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Protein

Kinesin-like protein KIN-14N

Gene

KIN14N

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi481 – 488ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: TAIR
  • ATP binding Source: UniProtKB-KW
  • microtubule binding Source: TAIR
  • microtubule motor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-ATH-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIN-14NCurated
Alternative name(s):
AtKIN14d1 Publication
Kinesin-like protein KatC2 Publications
Gene namesi
Name:KIN14NCurated
Synonyms:ATK3Curated, KATCImported
Ordered Locus Names:At5g54670Imported
ORF Names:K5F14.1Imported, MRB17.18
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G54670
TAIRilocus:2157533 AT5G54670

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001253821 – 754Kinesin-like protein KIN-14NAdd BLAST754

Proteomic databases

PaxDbiP46875
PRIDEiP46875

PTM databases

iPTMnetiP46875

Expressioni

Gene expression databases

ExpressionAtlasiP46875 baseline and differential
GenevisibleiP46875 AT

Interactioni

Subunit structurei

Bind to microtubules in an ATP-insensitive manner (in vitro) (PubMed:8075402, PubMed:17244481). Homodimer and heterodimer with KIN14M/KATB (in vitro) (PubMed:17244481).2 Publications

GO - Molecular functioni

  • microtubule binding Source: TAIR

Protein-protein interaction databases

BioGridi20800, 2 interactors
STRINGi3702.AT5G54670.1

Structurei

3D structure databases

ProteinModelPortaliP46875
SMRiP46875
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini396 – 733Kinesin motorPROSITE-ProRule annotationAdd BLAST338

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 45GlobularAdd BLAST45
Regioni74 – 86Microtubule-binding1 PublicationAdd BLAST13
Regioni207 – 754Microtubule-binding1 PublicationAdd BLAST548

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili85 – 209Sequence analysisAdd BLAST125
Coiled coili262 – 394Sequence analysisAdd BLAST133

Domaini

Composed of three structural domains; a small globular N-terminal, a central alpha-helical coiled coil and a large globular C-terminal which is responsible for the motor activity (it hydrolyzes ATP and binds microtubules).

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.1 Publication

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0239 Eukaryota
COG5059 LUCA
HOGENOMiHOG000116164
InParanoidiP46875
KOiK10405
OMAiSQSSQIR
OrthoDBiEOG0936041R
PhylomeDBiP46875

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P46875-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGAMANNGR IRSAFPVTNG SKDLTPNSAP ASTTGSEYGP VEFTREDVET
60 70 80 90 100
LLNERIKYKS KFNYKERCEN MMDYIKRLRL CIRWFQELEL DYAFEQEKLK
110 120 130 140 150
NALELNEKHC VDMEVSLKNK EEELNMIIEE LRKNFESVQV QLAREQTEKL
160 170 180 190 200
AANDSLGKEK EARLSVEKAQ AGLTEELGKA QGDLQTANQR IQSVNDMYKL
210 220 230 240 250
LQEYNSSLQL YNSKLQGDLD EAHETIKRGE KERTAIIENI GNLKGQFSAL
260 270 280 290 300
QEQLAASKAS QEDIMKQKGE LVNEIASLKV ELQQVKDDRD RHLVEVKTLQ
310 320 330 340 350
TEATKYNDFK DAITELETTC SSQSTQIRQL QDRLVNSERR LQVSDLSTFE
360 370 380 390 400
KMNEYEDQKQ SIIDLKSRVE EAELKLVEGE KLRKKLHNTI LELKGNIRVF
410 420 430 440 450
CRVRPLLPGE NNGDEGKTIS YPTSLEALGR GIDLMQNAQK HAFTFDKVFA
460 470 480 490 500
PTASQEDVFT EISQLVQSAL DGYKVCIFAY GQTGSGKTYT MMGRPGNVEE
510 520 530 540 550
KGLIPRCLEQ IFETRQSLRS QGWKYELQVS MLEIYNETIR DLLSTNKEAV
560 570 580 590 600
RTDSGVSPQK HAIKHDASGN THVAELTILD VKSSREVSFL LDHAARNRSV
610 620 630 640 650
GKTQMNEQSS RSHFVFTLRI SGVNESTEQQ VQGVLNLIDL AGSERLSKSG
660 670 680 690 700
STGDRLKETQ AINKSLSSLG DVIFALAKKE DHVPFRNSKL TYLLQPCLGG
710 720 730 740 750
DAKTLMFVNI APESSSTGES LCSLRFAARV NACEIGTPRR QTNIKPLENR

LSLG
Length:754
Mass (Da):85,030
Last modified:November 1, 1995 - v1
Checksum:i76091CD5B5D9C531
GO

Sequence cautioni

The sequence BAB09933 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21138 mRNA Translation: BAA04674.1
AB022214 Genomic DNA Translation: BAB09933.1 Sequence problems.
CP002688 Genomic DNA Translation: AED96525.1
CP002688 Genomic DNA Translation: ANM68862.1
BT003156 mRNA Translation: AAO24588.1
AK228138 mRNA Translation: BAF00095.1
PIRiS48020
RefSeqiNP_001330580.1, NM_001345094.1
NP_568811.1, NM_124848.3
UniGeneiAt.20653

Genome annotation databases

EnsemblPlantsiAT5G54670.1; AT5G54670.1; AT5G54670
AT5G54670.2; AT5G54670.2; AT5G54670
GeneIDi835556
GrameneiAT5G54670.1; AT5G54670.1; AT5G54670
AT5G54670.2; AT5G54670.2; AT5G54670
KEGGiath:AT5G54670

Similar proteinsi

Entry informationi

Entry nameiKN14N_ARATH
AccessioniPrimary (citable) accession number: P46875
Secondary accession number(s): Q0WS04, Q9FH38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health