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P46862

- PUNA_MYCLE

UniProt

P46862 - PUNA_MYCLE

Protein

Purine nucleoside phosphorylase

Gene

punA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine By similarity.By similarity

    Catalytic activityi

    Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. purine-nucleoside phosphorylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00606.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Purine nucleoside phosphorylase (EC:2.4.2.1)
    Short name:
    PNP
    Alternative name(s):
    Inosine phosphorylase
    Inosine-guanosine phosphorylase
    Gene namesi
    Name:punA
    Synonyms:deoD
    Ordered Locus Names:ML0707
    ORF Names:L308_F2_56
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML0707.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 268268Purine nucleoside phosphorylasePRO_0000184543Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Protein-protein interaction databases

    STRINGi272631.ML0707.

    Structurei

    3D structure databases

    ProteinModelPortaliP46862.
    SMRiP46862. Positions 7-268.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PNP/MTAP phosphorylase family.Curated

    Phylogenomic databases

    eggNOGiCOG0005.
    HOGENOMiHOG000045183.
    KOiK03783.
    OMAiTHFYEGR.
    OrthoDBiEOG6423M2.

    Family and domain databases

    Gene3Di3.40.50.1580. 1 hit.
    InterProiIPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR011269. PUNP.
    IPR011268. Purine_phosphorylase.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view]
    PANTHERiPTHR11904. PTHR11904. 1 hit.
    PTHR11904:SF9. PTHR11904:SF9. 1 hit.
    PfamiPF01048. PNP_UDP_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000477. PurNPase. 1 hit.
    SUPFAMiSSF53167. SSF53167. 1 hit.
    TIGRFAMsiTIGR01697. PNPH-PUNA-XAPA. 1 hit.
    TIGR01698. PUNP. 1 hit.
    PROSITEiPS01240. PNP_MTAP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P46862-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTYTLLDPDE LARRAAQVIG ERTGILKHDV AVVLGSGWSS AVAALGSSRA    50
    VFPQAELPGF ITPNAAGHTG ELLSVRIGAH RVLVLAGRIH PYEGHDLRHV 100
    VHPVRTACAA GARIIVLTNA AGGLRADMAV GQLVLISDHL NLTTRSPLVG 150
    THFVDLTNAY TTRLRKLASD TDPTLTEGVY AAQPGPHYET PAEIRMLRML 200
    GADLVGMSTV HETIAARAAG AEVLGVSLVT NLAAGITGKP LNHAEVLAAG 250
    TASANRIGSL LADIIARF 268
    Length:268
    Mass (Da):27,980
    Last modified:November 1, 1995 - v1
    Checksum:i46C622532FC96A0F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00022 Genomic DNA. Translation: AAA17341.1.
    AL583919 Genomic DNA. Translation: CAC30216.1.
    PIRiS73042.
    RefSeqiNP_301562.1. NC_002677.1.
    WP_010907886.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC30216; CAC30216; CAC30216.
    GeneIDi910380.
    KEGGimle:ML0707.
    PATRICi18052652. VBIMycLep78757_1272.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00022 Genomic DNA. Translation: AAA17341.1 .
    AL583919 Genomic DNA. Translation: CAC30216.1 .
    PIRi S73042.
    RefSeqi NP_301562.1. NC_002677.1.
    WP_010907886.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali P46862.
    SMRi P46862. Positions 7-268.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML0707.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC30216 ; CAC30216 ; CAC30216 .
    GeneIDi 910380.
    KEGGi mle:ML0707.
    PATRICi 18052652. VBIMycLep78757_1272.

    Organism-specific databases

    Lepromai ML0707.

    Phylogenomic databases

    eggNOGi COG0005.
    HOGENOMi HOG000045183.
    KOi K03783.
    OMAi THFYEGR.
    OrthoDBi EOG6423M2.

    Enzyme and pathway databases

    UniPathwayi UPA00606 .

    Family and domain databases

    Gene3Di 3.40.50.1580. 1 hit.
    InterProi IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR011269. PUNP.
    IPR011268. Purine_phosphorylase.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view ]
    PANTHERi PTHR11904. PTHR11904. 1 hit.
    PTHR11904:SF9. PTHR11904:SF9. 1 hit.
    Pfami PF01048. PNP_UDP_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000477. PurNPase. 1 hit.
    SUPFAMi SSF53167. SSF53167. 1 hit.
    TIGRFAMsi TIGR01697. PNPH-PUNA-XAPA. 1 hit.
    TIGR01698. PUNP. 1 hit.
    PROSITEi PS01240. PNP_MTAP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Smith D.R., Robison K.
      Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiPUNA_MYCLE
    AccessioniPrimary (citable) accession number: P46862
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3