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Protein

DNA polymerase I

Gene

polA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity.By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA damage, DNA repair, DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase I (EC:2.7.7.7)
Short name:
POL I
Gene namesi
Name:polA
Ordered Locus Names:ML1381
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1381.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 911911DNA polymerase IPRO_0000101246Add
BLAST

Interactioni

Subunit structurei

Single-chain monomer with multiple functions.

Protein-protein interaction databases

STRINGi272631.ML1381.

Structurei

3D structure databases

ProteinModelPortaliP46835.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA polymerase type-A family.Curated
Contains 1 3'-5' exonuclease domain.Curated
Contains 1 5'-3' exonuclease domain.Curated

Phylogenomic databases

eggNOGiENOG4105C2M. Bacteria.
COG0258. LUCA.
COG0749. LUCA.
HOGENOMiHOG000020997.
KOiK02335.
OMAiCFDTETT.
OrthoDBiPOG091H00PR.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.40.50.1010. 1 hit.
InterProiIPR002562. 3'-5'_exonuclease_dom.
IPR020046. 5-3_exonucl_a-hlix_arch_N.
IPR020045. 5-3_exonuclease_C.
IPR002421. 5-3_exonuclease_N.
IPR019760. DNA-dir_DNA_pol_A_CS.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR018320. DNA_polymerase_1.
IPR002298. DNA_polymerase_A.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF01367. 5_3_exonuc. 1 hit.
PF02739. 5_3_exonuc_N. 1 hit.
PF00476. DNA_pol_A. 1 hit.
[Graphical view]
PRINTSiPR00868. DNAPOLI.
SMARTiSM00474. 35EXOc. 1 hit.
SM00475. 53EXOc. 1 hit.
SM00279. HhH2. 1 hit.
SM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF88723. SSF88723. 1 hit.
TIGRFAMsiTIGR00593. pola. 1 hit.
PROSITEiPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46835-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAMTAEVC EDHTKPMLML LDGNSLAFRA FYALPTENFK TRGGLTTNAV
60 70 80 90 100
YGFTAMLINL LREEAPTHIA AAFDVSRKTF RSECYAGYKA NRSSIPAEFH
110 120 130 140 150
GQIDITKEVL GALGITVFAE AGFEADDLIA TLATQAENEG YRVLVVTGDR
160 170 180 190 200
DALQLVSNDV TVLYPRKGVS ELTRFTPEAV IEKYGVTPAQ YPDLAALRGD
210 220 230 240 250
PSDNLPGIPG VGEKTAAKWI VDYGSLQGLV DNVESVRGKV GEALRTHLAS
260 270 280 290 300
VVRNRELTEL VKDVPLVQTS DTLRLQPWDR DRIHRLFDNL EFRVLRDRLF
310 320 330 340 350
EALAAAGERV PEVDEGFDVR GGLLESGTVG RWLAKHADDG RRSGLAIVGT
360 370 380 390 400
HLPHGGDATA LAVAAADGNG GYIDTAMLTP DDDDALAAWL ADPDNPKALH
410 420 430 440 450
EAKLAMHDLA GRGWTLGGIT SDTALAAYLV RPGQRSFTLD DLSLRYLRRE
460 470 480 490 500
LRAETPEQEQ FSLLDNVDEV DKQAIQTLIL RARAVVDLAA ALDAELDLID
510 520 530 540 550
STSLLGEMEL PVQQVLADME KAGIAADLRL LTELQSQFGD QIRDAAEAAY
560 570 580 590 600
AVIGKQINLS SPKQLQVVLF EELGMPKTKR TKTGYTTDAD ALQSLFCKTE
610 620 630 640 650
HPFLQHLLTH RDVTRLKVTV DGLLNAVAAD GRIHTTFNQT IATTGRLSST
660 670 680 690 700
EPNLQNIPIR TNAGRQIRDA FVVGSENNGY TELMTADYSQ IEMRIMAHLS
710 720 730 740 750
RDEGLIEAFH TGEDLHSFVA SRAFGIPIED ITPELRRRVK AMSYGLAYGL
760 770 780 790 800
SAYGLATQLK ISTEEAKLQM EQYFARFGGV RDYLMDVVEQ ARKDGYTSTV
810 820 830 840 850
LGRRRYLPEL DSSNRQIREA AERAALNAPI QGSAADIIKV AMIAVDKSLK
860 870 880 890 900
QAKLASRMLL QVHDELLFEV AIGEREQIEA MVREQMGSAY PLDVPLEVSV
910
GFGRSWGAAA H
Length:911
Mass (Da):99,792
Last modified:November 1, 1995 - v1
Checksum:i12B4EA18B2BC9864
GO

Sequence cautioni

The sequence AAA50927 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46257 Genomic DNA. Translation: CAA86364.1.
U00021 Genomic DNA. Translation: AAA50927.1. Different initiation.
AL583921 Genomic DNA. Translation: CAC31762.1.
PIRiS77659.
RefSeqiNP_301982.1. NC_002677.1.
WP_010908303.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31762; CAC31762; CAC31762.
GeneIDi910507.
KEGGimle:ML1381.
PATRICi18055254. VBIMycLep78757_2560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46257 Genomic DNA. Translation: CAA86364.1.
U00021 Genomic DNA. Translation: AAA50927.1. Different initiation.
AL583921 Genomic DNA. Translation: CAC31762.1.
PIRiS77659.
RefSeqiNP_301982.1. NC_002677.1.
WP_010908303.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP46835.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1381.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31762; CAC31762; CAC31762.
GeneIDi910507.
KEGGimle:ML1381.
PATRICi18055254. VBIMycLep78757_2560.

Organism-specific databases

LepromaiML1381.

Phylogenomic databases

eggNOGiENOG4105C2M. Bacteria.
COG0258. LUCA.
COG0749. LUCA.
HOGENOMiHOG000020997.
KOiK02335.
OMAiCFDTETT.
OrthoDBiPOG091H00PR.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.40.50.1010. 1 hit.
InterProiIPR002562. 3'-5'_exonuclease_dom.
IPR020046. 5-3_exonucl_a-hlix_arch_N.
IPR020045. 5-3_exonuclease_C.
IPR002421. 5-3_exonuclease_N.
IPR019760. DNA-dir_DNA_pol_A_CS.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR018320. DNA_polymerase_1.
IPR002298. DNA_polymerase_A.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF01367. 5_3_exonuc. 1 hit.
PF02739. 5_3_exonuc_N. 1 hit.
PF00476. DNA_pol_A. 1 hit.
[Graphical view]
PRINTSiPR00868. DNAPOLI.
SMARTiSM00474. 35EXOc. 1 hit.
SM00475. 53EXOc. 1 hit.
SM00279. HhH2. 1 hit.
SM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF88723. SSF88723. 1 hit.
TIGRFAMsiTIGR00593. pola. 1 hit.
PROSITEiPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPO1_MYCLE
AccessioniPrimary (citable) accession number: P46835
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.