JW1884
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12862. uspC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 142142Universal stress protein CPRO_0000147408Add
BLAST

Proteomic databases

PaxDbiP46888.

Expressioni

Inductioni

During growth inhibition caused by the exhaustion of any of a variety of nutrients (carbon, nitrogen, phosphate, sulfate, required amino acid) or by the presence of a variety of toxic agents. Positively regulated by guanosine 3',5'-bisphosphate (ppGpp) and by a RecA/FtsK-dependent regulatory pathway.1 Publication

Interactioni

GO - Molecular functioni

  • protein complex scaffold Source: EcoCyc

Protein-protein interaction databases

BioGridi4259472. 9 interactions.
IntActiP46888. 11 interactions.
STRINGi511145.b1895.

Structurei

3D structure databases

ProteinModelPortaliP46888.
SMRiP46888. Positions 3-139.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the universal stress protein A family.Curated

Phylogenomic databases

eggNOGiENOG4108VA4. Bacteria.
COG0589. LUCA.
HOGENOMiHOG000238899.
InParanoidiP46888.
KOiK14064.
OMAiCGNHNQS.
OrthoDBiEOG6J74WR.
PhylomeDBiP46888.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR014729. Rossmann-like_a/b/a_fold.
IPR006015. Universal_stress_UspA.
IPR006016. UspA.
[Graphical view]
PfamiPF00582. Usp. 1 hit.
[Graphical view]
PIRSFiPIRSF006276. UspA. 1 hit.

Sequencei

Sequence statusi: Complete.

P46888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYSNILVAV AVTPESQQLL AKAVSIARPV KGHISLITLA SDPEMYNQLA
60 70 80 90 100
APMLEDLRSV MHEETQSFLD KLIQDAGYPV DKTFIAYGEL SEHILEVCHK
110 120 130 140
HHFDLVICGN HNHSFFSRAS CSAKRVIASS EVDVLLVPLT GD
Length:142
Mass (Da):15,633
Last modified:November 1, 1995 - v1
Checksum:i87DFEE19A8EE58FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27211 Genomic DNA. Translation: AAA68603.1.
U00096 Genomic DNA. Translation: AAC74965.1.
AP009048 Genomic DNA. Translation: BAA15716.1.
PIRiG64952.
RefSeqiNP_416409.1. NC_000913.3.
WP_000122416.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74965; AAC74965; b1895.
BAA15716; BAA15716; BAA15716.
GeneIDi946404.
KEGGiecj:JW1884.
eco:b1895.
PATRICi32119117. VBIEscCol129921_1976.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27211 Genomic DNA. Translation: AAA68603.1.
U00096 Genomic DNA. Translation: AAC74965.1.
AP009048 Genomic DNA. Translation: BAA15716.1.
PIRiG64952.
RefSeqiNP_416409.1. NC_000913.3.
WP_000122416.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP46888.
SMRiP46888. Positions 3-139.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259472. 9 interactions.
IntActiP46888. 11 interactions.
STRINGi511145.b1895.

Proteomic databases

PaxDbiP46888.

Protocols and materials databases

DNASUi946404.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74965; AAC74965; b1895.
BAA15716; BAA15716; BAA15716.
GeneIDi946404.
KEGGiecj:JW1884.
eco:b1895.
PATRICi32119117. VBIEscCol129921_1976.

Organism-specific databases

EchoBASEiEB2704.
EcoGeneiEG12862. uspC.

Phylogenomic databases

eggNOGiENOG4108VA4. Bacteria.
COG0589. LUCA.
HOGENOMiHOG000238899.
InParanoidiP46888.
KOiK14064.
OMAiCGNHNQS.
OrthoDBiEOG6J74WR.
PhylomeDBiP46888.

Enzyme and pathway databases

BioCyciEcoCyc:G7031-MONOMER.
ECOL316407:JW1884-MONOMER.

Miscellaneous databases

PROiP46888.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR014729. Rossmann-like_a/b/a_fold.
IPR006015. Universal_stress_UspA.
IPR006016. UspA.
[Graphical view]
PfamiPF00582. Usp. 1 hit.
[Graphical view]
PIRSFiPIRSF006276. UspA. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Estep P., O'Keeffe T., Robison K., Church G.M.
    Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12 / EMG2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "The universal stress protein paralogues of Escherichia coli are co-ordinately regulated and co-operate in the defence against DNA damage."
    Gustavsson N., Diez A., Nystroem T.
    Mol. Microbiol. 43:107-117(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, GENE NAME, TRANSCRIPTIONAL REGULATION.
    Strain: K12 / MC4100 / ATCC 35695 / DSM 6574.

Entry informationi

Entry nameiUSPC_ECOLI
AccessioniPrimary (citable) accession number: P46888
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 20, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.