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Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi417Magnesium 1By similarity1
Metal bindingi424Magnesium 1By similarity1
Metal bindingi424Magnesium 2By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligase (EC:6.1.1.6)
Alternative name(s):
Lysyl-tRNA synthetase
Short name:
LysRS
Gene namesi
Name:lysS
Ordered Locus Names:ML0233
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0233.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001526491 – 507Lysine--tRNA ligaseAdd BLAST507

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi272631.ML0233.

Structurei

3D structure databases

ProteinModelPortaliP46861.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CRK. Bacteria.
COG1190. LUCA.
HOGENOMiHOG000236578.
KOiK04567.
OMAiHHNTLDI.
OrthoDBiPOG091H0098.

Family and domain databases

HAMAPiMF_00252. Lys_tRNA_synth_class2. 1 hit.
InterProiIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR002313. Lys-tRNA-ligase_II.
IPR018149. Lys-tRNA-synth_II_C.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PANTHERiPTHR22594. PTHR22594. 1 hit.
PfamiPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
PRINTSiPR00982. TRNASYNTHLYS.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00499. lysS_bact. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNADPLETDA ALPEQFRIRR DKRARLLAEG RDPYPVAIER THTLAEVRAA
60 70 80 90 100
YPDLATDSAT DDIVGIAGRV IFARNSGKLC FATLQDGDGT NLQVMISLNK
110 120 130 140 150
VGSETLDAWK VDVDLGDIVY VHGNVISSRS GELSVLADSW QMVSKSLRPL
160 170 180 190 200
PVAHKEMSEE SRVRQRYVDL IVCPQVRIVA HQRIAVIRAI RTALERRGFL
210 220 230 240 250
EVETPMLQTL AGGAAARPFV THSNALDIDL YLRIAPELFL KRCIVGGFDK
260 270 280 290 300
VFELNRVFRN EGADSTHSPE FSMLETYQTY GTYDDSAVVT REIIQEVADE
310 320 330 340 350
AIGTRQLQMP DDSVYDIDGE WETIQMYPSL SAVLGEEITP QTSVDRLRAI
360 370 380 390 400
ADRLGRGIGP EILDKPSYGH GRLVEQLWEY TVGNTLSAPT FVKDFPVETT
410 420 430 440 450
PLTRQHRSIP GVTEKWDLYL RGVELATGYS ELNDPVVQRE RFGQQVRAAA
460 470 480 490 500
AEEDEAMALD EEFLAALEYA MPPCTGTGMG IDRLLMSLTG LSIRETVLFP

IVRPHSN
Length:507
Mass (Da):56,421
Last modified:April 27, 2001 - v2
Checksum:i52BF33D6287C96B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583917 Genomic DNA. Translation: CAC29741.1.
M67510 Genomic DNA. Translation: AAA25350.1.
PIRiA43601.
A86938.
RefSeqiNP_301293.1. NC_002677.1.
WP_010907617.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29741; CAC29741; CAC29741.
GeneIDi908650.
KEGGimle:ML0233.
PATRICi18050830. VBIMycLep78757_0366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583917 Genomic DNA. Translation: CAC29741.1.
M67510 Genomic DNA. Translation: AAA25350.1.
PIRiA43601.
A86938.
RefSeqiNP_301293.1. NC_002677.1.
WP_010907617.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP46861.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0233.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC29741; CAC29741; CAC29741.
GeneIDi908650.
KEGGimle:ML0233.
PATRICi18050830. VBIMycLep78757_0366.

Organism-specific databases

LepromaiML0233.

Phylogenomic databases

eggNOGiENOG4105CRK. Bacteria.
COG1190. LUCA.
HOGENOMiHOG000236578.
KOiK04567.
OMAiHHNTLDI.
OrthoDBiPOG091H0098.

Family and domain databases

HAMAPiMF_00252. Lys_tRNA_synth_class2. 1 hit.
InterProiIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR002313. Lys-tRNA-ligase_II.
IPR018149. Lys-tRNA-synth_II_C.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PANTHERiPTHR22594. PTHR22594. 1 hit.
PfamiPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
PRINTSiPR00982. TRNASYNTHLYS.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00499. lysS_bact. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYK_MYCLE
AccessioniPrimary (citable) accession number: P46861
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 27, 2001
Last modified: October 5, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.