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Protein

Cation-transporting P-type ATPase A

Gene

ctpA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi13 – 131PROSITE-ProRule annotation
Metal bindingi16 – 161PROSITE-ProRule annotation
Active sitei430 – 43014-aspartylphosphate intermediateBy similarity
Metal bindingi624 – 6241MagnesiumPROSITE-ProRule annotation
Metal bindingi628 – 6281MagnesiumPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cation-transporting P-type ATPase A (EC:3.6.3.-)
Gene namesi
Name:ctpA
Ordered Locus Names:ML1987
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1987.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8888CytoplasmicSequence analysisAdd
BLAST
Transmembranei89 – 11022HelicalSequence analysisAdd
BLAST
Topological domaini111 – 1199ExtracellularSequence analysis
Transmembranei120 – 13920HelicalSequence analysisAdd
BLAST
Topological domaini140 – 1467CytoplasmicSequence analysis
Transmembranei147 – 16721HelicalSequence analysisAdd
BLAST
Topological domaini168 – 19427ExtracellularSequence analysisAdd
BLAST
Transmembranei195 – 21521HelicalSequence analysisAdd
BLAST
Topological domaini216 – 344129CytoplasmicSequence analysisAdd
BLAST
Transmembranei345 – 36723HelicalSequence analysisAdd
BLAST
Topological domaini368 – 3747ExtracellularSequence analysis
Transmembranei375 – 39218HelicalSequence analysisAdd
BLAST
Topological domaini393 – 678286CytoplasmicSequence analysisAdd
BLAST
Transmembranei679 – 69820HelicalSequence analysisAdd
BLAST
Topological domaini699 – 7035ExtracellularSequence analysis
Transmembranei704 – 72219HelicalSequence analysisAdd
BLAST
Topological domaini723 – 78058CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 780780Cation-transporting P-type ATPase APRO_0000046164Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1987.

Structurei

3D structure databases

ProteinModelPortaliP46839.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 6866HMAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HMA domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2217. LUCA.
HOGENOMiHOG000250397.
OrthoDBiEOG6742RM.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR000579. Cation-trans_P-type_ATPase_A/B.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00940. CATPATPASEA.
SUPFAMiSSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46839-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRIQLNITG MSCSCCAPNG WNNLPNKLSD FSTLVNSATR VAAINLSEVT
60 70 80 90 100
QTAEVCEAVR RAALCTDGGE ALQRRQADAD NARYLLIRLA VAAALFVPLA
110 120 130 140 150
HLSVMFAVLP STHFPGWEWM LTALAIPVVT WAAWPFHRVA IHNARYHGAS
160 170 180 190 200
METLISTGIT AATIWSLYTV FGHHQSTEHR GVWRALLGSD AIYFEVAAGI
210 220 230 240 250
TVFVLAGKYY TARAKSHASI ALLALAALSA KDAAVLQPDG SEMVIPANEL
260 270 280 290 300
NEQQRFVVRP GQTIAADGLV IDGSATVSMS PITGEAKPVR VNPGAQVIGG
310 320 330 340 350
TVVLNGRLIV EAAAVGDETQ LAGMVRLVEQ AQQQNANAQR LADRIASVFV
360 370 380 390 400
PCVFAVAALT AVGWLIAGSG PDRVFSAAIA VLVIACPCAL GLATPTAMMV
410 420 430 440 450
ASGRGAQLGI LLKGHESFEA TRAVDTVVFD KTGTLTTGQL KVSAVTAAPG
460 470 480 490 500
WQANEVLQMA ATVESASEHA VALAIAASTT HREPVANFRA VPGHGVSGTV
510 520 530 540 550
AERAVRVGKP SWIASRCNST TLVTARRNAE LRGETAVFVE IDGEQCGVIA
560 570 580 590 600
VADAVKASAA DAVAALHDRG FRTALLTGDN PASAAAVASR IGIDEVIADI
610 620 630 640 650
LPEDKVDVIE QLRDRGHVVA MVGDGINDGP ALARADLGMA IGRGTDVAIG
660 670 680 690 700
AADIILVRDN LDVVPITLDL AAATMRTIKF NMVWAFGYNI AAIPIAAAGL
710 720 730 740 750
LNPLVAGAAM AFSSFFVVSN SLRLRNFGAI LSCGTSRHRT VKRWRCPPPT
760 770 780
RLRSTACSPV DASPLRPVAH RTGVKPPTHR
Length:780
Mass (Da):81,791
Last modified:April 27, 2001 - v2
Checksum:iBCA853E957F15C78
GO

Sequence cautioni

The sequence CAA86358.1 differs from that shown. Reason: Frameshift at positions 43, 57, 360 and 377. Curated
The sequence CAC30942.1 differs from that shown. Reason: Frameshift at position 16. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46257 Genomic DNA. Translation: CAA86358.1. Frameshift.
AL583924 Genomic DNA. Translation: CAC30942.1. Frameshift.
PIRiF87157.
S77652.
RefSeqiWP_010908658.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30942; CAC30942; CAC30942.
PATRICi18057644. VBIMycLep78757_3746.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46257 Genomic DNA. Translation: CAA86358.1. Frameshift.
AL583924 Genomic DNA. Translation: CAC30942.1. Frameshift.
PIRiF87157.
S77652.
RefSeqiWP_010908658.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP46839.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1987.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30942; CAC30942; CAC30942.
PATRICi18057644. VBIMycLep78757_3746.

Organism-specific databases

LepromaiML1987.

Phylogenomic databases

eggNOGiCOG2217. LUCA.
HOGENOMiHOG000250397.
OrthoDBiEOG6742RM.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR000579. Cation-trans_P-type_ATPase_A/B.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00940. CATPATPASEA.
SUPFAMiSSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Mycobacterium leprae genome: systematic sequence analysis identifies key catabolic enzymes, ATP-dependent transport systems and a novel polA locus associated with genomic variability."
    Fsihi H., Cole S.T.
    Mol. Microbiol. 16:909-919(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiCTPA_MYCLE
AccessioniPrimary (citable) accession number: P46839
Secondary accession number(s): Q9CBG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 27, 2001
Last modified: April 13, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.