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Protein

Kinesin-like protein Klp68D

Gene

Klp68D

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plus-end directed microtubule motor that may be used for anterograde axonal transport and could conceivably move cargos in fly neurons different than those moved by kinesin heavy chain or other plus-end directed motors.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi106 – 1138ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • microtubule motor activity Source: GO_Central
  • motor activity Source: FlyBase

GO - Biological processi

  • anterograde axonal transport Source: FlyBase
  • establishment or maintenance of microtubule cytoskeleton polarity Source: FlyBase
  • microtubule-based movement Source: UniProtKB
  • sensory perception of smell Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-5620924. Intraflagellar transport.
R-DME-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-DME-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein Klp68D
Gene namesi
Name:Klp68D
Synonyms:KLP5
ORF Names:CG7293
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0004381. Klp68D.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 784784Kinesin-like protein Klp68DPRO_0000125392Add
BLAST

Proteomic databases

PaxDbiP46867.
PRIDEiP46867.

Expressioni

Tissue specificityi

Expressed primarily in the central nervous system and in a subset of the peripheral nervous system during embryogenesis.1 Publication

Gene expression databases

BgeeiP46867.
ExpressionAtlasiP46867. differential.
GenevisibleiP46867. DM.

Interactioni

Protein-protein interaction databases

BioGridi64693. 3 interactions.
IntActiP46867. 1 interaction.
MINTiMINT-964304.
STRINGi7227.FBpp0075762.

Structurei

3D structure databases

ProteinModelPortaliP46867.
SMRiP46867. Positions 18-372.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 344326Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili351 – 38535Sequence analysisAdd
BLAST
Coiled coili426 – 582157Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0240. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129680.
InParanoidiP46867.
KOiK20196.
OMAiTQTTLYH.
OrthoDBiEOG7WX086.
PhylomeDBiP46867.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46867-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKSRRPGT GSSQTPNECV QVVVRCRPMS NRERSERSPE VVNVYPNRGV
60 70 80 90 100
VELQNVVDGN KEQRKVFTYD AAYDASATQT TLYHEVVFPL VSSVLEGFNG
110 120 130 140 150
CIFAYGQTGT GKTFTMEGVR GNDELMGIIP RTFEQIWLHI NRTENFQFLV
160 170 180 190 200
DVSYLEIYME ELRDLLKPNS KHLEVRERGS GVYVPNLHAI NCKSVEDMIK
210 220 230 240 250
VMQVGNKNRT VGFTNMNEHS SRSHAIFMIK IEMCDTETNT IKVGKLNLID
260 270 280 290 300
LAGSERQSKT GASAERLKEA SKINLALSSL GNVISALAES SPHVPYRDSK
310 320 330 340 350
LTRLLQDSLG GNSKTIMIAN IGPSNYNYNE TLTTLRYASR AKSIQNQPIK
360 370 380 390 400
NEDPQDAKLK EYQEEIERLK RLIGPQQQQR SEKQVTAKKQ RVKKPKKETV
410 420 430 440 450
TKEMSDSLQV STIEQPVEDD SDPEGAESES DKENEAEVAK SNEELERERV
460 470 480 490 500
ENSKLAAKLA ELEGQLVRGG KNLLDTYSER QIELEKKLVE IAERKKREIE
510 520 530 540 550
IQQQLELQEE TTLEIRERNV SLEQEVELKK RKLSKCYAKY LALQQELNDC
560 570 580 590 600
KSDHNQDLRE LEMAQNELVK ELKRQLLIID NFVPIEVKQR LYTQAKYDEE
610 620 630 640 650
QEEWKFSSMS LPTPPGGDGK FSSKRPVSHP QRRRPTSEYA LQEAKSNSPS
660 670 680 690 700
SLRFKSENIV NYELEMPCRT TQEYRTPKVS ASLQAVLAQA MQTGGDDIDI
710 720 730 740 750
VDSHTNSLRS RLENIINANA NGGAGPGAGV AVGSSIPNVR NIKSSRGLPS
760 770 780
AASNLDSNRR PPTGRLPAKK PASAYPKARG LVNK
Length:784
Mass (Da):88,207
Last modified:December 12, 2006 - v2
Checksum:i7A3C6716D22BC05D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti220 – 2212SS → TC in AAA28658 (PubMed:1924306).Curated
Sequence conflicti338 – 3425ASRAK → VRGQV in AAA28658 (PubMed:1924306).Curated
Sequence conflicti338 – 3381A → G in AAA69929 (PubMed:7525600).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15974 mRNA. Translation: AAA69929.1.
AE014296 Genomic DNA. Translation: AAF50008.1.
AY051583 mRNA. Translation: AAK93007.1.
M74431 Genomic DNA. Translation: AAA28658.1.
PIRiA55236.
RefSeqiNP_001261726.1. NM_001274797.1.
NP_524029.2. NM_079305.3.
UniGeneiDm.2788.

Genome annotation databases

EnsemblMetazoaiFBtr0076030; FBpp0075762; FBgn0004381.
FBtr0332129; FBpp0304439; FBgn0004381.
GeneIDi39332.
KEGGidme:Dmel_CG7293.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15974 mRNA. Translation: AAA69929.1.
AE014296 Genomic DNA. Translation: AAF50008.1.
AY051583 mRNA. Translation: AAK93007.1.
M74431 Genomic DNA. Translation: AAA28658.1.
PIRiA55236.
RefSeqiNP_001261726.1. NM_001274797.1.
NP_524029.2. NM_079305.3.
UniGeneiDm.2788.

3D structure databases

ProteinModelPortaliP46867.
SMRiP46867. Positions 18-372.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi64693. 3 interactions.
IntActiP46867. 1 interaction.
MINTiMINT-964304.
STRINGi7227.FBpp0075762.

Proteomic databases

PaxDbiP46867.
PRIDEiP46867.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0076030; FBpp0075762; FBgn0004381.
FBtr0332129; FBpp0304439; FBgn0004381.
GeneIDi39332.
KEGGidme:Dmel_CG7293.

Organism-specific databases

CTDi39332.
FlyBaseiFBgn0004381. Klp68D.

Phylogenomic databases

eggNOGiKOG0240. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129680.
InParanoidiP46867.
KOiK20196.
OMAiTQTTLYH.
OrthoDBiEOG7WX086.
PhylomeDBiP46867.

Enzyme and pathway databases

ReactomeiR-DME-5620924. Intraflagellar transport.
R-DME-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-DME-983189. Kinesins.

Miscellaneous databases

GenomeRNAii39332.
PROiP46867.

Gene expression databases

BgeeiP46867.
ExpressionAtlasiP46867. differential.
GenevisibleiP46867. DM.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the KLP68D kinesin-like protein in Drosophila: possible roles in axonal transport."
    Pesavento P.A., Stewart R.J., Goldstein L.S.B.
    J. Cell Biol. 127:1041-1048(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Embryo.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Head.
  5. "Identification and partial characterization of six members of the kinesin superfamily in Drosophila."
    Stewart R.J., Pesavento P.A., Woerpel D.N., Goldstein L.S.B.
    Proc. Natl. Acad. Sci. U.S.A. 88:8470-8474(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 220-342.
    Strain: DP CN BW.

Entry informationi

Entry nameiKLP68_DROME
AccessioniPrimary (citable) accession number: P46867
Secondary accession number(s): Q961H5, Q9VTN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 12, 2006
Last modified: July 6, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.