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Protein

Osmotic avoidance abnormal protein 3

Gene

osm-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May have a role during neurogenesis and axonal transport.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi87 – 948ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, plus-end-directed Source: WormBase
  • microtubule motor activity Source: WormBase

GO - Biological processi

  • cilium assembly Source: UniProtKB
  • dauer entry Source: UniProtKB
  • intraciliary anterograde transport Source: WormBase
  • nonmotile primary cilium assembly Source: WormBase
  • positive regulation of dauer larval development Source: UniProtKB
  • regulation of insulin receptor signaling pathway Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-5620924. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Osmotic avoidance abnormal protein 3
Alternative name(s):
Kinesin-like protein osm-3
Gene namesi
Name:osm-3
ORF Names:M02B7.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiM02B7.3a; CE31567; WBGene00003884; osm-3.
M02B7.3b; CE31568; WBGene00003884; osm-3.

Subcellular locationi

GO - Cellular componenti

  • ciliary basal body Source: MGI
  • kinesin complex Source: WormBase
  • microtubule Source: UniProtKB-KW
  • neuronal cell body Source: WormBase
  • neuron projection Source: WormBase
  • nonmotile primary cilium Source: WormBase
  • perinuclear region of cytoplasm Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Disruption phenotypei

Worms are defective in osmotic avoidance, chemotaxis and dauer formation.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 699699Osmotic avoidance abnormal protein 3PRO_0000125402Add
BLAST

Proteomic databases

PaxDbiP46873.
PRIDEiP46873.

Expressioni

Tissue specificityi

Expressed in an exclusive set of 26 chemosensory neurons whose dendritic endings are exposed to the external environment; six IL2 neurons of the inner labial sensilla, eight pairs of amphid neurons in the head, and two pairs of phasmid neurons in the tail.2 Publications

Gene expression databases

ExpressionAtlasiP46873. baseline.

Interactioni

Protein-protein interaction databases

BioGridi42280. 3 interactions.
DIPiDIP-26512N.
MINTiMINT-1042356.
STRINGi6239.M02B7.3b.

Structurei

3D structure databases

ProteinModelPortaliP46873.
SMRiP46873. Positions 2-353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 327324Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili339 – 523185Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4280. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129680.
HOGENOMiHOG000116164.
InParanoidiP46873.
KOiK10394.
OMAiYAATTEN.
OrthoDBiEOG7WX086.
PhylomeDBiP46873.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform b (identifier: P46873-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAESVRVAVR CRPFNQREKD LNTTLCVGMT PNVGQVNLNA PDGAAKDFTF
60 70 80 90 100
DGAYFMDSTG EQIYNDIVFP LVENVIEGYN GTVFAYGQTG SGKTFSMQGI
110 120 130 140 150
ETIPAQRGVI PRAFDHIFTA TATTENVKFL VHCSYLEIYN EEVRDLLGAD
160 170 180 190 200
NKQKLEIKEQ PDRGVYVAGL SMHVCHDVPA CKELMTRGFN NRHVGATLMN
210 220 230 240 250
KDSSRSHSIF TVYVEGMTET GSIRMGKLNL VDLAGSERQS KTGATGDRLK
260 270 280 290 300
EATKINLSLS ALGNVISALV DGKSKHIPYR DSKLTRLLQD SLGGNTKTIM
310 320 330 340 350
IACVSPSSDN YDETLSTLRY ANRAKNIKNK PTINEDPKDA LLREYQEEIA
360 370 380 390 400
RLKSMVQPGA VGVGAPAQDA FSIEEERKKL REEFEEAMND LRGEYEREQT
410 420 430 440 450
SKAELQKDLE SLRADYERAN ANLDNLNPEE AAKKIQQLQD QFIGGEEAGN
460 470 480 490 500
TQLKQKRMKQ LKEAETKTQK LAAALNVHKD DPLLQVYSTT QEKLDAVTSQ
510 520 530 540 550
LEKEVKKSKG YEREIEDLHG EFELDRLDYL DTIRKQDQQL KLLMQIMDKI
560 570 580 590 600
QPIIKKDTNY SNVDRIKKEA VWNEDESRWI LPEMSMSRTI LPLANNGYMQ
610 620 630 640 650
EPARQENTLL RSNFDDKLRE RLAKSDSENL ANSYFKPVKQ INVINKYKSD
660 670 680 690
QKLSTSKSLF PSKTPTFDGL VNGVVYTDAL YERAQSAKRP PRLASLNPK
Length:699
Mass (Da):78,779
Last modified:December 7, 2004 - v4
Checksum:i8A774E3EF3A07813
GO
Isoform a (identifier: P46873-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Show »
Length:671
Mass (Da):75,603
Checksum:i681B4874A33928BF
GO

Sequence cautioni

The sequence BAA07612.1 differs from that shown. Reason: Frameshift at several positions. Curated
The sequence BAA07612.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAA20996.1 differs from that shown. Reason: Frameshift at several positions. Curated
The sequence BAA20996.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 593DST → IRP in BAA07612 (PubMed:7714894).Curated
Sequence conflicti57 – 593DST → IRP in BAA20996 (PubMed:7690265).Curated
Sequence conflicti217 – 2171M → I in BAA07612 (PubMed:7714894).Curated
Sequence conflicti217 – 2171M → I in BAA20996 (PubMed:7690265).Curated
Sequence conflicti680 – 6801L → S in BAA07612 (PubMed:7714894).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2828Missing in isoform a. CuratedVSP_012172Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38632 Genomic DNA. Translation: BAA07612.1. Sequence problems.
FO081251 Genomic DNA. Translation: CCD70203.1.
FO081251 Genomic DNA. Translation: CCD70204.1.
D14968 Genomic DNA. Translation: BAA20996.1. Sequence problems.
PIRiS54351.
RefSeqiNP_001023308.1. NM_001028137.3. [P46873-1]
NP_741362.1. NM_171308.4. [P46873-2]
UniGeneiCel.12541.

Genome annotation databases

EnsemblMetazoaiM02B7.3b; M02B7.3b; WBGene00003884. [P46873-1]
GeneIDi177141.
KEGGicel:CELE_M02B7.3.
UCSCiM02B7.3b. c. elegans. [P46873-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38632 Genomic DNA. Translation: BAA07612.1. Sequence problems.
FO081251 Genomic DNA. Translation: CCD70203.1.
FO081251 Genomic DNA. Translation: CCD70204.1.
D14968 Genomic DNA. Translation: BAA20996.1. Sequence problems.
PIRiS54351.
RefSeqiNP_001023308.1. NM_001028137.3. [P46873-1]
NP_741362.1. NM_171308.4. [P46873-2]
UniGeneiCel.12541.

3D structure databases

ProteinModelPortaliP46873.
SMRiP46873. Positions 2-353.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi42280. 3 interactions.
DIPiDIP-26512N.
MINTiMINT-1042356.
STRINGi6239.M02B7.3b.

Proteomic databases

PaxDbiP46873.
PRIDEiP46873.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiM02B7.3b; M02B7.3b; WBGene00003884. [P46873-1]
GeneIDi177141.
KEGGicel:CELE_M02B7.3.
UCSCiM02B7.3b. c. elegans. [P46873-1]

Organism-specific databases

CTDi177141.
WormBaseiM02B7.3a; CE31567; WBGene00003884; osm-3.
M02B7.3b; CE31568; WBGene00003884; osm-3.

Phylogenomic databases

eggNOGiKOG4280. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129680.
HOGENOMiHOG000116164.
InParanoidiP46873.
KOiK10394.
OMAiYAATTEN.
OrthoDBiEOG7WX086.
PhylomeDBiP46873.

Enzyme and pathway databases

ReactomeiR-CEL-5620924. Intraflagellar transport.

Miscellaneous databases

PROiP46873.

Gene expression databases

ExpressionAtlasiP46873. baseline.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Exclusive expression of C. elegans osm-3 kinesin gene in chemosensory neurons open to the external environment."
    Tabish M., Siddiqui Z.K., Nishikawa K., Siddiqui S.S.
    J. Mol. Biol. 247:377-389(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "C. elegans osm-3 gene mediating osmotic avoidance behaviour encodes a kinesin-like protein."
    Shakir M.A., Fukushige T., Yasuda H., Miwa J., Siddiqui S.S.
    NeuroReport 4:891-894(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-397, FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    Strain: Bristol N2.

Entry informationi

Entry nameiOSM3_CAEEL
AccessioniPrimary (citable) accession number: P46873
Secondary accession number(s): Q8MPT7, Q8MPT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 7, 2004
Last modified: June 8, 2016
This is version 119 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.