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Protein

30S ribosomal protein S1

Gene

rpsA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
30S ribosomal protein S1
Gene namesi
Name:rpsA
Ordered Locus Names:ML1382
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1382.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001960411 – 48130S ribosomal protein S1Add BLAST481

Proteomic databases

PRIDEiP46836.

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1382.

Structurei

Secondary structure

1481
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi283 – 290Combined sources8
Beta strandi296 – 305Combined sources10
Beta strandi308 – 314Combined sources7
Beta strandi317 – 322Combined sources6
Helixi323 – 326Combined sources4
Helixi334 – 336Combined sources3
Beta strandi342 – 352Combined sources11
Turni353 – 356Combined sources4
Beta strandi357 – 361Combined sources5
Helixi362 – 367Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IE8NMR-A280-368[»]
ProteinModelPortaliP46836.
SMRiP46836.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 105S1 motif 1PROSITE-ProRule annotationAdd BLAST70
Domaini123 – 188S1 motif 2PROSITE-ProRule annotationAdd BLAST66
Domaini209 – 277S1 motif 3PROSITE-ProRule annotationAdd BLAST69
Domaini294 – 363S1 motif 4PROSITE-ProRule annotationAdd BLAST70

Sequence similaritiesi

Belongs to the ribosomal protein S1P family.Curated
Contains 4 S1 motif domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105CAV. Bacteria.
COG0539. LUCA.
HOGENOMiHOG000044053.
KOiK02945.
OMAiQEDPWQT.
OrthoDBiPOG091H01DI.

Family and domain databases

InterProiIPR012340. NA-bd_OB-fold.
IPR000110. Ribosomal_S1.
IPR022967. S1_dom.
IPR003029. S1_domain.
[Graphical view]
PfamiPF00575. S1. 4 hits.
[Graphical view]
PRINTSiPR00681. RIBOSOMALS1.
SMARTiSM00316. S1. 4 hits.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 4 hits.
PROSITEiPS50126. S1. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46836-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIPAVPSPQ IAVNDVGSSE DFLAAIDKTI KYFNDGDIVE GTIVKVDRDE
60 70 80 90 100
VLLDIGYKTE GVIPARELSI KHDVDPNEVV SVGDEVEALV LTKEDKEGRL
110 120 130 140 150
ILSKKRAQYE RAWGTIEALK EKDEAVKGIV IEVVKGGLIL DIGLRGFLPA
160 170 180 190 200
SLVEMRRVRD LQPYIGKEIE AKIIELDKNR NNVVLSRRAW LEQTQSEVRS
210 220 230 240 250
EFLNQLQKGA IRKGVVSSIV NFGAFVDLGG VDGLVHVSEL SWKHIDHPSE
260 270 280 290 300
VVQVGNEVTV EVLDVDMDRE RVSLSLKATQ EDPWRHFART HAIGQIVPGK
310 320 330 340 350
VTKLVPFGAF VRVEEGIEGL VHISELAERH VEVPDQVVAV GDDAMVKVID
360 370 380 390 400
IDLERRRISL SLKQANEDYI EEFDPAKYGM ADSYDEQGNY IFPEGFDPDS
410 420 430 440 450
NEWLEGFDTQ RAEWEARYAE AERRYKMHTI QMEKFAATEE AGHGSSEQPP
460 470 480
ASSTPSAKAT GGSLASDAQL AALREKLAGS A
Length:481
Mass (Da):53,279
Last modified:April 27, 2001 - v2
Checksum:i4F955F6D8EA8E09B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti224 – 228AFVDL → CVCRS in CAA86365 (PubMed:7476188).Curated5
Sequence conflicti364 – 393QANED…NYIFP → ADQRGLHRGVRPGKVRYGPT ATTSRATTSSL in CAA86365 (PubMed:7476188).CuratedAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46257 Genomic DNA. Translation: CAA86365.1.
AL583921 Genomic DNA. Translation: CAC31763.1.
PIRiH87081.
S77660.
RefSeqiNP_301983.1. NC_002677.1.
WP_010908304.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31763; CAC31763; CAC31763.
GeneIDi910498.
KEGGimle:ML1382.
PATRICi18055264. VBIMycLep78757_2565.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46257 Genomic DNA. Translation: CAA86365.1.
AL583921 Genomic DNA. Translation: CAC31763.1.
PIRiH87081.
S77660.
RefSeqiNP_301983.1. NC_002677.1.
WP_010908304.1. NC_002677.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IE8NMR-A280-368[»]
ProteinModelPortaliP46836.
SMRiP46836.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1382.

Proteomic databases

PRIDEiP46836.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31763; CAC31763; CAC31763.
GeneIDi910498.
KEGGimle:ML1382.
PATRICi18055264. VBIMycLep78757_2565.

Organism-specific databases

LepromaiML1382.

Phylogenomic databases

eggNOGiENOG4105CAV. Bacteria.
COG0539. LUCA.
HOGENOMiHOG000044053.
KOiK02945.
OMAiQEDPWQT.
OrthoDBiPOG091H01DI.

Family and domain databases

InterProiIPR012340. NA-bd_OB-fold.
IPR000110. Ribosomal_S1.
IPR022967. S1_dom.
IPR003029. S1_domain.
[Graphical view]
PfamiPF00575. S1. 4 hits.
[Graphical view]
PRINTSiPR00681. RIBOSOMALS1.
SMARTiSM00316. S1. 4 hits.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 4 hits.
PROSITEiPS50126. S1. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS1_MYCLE
AccessioniPrimary (citable) accession number: P46836
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 27, 2001
Last modified: November 2, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.