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Protein

DNA polymerase I

Gene

polA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA replication

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-1518-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase I (EC:2.7.7.7)
Short name:
POL I
Gene namesi
Name:polA
Ordered Locus Names:ML1381
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1381

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001012461 – 911DNA polymerase IAdd BLAST911

Proteomic databases

PRIDEiP46835

Interactioni

Subunit structurei

Single-chain monomer with multiple functions.

Protein-protein interaction databases

STRINGi272631.ML1381

Structurei

3D structure databases

ProteinModelPortaliP46835
SMRiP46835
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 2805'-3' exonucleaseSequence analysisAdd BLAST95
Domaini320 – 4973'-5' exonucleaseSequence analysisAdd BLAST178

Sequence similaritiesi

Belongs to the DNA polymerase type-A family.Curated

Phylogenomic databases

eggNOGiENOG4105C2M Bacteria
COG0258 LUCA
COG0749 LUCA
HOGENOMiHOG000020997
KOiK02335
OMAiETGRVHT
OrthoDBiPOG091H00PR

Family and domain databases

CDDicd09898 H3TH_53EXO, 1 hit
Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR002562 3'-5'_exonuclease_dom
IPR020046 5-3_exonucl_a-hlix_arch_N
IPR036279 5-3_exonuclease_C_sf
IPR002421 5-3_exonuclease_N
IPR019760 DNA-dir_DNA_pol_A_CS
IPR001098 DNA-dir_DNA_pol_A_palm_dom
IPR020045 DNA_polI_H3TH
IPR018320 DNA_polymerase_1
IPR002298 DNA_polymerase_A
IPR008918 HhH2
IPR029060 PIN-like_dom_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PANTHERiPTHR10133 PTHR10133, 1 hit
PfamiView protein in Pfam
PF01367 5_3_exonuc, 1 hit
PF02739 5_3_exonuc_N, 1 hit
PF00476 DNA_pol_A, 1 hit
PRINTSiPR00868 DNAPOLI
SMARTiView protein in SMART
SM00474 35EXOc, 1 hit
SM00475 53EXOc, 1 hit
SM00279 HhH2, 1 hit
SM00482 POLAc, 1 hit
SUPFAMiSSF47807 SSF47807, 1 hit
SSF53098 SSF53098, 1 hit
SSF88723 SSF88723, 1 hit
TIGRFAMsiTIGR00593 pola, 1 hit
PROSITEiView protein in PROSITE
PS00447 DNA_POLYMERASE_A, 1 hit

Sequencei

Sequence statusi: Complete.

P46835-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAMTAEVC EDHTKPMLML LDGNSLAFRA FYALPTENFK TRGGLTTNAV
60 70 80 90 100
YGFTAMLINL LREEAPTHIA AAFDVSRKTF RSECYAGYKA NRSSIPAEFH
110 120 130 140 150
GQIDITKEVL GALGITVFAE AGFEADDLIA TLATQAENEG YRVLVVTGDR
160 170 180 190 200
DALQLVSNDV TVLYPRKGVS ELTRFTPEAV IEKYGVTPAQ YPDLAALRGD
210 220 230 240 250
PSDNLPGIPG VGEKTAAKWI VDYGSLQGLV DNVESVRGKV GEALRTHLAS
260 270 280 290 300
VVRNRELTEL VKDVPLVQTS DTLRLQPWDR DRIHRLFDNL EFRVLRDRLF
310 320 330 340 350
EALAAAGERV PEVDEGFDVR GGLLESGTVG RWLAKHADDG RRSGLAIVGT
360 370 380 390 400
HLPHGGDATA LAVAAADGNG GYIDTAMLTP DDDDALAAWL ADPDNPKALH
410 420 430 440 450
EAKLAMHDLA GRGWTLGGIT SDTALAAYLV RPGQRSFTLD DLSLRYLRRE
460 470 480 490 500
LRAETPEQEQ FSLLDNVDEV DKQAIQTLIL RARAVVDLAA ALDAELDLID
510 520 530 540 550
STSLLGEMEL PVQQVLADME KAGIAADLRL LTELQSQFGD QIRDAAEAAY
560 570 580 590 600
AVIGKQINLS SPKQLQVVLF EELGMPKTKR TKTGYTTDAD ALQSLFCKTE
610 620 630 640 650
HPFLQHLLTH RDVTRLKVTV DGLLNAVAAD GRIHTTFNQT IATTGRLSST
660 670 680 690 700
EPNLQNIPIR TNAGRQIRDA FVVGSENNGY TELMTADYSQ IEMRIMAHLS
710 720 730 740 750
RDEGLIEAFH TGEDLHSFVA SRAFGIPIED ITPELRRRVK AMSYGLAYGL
760 770 780 790 800
SAYGLATQLK ISTEEAKLQM EQYFARFGGV RDYLMDVVEQ ARKDGYTSTV
810 820 830 840 850
LGRRRYLPEL DSSNRQIREA AERAALNAPI QGSAADIIKV AMIAVDKSLK
860 870 880 890 900
QAKLASRMLL QVHDELLFEV AIGEREQIEA MVREQMGSAY PLDVPLEVSV
910
GFGRSWGAAA H
Length:911
Mass (Da):99,792
Last modified:November 1, 1995 - v1
Checksum:i12B4EA18B2BC9864
GO

Sequence cautioni

The sequence AAA50927 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46257 Genomic DNA Translation: CAA86364.1
U00021 Genomic DNA Translation: AAA50927.1 Different initiation.
AL583921 Genomic DNA Translation: CAC31762.1
PIRiS77659
RefSeqiNP_301982.1, NC_002677.1
WP_010908303.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC31762; CAC31762; CAC31762
GeneIDi910507
KEGGimle:ML1381
PATRICifig|272631.5.peg.2560

Similar proteinsi

Entry informationi

Entry nameiDPO1_MYCLE
AccessioniPrimary (citable) accession number: P46835
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health