Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cation-transporting P-type ATPase B

Gene

ctpB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi28 – 281PROSITE-ProRule annotation
Metal bindingi31 – 311PROSITE-ProRule annotation
Active sitei445 – 44514-aspartylphosphate intermediateCurated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cation-transporting P-type ATPase B (EC:3.6.3.-)
Gene namesi
Name:ctpB
Ordered Locus Names:ML2000
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML2000.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei104 – 12421HelicalSequence analysisAdd
BLAST
Transmembranei129 – 14921HelicalSequence analysisAdd
BLAST
Transmembranei167 – 18721HelicalSequence analysisAdd
BLAST
Transmembranei200 – 22021HelicalSequence analysisAdd
BLAST
Transmembranei360 – 38021HelicalSequence analysisAdd
BLAST
Transmembranei389 – 40921HelicalSequence analysisAdd
BLAST
Transmembranei471 – 49121HelicalSequence analysisAdd
BLAST
Transmembranei500 – 52021HelicalSequence analysisAdd
BLAST
Transmembranei547 – 56721HelicalSequence analysisAdd
BLAST
Transmembranei663 – 68321HelicalSequence analysisAdd
BLAST
Transmembranei693 – 71321HelicalSequence analysisAdd
BLAST
Transmembranei715 – 73521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 750750Cation-transporting P-type ATPase BPRO_0000046167Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi272631.ML2000.

Structurei

3D structure databases

ProteinModelPortaliP46840.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 8164HMAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HMA domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C59. Bacteria.
COG2217. LUCA.
HOGENOMiHOG000250397.
KOiK12949.
OMAiIHHDEVE.
OrthoDBiEOG6742RM.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR000579. Cation-trans_P-type_ATPase_A/B.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
[Graphical view]
PRINTSiPR00940. CATPATPASEA.
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46840-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTASLVEDTN NNHESVRRIQ LDVAGMLCAA CASRVETKLN KIPGVRASVN
60 70 80 90 100
FATRVATIDA VDVAVDELRQ VIEQAGYRAT AHAESAVEEI DPDADYARNL
110 120 130 140 150
LRRLIVAALL FVPLADLSTM FAIVPTNRFP GWGYLLTALA APIVTWAAWP
160 170 180 190 200
FHRVALRNAR YRAASMETLI SAGILAATGW SLSTIFVDKE PRQTHGIWQA
210 220 230 240 250
ILHSDSIYFE VAAGVTVFVL AGRFFEARAK SKAGSALRAL AARGAKNVEV
260 270 280 290 300
LLPNGAELTI PAGELKKQQH FLVRPGETIT ADGVVIDGTA TIDMSAITGE
310 320 330 340 350
ARPVHASPAS TVVGGTTVLD GRLVIEATAV GGDTQFAAMV RLVEDAQVQK
360 370 380 390 400
ARVQHLADRI AAVFVPMVFV IAGLAGASWL LAGASPDRAF SVVLGVLVIA
410 420 430 440 450
CPCTLGLATP TAMMVASGRG AQLGIFIKGY RALETINAID TVVFDKTGTL
460 470 480 490 500
TLGQLSVSTV TSTGGWCSGE VLALASAVEA ASEHSVATAI VAAYADPRPV
510 520 530 540 550
ADFVAFAGCG VSGVVAEHHV KIGKPSWVTR NAPCDVVLES ARREGESRGE
560 570 580 590 600
TVVFVSVDGV ACGAVAIADT VKDSAADAIS ALCSRGLHTI LLTGDNQAAA
610 620 630 640 650
RAVAAQVGID TVIADMLPEA KVDVIQRLRD QGHTVAMVGD GINDGPALAC
660 670 680 690 700
ADLGLAMGRG TDVAIGAADL ILVRDSLGVV PVALDLARAT MRTIRINMIW
710 720 730 740 750
AFGYNVAAIP IASSGLLNPL IAGAAMAFSS FFVVSNSLRL SNFGLSQTSD
Length:750
Mass (Da):78,101
Last modified:April 27, 2001 - v2
Checksum:i1D58477D4A69B00D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti544 – 5485EGESR → RRRIT in CAA86363 (PubMed:7476188).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46257 Genomic DNA. Translation: CAA86363.1.
AL583924 Genomic DNA. Translation: CAC30955.1.
PIRiC87159.
S77653.
RefSeqiNP_302350.1. NC_002677.1.
WP_010908670.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30955; CAC30955; CAC30955.
GeneIDi909077.
KEGGimle:ML2000.
PATRICi18057672. VBIMycLep78757_3760.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46257 Genomic DNA. Translation: CAA86363.1.
AL583924 Genomic DNA. Translation: CAC30955.1.
PIRiC87159.
S77653.
RefSeqiNP_302350.1. NC_002677.1.
WP_010908670.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP46840.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML2000.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30955; CAC30955; CAC30955.
GeneIDi909077.
KEGGimle:ML2000.
PATRICi18057672. VBIMycLep78757_3760.

Organism-specific databases

LepromaiML2000.

Phylogenomic databases

eggNOGiENOG4105C59. Bacteria.
COG2217. LUCA.
HOGENOMiHOG000250397.
KOiK12949.
OMAiIHHDEVE.
OrthoDBiEOG6742RM.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR000579. Cation-trans_P-type_ATPase_A/B.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
[Graphical view]
PRINTSiPR00940. CATPATPASEA.
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Mycobacterium leprae genome: systematic sequence analysis identifies key catabolic enzymes, ATP-dependent transport systems and a novel polA locus associated with genomic variability."
    Fsihi H., Cole S.T.
    Mol. Microbiol. 16:909-919(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiCTPB_MYCLE
AccessioniPrimary (citable) accession number: P46840
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 27, 2001
Last modified: April 13, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.