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Protein

DNA utilization protein YhgH

Gene

gntX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for the use of extracellular DNA as a nutrient (PubMed:16707682). Has been suggested to be involved in gluconate metabolism (PubMed:9871335).1 Publication1 Publication

GO - Biological processi

  • carbon utilization Source: EcoCyc
  • DNA catabolic process Source: EcoCyc
  • nucleoside metabolic process Source: InterPro

Enzyme and pathway databases

BioCyciEcoCyc:G7747-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA utilization protein YhgH1 Publication
Alternative name(s):
Protein GntX
Gene namesi
Name:gntX1 Publication
Synonyms:yhgH
Ordered Locus Names:b3413, JW5691
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12934. gntX.

Pathology & Biotechi

Disruption phenotypei

Mutants are unable to use DNA as a sole carbon and energy source and show decreased competitive fitness when cocultured with wild-type cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002094581 – 227DNA utilization protein YhgHAdd BLAST227

Proteomic databases

PaxDbiP46846.
PRIDEiP46846.

Interactioni

Protein-protein interaction databases

BioGridi4261222. 7 interactors.
STRINGi316385.ECDH10B_3588.

Structurei

3D structure databases

ProteinModelPortaliP46846.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi8 – 54Cys-richAdd BLAST47

Sequence similaritiesi

Belongs to the ComF/GntX family.Curated

Phylogenomic databases

eggNOGiENOG4105MJ2. Bacteria.
COG1040. LUCA.
HOGENOMiHOG000075042.
InParanoidiP46846.
PhylomeDBiP46846.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
InterProiView protein in InterPro
IPR005222. Competence_ComF.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
PfamiView protein in Pfam
PF00156. Pribosyltran. 1 hit.
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR00201. comF. 1 hit.

Sequencei

Sequence statusi: Complete.

P46846-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTVPGLCWL CRMPLALGHW GICSVCSRAT RTDKTLCPQC GLPATHSHLP
60 70 80 90 100
CGRCLQKPPP WQRLVTVADY APPLSPLIHQ LKFSRRSEIA SALSRLLLLE
110 120 130 140 150
VLHARRTTGL QLPDRIVSVP LWQRRHWRRG FNQSDLLCQP LSRWLHCQWD
160 170 180 190 200
SEAVTRTRAT ATQHFLSARL RKRNLKNAFR LELPVQGRHM VIVDDVVTTG
210 220
STVAEIAQLL LRNGAAAVQV WCLCRTL
Length:227
Mass (Da):25,726
Last modified:July 15, 1999 - v2
Checksum:iBA8768610CDA03BE
GO

Sequence cautioni

The sequence AAA58211 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58211.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76438.2.
AP009048 Genomic DNA. Translation: BAE77878.1.
PIRiH65136.
RefSeqiNP_417872.2. NC_000913.3.
WP_001333371.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76438; AAC76438; b3413.
BAE77878; BAE77878; BAE77878.
GeneIDi947915.
KEGGiecj:JW5691.
eco:b3413.
PATRICifig|1411691.4.peg.3315.

Similar proteinsi

Entry informationi

Entry nameiGNTX_ECOLI
AccessioniPrimary (citable) accession number: P46846
Secondary accession number(s): Q2M778
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 15, 1999
Last modified: August 30, 2017
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families