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P46862 (PUNA_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Purine nucleoside phosphorylase

Short name=PNP
EC=2.4.2.1
Alternative name(s):
Inosine phosphorylase
Inosine-guanosine phosphorylase
Gene names
Name:punA
Synonyms:deoD
Ordered Locus Names:ML0707
ORF Names:L308_F2_56
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine By similarity.

Catalytic activity

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.

Pathway

Purine metabolism; purine nucleoside salvage.

Subunit structure

Homotrimer By similarity.

Sequence similarities

Belongs to the PNP/MTAP phosphorylase family.

Ontologies

Keywords
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processnucleoside metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionpurine-nucleoside phosphorylase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 268268Purine nucleoside phosphorylase
PRO_0000184543

Sequences

Sequence LengthMass (Da)Tools
P46862 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 46C622532FC96A0F

FASTA26827,980
        10         20         30         40         50         60 
MTYTLLDPDE LARRAAQVIG ERTGILKHDV AVVLGSGWSS AVAALGSSRA VFPQAELPGF 

        70         80         90        100        110        120 
ITPNAAGHTG ELLSVRIGAH RVLVLAGRIH PYEGHDLRHV VHPVRTACAA GARIIVLTNA 

       130        140        150        160        170        180 
AGGLRADMAV GQLVLISDHL NLTTRSPLVG THFVDLTNAY TTRLRKLASD TDPTLTEGVY 

       190        200        210        220        230        240 
AAQPGPHYET PAEIRMLRML GADLVGMSTV HETIAARAAG AEVLGVSLVT NLAAGITGKP 

       250        260 
LNHAEVLAAG TASANRIGSL LADIIARF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00022 Genomic DNA. Translation: AAA17341.1.
AL583919 Genomic DNA. Translation: CAC30216.1.
PIRS73042.
RefSeqNP_301562.1. NC_002677.1.

3D structure databases

ProteinModelPortalP46862.
SMRP46862. Positions 7-268.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML0707.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC30216; CAC30216; CAC30216.
GeneID910380.
KEGGmle:ML0707.
PATRIC18052652. VBIMycLep78757_1272.

Organism-specific databases

LepromaML0707.
CMRSearch...

Phylogenomic databases

eggNOGCOG0005.
HOGENOMHOG000045183.
KOK03783.
OMATHFYEGR.
OrthoDBEOG6423M2.

Enzyme and pathway databases

UniPathwayUPA00606.

Family and domain databases

Gene3D3.40.50.1580. 1 hit.
InterProIPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR011269. PUNP.
IPR011268. Purine_phosphorylase.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view]
PANTHERPTHR11904. PTHR11904. 1 hit.
PTHR11904:SF9. PTHR11904:SF9. 1 hit.
PfamPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
PIRSFPIRSF000477. PurNPase. 1 hit.
SUPFAMSSF53167. SSF53167. 1 hit.
TIGRFAMsTIGR01697. PNPH-PUNA-XAPA. 1 hit.
TIGR01698. PUNP. 1 hit.
PROSITEPS01240. PNP_MTAP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUNA_MYCLE
AccessionPrimary (citable) accession number: P46862
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways